Am J Physiol Regul Integr Comp Physiol February 2021 PMID 33175586

Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem.

Sasha Adams, Tanya Zubov, Nikolaus Bueschke, Joseph M Santin

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Mentions

9
Peak: 4 in Dec 2020
across 3 sources since Nov 2020

Extended reach

13,521
potential audience

Total likes

12

Video views

57

Mentions per month

Nov 2020 – Apr 2021

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

The discussions mostly involve sharing links and brief mentions of the research article, with some hashtags like #hypoxiatolerance and #brainstem indicating an interest in specific scientific concepts. Words such as 'new research' and 'metabolic limitations' highlight a factual tone, with limited emotional or critical engagement, reflecting a general curiosity but not strong affirmation or debate about the study's significance.

AgreementNeither agree nor disagree

The discussions are mostly neutral, with no clear consensus or disagreement expressed about the significance of the research.

InterestModerate interest

The posts show moderate curiosity, especially through hashtags and invites to explore the study further, indicating some interest but no deep excitement.

EngagementNeutral engagement

While some quotes reference the core findings, the interactions lack in-depth analysis or critical discussion, suggesting a superficial engagement.

ImpactModerate impact

The shared links and references imply the research might be relevant to fields like neurophysiology and metabolism, though overall perceived impact seems moderate.

Abstract in brief

  • Hypoxia silences the amphibian brainstem's network primarily due to energy failure (reduced ATP production), not because of neuromodulators like norepinephrine.
  • While hypoxia triggers responses such as norepinephrine release, the shutdown of network activity still occurs even when norepinephrine signaling is blocked, indicating energy failure is the main cause.
  • Pharmacological experiments mimicking low oxygen conditions showed that decreased ATP synthesis alone can account for the network silencing, emphasizing that energy limitation, not neuromodulator activity, drives the shutdown during hypoxia.]

Top posts

Most liked on X and Bluesky
AJP-Regulatory, Integrative Comparative Physiology
@AJPRegu · X

We have a gift to share! Follow the link to our YouTube channel for a special holiday message from our Editors to you. From our home to yours, wishing you a very happy holiday season! https://t.co/x04CgH2J2B

Dec 25, 2020 · 5 likes · 1 share · 1,165 followers View post →
APS Publications
@APSPublications · X

Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem - new research in @AJPRegu https://t.co/6q9ioLxos6 #hypoxiatolerance #brainstem #respiratorycontrol #metabolism #articlesinpress https://t.co/fNRae61QdJ

Nov 12, 2020 · 3 likes · 1 share · 7,395 followers View post →
AJP-Regulatory, Integrative Comparative Physiology
@AJPRegu · X

Don't forget to check out the holiday message from our Editors. https://t.co/znTRdnfu9h

Dec 30, 2020 · 2 likes · 1,165 followers View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @AJPRegu: We have a gift to share! Follow the link to our YouTube channel for a special holiday message from our Editors to you. From…

Dec 25, 2020 · 1 share · 3,373 followers View post →
Mike Burton
@mike_burton15 · X

RT @APSPublications: Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem - n…

Nov 12, 2020 · 1 share · 226 followers View post →
Guillaume Toffoli
@toffoli_g · X

Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology https://t.co/6QbnEtfWLR

Nov 16, 2020 · 123 followers View post →

All mentions

AJP-Regulatory, Integrative Comparative Physiology
@AJPRegu · X

Don't forget to check out the holiday message from our Editors. https://t.co/znTRdnfu9h

Dec 30, 2020 · 2 likes · 1,165 followers View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @AJPRegu: We have a gift to share! Follow the link to our YouTube channel for a special holiday message from our Editors to you. From…

Dec 25, 2020 · 1 share · 3,373 followers View post →
AJP-Regulatory, Integrative Comparative Physiology
@AJPRegu · X

We have a gift to share! Follow the link to our YouTube channel for a special holiday message from our Editors to you. From our home to yours, wishing you a very happy holiday season! https://t.co/x04CgH2J2B

Dec 25, 2020 · 5 likes · 1 share · 1,165 followers View post →
Guillaume Toffoli
@toffoli_g · X

Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology https://t.co/6QbnEtfWLR

Nov 16, 2020 · 123 followers View post →
Mike Burton
@mike_burton15 · X

RT @APSPublications: Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem - n…

Nov 12, 2020 · 1 share · 226 followers View post →
APS Publications
@APSPublications · X

Neuromodulation or energy failure? Metabolic limitations silence network output in the hypoxic amphibian brainstem - new research in @AJPRegu https://t.co/6q9ioLxos6 #hypoxiatolerance #brainstem #respiratorycontrol #metabolism #articlesinpress https://t.co/fNRae61QdJ

Nov 12, 2020 · 3 likes · 1 share · 7,395 followers View post →
Joe Santin | American Physiological Society (APS) |
News

doi.org/10.1152/ajpregu.00209.2020 Burton, M. T., & Santin, J.M. A direct excitatory action of lactate ions in the central respiratory network. 2020 ...

Dec 28, 2025 View →