C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv https://t.co/1lQavpb5NE
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin α.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Jan 2021 – Feb 2025Where it's discussed
-
X / Twitter8 posts
-
YouTube6 videos
AI synopsis
What people are saying
Several discussions highlight the link between high C1GALT1 expression and decreased survival in pancreatic cancer, using words like 'poor survival' and 'promotes cell invasiveness' to underscore the findings' significance. The tone is mostly supportive and emphasizes the potential therapeutic implications, indicating a recognition of the study’s impact without deep technical critique.
The discussions clearly express strong support for the article’s findings and emphasize its significance, reflecting high agreement with its conclusions.
Participants show moderate curiosity, with some posts noting the importance of the research but not delving deeply into technical details.
The conversations indicate a basic level of engagement, such as sharing the study and noting its potential implications, but lack detailed critique or extensive discussion.
The posts suggest the research is considered impactful for understanding pancreatic cancer and potential therapies, highlighting its relevance in the oncology community.
Abstract in brief
- High expression of C1GALT1 is linked to poorer survival rates in pancreatic ductal adenocarcinoma (PDAC) patients and promotes tumor cell invasiveness by affecting integrin function.
- Experimental studies showed that knocking down C1GALT1 reduces PDAC cell viability, migration, invasion, and tumor growth, while overexpression has the opposite effect, enhancing invasiveness.
- Mechanistically, C1GALT1 influences cell invasion through its role in O-glycosylation of integrins, affecting cell-extracellular matrix adhesion via FAK phosphorylation, identifying C1GALT1 as a potential target for PDAC therapy.
Top posts
Most liked on X and BlueskyRT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
New article: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. https://t.co/oCRcxqGlGv #pancreaticcancer #oncology https://t.co/QAGRMgk26Z
All mentions
Restoring Gemcitabine Sensitivity in Pancreatic Cancer by Targeting C1GALT1
C1GALT1 high expression is linked to poor survival rates in pancreatic ductal adenocarcinoma and promotes tumor invasiveness. Knocking down C1GALT1 reduces cell viability, migration, and invasion, highlighting its…
Role of C1GALT1 in Pancreatic Cancer Progression and Survival
High expression of C1GALT1 is linked to poorer survival rates in pancreatic ductal adenocarcinoma and promotes tumor cell invasiveness by affecting integrin function, suggesting it as a potential therapeutic target.
C1GALT1 Knockdown Reduces Pancreatic Cancer Growth and Metastasis
C1GALT1 knockdown inhibits tumor growth and metastasis in NOD/SCID mice. High C1GALT1 expression correlates with poor survival in pancreatic ductal adenocarcinoma by promoting invasiveness through integrin glycosylation…
C1GALT1 Knockdown Reduces Malignant Behavior in Pancreatic Cancer
Knocking down C1GALT1 suppresses tumor cell viability, migration, and invasion in pancreatic ductal adenocarcinoma, highlighting its potential as a therapeutic target by impacting integrin function and cell adhesion.
Role of Integrin αv in C1GALT1-Mediated Pancreatic Cancer Invasion
High C1GALT1 expression is linked to poorer survival in pancreatic ductal adenocarcinoma and promotes tumor invasiveness through integrin function. Knockdown reduces invasion, highlighting potential therapeutic targets.
C1GALT1 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Adhesion
C1GALT1 high expression is linked to poorer survival in pancreatic ductal adenocarcinoma and promotes tumor invasiveness by affecting integrin function. Knocking down C1GALT1 impairs cell viability, migration, and tumor…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv https://t.co/1lQavpb5NE
New article: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. https://t.co/oCRcxqGlGv #pancreaticcancer #oncology https://t.co/QAGRMgk26Z