November 2020 PMID 33298900

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.

Qi Zhang, Catherine Zhengzheng Chen, Manju Swaroop, Miao Xu, Lihui Wang, Juhyung Lee, Amy Qiu Wang, Manisha Pradhan, Natalie Hagen, Lu Chen, Min Shen, Zhiji Luo, Xin Xu, Yue Xu, Wenwei Huang

Mentions

3
Peak: 2 in Mar 2021
across 2 sources since Mar 2021

Extended reach

1,012,107
potential audience

Total likes

37,324

Video views

1,009,203

Mentions per month

Mar 2021 – Mar 2024

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The overall tone reflects a strong interest in the potential to target HS with existing drugs, exemplified by remarks on how approved medications could be repurposed to prevent viral entry, and discussions of mechanisms such as disrupting the cell's actin network. Words like 'breakthrough' and 'promising' signal recognition of the research's importance, while mentions of 'in vitro' findings suggest cautious optimism about real-world impact.

AgreementModerate agreement

Most discussions acknowledge the findings about HS's role in viral entry and the potential for existing drugs to inhibit this process, reflecting general support.

InterestHigh interest

The posts demonstrate high interest, with many referencing drug repurposing and implications for COVID-19 treatment strategies.

EngagementModerate engagement

Participants actively analyze mechanisms, citing specific drugs like Mitoxantrone and Sunitinib, showing moderate deep engagement.

ImpactModerate impact

Analysis suggests that the discussions recognize the research's potential in guiding future treatments, but some posts temper optimism, indicating cautious acknowledgment of the findings' significance.

Abstract in brief

  • Heparan sulfate (HS) on the cell surface helps SARS-CoV-2 enter cells by working alongside the ACE2 receptor, and drugs that interfere with HS can block this process.
  • The study found that certain approved drugs, like Mitoxantrone, directly inhibit HS, while others like Sunitinib and BNTX disrupt the cell's actin network to prevent viral entry, and combining these drugs might be more effective.
  • Overall, the research shows HS is a key factor in the virus's ability to infect cells and identifies potential drug targets to prevent COVID-19 infection.]

Top posts

Most liked on X and Bluesky
bioRxiv Published
@biorxiv_pubd · X

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro published as: https://t.co/4oseqirgr1 #Cell_Discovery #biorxiv

Mar 5, 2024 · 2,905 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro published as: https://t.co/4oseqirgr1 #Cell_Discovery #biorxiv

Mar 5, 2024 · 2,905 followers View post →