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J Pineal Res January 2021 PMID 33125735

The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice.

Hikaru Iwashita, Yukihisa Matsumoto, Yusuke Maruyama, Kazuki Watanabe, Atsuhiko Chiba, Atsuhiko Hattori

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Mentions

56
Peak: 13 in Dec 2020
across 4 sources since Nov 2020

Extended reach

121,594
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171

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855

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Nov 2020 – Jun 2024

Where it's discussed

  • X / Twitter33 posts
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AI synopsis

What people are saying

The collective discussions reflect strong support and fascination with the research, with examples like mentions of the study’s implications, references to related scientific work, and personal anecdotes about improved memory. The tone emphasizes curiosity and optimism, demonstrating deep engagement with the topic's potential impacts on health and cognition.

AgreementStrong agreement

Most discussions support the findings, highlighting the potential benefits of AMK for memory.

InterestHigh interest

Users show high curiosity, referencing studies, and personal experiences related to memory and melatonin.

EngagementHigh engagement

Several comments dive into scientific explanations, connecting previous research and discussing mechanisms.

ImpactHigh impact

The discussions suggest the research could influence future treatments for memory decline and cognitive health.

Abstract in brief

  • The study found that the melatonin metabolite N1acetyl5methoxykynuramine (AMK) significantly improves long-term object memory in both young and aging mice, more effectively than melatonin (MEL) itself or its other metabolite AFMK.
  • AMK appears to aid memory consolidation and can even reverse age-related memory impairments when tested days after training, suggesting its role in supporting long-term memory formation.
  • The research also showed that melatonin quickly converts into AMK in the brain and that inhibiting this conversion impairs memory, indicating endogenous AMK is important for maintaining proper memory function.]
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Top posts

Most liked on X and Bluesky
東京医科歯科大学
@tmdu_pr · X

【研究成果発表】 「メラトニンの代謝産物AMKが長期記憶を促進する」－加齢に伴う記憶力低下の改善に期待－（教養部 教授 服部 淳彦） プレスリリース https://t.co/udF7SHKudr DOI: https://t.co/jgfH1JM3Op #東京医科歯科大学 #tmdu #上智大学 https://t.co/duWBoyuV6S

Nov 29, 2020 · 43 likes · 6 shares · 3,518 followers View post →
Doris Loh
@DorissLoh · X

MB oxidizes MEL to produce AFMK. Is that the reason for some of the nootropic effects observed with the use of MB? Very possible. AFMK has been shown to significantly improve long-term object memory in both young and aging mice. https://t.co/0d8VVMvN4w

Jul 17, 2023 · 37 likes · 3 shares · 6,380 followers View post →
Doris Loh
@DorissLoh · X

https://t.co/0d8VVMwkU4

Dec 13, 2022 · 22 likes · 3 shares · 6,380 followers View post →
TMDU - Tokyo Medical and Dental University
@TMDUniversity · X

A new paper by Atsuhiko Hattori et al: The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice on Journal of Pineal Research. https://t.co/RAZtQ7dy5g DOI: https://t.co/1cu7nus5Vt #tmdu https://t.co/5l75uNr6BP

Nov 29, 2020 · 20 likes · 1 share · 723 followers View post →
Agingdoc
@agingdoc1 · X

The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice https://t.co/dEtYT9tZpR

Dec 12, 2020 · 5 likes · 41,929 followers View post →
Thrivous
@thrivous · X

Melatonin might also enhance memory. Yet another reason to add this super supplement to your regimen. Thrivous Serenity is the way to go. https://t.co/rcQz8twL90

Dec 10, 2020 · 3 likes · 2 shares · 11,792 followers View post →

All mentions

Melatonin Metabolite Enhances Memory in Mice

Researchers at Tokyo Medical and Dental University show that the melatonin metabolite N1-acetyl-5-methoxykynuramine significantly improves long-term object memory in young and aging mice, supporting its role in memory…

VHFILM · Dec 16, 2020 855 views
Doris Loh
@DorissLoh · X

@PaulPaul49 Also consider this: https://t.co/0d8VVMvN4w

Jun 12, 2024 · 6,380 followers View post →
Doris Loh
@DorissLoh · X

@InquilineKea @s_batzoglou Yes, a continuation of their work published in 2021 https://t.co/0d8VVMvN4w

Mar 6, 2024 · 6,380 followers View post →
Patrick
@pkamaukinyenje · X

RT @DorissLoh: MB oxidizes MEL to produce AFMK. Is that the reason for some of the nootropic effects observed with the use of MB? Very…

Jul 18, 2023 · 3 shares · 714 followers View post →
Eileen
@dreamsharp · X

The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice https://t.co/QLbzhOt4Yn

Jul 17, 2023 · 285 followers View post →
St. Michael, the Archangel
@aveng_angel · X

RT @DorissLoh: MB oxidizes MEL to produce AFMK. Is that the reason for some of the nootropic effects observed with the use of MB? Very…

Jul 17, 2023 · 3 shares · 1,173 followers View post →
bvw
@bvw_redux · X

RT @DorissLoh: MB oxidizes MEL to produce AFMK. Is that the reason for some of the nootropic effects observed with the use of MB? Very…

Jul 17, 2023 · 3 shares · 1,485 followers View post →
Doris Loh
@DorissLoh · X

MB oxidizes MEL to produce AFMK. Is that the reason for some of the nootropic effects observed with the use of MB? Very possible. AFMK has been shown to significantly improve long-term object memory in both young and aging mice. https://t.co/0d8VVMvN4w

Jul 17, 2023 · 37 likes · 3 shares · 6,380 followers View post →
SabineRing
@ring_sabine · X

RT @DorissLoh: https://t.co/0d8VVMwkU4

Mar 21, 2023 · 3 shares · 51 followers View post →
G.Wenger
@bricolix · X

RT @DorissLoh: https://t.co/0d8VVMwkU4

Dec 14, 2022 · 3 shares · 1,542 followers View post →
Doris Loh
@DorissLoh · X

https://t.co/0d8VVMwkU4

Dec 13, 2022 · 22 likes · 3 shares · 6,380 followers View post →
Shinnosuke Mizuno
@Shinmizno · X

マウス脳でのMEL、AFMK、AMKの代謝経路が長期記憶に与える正の影響と、加齢の影響について https://t.co/Y7iqVUjmzd

Nov 12, 2021 · 1 like · 131 followers View post →
Vitamins Improve Memory
@VitaminsMemory · X

According to this study melatonin can improve your #memory too.

Jul 10, 2021 · 3 likes · 3,793 followers View post →
[sɝ maɾi pɛænts] ⚓
@SirMattypants · X

started taking #melatonin for sleep recently and noticed all of a sudden i could remember my dreams again instead of forgetting them like the past 5+ years it seems this has been looked into with promising results #AMK #N1‐acetyl‐5‐methoxykynuramine https://t.co/nbmVnHDCpz

Jan 30, 2021 · 471 followers View post →
Johns Hopkins Memory & Aging
@JH_Memory_Aging · X

The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice https://t.co/Rd5eOmdzbs

Jan 27, 2021 · 2,897 followers View post →
AMD_Enthusiast
@AMD_Enthusiast · X

"Overall, these results support AMK (Melatonin metabolite) as a potential therapeutic agent to improve or prevent memory decline." -- @rzesz https://t.co/eCZIzmq3lT

Jan 27, 2021 · 299 followers View post →
Ralph Turchiano
@RalphTurchiano · X

Melatonin May Rapidly Improve Memory https://t.co/mHEGrqYHMr via @YouTube #memory #melatonin #AMK

Dec 15, 2020 · 128 followers View post →
@peterdkramer
@PeterDKramer · X

@pivanputs @Dereklowe @justsaysinmice While we're waiting for ISRIB, it looks at though melatonin or one of its metabolites boosts memory in mice. https://t.co/WzMjpvquIe

Dec 14, 2020 · 2,802 followers View post →
Agingdoc
@agingdoc1 · X

The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice https://t.co/dEtYT9tZpR

Dec 12, 2020 · 5 likes · 41,929 followers View post →
Pooja
@pm_girl · X

#The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice https://t.co/QZswy3qUUE #science

Dec 12, 2020 · 2,055 followers View post →
安西英雄
@deoanzai · X

メラトニンの代謝物AMKが、加齢にともなう長期記憶の減退を抑制するのではないか、という日本からの研究報告。 マウスのデータだけど説得力あるな。https://t.co/zz1FgQhZnW

Dec 11, 2020 · 1 like · 864 followers View post →
Thrivous
@thrivous · X

RT @thrivous: Melatonin might also enhance memory. Yet another reason to add this super supplement to your regimen. Thrivous Serenity is th…

Dec 11, 2020 · 2 shares · 11,792 followers View post →
Neonatal Neurology: Dr. Dudink
@Neonatal_Brain · X

Very interesting study: The melatonin metabolite facilitates long‐term object memory in young and aging mice https://t.co/OwIq82gxSZ

Dec 11, 2020 · 1 like · 1,036 followers View post →
The Aegean Society
@aegeansociety · X

Çalışma “The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice” başlığı ile 30 Kasım 2020 tarihinde Journal of Pineal Research dergisinde yayınlandı. https://t.co/x0oI1rUACO

Dec 11, 2020 · 464 followers View post →
Maurício Lima
@dj_surfista · X

Pesquisadores mostram que a melatonina e seus metabólitos promovem a formação de memórias de longo prazo em camundongos e protegem contra o declínio cognitivo. #melatonin https://t.co/ivpSSGs06N

Dec 11, 2020 · 1 like · 742 followers View post →
Shaobo Jia
@JiaShaobo · X

The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice https://t.co/NP1vFnMk7i

Dec 11, 2020 · 19 followers View post →
Lincoln Cannon LLC
@lincolncannonco · X

RT @thrivous: Melatonin might also enhance memory. Yet another reason to add this super supplement to your regimen. Thrivous Serenity is th…

Dec 11, 2020 · 2 shares · 1,357 followers View post →
Thrivous
@thrivous · X

Melatonin might also enhance memory. Yet another reason to add this super supplement to your regimen. Thrivous Serenity is the way to go. https://t.co/rcQz8twL90

Dec 10, 2020 · 3 likes · 2 shares · 11,792 followers View post →
花火日和(はなびびより)871
@hanabi_biyori87 · X

RT @tmdu_pr: 【研究成果発表】 「メラトニンの代謝産物AMKが長期記憶を促進する」－加齢に伴う記憶力低下の改善に期待－（教養部 教授 服部 淳彦） プレスリリース https://t.co/udF7SHKudr DOI: https://t.co/jgfH1J…

Nov 30, 2020 · 6 shares · 521 followers View post →
東京医科歯科大学
@tmdu_pr · X

【研究成果発表】 「メラトニンの代謝産物AMKが長期記憶を促進する」－加齢に伴う記憶力低下の改善に期待－（教養部 教授 服部 淳彦） プレスリリース https://t.co/udF7SHKudr DOI: https://t.co/jgfH1JM3Op #東京医科歯科大学 #tmdu #上智大学 https://t.co/duWBoyuV6S

Nov 29, 2020 · 43 likes · 6 shares · 3,518 followers View post →
しゃぼん
@shabon_cuber · X

RT @TMDUniversity: A new paper by Atsuhiko Hattori et al: The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term obje…

Nov 29, 2020 · 1 share · 1,746 followers View post →
TMDU - Tokyo Medical and Dental University
@TMDUniversity · X

A new paper by Atsuhiko Hattori et al: The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice on Journal of Pineal Research. https://t.co/RAZtQ7dy5g DOI: https://t.co/1cu7nus5Vt #tmdu https://t.co/5l75uNr6BP

Nov 29, 2020 · 20 likes · 1 share · 723 followers View post →
a watcher
@awa19232818 · X

2020年11月24日【東京医科歯科大学】『メラトニンの代謝産物 AMK が長期記憶を促進する｜加齢に伴う記憶力低下の改善に期待』が公開 生物学 教授 服部淳彦 ら 上智大学 と AMK を、学習前・学習後にマウスに１回投与するだけで長期記憶が誘導 https://t.co/6tiX2hOkJ4 https://t.co/UEdwj3KI8y

Nov 25, 2020 · 421 followers View post →
alephh
@alephh · X

Melatonin metabolite N1‐acetyl‐5‐methoxykynuramine (AMK) facilitates long‐term object memory — We analyzed MEL/AMK in hippocampus & temporal lobe — AMK’s effects reflect memory consolidation, reduced MEL‐to‐AMK disrupted object memory at 24-h post‐training https://t.co/Slk1NLUkHc https://t.co/TuCmI7juVB

Nov 15, 2020 · 387 followers View post →