Nat Protoc February 2021 PMID 33424024

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei.

Jude M Phillip, Kyu-Sang Han, Wei-Chiang Chen, Denis Wirtz, Pei-Hsun Wu

Mentions

67
Peak: 61 in Jan 2021
across 2 sources since Jan 2021

Extended reach

247,957
potential audience

Total likes

253

Video views

191

Mentions per month

Jan 2021 – Aug 2021

Where it's discussed

  • X / Twitter65 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions revolve around the advanced features of the VAMPIRE algorithm, with some users highlighting its application for spatial transcriptomics, showcasing excitement with terms like 'supercool' and 'must read'. Others simply reiterate the publication's title, indicating varied levels of engagement, yet maintaining a positive tone that emphasizes the algorithm’s transformative potential in cell analysis.

AgreementStrong agreement

The majority of discussions reflect strong support and enthusiasm for the findings from the publication, indicating a high level of agreement with its implications.

InterestHigh interest

Participants in the discussions express significant curiosity and relevance, often highlighting the importance of the VAMPIRE algorithm for ongoing research.

EngagementModerate engagement

While many posts reiterate the title and key concepts, a few engage more deeply by discussing integrations and applications of the method, suggesting moderate to high engagement.

ImpactHigh impact

The consensus is that the work has substantial potential influence on how researchers analyze cellular morphology, indicating a belief in its high impact.

Abstract in brief

  • The study introduces a new unsupervised machine learning method called the VAMPIRE algorithm for quantifying the morphological diversity of cells and their nuclei using fluorescence or brightfield images.
  • This algorithm classifies cells by identifying distinct shape modes based on their outer contours, facilitating an advanced visualization of cellular morphology related to different cell types and conditions.
  • The method is highly automated, allowing rapid analysis of large datasets (up to 20,000 cells) in under 60 minutes, while effectively measuring the morphological heterogeneity within cell populations.

Top posts

Most liked on X and Bluesky
Denis Wirtz
@deniswirtz · X

VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/G8lnkquwL2 https://t.co/kliUKnGPCj

Jan 11, 2021 · 172 likes · 42 shares · 40,065 followers View post →
Jude Phillip
@JudeM_Phillip · X

I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei. Please do check it out

Jan 11, 2021 · 53 likes · 15 shares · 832 followers View post →
Celeste Karch
@karchlab · X

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei | Nature Protocols https://t.co/ruaO1ImcBi

Jan 11, 2021 · 10 likes · 1 share · 4,274 followers View post →
MadhaviTippani
@MadhaviTippani · X

Below is my presentation on how VAMPIRE https://t.co/1gVNUrJnx7 works for extracting data about cell morphology to add additional information for spatial transcriptomics analysis when integrated with #VistoSeg https://t.co/tfA2YzHbFu

Aug 6, 2021 · 6 likes · 2 shares · 86 followers View post →
Carmelo Ferrai
@CarmeloFerrai · X

Supercool must read! VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/6fS19rZLft

Jan 11, 2021 · 4 likes · 1 share · 2,490 followers View post →
Data science
@Datascience__ · X

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/Q2JO1Fqnte #MachineLearning

Jan 12, 2021 · 2 likes · 33,277 followers View post →

All mentions

LIBD rstats club
@LIBDrstats · X

RT @MadhaviTippani: Below is my presentation on how VAMPIRE https://t.co/1gVNUrJnx7 works for extracting data about cell morphology to add…

Aug 25, 2021 · 2 shares · 410 followers View post →
lcolladotor
@lcolladotor · X

RT @MadhaviTippani: Below is my presentation on how VAMPIRE https://t.co/1gVNUrJnx7 works for extracting data about cell morphology to add…

Aug 25, 2021 · 2 shares · 2,947 followers View post →
MadhaviTippani
@MadhaviTippani · X

Below is my presentation on how VAMPIRE https://t.co/1gVNUrJnx7 works for extracting data about cell morphology to add additional information for spatial transcriptomics analysis when integrated with #VistoSeg https://t.co/tfA2YzHbFu

Aug 6, 2021 · 6 likes · 2 shares · 86 followers View post →
George
@GeorgeMatheson_ · X

RT @vnzloy: "A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei. Phillip JM, Han…

Mar 12, 2021 · 1 share · 246 followers View post →
Volodymyr Nechyporuk-Zloy
@vnzloy · X

"A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei. Phillip JM, Han KS, Chen WC, Wirtz D, Wu PH. Nat Protoc. 2021 Feb;16(2):754-774. doi: https://t.co/5bRObn42NN https://t.co/YJJ5YGezoi

Mar 9, 2021 · 1 like · 1 share · 1,278 followers View post →
Bree
@BreeKB_ · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 20, 2021 · 15 shares · 3,684 followers View post →
Rong Fan
@RongFan8 · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 12, 2021 · 15 shares · 10,853 followers View post →
Giuseppe Ciccone
@GiusCiccone · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 12, 2021 · 42 shares · 372 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 12, 2021 · 42 shares · 621 followers View post →
Jennifer Yokoyama
@YokoyamaLabUCSF · X

RT @karchlab: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei | Nature Protoc…

Jan 12, 2021 · 1 share · 1,368 followers View post →
GoogleAndi
@developercs · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 12, 2021 · 42 shares · 75 followers View post →
Saubashya Sur, PhD
@SaubashyaSur · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 12, 2021 · 42 shares · 770 followers View post →
Data science
@Datascience__ · X

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/Q2JO1Fqnte #MachineLearning

Jan 12, 2021 · 2 likes · 33,277 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 12, 2021 · 15 shares · 3,643 followers View post →
T Tian
@gdsttian · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 12, 2021 · 42 shares · 136 followers View post →
Cristian Cardona
@adircinho · X

RT @machinelearnflx: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://…

Jan 11, 2021 · 1 share · 1,336 followers View post →
Kaustav Bera
@KaustavBera11 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 519 followers View post →
David Rosenthal MD
@davidrosenthal · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 2,878 followers View post →
Winston Timp
@timp0 · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 1,360 followers View post →
Janitza Montalvo-Ortiz
@JanitzaMontalvo · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 1,233 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 14,322 followers View post →
Celeste Karch
@karchlab · X

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei | Nature Protocols https://t.co/ruaO1ImcBi

Jan 11, 2021 · 10 likes · 1 share · 4,274 followers View post →
Sergio Sánchez S
@sergio_sstban · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 188 followers View post →
Prit Benny Malgulwar
@PritBenny · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 363 followers View post →
MelStuart9
@MelStuart9 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 406 followers View post →
Raleigh M. Linville
@LinvilleRaleigh · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 1,253 followers View post →
Quinton Smith
@telomerase2 · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 2,042 followers View post →
Warren Grayson
@GraysonLab · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 1,128 followers View post →
Mark Allenby
@MCAllenby · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 1,430 followers View post →
Raúl Jiménez Castaño
@ruljc · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 168 followers View post →
Liudmila Sosulina
@LSNN13 · X

RT @CarmeloFerrai: Supercool must read! VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity…

Jan 11, 2021 · 1 share · 125 followers View post →
amelie bonnet
@amelie_bonnet · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 306 followers View post →
raghav1vij
@raghav1vij · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 231 followers View post →
Glenn Bantug
@gbantug2000 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 124 followers View post →
Nexample
@Nexample_Twits · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 444 followers View post →
Jorge Marchand
@SyntBio · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 646 followers View post →
Vicky R
@vic_rev · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 633 followers View post →
Mostafa Aakhte
@aakhte · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 378 followers View post →
Natalie Stanley
@natstann · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 1,446 followers View post →
David Van Valen
@davidvanvalen · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 3,153 followers View post →
Johns Hopkins BME
@JHUBME · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 5,032 followers View post →
Johns Hopkins Engineering
@HopkinsEngineer · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 17,509 followers View post →
Pat Malkòm
@JediMasterWho · X

RT @JudeM_Phillip: I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning…

Jan 11, 2021 · 15 shares · 1,047 followers View post →
Jude Phillip
@JudeM_Phillip · X

I'm excited to share our latest work published in @NatureProtocols on developing a robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei. Please do check it out

Jan 11, 2021 · 53 likes · 15 shares · 832 followers View post →
Jon Humphries
@JDHL18 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 2,505 followers View post →
Jude Phillip
@JudeM_Phillip · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 832 followers View post →
Alexey Gavrikov
@SayAlexey · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 134 followers View post →
Alex Chamessian
@achamess · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 2,741 followers View post →
Shao-Tuan Chen
@shao_tuan · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 315 followers View post →
Vittorio Stumpo
@vittoriostumpo_ · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 615 followers View post →
Paul Macklin
@MathCancer · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 5,880 followers View post →
Nishit Srivastava
@Nishit24 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 644 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 3,643 followers View post →
Jan FM Van Impe
@janfmVI · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 3,550 followers View post →
Bindikannan
@Bindikannan963 · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 1,102 followers View post →
Jenn Cremins
@CreminsLab · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 3,527 followers View post →
Johns Hopkins Kimmel Cancer Center
@hopkinskimmel · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 5,239 followers View post →
Macha Nikolski
@MachaNikolski · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 579 followers View post →
Carmelo Ferrai
@CarmeloFerrai · X

Supercool must read! VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/6fS19rZLft

Jan 11, 2021 · 4 likes · 1 share · 2,490 followers View post →
Matt Watson
@BioAndBaseball · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 2,987 followers View post →
The Johns Hopkins Institute for NanoBioTechnology
@INBT_JHU · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 3,346 followers View post →
Rita Strack
@rita_strack · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 21,557 followers View post →
Johns Hopkins Engineering
@HopkinsEngineer · X

RT @deniswirtz: VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei ht…

Jan 11, 2021 · 42 shares · 17,509 followers View post →
Denis Wirtz
@deniswirtz · X

VAMPIRE: A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/G8lnkquwL2 https://t.co/kliUKnGPCj

Jan 11, 2021 · 172 likes · 42 shares · 40,065 followers View post →
Oncology & Machine Learning
@MlOncology · X

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei https://t.co/S993bgXF4k

Jan 11, 2021 · 213 followers View post →