March 2021 PMID 33241624

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.

Arne Hinrichs, Evamaria O Riedel, Nikolai Klymiuk, Andreas Blutke, Elisabeth Kemter, Matthias Längin, Maik Dahlhoff, Barbara Keßler, Mayuko Kurome, Valeri Zakhartchenko, Eva-Maria Jemiller, David Ayares, Martin Bidlingmaier, Florian Flenkenthaler, Martin Hrabĕ de Angelis

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Mentions

Peak: 1 in Jan 2022

across 3 sources since Jan 2022

Extended reach

158,909

potential audience

Total likes

2,432

Video views

158,655

Mentions per month

Jan 2022 – Jun 2022

Where it's discussed

News3 articles
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YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the importance of the research by referencing its high download ranking and technical methods like CRISPR, with enthusiastic phrases such as 'top downloaded' and 'innovative.' The tone indicates a recognition of its potential to revolutionize transplant research, demonstrating both excitement and respect for the scientific advancements involved.

AgreementStrong agreement

Most discussions align positively with the article, emphasizing its innovative use of gene editing to control pig size for transplantation purposes.

InterestHigh interest

The discussions reflect high engagement with the topic, mentioning techniques like CRISPR and implications for xenotransplantation, showing genuine curiosity.

EngagementModerate engagement

While many users actively comment and share excitement, some discussions remain superficial or appreciative without deep technical analysis.

ImpactHigh impact

The prominence of the article in downloads and the positive tone suggest it is perceived as having significant scientific and medical impact.

Abstract in brief

Researchers used gene editing (CRISPR-Cas9) to delete the growth hormone receptor (GHR) in genetically modified pigs to control their size for transplant studies.
GHRKO pigs showed significantly reduced body and heart size by 6 months of age, with normal organ function and no major changes in heart protein profiles, making them suitable donors.
This approach allows for the use of mature, appropriately sized pigs for xenotransplantation, potentially improving long-term success of pig organ transplants in primates.

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All mentions

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