Oncogene February 2021 PMID 33420364

C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin α.

Ting-Chun Kuo, Ming-Hsun Wu, Shih-Hung Yang, Syue-Ting Chen, Tzu-Wen Hsu, Jie-Yang Jhuang, Ying-Yu Liao, Yu-Wen Tien, Min-Chuan Huang

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Mentions

14
Peak: 7 in Jan 2021
across 2 sources since Jan 2021

Extended reach

11,033
potential audience

Total likes

9

Video views

113

Mentions per month

Jan 2021 – Feb 2025

Where it's discussed

  • X / Twitter8 posts
  • YouTube6 videos

AI synopsis

What people are saying

Several discussions highlight the link between high C1GALT1 expression and decreased survival in pancreatic cancer, using words like 'poor survival' and 'promotes cell invasiveness' to underscore the findings' significance. The tone is mostly supportive and emphasizes the potential therapeutic implications, indicating a recognition of the study’s impact without deep technical critique.

AgreementStrong agreement

The discussions clearly express strong support for the article’s findings and emphasize its significance, reflecting high agreement with its conclusions.

InterestModerate interest

Participants show moderate curiosity, with some posts noting the importance of the research but not delving deeply into technical details.

EngagementModerate engagement

The conversations indicate a basic level of engagement, such as sharing the study and noting its potential implications, but lack detailed critique or extensive discussion.

ImpactHigh impact

The posts suggest the research is considered impactful for understanding pancreatic cancer and potential therapies, highlighting its relevance in the oncology community.

Abstract in brief

  • High expression of C1GALT1 is linked to poorer survival rates in pancreatic ductal adenocarcinoma (PDAC) patients and promotes tumor cell invasiveness by affecting integrin function.
  • Experimental studies showed that knocking down C1GALT1 reduces PDAC cell viability, migration, invasion, and tumor growth, while overexpression has the opposite effect, enhancing invasiveness.
  • Mechanistically, C1GALT1 influences cell invasion through its role in O-glycosylation of integrins, affecting cell-extracellular matrix adhesion via FAK phosphorylation, identifying C1GALT1 as a potential target for PDAC therapy.

Top posts

Most liked on X and Bluesky
Elena Rainero
@ERainero_lab · X

C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv https://t.co/1lQavpb5NE

Jan 13, 2021 · 6 likes · 5 shares · 1,504 followers View post →
Ivaska Lab
@IvaskaLab · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 14, 2021 · 5 shares · 2,973 followers View post →
Jon Humphries
@JDHL18 · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 14, 2021 · 5 shares · 2,505 followers View post →
Glycans in Cancer
@GlycansC · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 13, 2021 · 5 shares · 1,624 followers View post →
Matt Jones
@DrMCJones33 · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 13, 2021 · 5 shares · 1,131 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. https://t.co/oCRcxqGlGv #pancreaticcancer #oncology https://t.co/QAGRMgk26Z

Jan 10, 2021 · 891 followers View post →

All mentions

Tina Ting-Chun Kuo
@tinakuo1204 · X

Feb 5, 2025 · 7 followers View post →
Ivaska Lab
@IvaskaLab · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 14, 2021 · 5 shares · 2,973 followers View post →
Jon Humphries
@JDHL18 · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 14, 2021 · 5 shares · 2,505 followers View post →
Glycans in Cancer
@GlycansC · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 13, 2021 · 5 shares · 1,624 followers View post →
Rebecca Bennion
@RebeccaBennion_ · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 13, 2021 · 5 shares · 227 followers View post →
Matt Jones
@DrMCJones33 · X

RT @ERainero_lab: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes c…

Jan 13, 2021 · 5 shares · 1,131 followers View post →
Elena Rainero
@ERainero_lab · X

C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv https://t.co/1lQavpb5NE

Jan 13, 2021 · 6 likes · 5 shares · 1,504 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. https://t.co/oCRcxqGlGv #pancreaticcancer #oncology https://t.co/QAGRMgk26Z

Jan 10, 2021 · 891 followers View post →