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bioRxiv October 2020 PMID 33140052

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility.

Bin Zhou, Tran Thi Nhu Thao, Donata Hoffmann, Adriano Taddeo, Nadine Ebert, Fabien Labroussaa, Anne Pohlmann, Jacqueline King, Jasmine Portmann, Nico Joel Halwe, Lorenz Ulrich, Bettina Salome Trüeb, Jenna N Kelly, Xiaoyu Fan, Bernd Hoffmann

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Mentions

65
Peak: 51 in Oct 2020
across 4 sources since Oct 2020

Extended reach

773,570
potential audience

Total likes

82

Video views

87

Mentions per month

Oct 2020 – Apr 2021

Where it's discussed

  • X / Twitter57 posts
  • News4 articles
  • Blogs3 articles
  • YouTube1 videos

AI synopsis

What people are saying

Numerous discussions reference key aspects of the publication, with comments noting the findings' implications for enhanced transmissibility and replication of the D614G variant. Phrases like 'dominant variant' and mentions of 'competitive advantage' illustrate the seriousness of the findings, while expressions of concern about its role in renewed outbreak activity in Europe demonstrate the high stakes involved.

AgreementModerate agreement

Many discussions indicate a general consensus on the findings of the publication, highlighting increased transmission and replication capabilities of the new variant.

InterestHigh interest

The posts reflect high interest, with users sharing their thoughts and reactions to the implications of the research, indicating its relevance.

EngagementModerate engagement

While most posts are supportive, they demonstrate a moderate level of engagement, referencing methods or sharing specific implications of the findings.

ImpactHigh impact

The majority of discussions suggest that users believe the findings have a significant impact on understanding the virus's behavior and its implications for the pandemic.

Abstract in brief

  • The D614G substitution in the SARS-CoV-2 spike protein became the dominant variant during the COVID-19 pandemic, but its advantages in replication and transmission were unclear.
  • Research shows that the S-614G variant binds more effectively to human ACE2 and replicates better in human airway cultures and animal models.
  • The findings indicate that the S-614G variant offers a competitive edge, especially during transmission phases, explaining its spread and prevalence globally.
Read the full abstract

Top posts

Most liked on X and Bluesky
Volker Thiel
@ProfVolkerThiel · X

Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great collaborative effort @Loeffler_News @DewIvcp @CharafBenarafa #D614G https://t.co/7mQ6loIOfp

Oct 28, 2020 · 66 likes · 26 shares · 2,462 followers View post →
原口　一博
@kharaguchi · X

https://t.co/dMyNtnW9cH 「SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility」

Oct 28, 2020 · 4 likes · 423,342 followers View post →
bioRxiv
@biorxivpreprint · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/besI0v6I7Y #bioRxiv

Oct 27, 2020 · 4 likes · 1 share · 137,015 followers View post →
Oxford Nanopore
@nanopore · X

Genomic epidemiological study reveals mechanism behind the competitive advantage #SARSCov2 has in relation to entering host cells and replicating, providing an explanation for its global spread. https://t.co/0AlswLX33N https://t.co/YDBi3ZQ8Mm

Nov 13, 2020 · 3 likes · 2 shares · 65,702 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

#SARS_CoV_2 spike #D614G variant confers enhanced replication and transmissibility #COVID_19 https://t.co/Vz8ji62KQj

Oct 28, 2020 · 1 like · 1 share · 14,494 followers View post →
Hacker News 100
@newsyc100 · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmis https://t.co/GZepMAP4wf (https://t.co/4jNOLVii31)

Oct 28, 2020 · 1 like · 9,438 followers View post →

All mentions

Rod Lawson
@clavedoc · X

@pinangodan @CreativeDeduct @LozzaFox It’s dominance, achieved in a short period suggests increased transmission. Lab data supports eg https://t.co/58spLSQvUg

Apr 19, 2021 · 940 followers View post →
SciScore Reports
@SciscoreReports · X

The preprint “SARS-CoV-2 spike D614G variant confers enhanced re…” (https://t.co/uiUiC3nLA8) has been reviewed by automated tools, find results here: https://t.co/FXThpgsPgn. We detected 0 of 6 rigor criteria, 12 resources, and no limitations statement.

Mar 7, 2021 · 330 followers View post →
Vincent
@realgbolashow · X

RT @nanopore: Genomic epidemiological study reveals mechanism behind the competitive advantage #SARSCov2 has in relation to entering host c…

Nov 13, 2020 · 2 shares · 495 followers View post →
Oxford Nanopore
@nanopore · X

Genomic epidemiological study reveals mechanism behind the competitive advantage #SARSCov2 has in relation to entering host cells and replicating, providing an explanation for its global spread. https://t.co/0AlswLX33N https://t.co/YDBi3ZQ8Mm

Nov 13, 2020 · 3 likes · 2 shares · 65,702 followers View post →
DDB
@DutchDrB · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility | bioRxiv https://t.co/r25CooGmhG

Nov 4, 2020 · 496 followers View post →
S P
@toutvaencore · X

C'est bien l'arrivée d'un nouveau variant plus contagieux, et donc une mutation génétique, qui semble avoir relancé l'épidémie en Europe. SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/9nHK8IMnCe

Nov 3, 2020 · 85 followers View post →
welfare justice
@JusticeWelfare · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 30, 2020 · 26 shares · 8 followers View post →
Peter Struik
@BeterNRE · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 30, 2020 · 26 shares · 720 followers View post →
Xander de Haan
@HaanXander · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 29, 2020 · 26 shares · 687 followers View post →
ICYMI HN
@icymihn · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/49dN6MVQpW comm: https://t.co/rpSJ0fJk5q

Oct 29, 2020 · 271 followers View post →
Bat Researcher - A.Prof. Aaron Irving
@BatResearch · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 29, 2020 · 26 shares · 2,537 followers View post →
Wiep Klaas Smits
@SmitsLab · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/YK4xO1bDix

Oct 29, 2020 · 2,359 followers View post →
Andras Toth
@tothur · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility | bioRxiv - https://t.co/BEindMC5JY

Oct 29, 2020 · 1,823 followers View post →
HackerNews: With Privacy!*
@HackerNewsWP · X

Oct 29, 2020 · 40 followers View post →
Tran_TN_Thao
@Thao_TTN · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 29, 2020 · 26 shares · 90 followers View post →
Covid Expert Tweets
@covidexpertlist · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 112 followers View post →
tweetbix
@tweetbix · X

@MackayIM Soz I should have included ref: https://t.co/2uK6DpJ93Y SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility" Which you're quite right in indicating: is not Virulence. V="severity or harmfulness". My bad, learn something everyday, if you lucky. Taa

Oct 28, 2020 · 566 followers View post →
Dr FRACP
@Chiasm99 · X

FFS #covidau SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/T7p2PRhjMx

Oct 28, 2020 · 190 followers View post →
原口　一博
@kharaguchi · X

https://t.co/dMyNtnW9cH 「SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility」

Oct 28, 2020 · 4 likes · 423,342 followers View post →
AurelG
@AurelG7 · X

SARS-CoV-2 spike #D614G variant confers enhanced #replication and transmissibility | #SARSCoV2 #transmission #epidemiology #covid19 https://t.co/4JjFjJTv3Q

Oct 28, 2020 · 30 followers View post →
Bernomics
@bernomics · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 447 followers View post →
Sangeeta Motiani
@sangmotiani · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 285 followers View post →
MetaJournalist
@MetaJournalist · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/61maoyxIQY

Oct 28, 2020 · 303 followers View post →
Hacker News 100
@newsyc100 · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmis https://t.co/GZepMAP4wf (https://t.co/4jNOLVii31)

Oct 28, 2020 · 1 like · 9,438 followers View post →
DevPup
@dev_pup · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/KTGfsHRqyX

Oct 28, 2020 · 234 followers View post →
tweetbix
@tweetbix · X

@MackayIM The sidebar "those mutterings that SARS-CoV-2 is less virulent?" In fact, opposite; "increased affinity to hACE2,...SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility". That now is the dominant variant.

Oct 28, 2020 · 1 like · 566 followers View post →
Richard L. Weiss
@RichardLWeiss · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 2,712 followers View post →
Future ♢ Megatrends
@TrendsFM · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility | bioRxiv https://t.co/kggZp280ts, see more https://t.co/6OviBDuCU4

Oct 28, 2020 · 2,469 followers View post →
Hacker News 50
@betterhn50 · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/WswiN9C0Ba (https://t.co/35hQqmq4C5)

Oct 28, 2020 · 1,711 followers View post →
Gal Haimovich ☣
@grnfluoresceblg · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 2,515 followers View post →
Kristin Whiteley
@causalitybrunch · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 1,402 followers View post →
Ortego´s lab
@s_ortego · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 502 followers View post →
Hacker News 20
@betterhn20 · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/3NfkzlZiFa (https://t.co/hAPvkPf0YC)

Oct 28, 2020 · 2,232 followers View post →
Angsuman Chakraborty ✪
@angsuman · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/YFnzLF1Y9u

Oct 28, 2020 · 7,556 followers View post →
Winson Tang
@winsontang · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/dnLcg6J3yn

Oct 28, 2020 · 9,042 followers View post →
HN Front Page
@hn_frontpage · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility L: https://t.co/qM88z3ejUa C: https://t.co/1xCVET9uWU

Oct 28, 2020 · 2,550 followers View post →
Corcoran Lab
@corcoran_lab · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 1,362 followers View post →
PromisingPreprints
@PromPreprint · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/3cpfRSYAGx

Oct 28, 2020 · 1 like · 3,309 followers View post →
Marcelli
@Marcelli1314 · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 520 followers View post →
HB Valerie
@valerie_hb · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 17 followers View post →
A. Lizard
@alizardx · X

RT @Marieaaow: #SARS_CoV_2 spike #D614G variant confers enhanced replication and transmissibility #COVID_19 https://t.co/Vz8ji62KQj

Oct 28, 2020 · 1 share · 3,435 followers View post →
Aha?
@Aha_31X3 · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 211 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

#SARS_CoV_2 spike #D614G variant confers enhanced replication and transmissibility #COVID_19 https://t.co/Vz8ji62KQj

Oct 28, 2020 · 1 like · 1 share · 14,494 followers View post →
@Titusintwittmo
@titusintwittmo · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 28 followers View post →
NCCR RNA & Disease
@NCCR_RNADisease · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 1,417 followers View post →
CitizenBot
@CitizenBot · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 228 followers View post →
No one
@ungubunugu1274 · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 3,518 followers View post →
SahaL Sabilil M
@sahal_sabilil · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 396 followers View post →
preprintsifter
@preprintsifter · X

RT KrutikaKuppalli https://t.co/4cZ7HGUjMU "RT ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…"

Oct 28, 2020 · 512 followers View post →
Krutika Kuppalli, MD FIDSA
@KrutikaKuppalli · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 35,766 followers View post →
Bea
@bealro_ · X

RT @ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…

Oct 28, 2020 · 26 shares · 380 followers View post →
preprintsifter
@preprintsifter · X

RT EckerleIsabella https://t.co/F44tdwwutL "RT ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…"

Oct 28, 2020 · 512 followers View post →
preprintsifter
@preprintsifter · X

RT C_Althaus https://t.co/ZKy6SAYf6Y "RT ProfVolkerThiel: Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great col…"

Oct 28, 2020 · 512 followers View post →
Volker Thiel
@ProfVolkerThiel · X

Online now: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility Thanks for the great collaborative effort @Loeffler_News @DewIvcp @CharafBenarafa #D614G https://t.co/7mQ6loIOfp

Oct 28, 2020 · 66 likes · 26 shares · 2,462 followers View post →
CellFree Sciences
@CFSciences · X

RT @biorxivpreprint: SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/besI0v6I7Y #bioRxiv

Oct 27, 2020 · 1 share · 497 followers View post →
bioRxiv Microbiology
@biorxiv_micrbio · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/jbepeSD3sR #biorxiv_micrbio

Oct 27, 2020 · 20,841 followers View post →
bioRxiv
@biorxivpreprint · X

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility https://t.co/besI0v6I7Y #bioRxiv

Oct 27, 2020 · 4 likes · 1 share · 137,015 followers View post →