Geroscience February 2021 PMID 33191466

Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Melod Mehdipour, Taha Mehdipour, Colin M Skinner, Nathan Wong, Chao Liu, Chia-Chien Chen, Ok Hee Jeon, Yi Zuo, Michael J Conboy, Irina M Conboy

Mentions

95
Peak: 17 in Nov 2020
across 5 sources since Nov 2020

Extended reach

762,244
potential audience

Total likes

915

Video views

21,290

Mentions per month

Nov 2020 – Sep 2025

Where it's discussed

  • X / Twitter68 posts
  • News17 articles
  • Blogs4 articles
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

The discussions highlight excitement around the findings, with users describing plasma dilution as a potential 'game changer' for cognitive health. For instance, phrases like 'easily achieved by plasma donation' and references to the efficacy of plasma dilution over young blood transfusions indicate a practical and impactful perspective. The tone remains enthusiastic, with many seeking further information and expressing a sense of urgency regarding the research's implications for aging.

AgreementModerate agreement

Many discussions show a positive outlook on the publication, indicating that the findings are generally welcomed and supported by the community.

InterestHigh interest

Posts reflect a strong curiosity in the implications of plasma dilution, with users eager to explore its effects on cognition and neuroinflammation.

EngagementHigh engagement

Users delve deeply into the research methods and implications, sharing insights and additional references that enhance the discussion.

ImpactHigh impact

The majority believe the publication has significant implications for future studies and therapeutic approaches in aging and cognitive health.

Abstract in brief

  • NBE (Neutral Blood Exchange) significantly improves cognitive performance and reduces neuroinflammation in older mice, leading to better brain health.
  • The study found that NBE was more effective in enhancing brain rejuvenation than the senolytic drug ABT 263, highlighting that simply reducing senescence isn't enough for cognitive benefits.
  • Proteomic analyses indicated that diluting old blood plasma boosts factors that support brain maintenance and repair, thereby promoting overall cognitive function in aging mammals.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting old blood is in. Therapeutic plasma exchange is already an FDA approved procedure https://t.co/aafH1CjGdB

Dec 7, 2020 · 86 likes · 13 shares · 292,462 followers View post →
Colim
@C0l1m · X

@Sturgeons_Law @forwardourmotto https://t.co/UbJTM0UGl1 i found it. Young blood doesnt seem to rejuvenate as much as old blood is just full of gunk. They even did a followup! https://t.co/sjB7EQwWsn

Mar 6, 2024 · 52 likes · 30 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> https://t.co/R5Clyt0ZTu #aging #rejuvenation #plasmaexchange #scicomm #AcademicYouTube @WeCreateEdu https://t.co/KvVSdjMQP1

Mar 6, 2021 · 11 likes · 5 shares · 4,889 followers View post →
Eli Dourado
@elidourado · X

Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 6, 2021 · 10 likes · 5 shares · 43,281 followers View post →
Aging Science News
@AgingBiology · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/6cOvMFMRZK

Nov 20, 2020 · 7 likes · 1 share · 30,820 followers View post →
Ægean
@Aegean_E · X

https://t.co/F8g3NjVWtK

Feb 17, 2024 · 6 likes · 28,726 followers View post →

All mentions

Joseph A. Hazani
@jhazani · X

https://t.co/B9g0dmVtcx #HBOTisthenewtanningsalon #letsgetperky #forever21

Jun 5, 2025 · 98 followers View post →
Maria Robles
@RBioceutics · X

Diluting out the senescent components of old blood increases cognitive ability of old animals through stimulation of neurogenesis. https://t.co/RuMFCKZJSs

Dec 29, 2024 · 2,772 followers View post →
Taylor Thompson
@TJThomps · X

5/ A Mouse Study on cognition and neuroinflammation. https://t.co/zbgKXSqXUV

Dec 15, 2024 · 258 followers View post →
T.J. Allcot
@allcot_j · X

@ScottDavidKeefe @siimland Oddly enough... It certainly seems unusual. https://t.co/nhGSYtPJoA

Nov 27, 2024 · 417 followers View post →
Madam Mitochondria
@Madam_Mito · X

@pieter_mj_j @MitoPsychoBio “Age elevated systemic proteome was restored to youth with maintenance and repair of muscle, liver, and brain, without any added young blood, young plasma, or young factors” - ref; https://t.co/gRHxXJaWAt

Oct 29, 2024 · 1 like · 10,591 followers View post →
Colim
@C0l1m · X

@Sturgeons_Law @forwardourmotto https://t.co/UbJTM0UGl1 i found it. Young blood doesnt seem to rejuvenate as much as old blood is just full of gunk. They even did a followup! https://t.co/sjB7EQwWsn

Mar 6, 2024 · 52 likes · 30 followers View post →
Ægean
@Aegean_E · X

https://t.co/F8g3NjVWtK

Feb 17, 2024 · 6 likes · 28,726 followers View post →
Scott V
@Jean_Banjovee · X

@chydorina 1) https://t.co/9HYnzOrjgt 2) https://t.co/XiozoH2dHl

Aug 6, 2023 · 50 followers View post →
Enea Fioretti
@EneaFioretti · X

@newscientist # The news spread, but it should be noticed that even a plasma dilution can have similar positive effects: Plasma dilution improves cognition and attenuates neuroinflammation in old mice: https://t.co/ek5gxhzAoD

Jul 30, 2023 · 296 followers View post →
Enea Fioretti
@EneaFioretti · X

# The news spread, but it should be noticed that even a plasma dilution can have similar positive effects: Plasma dilution improves cognition and attenuates neuroinflammation in old mice: https://t.co/ek5gxhzAoD https://t.co/H2mZJ9u6kN

Jul 29, 2023 · 296 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

RT @YujiMarutani: Watch "Rejuvenation by dilution? (Therapeutic plasma exchange)" on YouTube https://t.co/KtCM5hKJXW

Jan 6, 2023 · 1 share · 1,570 followers View post →
Orlando_uy
@Orlando_uy · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice. https://t.co/ipb7s75xhy

Sep 11, 2022 · 1 like · 694 followers View post →
Ursula Pirzer
@CiaoDottoressa · X

Easily achieved by plasma donation and substitution with NaCl -very intriguing! https://t.co/30mRyAVFOX

Jul 29, 2022 · 183 followers View post →
John Hemming
@johnhemming4mp · X

@jpsenescence @mlurker444 It works in the sense of reducing senescence (or transferring it) or reducing the hallmarks of aging. It is, however, not really a practical solution. It has similarities to plasma dilution which is more practical and ethical. https://t.co/4jbN0GvUkr

Jul 28, 2022 · 10,847 followers View post →
GeroScience
@GeroScienceAGE · X

Open

Jul 27, 2022 · 3 likes · 3,665 followers View post →
GeroScience
@GeroScienceAGE · X

Open

Mar 30, 2022 · 1 like · 3,665 followers View post →
Agingdoc
@agingdoc1 · X

@kevinnbass Aside from the sm. segment w/ HH & debate whether we benefit w/ lower-end of HCT/HgB range (iron bioacc), in the parabiosis lit there's stronger evidence for plasma dilution of old-factors than for young blood health factors (but both likely). Conboy et al https://t.co/ebtk34r1Sf

Feb 4, 2022 · 1 like · 41,943 followers View post →
KU BK21 Convergence & Translational Biomedicine
@bk21kumc2 · X

RT @bk21kumc: https://t.co/wl0VXX95C9 Geroscience. 2021 Feb;43(1):1-18. doi: 10.1007/s11357-020-00297-8. Epub 2020 Nov 15. Plasma dilutio…

Jul 28, 2021 · 1 share · 4 followers View post →
Korea University Department of Biomedical Sciences
@bk21kumc · X

https://t.co/wl0VXX95C9 Geroscience. 2021 Feb;43(1):1-18. doi: 10.1007/s11357-020-00297-8. Epub 2020 Nov 15. Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Jul 28, 2021 · 1 share · 19 followers View post →
NootropicReddit
@NootropicReddit · X

Blood plasma dilution improves cognition and attenuates neuroinflammation in old mice (2021) via /r/Nootropics https://t.co/kS2UzQHMoU

Jul 24, 2021 · 792 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

Watch "Rejuvenation by dilution? (Therapeutic plasma exchange)" on YouTube https://t.co/KtCM5hKJXW

Mar 11, 2021 · 1 share · 1,570 followers View post →
Bill Walker
@BWalkerTTAGGG · X

RT @EleanorSheekey: Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> h…

Mar 7, 2021 · 5 shares · 1,392 followers View post →
Kalpit Shah
@kalpitsh · X

RT @elidourado: Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 7, 2021 · 5 shares · 81 followers View post →
Tina Helg
@TinaHelg · X

RT @EleanorSheekey: Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> h…

Mar 7, 2021 · 5 shares · 24 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

RT @elidourado: Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 7, 2021 · 5 shares · 4,889 followers View post →
francisco
@filterfold · X

RT @elidourado: Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 7, 2021 · 5 shares · 50 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> h…

Mar 6, 2021 · 5 shares · 2,105 followers View post →
José Luis Ricón Fernández de la Puente
@ArtirKel · X

RT @elidourado: Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 6, 2021 · 5 shares · 22,260 followers View post →
Eli Dourado
@elidourado · X

Another phenomenal video from @EleanorSheekey, this time explaining blood plasma dilution. https://t.co/fFDSjPyXFz

Mar 6, 2021 · 10 likes · 5 shares · 43,281 followers View post →
ScienceStop
@B0tSci · X

RT @EleanorSheekey: Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> h…

Mar 6, 2021 · 5 shares · 4,072 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Rejuvenation by dilution? In this video i discuss the latest work from the Conboy lab on neutral blood exchange! --> https://t.co/R5Clyt0ZTu #aging #rejuvenation #plasmaexchange #scicomm #AcademicYouTube @WeCreateEdu https://t.co/KvVSdjMQP1

Mar 6, 2021 · 11 likes · 5 shares · 4,889 followers View post →
Positivity ♊️
@positivityILV · X

1/2 Hi @sbarnettARK - I’ve read a paper from the Conboy couple regarding their longevity research (https://t.co/nEHX72fPne) it seems to me that a breakthrough in this area could pose a significant risk to many of the companies tackling disease which relates to age (ie cancer)

Feb 8, 2021 · 111 followers View post →
mindfulrevolution
@mndflrvltn · X

RT @rewireupgrade: Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/UUaUfCNedo

Jan 5, 2021 · 1 share · 34 followers View post →
REJUVENS
@rejuvens · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/UUaUfCNedo

Jan 5, 2021 · 1 like · 1 share · 68 followers View post →
Rapamycin News
@RapaNews · X

RT @alfredopietraca: A procedure referred to as neutral blood exchange (NBE) resets signaling milieu to a pro-regenerative state through di…

Jan 4, 2021 · 1 share · 5,323 followers View post →
AlfredoPietracatella
@alfredopietraca · X

A procedure referred to as neutral blood exchange (NBE) resets signaling milieu to a pro-regenerative state through dilution of old plasma, enhanced the health and repair of the muscle and liver, and promoted better hippocampal neurogenesis. https://t.co/nr9j0tXYGx

Jan 4, 2021 · 3 likes · 1 share · 244 followers View post →
Anders Sandberg
@anderssandberg · X

@palace Att hälso- och livsförlängningen man sett när man ger ungt blod till åldrade möss mycket väl kan bero på att man spär ut något ohälsosamt i blodplasman snarare än att det unga blodet i sig är bra: https://t.co/OHiL9g0YgN

Jan 3, 2021 · 1 like · 29,422 followers View post →
(((JReuben1)))
@jreuben1 · X

Simple Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/FDP0uceLIw

Dec 27, 2020 · 1 like · 1,961 followers View post →
Rich Giadone
@rmgiadone · X

RT @AgingBiology: Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/6cOvMFMRZK

Dec 10, 2020 · 1 share · 728 followers View post →
Vitamin Jeet Singh Parmar ☬
@VitaminVikram · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 1,225 followers View post →
hubskihose
@hubskihose · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice #science #biology https://t.co/0kixq2a2iw

Dec 7, 2020 · 119 followers View post →
Dmitry
@argutic8 · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 365 followers View post →
bruce
@bruce99340413 · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 206 followers View post →
D Shepard
@shepdf · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 3,218 followers View post →
Neil is where?
@Neil_is_where · X

Think about basic chemistry: things diffuse from higher concentrations to lower. Clean your brain by lowering your plasma concentrations: 1. Drink water. 2. Donate plasma. https://t.co/AuFt8DSpNi

Dec 7, 2020 · 80 followers View post →
Rabois Likes
@rabois_likes · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 1,013 followers View post →
Isegoria
@Isegoria · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 1,645 followers View post →
Discover Catholic Businesses
@zacorbett · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 577 followers View post →
Canario en la Mina de Oro
@canyonoutlook · X

RT @Mangan150: Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting…

Dec 7, 2020 · 13 shares · 107 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice Young blood transfusions are out; diluting old blood is in. Therapeutic plasma exchange is already an FDA approved procedure https://t.co/aafH1CjGdB

Dec 7, 2020 · 86 likes · 13 shares · 292,462 followers View post →
Z Валерий Гамзатов
@wgamzatov · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/htbRbbkfFK

Dec 1, 2020 · 1 like · 1,936 followers View post →
Dominique D.
@dm_devito · X

RT @hkanji: Aging is partially caused by aging factors found in our blood https://t.co/JSbQry36JG

Nov 29, 2020 · 2 shares · 1,000 followers View post →
Marvin Liao
@marvinliao · X

RT @hkanji: Aging is partially caused by aging factors found in our blood https://t.co/JSbQry36JG

Nov 29, 2020 · 2 shares · 6,985 followers View post →
Hussein Kanji
@hkanji · X

Aging is partially caused by aging factors found in our blood https://t.co/JSbQry36JG

Nov 29, 2020 · 3 likes · 2 shares · 26,871 followers View post →
Orlando_uy
@Orlando_uy · X

"Plasma dilution improves cognition and attenuates neuroinflammation in old mice, with this, heterochronic parabiosis studies seeded the field of systemic aging and rejuvenation." https://t.co/ipb7s74Zs0

Nov 25, 2020 · 694 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

https://t.co/bgWNjbTvSs

Nov 21, 2020 · 1,353 followers View post →
Collin Ewald
@CollinEwald · X

RT @MariaErmolaev13: Replacing half of old plasma with saline containing 5% albumin recapitulates the rejuvinating effect of the heterochro…

Nov 21, 2020 · 1 share · 4,532 followers View post →
Maria Ermolaeva
@MariaErmolaev13 · X

Replacing half of old plasma with saline containing 5% albumin recapitulates the rejuvinating effect of the heterochronic blood transfer? Is it really that simple? https://t.co/aXR4GgZy62

Nov 20, 2020 · 4 likes · 1 share · 2,145 followers View post →
Orlando_uy
@Orlando_uy · X

These findings confirm the paradigm of rejuvenation through dilution of age-elevated systemic factors and extrapolate it to brain health and function. https://t.co/ipb7s74Zs0

Nov 20, 2020 · 694 followers View post →
Aging Science News
@AgingBiology · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/6cOvMFMRZK

Nov 20, 2020 · 7 likes · 1 share · 30,820 followers View post →
Stem Development
@StemDevelopment · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice. https://t.co/zmH3uDAxPN

Nov 17, 2020 · 72 followers View post →
Eli Dourado
@elidourado · X

Another paper on plasma dilution from the Conboy Lab (which is leading the charge on this line of research). Plasma dilution is more effective for brain rejuvenation than senolytics, suggesting there are age-elevated blood factors beyond the SASP. https://t.co/VWc8jrR2cR

Nov 17, 2020 · 2 likes · 43,281 followers View post →
Ronnie Cutler
@cutleraging · X

RT @MattYousefzadeh: https://t.co/S7dAgsqasl

Nov 16, 2020 · 1 share · 462 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

https://t.co/S7dAgsqasl

Nov 16, 2020 · 1 like · 1 share · 4,791 followers View post →
Nutriop Longevity
@nutriop · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice https://t.co/RdUTVlgJli https://t.co/mWEs2DOWjW

Nov 16, 2020 · 80 followers View post →
Taranjit Singh Rai
@RaiLabCTRIC · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice | SpringerLink https://t.co/nx3Tq2UkTt

Nov 16, 2020 · 543 followers View post →
Agingdoc
@agingdoc1 · X

Plasma dilution improves cognition and attenuates neuroinflammation in old mice. “Summarily, this work supports the paradigm that diluting and resetting to health and youth systemic signaling milieu promotes the “young” determinants of tissue health” https://t.co/cE1lJXSx3Y

Nov 16, 2020 · 1 like · 41,943 followers View post →
Agingdoc
@agingdoc1 · X

Corrected URL here: https://t.co/cE1lJXSx3Y

Nov 16, 2020 · 41,943 followers View post →