Does thiamine (
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
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Nov 2020 – Nov 2025Where it's discussed
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X / Twitter142 posts
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YouTube2 videos
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What people are saying
The discussions overwhelmingly agree on the promising results of the trial, with phrases like 'significant relief,' 'brilliant and cheap treatment,' and 'groundbreaking' indicating strong support and interest. Words such as 'effective,' 'well tolerated,' and references to detailed studies reflect deep engagement and recognition of the potential impact, though some tone down expectations by considering the preliminary nature of the research.
Most discussions highlight the positive findings of the trial, supporting thiamine's benefits.
The majority express strong curiosity and excitement about the potential for a simple, effective treatment.
Many discussions reference specific data points, study design, and implications, showing deep engagement.
While several posts emphasize potential clinical impact, some still see it as preliminary and in need of further validation.
Abstract in brief
- This study tested whether high-dose oral thiamine (600-1800 mg daily) can help reduce chronic fatigue in patients with inactive inflammatory bowel disease (IBD), comparing it to a placebo in a carefully controlled trial.
- Results showed that patients taking thiamine experienced a significant reduction in fatigue (about 4.5 points on the fatigue questionnaire), with more than half showing improvement, and side effects were mild, indicating it’s safe and potentially effective.
- The findings suggest that high-dose thiamine could be a promising treatment for managing fatigue in IBD patients, which is a common and challenging symptom with few effective options.]
Top posts
Most liked on X and Bluesky"We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well tolerated." https://t.co/AyqKLZq3bR
Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease' #IBD #fatigue #thiamine @hepgas #Crohns #colitis "significant beneficial effect of high‐dose oral thiamine on chronic fatigue in IBD."
Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @PalleBager in @APandT https://t.co/X7gQ0bP6Zm @HepGas @AUHdk
All mentions
The Health Benefits of Coffee: Caffeine and Your Well-being
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Exploring High-Dose Thiamine for Fibromyalgia and ME/CFS
This video examines the potential benefits of high-dose thiamine for those suffering from fibromyalgia and ME/CFS. It covers dosage, symptoms of deficiency, and relevant research findings. Join us to learn about the…
@seanstidston https://t.co/1OFqROawjW
RT @Outdoctrination: We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
RT @PDobrano: https://t.co/FPhfJzJIUD A RCT of high-dose thiamine (up to 6x 300mg pills per day) found a significant improvement in self-r…
https://t.co/FPhfJzJIUD A RCT of high-dose thiamine (up to 6x 300mg pills per day) found a significant improvement in self-reported #fatigue in #IBD patients in remission.
RT @Outdoctrination: We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
Why Coffee is GOOD for You | Is Coffee a Drug? https://t.co/kHOctn8ewb via @YouTube
RT @Outdoctrination: We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
RT @fseiichizb4: 高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。…
RT @Mangan150: Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammator…
RT @Mangan150: Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammator…
RT @Mangan150: Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammator…
RT @Mangan150: Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammator…
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease Patients took 600-1800 mg/d of thiamine (vitamin B1) and got significant relief from fatigue. https://t.co/PGVSLR1oC0
@Outdoctrination I wonder how much of the benefit comes from the thiamine and how much from the stomach acid ph lowering effects of HCl My 78-year-old father started taking Betaine HCl and it solved his gut issues and increased his energy within the first couple of days https://t.co/mpVUFN3En8
@Naomi_D_Harvey @AmazingWomenTo1 There is some recent support for a high threshold dose, at least for some conditions. In this paper, the authors conducted a randomized controlled trial of high-dose thiamine for IBD fatigue. Dosage varied by weight and gender from 600 to 1800 mg daily. https://t.co/tHJo2ievIA
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
RT @hirokazupapi: ⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
⚫︎チアミンと潰瘍性大腸炎・クローン病 ランダム化臨床試験:静止状態の炎症性腸疾患患者の慢性疲労に対する高用量経口チアミン対プラセボ
@yecksd I think you will like this video https://t.co/YQl8zQO4R1
@detoxdudeslogan I feel like coffee is not inherently bad: https://t.co/kCVUBY46TQ I think there is only a problem if it interferes with sleep or someone is sensitive to it. Personally, I am pretty sensitive so I see where you are coming from
RT @Outdoctrination: We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
RT @Outdoctrination: We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
We made an in depth video on this topic so be sure to check that out for more: https://t.co/KAz7qaToWS
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
RT @drkohilathas: "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well t…
"We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well tolerated." https://t.co/AyqKLZq3bR
@ItsJustinRhodes @Ry_Dhillon You should watch this! It takes a very positive angle on coffee. Its maybe geared a little more towards the younger generation, but it still has helpful info. God bless! https://t.co/wEasfMB7hY
@CrypTractor Atleast 5 black! https://t.co/87M2e5MrKq
@DKgolfsUT @sam_gzstrength https://t.co/UmSIwrQ08R
RT @CCYANetwork: Check this out!! Super interesting study on the effects of Thiamine on chronic fatigue in IBD patients. https://t.co/ds9…
Check this out!! Super interesting study on the effects of Thiamine on chronic fatigue in IBD patients. https://t.co/ds9urkApkA https://t.co/xOqWdOPHfj
@CCYANetwork @oridamas @moss_md https://t.co/kwqSt5au4F
RT @Outdoctrination: Our most recent video goes into greater detail, and we'd really appreciate it if you guys want to check it out: https:…
RT @Outdoctrination: Our most recent video goes into greater detail, and we'd really appreciate it if you guys want to check it out: https:…
inflammatory bowel disease (IBD) "We showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue in IBD. The treatment was well tolerated." https://t.co/ywWDpzovO7
RT @HansAmato: However, large doses of vitamin B1 (600-1800mg) is very effective at reducing fatigue. B1 enhances glucose oxidation, increa…
RT @HansAmato: However, large doses of vitamin B1 (600-1800mg) is very effective at reducing fatigue. B1 enhances glucose oxidation, increa…
However, large doses of vitamin B1 (600-1800mg) is very effective at reducing fatigue. B1 enhances glucose oxidation, increases ATP production and increases dopamine levels. https://t.co/pUDuNPvICm
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
@martinfinne https://t.co/GkbI69RPqP
@gaitanalyst Peater friend’s video @Outdoctrination https://t.co/vZWkt8vfsz
Doing research for the coffee video was one of the easiest I’ve had to do Very hard to make it look bad, even with studies designed to https://t.co/KAz7qbaZOq
@OGadeholt @PerHelgeM @KristianGunder @AnnMauseth @Ventzakov @SFlottorp @SigridSollund Ibs som dx etter utelukkingsdiagnostistikk men fortsatt kronisk tarmkatarr? ( Ja, debatten fins i gastroforskstudier) Hvis du skjønner hva jeg sier (-: Lite tips om fatigue: https://t.co/BxpcopzsZp
RT @inuoinmusicPho: Megadoses of vitamin B1 shows significant reduction in the chronic fatigue of patients with intestinal bowel disease, i…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @inuoinmusicPho: Megadoses of vitamin B1 shows significant reduction in the chronic fatigue of patients with intestinal bowel disease, i…
Megadoses of vitamin B1 shows significant reduction in the chronic fatigue of patients with intestinal bowel disease, in a randomized controlled trial: https://t.co/o8QQBgqA4J
@Outdoctrination I think your past self answered this question quite nicely: https://t.co/JpBtXSGMNw
@rawmilkhoney We have a video on it! https://t.co/KAz7qaToWS
RT @Outdoctrination: High dose thiamine (vitamin B1) treats chronic fatigue “mean reduction of 4.5 points in fatigue after thiamine compar…
RT @Outdoctrination: High dose thiamine (vitamin B1) treats chronic fatigue “mean reduction of 4.5 points in fatigue after thiamine compar…
High dose thiamine (vitamin B1) treats chronic fatigue “mean reduction of 4.5 points in fatigue after thiamine compared with a mean increase of 0.75 point (P = 0.0003) after placebo. https://t.co/04VC7iKVY9
RT @boretrol: Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease https://t.co/fdinS85MoU
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease https://t.co/jqd0DoKu5e
@IBS_Maastricht @AGA_CGH @bottomlineibd @john_damianosMD @SultanMahmoodMD @drkeithsiau @stevenbollipo @RomeGastroPsych @DrTiffTaft @MujagicZlatan @michaelbassGI @DrvanTilburg Worth highlighting the great X-over study which found that high-dose thiamine was useful for fatigue. https://t.co/92sg9qEmJ9
@cathymac40 @WesElyMD In addition to the research collected in the Sedhai metanalysis that I think you are referencing, there is a small but growing body of literature suggesting that high-dose oral thiamine HCL reduces fatigue in patients with inflammatory conditions. E.g. https://t.co/vGZnmXyxeN
RT @B_Holmer: Just got around to watching this. AWESOME video @Outdoctrination ☕️ Why You SHOULDN'T Quit Coffee https://t.co/I2vYouXTPK
Just got around to watching this. AWESOME video @Outdoctrination ☕️ Why You SHOULDN'T Quit Coffee https://t.co/I2vYouXTPK
RT @beejereeno: Great video "Why You SHOULDN'T Quit Coffee" by @Outdoctrination https://t.co/o2giFjpD0O
Great video "Why You SHOULDN'T Quit Coffee" by @Outdoctrination https://t.co/o2giFjpD0O
@Runsforcoffee1 @ProfWhelan @bottomlineibd @charlie_lees https://t.co/4Kp321hIVd
RT @Outdoctrination: Good quality coffee is also rich in magnesium and thiamine, two nutrients that are absolutely critical for energy prod…
RT @Outdoctrination: Our most recent video goes into greater detail, and we'd really appreciate it if you guys want to check it out: https:…
@Sonadina https://t.co/BokPJeC4Jb Ironically this is just out!
RT @Outdoctrination: Our most recent video goes into greater detail, and we'd really appreciate it if you guys want to check it out: https:…
Good quality coffee is also rich in magnesium and thiamine, two nutrients that are absolutely critical for energy production. Thiamine has even been tested in certain trials of chronic fatigue syndrome, with encouraging results: https://t.co/KgOqD92shy
Our most recent video goes into greater detail, and we'd really appreciate it if you guys want to check it out: https://t.co/eOGZXwJi6n fully referenced in the description
RT @arvtuyll: Thought came from the first minute of this video by @Outdoctrination https://t.co/xx8FQXCYtn
Thought came from the first minute of this video by @Outdoctrination https://t.co/xx8FQXCYtn
RT @mediumwhite: @NeeraGuptaMD @DrTiffTaft There was a really interesting and successful Dbl-Blind X-over trial showing high-dose thiamine…
RT @fseiichizb4: 高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。…
RT @fseiichizb4: 高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。…
RT @fseiichizb4: 高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。…
RT @fseiichizb4: 高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。…
高用量ビタミンB1は炎症性腸疾患患者の慢性疲労を軽減する。 非活動性の炎症性腸疾患を持つ慢性疲労患者40人に高用量ビタミンB1(600~1800㎎/日)を4週間投与するダブルブラインドテスト。高用量ビタミンB1群は4.5ポイントの倦怠感減少。 素晴らしい(^^) https://t.co/ODWjNUjxtr
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent in… https://t.co/jqd0DoKu5e
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
RT @Mangan150: Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
Thiamine (vitamin B1) reduces chronic fatigue in patients with IBD, randomized controlled trial. https://t.co/X5F4MfBnRD
My letter comments on a groundbreaking RCT which found that high-dose thiamine reduced fatigue in patients with quiescent IBD. https://t.co/tHJo2ievIA. The authors' response to my letter can be found here: https://t.co/GaMflMfWOf
@ibdrelief Oral Thiamine for fatigue in quiescent IBD https://t.co/Le8ivO63R1
@LaddsEmma @Leicnut I think he is referring to this study, which is small, but statistically significant. It feels like the kind of cheap & easy therapy which could be tested fast through the LongCovid clinics. Given the lack of options, it would be great to test these. https://t.co/xJ5d3GFCZ5
RT @JeffLubell_C19: New study found high-dose thiamine effective in treating IBD fatigue. First randomized trial I believe. https://t.co/9…
New study found high-dose thiamine effective in treating IBD fatigue. First randomized trial I believe. https://t.co/9bVk06U3BM. Builds on a series of case studies by Dr. Costantini and colleagues finding high-dose thiamine effective for a range of neurological conditions. https://t.co/kzy713xaQC
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
Interesting RCT suggesting that high dose oral thiamine is beneficial in the management of fatigue in patients with IBD and quiescent disease https://t.co/eUcqucm8jG
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease. https://t.co/JSQYwqZQ1i
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @drkeithsiau: Does thiamine (
RT @drkeithsiau: Does thiamine (
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
Does thiamine (
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
https://t.co/FFJno5WGaA https://t.co/QdP9pkONjf
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
RT @APandT: 'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory…
'Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease' #IBD #fatigue #thiamine @hepgas #Crohns #colitis "significant beneficial effect of high‐dose oral thiamine on chronic fatigue in IBD."
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease https://t.co/zyOvxerLoy
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
RT @JulsgaardMette: Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @…
Oral thiamine, a brilliant and cheap treatment for chronic fatigue in quiescent #IBD. Just published by my colleague @PalleBager in @APandT https://t.co/X7gQ0bP6Zm @HepGas @AUHdk
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