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Comput Struct Biotechnol J December 2020 PMID 33312453

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses.

Guobing Li, Shasha Ruan, Xiaolu Zhao, Qi Liu, Yali Dou, Fengbiao Mao

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Mentions

11
Peak: 5 in Jan 2021
across 3 sources since Dec 2020

Extended reach

18,636
potential audience

Total likes

12

Video views

32

Mentions per month

Dec 2020 – Jan 2023

Where it's discussed

  • X / Twitter8 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects curiosity and recognition of the publication’s importance, with mentions of 'drug repurposing,' 'potential treatments,' and the involvement of notable researchers, which suggests a measured but positive reception. The use of words such as 'findings,' 'significance,' and referencing authors indicates a moderate level of engagement and interest rooted in the hope for impactful medical advances.

AgreementModerate agreement

Most discussions acknowledge the significance of the study and support the idea of drug repurposing for COVID-19.

InterestModerate interest

The discussions indicate moderate interest, focusing on potential treatments and the research methodology.

EngagementModerate engagement

Comments show a superficial engagement with some referring to the authors and the publication, but lacking detailed analysis.

ImpactModerate impact

Participants view the research as potentially influential in COVID-19 treatment strategies, emphasizing the importance of bioinformatics findings.

Abstract in brief

  • The study used bioinformatics techniques to analyze gene expression data from COVID-19 patients' lung tissue and blood, revealing that the disease triggers a "cytokine storm"—a harmful overactivation of the immune system involving molecules like interferon, TNF, and IL6.
  • It identified two key gene modules linked to COVID-19 severity and suggested that anti-inflammatory treatments could help manage the disease by calming this immune overreaction.
  • The research also proposed existing drugs, such as TNF inhibitors (like etanercept) and GABAB receptor agonists (like baclofen), as potential repurposing options for COVID-19, though clinical trials are needed to confirm their effectiveness.]
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Top posts

Most liked on X and Bluesky
UMich RNA Center 〽️
@umichrna · X

Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses" co-authors Guobing Li and Yali Dou from @UMichPath https://t.co/07b1j8SV3C https://t.co/nDTqo4duLp

Jan 15, 2021 · 8 likes · 3 shares · 3,581 followers View post →
CSBJ
@CSB_Journal · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses. Read the article here: https://t.co/WnfIhSMKwG https://t.co/TgqiqARx6F

Jan 31, 2021 · 2 likes · 538 followers View post →
D.B.R.K Gupta Udatha
@DBRK_Gupta · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses https://t.co/F1H6mUvioC https://t.co/tBD5CrVO36

Dec 27, 2020 · 1 like · 302 followers View post →
Angela Reiersen, MD, MPE
@AngelaReiersen · X

RT @umichrna: Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinform…

Jan 22, 2021 · 3 shares · 5,415 followers View post →
Your HPLC DataBase
@LC_Analysis · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses https://t.co/VFRF2npDy4

May 18, 2021 · 3,545 followers View post →
Fabrice Leclerc
@rnomics · X

RT @umichrna: Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinform…

Jan 16, 2021 · 3 shares · 2,759 followers View post →

All mentions

Your HPLC DataBase
@LC_Analysis · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses https://t.co/VFRF2npDy4

May 18, 2021 · 3,545 followers View post →
CSBJ
@CSB_Journal · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses. Read the article here: https://t.co/WnfIhSMKwG https://t.co/TgqiqARx6F

Jan 31, 2021 · 2 likes · 538 followers View post →
Angela Reiersen, MD, MPE
@AngelaReiersen · X

RT @umichrna: Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinform…

Jan 22, 2021 · 3 shares · 5,415 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @umichrna: Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinform…

Jan 16, 2021 · 3 shares · 632 followers View post →
Fabrice Leclerc
@rnomics · X

RT @umichrna: Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinform…

Jan 16, 2021 · 3 shares · 2,759 followers View post →
UMich RNA Center 〽️
@umichrna · X

Repurposing drugs for #COVID19: "Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses" co-authors Guobing Li and Yali Dou from @UMichPath https://t.co/07b1j8SV3C https://t.co/nDTqo4duLp

Jan 15, 2021 · 8 likes · 3 shares · 3,581 followers View post →
D.B.R.K Gupta Udatha
@DBRK_Gupta · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses https://t.co/F1H6mUvioC https://t.co/tBD5CrVO36

Dec 27, 2020 · 1 like · 302 followers View post →
Transcriptomes
@transcriptomes · X

Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinforma... https://t.co/cAx4IrbD9m

Dec 15, 2020 · 1,809 followers View post →