PubHawk
February 2021 PMID 33340456

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Amir Tirosh, Gurol Tuncman, Ediz S Calay, Moran Rathaus, Idit Ron, Amit Tirosh, Abdullah Yalcin, Yankun G Lee, Rinat Livne, Sophie Ron, Neri Minsky, Ana Paula Arruda, Gökhan S Hotamisligil

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Mentions

61
Peak: 32 in Dec 2020
across 4 sources since Dec 2020

Extended reach

248,427
potential audience

Total likes

215

Video views

2,040

Mentions per month

Dec 2020 – Feb 2022

Where it's discussed

  • X / Twitter50 posts
  • News6 articles
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions highlight the publication's contributions, with comments praising the sophisticated approach and curiosity about the role of metabolites. For instance, phrases like 'very cool' and 'excellent contribution' convey enthusiasm and appreciation for the research, reflecting an engaged and positive tone that enhances the perception of the work's importance.

AgreementModerate agreement

The discussions predominantly support the conclusions of the publication, indicating a moderate level of agreement.

InterestHigh interest

Participants express a high level of interest, with many indicating curiosity about the implications of the research.

EngagementModerate engagement

While some posts merely share the article, a few show deeper engagement by discussing methods and potential impacts.

ImpactHigh impact

Overall, the discussions suggest that users perceive the publication to have significant implications for understanding obesity.

Abstract in brief

  • Endoplasmic reticulum stress (ERS) contributes to insulin resistance linked to obesity, but how tissues respond to it is not well understood.
  • Increased connexin 43 (Cx43) in liver cells (hepatocytes) enhances communication between stressed and unstressed cells, leading to a “bystander response” where ERS spreads from stressed to healthy cells.
  • Blocking Cx43 can protect against diet-induced ERS and insulin resistance, suggesting that Cx43-mediated cell coupling worsens the effects of obesity on liver function and glucose metabolism.
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Cell Metabolism
@Cell_Metabolism · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 92 likes · 21 shares · 53,671 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

Feb 3, 2021 · 43 likes · 5 shares · 53,671 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism An excellent contribution from ⁦@ghotamis⁩ and authors https://t.co/jQ9mm3ATPv

Dec 18, 2020 · 22 likes · 2 shares · 1,480 followers View post →
fabienne foufelle
@FFoufelle · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 18, 2020 · 21 likes · 6 shares · 294 followers View post →
Bruna Martins Garcia
@BrunaMartinsGa2 · X

Today at our JC we discussed this really nice work from @AmirTirosh @ghotamis @apsarruda and co-authors. We enjoyed the sophisticated and precise approaches and we are super curious about possible exchange of metabolites in this context :) https://t.co/xIkxitcfPA

Feb 9, 2022 · 20 likes · 2 shares · 1,191 followers View post →
FET_PANACHE
@FET_PANACHE · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism - ScienceDirect https://t.co/N6ddrIyjjd

Jan 17, 2021 · 7 likes · 1 share · 92 followers View post →

All mentions

Impact of ER Stress on Metabolism in Obesity

This video highlights the role of endoplasmic reticulum stress (ERS) in insulin resistance associated with obesity. It explores how increased connexin 43 (Cx43) in liver cells facilitates intercellular communication…

Nelson Arenas · Jan 20, 2021 2,006 views
Srikanta
@Drskrath · X

RT @saip_pydi: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism: Cell Metabolism https://t.co/6sWOlV…

Feb 21, 2022 · 1 share · 1,142 followers View post →
Sai P Pydi
@saip_pydi · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism: Cell Metabolism https://t.co/6sWOlV8xuv

Feb 17, 2022 · 1 like · 1 share · 646 followers View post →
franzappa
@franzappa2 · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism: Cell Metabolism - another evidence of cell-to-cell stress propagation, very cool! https://t.co/aZeGSDlKuc

Feb 17, 2022 · 514 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @BrunaMartinsGa2: Today at our JC we discussed this really nice work from @AmirTirosh @ghotamis @apsarruda and co-authors. We enjoyed t…

Feb 9, 2022 · 2 shares · 2,811 followers View post →
Bruna Martins Garcia
@BrunaMartinsGa2 · X

Today at our JC we discussed this really nice work from @AmirTirosh @ghotamis @apsarruda and co-authors. We enjoyed the sophisticated and precise approaches and we are super curious about possible exchange of metabolites in this context :) https://t.co/xIkxitcfPA

Feb 9, 2022 · 20 likes · 2 shares · 1,191 followers View post →
Marisol OI
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/qWaTyUKGRo

Aug 7, 2021 · 3 shares · 84 followers View post →
Zewen (Owen) Jiang, PhD
@OwenJ457 · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/qWaTyUKGRo

Aug 7, 2021 · 3 shares · 162 followers View post →
Atsushi_Tanaka_PhD
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/qWaTyUKGRo

Aug 7, 2021 · 3 shares · 569 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Intercellular Transmission of Hepatic ER Stress in…" (https://t.co/IlC0Sxo9nn) included RRIDs in their paper! We appreciate the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience

May 1, 2021 · 161 followers View post →
Agingdoc
@agingdoc1 · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/jgMPOhDjSZ

Feb 6, 2021 · 41,446 followers View post →
Sakamoto Lab
@LabSakamoto · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

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Pierre-Henri Ducluzeau
@PHDucluzeau · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

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Te-Yueh (Derek) Lin
@Derek_Lin_57 · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

Feb 3, 2021 · 5 shares · 93 followers View post →
Shijun Deng
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

Feb 3, 2021 · 5 shares · 117 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/ibfNxFB35t

Feb 3, 2021 · 43 likes · 5 shares · 53,671 followers View post →
FET_PANACHE
@FET_PANACHE · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism - ScienceDirect https://t.co/N6ddrIyjjd

Jan 17, 2021 · 7 likes · 1 share · 92 followers View post →
Imran Dastan
@dastan_imran · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Jan 8, 2021 · 21 shares · 153 followers View post →
Gökhan Hotamışlıgil
@ghotamis · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Jan 7, 2021 · 21 shares · 48,543 followers View post →
りっくる
@rikkururikkuru · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 30, 2020 · 21 shares · 1 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/pcYJqTCdmD

Dec 21, 2020 · 876 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/aSgusJsDaC https://t.co/iFqiXpI6FF https://t.co/LXjYRbvTMt

Dec 21, 2020 · 876 followers View post →
Connexin Papers
@ConnexinPapers · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. https://t.co/A1iknaxQBy

Dec 20, 2020 · 212 followers View post →
Maribel Hernandez Alvarez
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 19, 2020 · 21 shares · 272 followers View post →
Emmanuelle Lecornet Sokol
@EmmanuelleLeco8 · X

RT @FFoufelle: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 19, 2020 · 6 shares · 572 followers View post →
Dipsikha Biswas
@itsmedipsikha · X

RT @FFoufelle: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 19, 2020 · 6 shares · 904 followers View post →
Amaya Lopez-Pascual
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RT @FFoufelle: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

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Laura Poillet
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 19, 2020 · 21 shares · 331 followers View post →
Dr Anthony Martin
@AMAinsight · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism - ScienceDirect https://t.co/O61wljrX96

Dec 19, 2020 · 913 followers View post →
Petra Hirsova
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Taner
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Brittany Moyce Gruber @bmgruber.bsky.social
@brittany_moyce · X

RT @SchertzerLab: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism An excellent contribution from ⁦…

Dec 18, 2020 · 2 shares · 647 followers View post →
John R. Ussher
@JussherLab · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 892 followers View post →
Ebru Erbay
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RT @FFoufelle: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 18, 2020 · 6 shares · 3,297 followers View post →
Mychael Lourenco
@mvlourenco · X

RT @FFoufelle: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 18, 2020 · 6 shares · 3,018 followers View post →
fabienne foufelle
@FFoufelle · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/gFyH1CutwQ

Dec 18, 2020 · 21 likes · 6 shares · 294 followers View post →
Moir2_IR
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Alfredo I. Sagredo
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Tony K.T. Lam
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RT @SchertzerLab: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism An excellent contribution from ⁦…

Dec 18, 2020 · 2 shares · 1,388 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism An excellent contribution from ⁦@ghotamis⁩ and authors https://t.co/jQ9mm3ATPv

Dec 18, 2020 · 22 likes · 2 shares · 1,480 followers View post →
SEBCell
@SEBCellular · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 440 followers View post →
Lauren Lynch
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 43 followers View post →
Alan Tung 童聖驊
@alanshtung · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 803 followers View post →
Paul Humphries
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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism - https://t.co/yrYjPMjUyO

Dec 18, 2020 · 2,603 followers View post →
Marta Varela-Rey
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Vargas-Vazquez A
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Mayke Briggs
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Bruno Ramos-Molina, PhD
@Brunorm84 · X

RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 6,437 followers View post →
BANT
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

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Peter Crawford
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RT @Cell_Metabolism: Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 21 shares · 1,689 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism https://t.co/o6t3T65s6S

Dec 18, 2020 · 92 likes · 21 shares · 53,671 followers View post →