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Nat Struct Mol Biol December 2020 PMID 33177698

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers.

Venkata S Mandala, Matthew J McKay, Alexander A Shcherbakov, Aurelio J Dregni, Antonios Kolocouris, Mei Hong

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Mentions

62
Peak: 25 in Nov 2020
across 5 sources since Sep 2020

Extended reach

70,885
potential audience

Total likes

40

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68

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Sep 2020 – Dec 2020

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AI synopsis

What people are saying

Discussions emphasize the importance of the structural details revealed in the study, such as the drug-binding sites and the effects of pH on the E protein, with wording like 'sets the stage for designing E inhibitors' and 'potential for antiviral drugs' indicating both curiosity and recognition of significance. The tone varies from scientific technicality to optimistic implications for future therapies, showing active engagement and appreciation for the research's potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the structural insights for drug development, with some explicitly emphasizing the potential for designing inhibitors targeting the E protein.

InterestHigh interest

Participants show high curiosity about the technical methods used, such as solid-state NMR, and the implications for antiviral research, indicating strong interest.

EngagementModerate engagement

Posts include references to the structural details, drug-binding sites, and experimental techniques, reflecting active engagement in understanding the study's findings.

ImpactModerate impact

The discussions highlight the potential influence of this research on future antiviral drug strategies and COVID-19 treatments, suggesting moderate perceived impact.

Abstract in brief

  • The SARS-CoV-2 envelope protein (E) forms a pentameric ion channel in lipid bilayers, with a structure revealed by solid-state NMR showing a five-helix bundle featuring unique phenylalanine stacking that causes a dehydrated pore.
  • The study identifies drug-binding sites, where Hexamethylene amiloride binds within the polar lumen, and notes that acidic pH influences the protein's conformation, especially at the C-terminal.
  • These structural insights suggest that different parts of the channel may interact with viral and host proteins independently, providing a basis for designing antiviral drugs targeting the E protein.]
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Magnetic Resonance News
@nmr900 · X

. @NatureSMB Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers, corresponding Mei Hong @MeiHongLab @ChemistryMIT https://t.co/x4Jcx2C8iP #NMRchat #NMR

Nov 11, 2020 · 16 likes · 3 shares · 6,114 followers View post →
笹山登生
@keyaki1117 · X

11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2 envelope protein 」 https://t.co/cjySLVRaDp エンベロープ（E）タンパク質が宿主細胞の炎症反応刺激に重要役割を果たしていると

Nov 17, 2020 · 15 likes · 12 shares · 28,851 followers View post →
Sonic Reducer
@indole_gaines · X

11.11.2020 Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers Venkata S. Mandala, Matthew J. McKay, Alexander A. Shcherbakov, Aurelio J. Dregni, Antonios Kolocouris & Mei Hong Nature Structural & Molecular Biology (2020)

Nov 30, 2020 · 2 likes · 959 followers View post →
Nanion Technologies
@NanionTech · X

Dec 2, 2020 · 2 likes · 1 share · 881 followers View post →
Creative Biostructure
@CreBiostructure · X

New Article: Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers "Here we report a 2.1-Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy." https://t.co/KLAzIPSRQJ

Nov 11, 2020 · 2 likes · 103 followers View post →
Sonic Reducer
@indole_gaines · X

DOI https://t.co/b49KvLLnSg

Nov 30, 2020 · 1 like · 959 followers View post →

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@MB2BORNOT2B · X

@marcinwarchol @MZ_GOV_PL https://t.co/hLFgOfsL4K Article Published: 11 November 2020 Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

Dec 14, 2020 · 412 followers View post →
Ion Channel Library
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RT @NanionTech:

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Nanion Technologies
@NanionTech · X

Dec 2, 2020 · 2 likes · 1 share · 881 followers View post →
Sonic Reducer
@indole_gaines · X

DOI https://t.co/b49KvLLnSg

Nov 30, 2020 · 1 like · 959 followers View post →
Sonic Reducer
@indole_gaines · X

11.11.2020 Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers Venkata S. Mandala, Matthew J. McKay, Alexander A. Shcherbakov, Aurelio J. Dregni, Antonios Kolocouris & Mei Hong Nature Structural & Molecular Biology (2020)

Nov 30, 2020 · 2 likes · 959 followers View post →
ヨースギ
@akira40423628 · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 56 followers View post →
しとらす＠京都
@citrus_kyoto · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 1,355 followers View post →
クラウド@生物濃縮放射能は人に返る。。。
@palebrown · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 2,570 followers View post →
もちもち大魔王ユウト
@carefree_people · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 498 followers View post →
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@_BWWN_ · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 805 followers View post →
necofish
@mizubeasobizuki · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 213 followers View post →
メカゴリラ
@mecagolira · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 71 followers View post →
chrome(
@copymaco · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 395 followers View post →
氷室隆
@qNcGqjcj68Vx8CS · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 868 followers View post →
take01
@take01_98 · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 237 followers View post →
ノルノル
@nolnolnol · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 1,822 followers View post →
阿晴 明清
@ahare_asayaka · X

RT @keyaki1117: 11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2…

Nov 17, 2020 · 12 shares · 1,291 followers View post →
笹山登生
@keyaki1117 · X

11月11日の「Nature Structural & Molecular Biology」に発表されたMIT大学の新型コロナウイルス研究が話題に。 論文は「Structure and drug binding of the SARS-CoV-2 envelope protein 」 https://t.co/cjySLVRaDp エンベロープ（E）タンパク質が宿主細胞の炎症反応刺激に重要役割を果たしていると

Nov 17, 2020 · 15 likes · 12 shares · 28,851 followers View post →
Microbiology@UCL
@MICROBIOLOGYUCL · X

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid... - https://t.co/EMuRJPJPhe #ScholarAlerts

Nov 14, 2020 · 1,978 followers View post →
micropapers
@micro_papers · X

NJs/ Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers.https://t.co/gVODFpGKRi

Nov 13, 2020 · 332 followers View post →
Chinmayi Prasanna
@chnzzy · X

RT @nmr900: . @NatureSMB Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers, correspondin…

Nov 12, 2020 · 3 shares · 300 followers View post →
Creative Biostructure
@CreBiostructure · X

New Article: Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers "Here we report a 2.1-Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy." https://t.co/KLAzIPSRQJ

Nov 11, 2020 · 2 likes · 103 followers View post →
Professor Erwin Loh
@erwinloh · X

Structure and drug binding of the SARS-CoV-2 envelope protein E transmembrane domain (ETM) sets the stage for designing E inhibitors as #antiviral drugs. #COVID19 #coronavirus (#Nature, 11 Nov 2020) Source in comments. https://t.co/hsnS1YRHRm

Nov 11, 2020 · 10,343 followers View post →
Callie Saeher
@calliesayshi · X

RT @nmr900: . @NatureSMB Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers, correspondin…

Nov 11, 2020 · 3 shares · 866 followers View post →
Matthew Eddy
@MatthewEddyLab · X

RT @nmr900: . @NatureSMB Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers, correspondin…

Nov 11, 2020 · 3 shares · 762 followers View post →
Magnetic Resonance News
@nmr900 · X

. @NatureSMB Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers, corresponding Mei Hong @MeiHongLab @ChemistryMIT https://t.co/x4Jcx2C8iP #NMRchat #NMR

Nov 11, 2020 · 16 likes · 3 shares · 6,114 followers View post →
smartredhead
@smartredhead · X

⁦@APSFA⁩ Structure and Drug Binding of the SARS-CoV-2 Envelope Protein in Phospholipid Bilayers | Research Square https://t.co/KhM4MfiQ4a

Oct 24, 2020 · 44 followers View post →
Magnetic Resonance News
@nmr900 · X

(Nature in review) Structure and Drug Binding of the SARS-CoV-2 Envelope Protein in Phospholipid Bilayers, Mei Hong, Venkata Mandala, Matthew McKay, Alexander Shcherbakov, Aurelio Dregni, Antonios Kolocouris https://t.co/xYQ8beW0Hs #NMRchat #NMR

Sep 25, 2020 · 6,114 followers View post →