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JCI Insight December 2020 PMID 33328385

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation.

Augusto F Schmidt, Paranthaman S Kannan, James Bridges, Pietro Presicce, Courtney M Jackson, Lisa A Miller, Suhas G Kallapur, Claire A Chougnet, Alan H Jobe

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Mentions

10
Peak: 8 in Dec 2020
across 2 sources since Dec 2020

Extended reach

75,182
potential audience

Total likes

29

Video views

639

Mentions per month

Dec 2020 – Sep 2021

Where it's discussed

  • X / Twitter9 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall discourse reflects positive reception of the study's findings, with many posts highlighting the beneficial effects of inflammation on fetal lung maturation, such as 'promotes preterm lung maturation,' while also acknowledging potential risks like 'treatment may be associated with increased risk of chronic lung disease.' The tone is curious and forward-looking, emphasizing both the promising results and the need for cautious interpretation.

AgreementModerate agreement

Most comments agree that prenatal inflammation can improve fetal lung maturation when combined with corticosteroid treatment, as indicated by positive phrasing like 'enhances' and sharing of supporting evidence.

InterestHigh interest

The discussions clearly show high interest, with multiple mentions of the study and enthusiasm conveyed through hashtags and phrases like 'promote' and 'potentially offering' those suggest engagement with the topic.

EngagementModerate engagement

Some posts reference specific studies, methods, and implications, indicating a moderate level of engagement, but few delve deeply into mechanisms or long-term consequences.

ImpactModerate impact

There is a recognition that this research could influence clinical strategies, but the tone suggests cautious optimism rather than definitive impact, as reflected in cautious language about risks and benefits.

Abstract in brief

  • Prenatal inflammation combined with low-dose antenatal corticosteroids (ACS) in rhesus macaques improves lung function and surfactant production, potentially offering preterm infants a respiratory advantage.
  • The study reveals that this combined treatment suppresses cellular proliferation and promotes mesenchymal cell death through TP53 pathways, leading to a mature lung-like gene expression profile, but also inhibits extracellular matrix development, which could affect long-term lung health.
  • While ACS in an inflamed environment may provide early respiratory benefits, it might also pose risks for abnormal lung tissue development and chronic lung disease due to interference with normal extracellular matrix and lung progenitor cell activity.]
Read the full abstract

Top posts

Most liked on X and Bluesky
JCI insight
@JCI_insight · X

Low-dose antenatal corticosteroids and inflammation promote preterm NHP lung maturation: https://t.co/wUVz8nJsAj @_gusschmidt_ @CincyChildrens #Development #Pulmonology https://t.co/57FPZfX9t5

Dec 21, 2020 · 10 likes · 39,985 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/35iYIdc5Ld

Dec 19, 2020 · 1 like · 2 shares · 5,770 followers View post →
rochatka_dla_zdrowia
@jerochatka · X

Treatment with ACS in the setting of inflammation may be associated with increased risk of chronic lung disease. https://t.co/WX2A4pSpji

Sep 3, 2021 · 1 like · 820 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/hMbIIegpLE

Dec 18, 2020 · 5,770 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/xjX9iW3fsm

Dec 24, 2020 · 5,770 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/Wk7w6ySyPd

Dec 23, 2020 · 5,770 followers View post →

All mentions

rochatka_dla_zdrowia
@jerochatka · X

Treatment with ACS in the setting of inflammation may be associated with increased risk of chronic lung disease. https://t.co/WX2A4pSpji

Sep 3, 2021 · 1 like · 820 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/xjX9iW3fsm

Dec 24, 2020 · 5,770 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/Wk7w6ySyPd

Dec 23, 2020 · 5,770 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/XXSuwvuyQU

Dec 21, 2020 · 5,770 followers View post →
JCI insight
@JCI_insight · X

Low-dose antenatal corticosteroids and inflammation promote preterm NHP lung maturation: https://t.co/wUVz8nJsAj @_gusschmidt_ @CincyChildrens #Development #Pulmonology https://t.co/57FPZfX9t5

Dec 21, 2020 · 10 likes · 39,985 followers View post →
neo_twiter
@neo_twiter · X

RT @neo_papers: Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/35iYIdc5Ld

Dec 19, 2020 · 2 shares · 2,916 followers View post →
Marcio Fossari
@marciofossari · X

RT @neo_papers: Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/35iYIdc5Ld

Dec 19, 2020 · 2 shares · 1,960 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/35iYIdc5Ld

Dec 19, 2020 · 1 like · 2 shares · 5,770 followers View post →
neo_papers
@neo_papers · X

Prenatal inflammation enhances antenatal corticosteroid-induced fetal lung maturation #NeoPapers https://t.co/hMbIIegpLE

Dec 18, 2020 · 5,770 followers View post →