J Neurol January 2022 PMID 33417003

Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.

Gholami Fatemeh, Moradi Sajjad, Rasaei Niloufar, Soveid Neda, Setayesh Leila, Mirzaei Khadijeh

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Mentions

238

Peak: 48 in Feb 2021

across 5 sources since Feb 2021

Extended reach

1,854,443

potential audience

Total likes

4,621

Video views

495,531

Mentions per month

Feb 2021 – Jul 2025

Where it's discussed

News130 articles
X / Twitter97 posts
YouTube6 videos
Facebook3 posts
Blogs2 articles

AI synopsis

What people are saying

Discussions generally reinforce the positive impact of melatonin on sleep, referencing systematic reviews and meta-analyses, with phrases like 'it works' and 'safety at high doses,' indicating a broad consensus on its effectiveness and significance. Words like 'confirmed,' 'scientifically supported,' and mentions of 'meta-analyses' highlight the serious and research-backed nature of the conversations, contributing to the high agreement and impact scores.

AgreementStrong agreement

Most discussions echo support for the research’s findings, with posts emphasizing the positive effects of melatonin on sleep quality, such as 'melatonin funguje!' and 'verificamos que o tratamento com melatonina exógena tem efectos positivos na qualidade

InterestHigh interest

The posts demonstrate high curiosity and engagement, referencing specific scientific studies, meta-analyses, and discussions of doses and safety, indicating strong interest in the topic.

EngagementModerate engagement

Many posts cite the methodology, data, and implications of the research, showing moderate to deep engagement, though some simply affirm the findings without detailed analysis.

ImpactHigh impact

The widespread mention of the meta-analyses, safety, and potential health benefits reflects the perceived high impact of this research on sleep treatment approaches and health perspectives.

Abstract in brief

The study systematically reviewed 23 randomized controlled trials to assess how melatonin affects sleep quality in adults with various health conditions, finding that melatonin generally improves sleep as measured by the Pittsburgh Sleep Quality Index.
The results showed a significant overall benefit of melatonin on sleep quality, especially in people with respiratory diseases, metabolic disorders, and sleep disorders, though there was variability (heterogeneity) among the studies.
Subgroup analysis indicated that melatonin's positive effects are more pronounced in certain groups, such as those with respiratory or metabolic issues, but less so for mental or neurodegenerative disorders.]

Read the full abstract

All mentions

Melatonin for Sleep and Its Broader Health Benefits

Explore how melatonin regulates sleep and its potential medical uses, including anti-inflammatory and cardiovascular protection. Learn about safe dosage, side effects, and its possible role during health crises like…

Tagalog Health Talks · Mar 7, 2023 308,258 views

Evaluating Melatonin's Effectiveness in Delirium Prevention in Hospitalized Patients

This review investigates whether melatonin can prevent delirium in hospitalized patients, analyzing 16 trials with 1634 patients. Melatonin shortens ICU stay but shows no significant impact on delirium incidence or…

Dr. med. Ulrich Selz · Jul 12, 2025 119,952 views

Melatonin's Impact on Delirium Prevention in Hospitalized Patients

This systematic review and meta-analysis examined whether melatonin can prevent delirium in hospitalized patients. The analysis of 16 trials with 1634 patients found no significant reduction in delirium incidence but…

Dr. med. Ulrich Selz · Jun 10, 2025 67,175 views

Melatonin Uses and Benefits for Sleep Regulation

Melatonin is a hormone produced by the pineal gland that regulates circadian rhythms and sleep cycles. This video covers its functions, optimal usage, safety, and effects on sleep quality, supported by scientific…

BeePharma com Dra. Débora Costa · Jan 14, 2023 96 views

Natural Foods to Improve Sleep Quality and Efficiency

Discover natural foods that help you fall asleep faster and stay asleep longer. This video highlights 10 science-backed foods, including magnesium-rich bananas and tart cherries, that support better sleep without…

Everyday Wellness · Jul 29, 2025 41 views

Melatonin and Diet Strategies to Improve Sleep Quality

This video explores how melatonin and dietary choices influence sleep quality. We discuss how melatonin supplements can help regulate sleep cycles and improve overall sleep. Practical tips include maintaining a balanced…

Nutricionista Allan Fernandes · Jan 30, 2025 11 views

Alexandr Slunsky

@slunsky · X

@janadubova21 Melatonin funguje! Davam ho pacientum a funguje

Oct 30, 2024 · 3 likes · 4,348 followers View post →

レノン | self-discipline

@lenon_up · X

https://t.co/bg7u0148CF… https://t.co/F84tQqWvjI https://t.co/rFZFIsGqfo https://t.co/wX7e10VDwa https://t.co/68dSPLefm8 https://t.co/EAICMpjgiD 参考動画 https://t.co/e2vYQwBWpC https://t.co/D0RZeEYwZo

Aug 15, 2024 · 1 like · 4,918 followers View post →

レノン | self-discipline

@lenon_up · X

https://t.co/4HuyaABq5o https://t.co/IPcZ1kWDQP https://t.co/rFZFIsGqfo https://t.co/HBayusoyjc https://t.co/68dSPLefm8 https://t.co/HKkPyisTT4 https://t.co/XIeGv1Uoex

Jul 18, 2024 · 1 like · 4,918 followers View post →

وازن

@SaudiHealthy · X

https://t.co/2yZlg0prcl

Apr 11, 2024 · 1 like · 5,461 followers View post →

Entrega Corisco

@entregacorisco · X

@FredLAFernandes E esquece que tem coisa robusta dizendo que funciona no sono. “Our results indicated that melatonin had significant effect on sleep quality” https://t.co/d7kYS8UORZ

Nov 23, 2023 · 111 followers View post →

J.Yasuda/PhD/Dietitian/CSCS

@yasu_junne · X

一般人を対象とした研究もあるようです。 https://t.co/Uqou1Qdh28 ただ、このキウイフルーツ内のメラトニンの容量（約500μg/2個）で睡眠の質が改善されるかは賛否ありそう。システマティックレビューでは2-10mgの研究が多く、3mgは改善に必要かもとのこと。 https://t.co/uLxk7D7gDc

Nov 6, 2023 · 624 followers View post →

gleb gladwin

@GladwinGleb · X

@theliverdr Some of these supplements are effective in alleviating many health conditions. I will pick two from both ends to show your scale doesnt convey anything significant. Plz don’t oversell. Be objective Turmeric https://t.co/0rdLC2L4K0 Melatonin https://t.co/u2s2T7Fis9

Sep 14, 2023 · 74 followers View post →

frank

@frankwikson · X

RT @BradStanfieldMD: References: https://t.co/N0t5brN8LK https://t.co/UFRJfnteoY https://t.co/ctQMEGGnsb https://t.co/vGR3sEx7qW https://t.…

Aug 27, 2023 · 1 share · 28 followers View post →

Dr Brad Stanfield

@BradStanfieldMD · X

Aug 27, 2023 · 3 likes · 1 share · 29,170 followers View post →

Marc_privat

@m_s_doc · X

@franzjaeger_ber @LabAndMedSchool Kennen Sie PubMed und verstehen sie englisch ? https://t.co/i29ehQpmWW

Aug 26, 2023 · 2 likes · 760 followers View post →

طالب

@Tl_cjj · X

@_Abdulku @duqsey و في دراسة اخرى، وجدوا ان الميلاتونين له تأثير واضح في تحسين جودة النوم للأشخاص الي يعانون من اضطرابات في النوم Pub med: https://t.co/S1sgk0QbWT https://t.co/GMPNoBOxnZ https://t.co/PM2Hi892fe https://t.co/JXZDuP1lGg

May 27, 2023 · 1,089 followers View post →

Dr Menka Gupta

@NutraNourish · X

References: https://t.co/uN9S7z9Joq https://t.co/JLHwpcbpS2 https://t.co/TbILoioc3G #sghealthy #sghealthyliving #healthsg #singaporehealth

Mar 10, 2023 · 485 followers View post →

1man

@1mantruthsquad · X

@newscientist For those annoyed that any interesting info (if there be any in this stupid sensational headlines and tweets) is behind a paywall. Here is some relevant info: https://t.co/m7Kw5JlAa9 https://t.co/R9ebUDNoq6

Dec 28, 2022 · 272 followers View post →

Saúl Sánchez

@SaulNutri · X

@Nomegustalayema Pásame el enlace de la comprobación por favor. Yo te dejo esta meta analisis con revisión sistemática de este año que demuestra que sí funciona https://t.co/oGRFW1QlDk

Dec 9, 2022 · 107,756 followers View post →

Julius

@julius_1108 · X

@HoneyPuu_ Bei kranken Menschen hilft es wohl… ob es dir was bringt musst du wohl selber rausfinden https://t.co/j4OTutNBaH

Dec 8, 2022 · 11 followers View post →

Manuel Bravo

@drmanolobravo · X

la evidencia científica –meta-analysis , a sus datos me remito– (https://t.co/a8n39KGZIB ) de que la melatonina es una sustancia atóxica al ciento por ciento y de que, por lo tanto, su ingesta, sea cual sea la dosis, no entraña riesgo alguno para la salud.

Nov 7, 2022 · 8,617 followers View post →

Marina González

@enferactive · X

@Guillamon_ @PauMatalap @hEIRmione_ Gracias Guille! La vd que el estudio es bueno y la muestra no es insignificante. Aunque es de 2013 y mirando hay evidencia más reciente que tb lo apoya. Me pongo puntito en la boca

Oct 19, 2022 · 2 likes · 13,616 followers View post →

Centro de Nutrición y Medicina Basados n Evidencia

@CentroNutMedUMM · X

Efecto de la suplementación con melatonina en la calidad del sueño: una revisión sistemática y metanálisis de ensayos controlados aleatorios. Doi: https://t.co/TOOzXneNxY https://t.co/Qz4gyvOutb

Sep 21, 2022 · 12 followers View post →

Dr.Roberto Fr Amaral

@doutorsaude_ · X

https://t.co/Kk2okL3sXs

Sep 15, 2022 · 1 like · 836 followers View post →

AR.Trades

@andre22reis · X

@theo_crypto99 https://t.co/xjUT69B2YK

Sep 13, 2022 · 21 followers View post →

Sofia Anastasia

@SofiaAnastasi14 · X

RT @alesolicienta: Referencia:

Jun 19, 2022 · 10 shares · 30 followers View post →

galactic baseballer

@reignitedx · X

RT @alesolicienta: Referencia:

Jun 17, 2022 · 10 shares · 242 followers View post →

JUGO NEGRO

@jugo_negro · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 35 followers View post →

Susana Paz Chahud

@SusanaPazChahud · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 139 followers View post →

JosVet

@pepboyswim · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 205 followers View post →

Sebas Barrionuevo

@sebasbarrio · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 116 followers View post →

@totto

@MspEspinosa · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 23 followers View post →

Di Isor

@dioraluna · X

RT @alesolicienta: Referencia:

Jun 6, 2022 · 10 shares · 203 followers View post →

Ale Somnóloga

@AleSomnologa · X

Referencia:

Jun 5, 2022 · 128 likes · 10 shares · 40,079 followers View post →

SHAUN

@shaun8990 · X

@gerardo_gamba https://t.co/c98oO4PFE9 por aqui le dejo esto Doc. También me ha ayudado con IBS.

Apr 1, 2022 · 31 followers View post →

Katie Lin MD MPH

@lilninjadoc · X

Very gratified to confirm that my post-dinner melatonin gummy candy habit is grounded in evidence #NerdAlert Side note: whoever decided to embed vitamins in gummies is a marketing genius. https://t.co/OQPv9qWWQN

Mar 20, 2022 · 927 followers View post →

JulianCoM

@JulianCoMx · X

@FrayFN "We found that the treatment with exogenous melatonin has positive effects on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adult." https://t.co/ev9YwiJ9pM

Feb 25, 2022 · 4 likes · 18,581 followers View post →

Dr Almothana Altamimi MD, BSc

@AlmothanaAlt · X

1. Melatonin supplementation showed improved sleep quality https://t.co/FmLNaipDKT

Jan 31, 2022 · 3,182 followers View post →

carol solon

@SolonCarol · X

@collucciclaudia https://t.co/OYDwQiZG9u. https://t.co/a45GPF8k6a

Nov 29, 2021 · 2 likes · 116 followers View post →

Maurício Lima

@dj_surfista · X

Efeito da #suplementação de #melatonina na qualidade do #sono: uma revisão sistemática e meta-análise de ensaios clínicos randomizados. "Verificamos que o tratamento com melatonina exógena tem efeitos positivos na qualidade do sono." #melatonin #sleep https://t.co/uqiF3dHSAn

Apr 19, 2021 · 1 like · 741 followers View post →

Austin bode

@austin_bode · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 40 followers View post →

DMT Quest

@dmt_quest · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 2,435 followers View post →

Thomas C. Jordan

@ThomasCJordan · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 3,984 followers View post →

Joel Evan

@coachjoelevan · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 376 followers View post →

Louis Dutch

@EmailLD · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 149 followers View post →

rgsbenavides

@rgsbenavides · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 166 followers View post →

Lông

@aaron_s_tran · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 118 followers View post →

Johnnie O

@johnnie_O · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 1,568 followers View post →

Cathy Andruzzi

@CathyAndruzzi · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 824 followers View post →

Lotusmonkey ✝️

@TheLotusMonkey · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 2,388 followers View post →

lsardanelli

@lsardanelli · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 612 followers View post →

@biohackopedia · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 84 followers View post →

└cs

@lcsmdlms · X

RT @bengreenfield: New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for th…

Apr 19, 2021 · 21 shares · 158 followers View post →

Ben Greenfield

@bengreenfield · X

New paper shows melatonin safe at high doses, you don't build tolerance and it helps a lot with sleep. Click here for the full study

Apr 19, 2021 · 96 likes · 21 shares · 94,732 followers View post →

John Siracusa

@john_siracusa · X