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J Transl Med November 2020 PMID 33246476

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine.

Sepideh Nikfarjam, Jafar Rezaie, Naime Majidi Zolbanin, Reza Jafari

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Abstract in brief

  • Mesenchymal stem cell (MSC) derived exosomes are emerging as a promising cell-free therapy in regenerative medicine, primarily due to their ability to deliver functional molecules like miRNA, proteins, and cytokines that promote tissue healing.
  • Unlike MSCs themselves, exosomes are more stable and present fewer safety risks, such as clogging blood vessels, making them advantageous for therapeutic applications across various diseases including heart, kidney, liver, immune, neurological conditions, and wound healing.
  • The review highlights different methods of isolating MSC-derived exosomes and summarizes current clinical research, emphasizing their potential as a modern, safe, and effective approach in translational medicine.
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