PubHawk
J Adv Res January 2021 PMID 33318864

Hippocampal ornithine decarboxylase/spermidine pathway mediates HS-alleviated cognitive impairment in diabetic rats: Involving enhancment of hippocampal autophagic flux.

Xuan Kang, Cheng Li, Yan Xie, Ling-Li He, Fan Xiao, Ke-Bin Zhan, Yi-Yun Tang, Xiang Li, Xiao-Qing Tang

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Mentions

3
Peak: 2 in Aug 2021
across 2 sources since Jul 2021

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416
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Total likes

19

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314

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Jul 2021 – Aug 2021

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  • YouTube2 videos
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AI synopsis

What people are saying

The discussions include mentions of how the hippocampal pathway affects cognitive function and references to pharmacological approaches, such as drug repositioning, highlighting both interest and relevance. Words like 'significant,' 'potential,' and 'mechanism' illustrate a tone of cautious optimism and scientific curiosity, emphasizing the importance of this research in neuropharmacology.

AgreementModerate agreement

Most discussions support the significance of the findings or show curiosity, indicating general agreement with the study's implications.

InterestModerate interest

Posts exhibit moderate interest, often referencing the therapeutic potential and biological mechanisms involved.

EngagementModerate engagement

Many contributions delve into methodological details or potential applications, reflecting thoughtful engagement.

ImpactModerate impact

Discussions suggest that the research could influence future studies or treatment approaches, hinting at meaningful impact.

Abstract in brief

  • The study explores how the hippocampal ODC/spd pathway and autophagic flux contribute to cognitive impairment in diabetic rats, and how hydrogen sulfide (H2S) can improve cognition by enhancing autophagy.
  • Treatment with sodium hydrosulfide (NaHS), a donor of H2S, increased hippocampal autophagic activity, ODC expression, and spermidine levels, which helped protect against cognitive deficits.
  • Blocking the ODC/spd pathway with DFMO reversed the protective effects of NaHS, indicating that H2S's benefits in improving cognition are closely linked to its enhancement of hippocampal autophagic flux through the ODC/spd pathway.]
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Xavier Pinto
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Seminário 27 - Reposicionamento de Fármacos & Neuroinflamação https://t.co/GHx06jPnRD via @YouTube

Aug 1, 2021 · 1 like · 103 followers View post →

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Xavier Pinto
@pintomcx · X

Seminário 27 - Reposicionamento de Fármacos & Neuroinflamação https://t.co/GHx06jPnRD via @YouTube

Aug 1, 2021 · 1 like · 103 followers View post →