Psychopharmacology (Berl) February 2021 PMID 33427944

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants.

Nicole L Galvão-Coelho, Wolfgang Marx, Maria Gonzalez, Justin Sinclair, Michael de Manincor, Daniel Perkins, Jerome Sarris

Mentions

64
Peak: 40 in Jan 2021
across 4 sources since Jan 2021

Extended reach

341,178
potential audience

Total likes

104

Video views

356

Mentions per month

Jan 2021 – Nov 2023

Where it's discussed

  • X / Twitter58 posts
  • News3 articles
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

The discussions show strong agreement with the article's findings, with users citing examples such as the meta-analysis showing mood improvements up to 60 days, and emphasizing the therapeutic potential with words like 'promising' and 'game changer.' The tone and choice of words reflect high interest and belief in the importance of these findings for future mental health practices.

AgreementStrong agreement

Most discussions express strong support for the findings, emphasizing the positive therapeutic potential of psychedelics.

InterestHigh interest

The posts demonstrate high curiosity, highlighting meta-analyses, key studies, and the significance of the results.

EngagementHigh engagement

Many discussions include detailed references to specific studies, effect sizes, and methodological considerations, indicating deep engagement.

ImpactHigh impact

There is broad consensus that this research could have a transformative effect on mental health treatment, underscored by phrases like 'promising data' and 'significant effects.'

Abstract in brief

  • This meta-analysis reviews 12 studies involving both healthy individuals and those with mood disorders to evaluate the effects of classic serotonergic psychedelics like psilocybin, LSD, and ayahuasca on mood and depression symptoms.
  • Results showed that psychedelics provided moderate to significant improvements in mood immediately after treatment and up to 60 days later, especially in reducing depression symptoms in mood disorder patients.
  • Despite concerns about unblinding and expectancy effects, the fast and lasting mood improvements suggest that these psychedelics have strong therapeutic potential, warranting more rigorous clinical trials.]

Top posts

Most liked on X and Bluesky
Jerome Sarris
@JeromeSarris · X

The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Further robust research still needing to occur, with application within a psychotherapeutic framework & adequate medical oversight @MAPS https://t.co/7EtYENJL6j

Jan 11, 2021 · 34 likes · 9 shares · 343 followers View post →
Mike Hart, M.D
@drmikehart · X

Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed in healthy subjects immediately after use and lasted up to 60 days. Depression was acutely alleviated in those with mood disorders. https://t.co/inOuMar6ZS

Jan 25, 2021 · 28 likes · 8 shares · 66,610 followers View post →
Grinspoon: Grinspoon on Drugs
@Peter_Grinspoon · X

For patients with mood disorder, significant effect sizes were detected on the acute, medium (2–7 days after treatment) & longer-term outcomes favoring psychedelics on the reduction of depressive symptoms. (one problem: blinding with #psychedelics) https://t.co/BywXeQI3Wl

Jan 20, 2021 · 6 likes · 1 share · 35,369 followers View post →
Sean Last
@Sean__Last · X

Latest meta-analysis of the small sample studies on how psychedelic's impact depression. Still finds such drugs have positive effects. But the data is still of low quality. https://t.co/hR8pEgf4Ld

Feb 20, 2021 · 5 likes · 2 shares · 10,408 followers View post →
Chacruna Institute
@Chacruna_Inst · X

Meta-analytic review of classic serotonergic psychedelics found significant effect sizes for the acute, medium (2–7 days after treatment), and longer-term outcomes favoring psychedelics over placebo on the reduction of depressive symptoms. https://t.co/lntmvyLYTd https://t.co/9Ed3SX7vJv

Jan 17, 2021 · 4 likes · 2 shares · 12,581 followers View post →
Mike Hart, M.D
@drmikehart · X

Patients with & without mood disorders can benefit from psychedelics. Healthy volunteers benefit from psychedelics both acutely and in the long-term. Patients with mood disorders report alleviation of depression both acutely and in the long-term. https://t.co/inOuMar6ZS

Feb 8, 2021 · 3 likes · 1 share · 66,610 followers View post →

All mentions

Ali
@kekuleali · X

Meta-analyses on effects + therapy: psilocybin, LSD, ayahuasca on mood disorders and depression https://t.co/BvhscQqdyx psilocybin on anxiety and depression https://t.co/8472mNCDAN psilocybin, ayahuasca, LSD on depression https://t.co/H5odtsz2pC

Nov 30, 2023 · 175 followers View post →
Brenton Wiernik
@bmwiernik · X

@armerner_psych One of these? https://t.co/6pF0gxsCFu https://t.co/T2FnJgEdLR https://t.co/y5A4fTeHKm https://t.co/tpssDRcE89 https://t.co/7ZMoPwSRas

Jan 14, 2023 · 2 likes · 6,182 followers View post →
Psicodélicos News
@psiquedelicos · X

2021. Metanálise de 12 estudos clínicos controlados e randomizados sobre uso de psicodélicos serotoninergicos clássicos no tratamento de sintomas depressivos. Apesar da amostra total ser pequena, todos os estudos evidenciaram boa resposta terapêutica. https://t.co/2b4FfdbKoC

Nov 16, 2022 · 1 like · 72 followers View post →
Prakash Masand
@PMasand · X

First meta-analytic review evaluating the clinical effects of classic #serotonergic #psychedelics vs #placebo for #mood disorders.https://t.co/vR8JXXldqA #nursepractitioner #mentalhealth #psychiatry #medicine #primarycare #depression #mhchat #mh #Psilocybin

Dec 27, 2021 · 2 likes · 485 followers View post →
Blossom
@blossomact · X

We didn't include studies with healthy (non-depressed) participants which usually are done first as open-label Two of the best-known psilocybin studies (Griffiths et al 2006, Hasler et al 2004) are thus not included For all notable psi studies https://t.co/vIIR5m59tc 3/8

Nov 3, 2021 · 3,343 followers View post →
Frayme
@Frayme_Cadre · X

Resources: [1] https://t.co/YQTyjoHxBR; https://t.co/wAjw5lSkxQ [2] https://t.co/1acKtIejWJ

Sep 16, 2021 · 3,328 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @TatumPsych: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and h… https:…

Aug 31, 2021 · 1 share · 6,693 followers View post →
Tatum Psychiatry & Ketamine Clinic
@TatumPsych · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and h… https://t.co/zVgNZ5rgqs

Aug 31, 2021 · 1 share · 15 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and h…

Jun 26, 2021 · 3 shares · 2,055 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants https://t.co/fAqZd2I9xX

Mar 9, 2021 · 1 like · 4,000 followers View post →
DKshadow
@DKshad0w · X

RT @Sean__Last: Latest meta-analysis of the small sample studies on how psychedelic's impact depression. Still finds such drugs have positi…

Feb 20, 2021 · 2 shares · 1,706 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @Sean__Last: Latest meta-analysis of the small sample studies on how psychedelic's impact depression. Still finds such drugs have positi…

Feb 20, 2021 · 2 shares · 6,693 followers View post →
Sean Last
@Sean__Last · X

Latest meta-analysis of the small sample studies on how psychedelic's impact depression. Still finds such drugs have positive effects. But the data is still of low quality. https://t.co/hR8pEgf4Ld

Feb 20, 2021 · 5 likes · 2 shares · 10,408 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @drugSciBot: Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and health…

Feb 18, 2021 · 2 shares · 2,055 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @drugSciBot: Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and health…

Feb 18, 2021 · 2 shares · 6,693 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and healthy participants https://t.co/lC5seGlPxC

Feb 18, 2021 · 2 shares · 2,055 followers View post →
Noia Soft
@menezes98biel · X

https://t.co/8RVvBP2qlq Artigo sobre o uso de psicodélicos (LSD, Ayuhasca e cogumelos) em psicoterapia assistida e a eficácia pra depressão e transtornos psilogicos ❤️❤️❤️❤️❤️❤️

Feb 10, 2021 · 251 followers View post →
Mike Hart, M.D
@drmikehart · X

Patients with & without mood disorders can benefit from psychedelics. Healthy volunteers benefit from psychedelics both acutely and in the long-term. Patients with mood disorders report alleviation of depression both acutely and in the long-term. https://t.co/inOuMar6ZS

Feb 8, 2021 · 3 likes · 1 share · 66,610 followers View post →
Kassie
@KassandraKitson · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 31, 2021 · 8 shares · 13,721 followers View post →
José Carlos
@JoselitoCarloss · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 26, 2021 · 8 shares · 41 followers View post →
The Psychedelic Bull
@psychedelicbull · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 26, 2021 · 8 shares · 3,621 followers View post →
Truth Seeker NYC
@TruthSeeker2160 · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 25, 2021 · 8 shares · 1,182 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 25, 2021 · 8 shares · 4,079 followers View post →
Henrik (dadnoises)
@dengamleochlede · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 25, 2021 · 8 shares · 906 followers View post →
Canadian Cossack
@CanadianCossak · X

RT @drmikehart: Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed i…

Jan 25, 2021 · 8 shares · 1,034 followers View post →
Mike Hart, M.D
@drmikehart · X

Psychedelics can improve mood in both healthy subjects and patients with mood disorders. The improved mood was observed in healthy subjects immediately after use and lasted up to 60 days. Depression was acutely alleviated in those with mood disorders. https://t.co/inOuMar6ZS

Jan 25, 2021 · 28 likes · 8 shares · 66,610 followers View post →
Pugachev with a Ph.D.
@chernyshesvky · X

RT @Peter_Grinspoon: For patients with mood disorder, significant effect sizes were detected on the acute, medium (2–7 days after treatment…

Jan 21, 2021 · 1 share · 169 followers View post →
anne olivia campbell
@AnniecampbellA · X

First meta-analytic review evaluating the clinical effects of classic serotonergic psychedelics vs placebo for mood state and symptoms of depression https://t.co/D2aDIOFLfY

Jan 20, 2021 · 866 followers View post →
Grinspoon: Grinspoon on Drugs
@Peter_Grinspoon · X

For patients with mood disorder, significant effect sizes were detected on the acute, medium (2–7 days after treatment) & longer-term outcomes favoring psychedelics on the reduction of depressive symptoms. (one problem: blinding with #psychedelics) https://t.co/BywXeQI3Wl

Jan 20, 2021 · 6 likes · 1 share · 35,369 followers View post →
DdC
@DendeCannabist · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants https://t.co/GxhKAdPpp2 https://t.co/O9c3nJ5i9A

Jan 20, 2021 · 1,354 followers View post →
Psychedelic Health Professionals Network
@PsychedelicHea6 · X

The abstract of this free full-text paper reads: "Rationale Major depressive disorder is one of the leading global causes of disability, for which the classic serotonergic psychedelics have recently reemerged as a potential therapeutic treatment option. https://t.co/cSO6nFJBNM https://t.co/GnKY5r3IZl

Jan 20, 2021 · 71 followers View post →
Chacruna Latinoamérica
@ChacrunaLa · X

La revisión metaanalítica de los psicodélicos clásicos encontró el tamaño de los efectos significativos para los resultados agudos, medios (2 a 7 días después del tratamiento) y a largo plazo sobre el placebo en la reducción de los síntomas depresivos.

Jan 18, 2021 · 2,828 followers View post →
Javier Víllora Fernández
@VilloraJavier · X

RT @Chacruna_net: Meta-analytic review of classic serotonergic psychedelics found significant effect sizes for the acute, medium (2–7 days…

Jan 18, 2021 · 2 shares · 425 followers View post →
TripsForTheSoul
@Tripsforthesoul · X

RT @Chacruna_net: Meta-analytic review of classic serotonergic psychedelics found significant effect sizes for the acute, medium (2–7 days…

Jan 18, 2021 · 2 shares · 826 followers View post →
Chacruna Institute
@Chacruna_Inst · X

Meta-analytic review of classic serotonergic psychedelics found significant effect sizes for the acute, medium (2–7 days after treatment), and longer-term outcomes favoring psychedelics over placebo on the reduction of depressive symptoms. https://t.co/lntmvyLYTd https://t.co/9Ed3SX7vJv

Jan 17, 2021 · 4 likes · 2 shares · 12,581 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @YockeyAndrew: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy…

Jan 16, 2021 · 2 shares · 6,693 followers View post →
Dr. Z
@outofthewoodZ_ · X

RT @YockeyAndrew: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy…

Jan 16, 2021 · 2 shares · 793 followers View post →
Andrew Yockey, PhD (He/Him)
@YockeyAndrew · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants | SpringerLink https://t.co/aFYIfQWRc0

Jan 16, 2021 · 2 likes · 2 shares · 1,208 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @UpToPhate: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy pa…

Jan 16, 2021 · 1 share · 6,693 followers View post →
UpToPhate
@UpToPhate · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants. https://t.co/Lvxq6hTh6e

Jan 16, 2021 · 2 likes · 1 share · 197 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @drugSciBot: Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and health…

Jan 16, 2021 · 3 shares · 2,055 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @drugSciBot: Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and health…

Jan 16, 2021 · 3 shares · 6,693 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

Classic #serotonergic #psychedelics for mood and depressive symptoms: a #meta-analysis of mood disorder patients and healthy participants https://t.co/t6Q9PTddAg

Jan 16, 2021 · 1 like · 3 shares · 2,055 followers View post →
Lily Aleksandrova, PhD
@NeuroLilyAleks · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 15, 2021 · 9 shares · 523 followers View post →
Blossom
@blossomact · X

See which 12 studies were included and learn more about what this study concluded on our website https://t.co/vIIR5m59tc

Jan 15, 2021 · 3,343 followers View post →
Blossom
@blossomact · X

This meta-analytic review (2021, n=257) found that psychedelics provide improvements in mood for patients with mood disorders, both short (3h to 1d) and long-term (up to 60 days). https://t.co/4seWaHiLcK

Jan 15, 2021 · 2 likes · 3,343 followers View post →
maria gonzalez
@mariasgonzalez · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 14, 2021 · 9 shares · 118 followers View post →
Michel Blanc
@Blanc07Michel · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 13, 2021 · 9 shares · 1,664 followers View post →
Michael Hermann
@MichaelManurun9 · X

RT @APRA_bot: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy par…

Jan 12, 2021 · 2 shares · 580 followers View post →
Michele Metelli
@michelemetelli · X

RT @APRA_bot: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy par…

Jan 12, 2021 · 2 shares · 802 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants. https://t.co/Zas5ONeMDJ

Jan 12, 2021 · 3 likes · 2 shares · 4,000 followers View post →
A/Prof Carolyn Ee MBBS
@drcarolynee · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 12, 2021 · 9 shares · 2,120 followers View post →
Jacinta Brinsley
@jacintabrinsley · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 12, 2021 · 9 shares · 360 followers View post →
Dr Carrie Thomson-Casey
@habits4happier · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 12, 2021 · 9 shares · 413 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @JeromeSarris: The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Fu…

Jan 11, 2021 · 9 shares · 6,693 followers View post →
Jerome Sarris
@JeromeSarris · X

The first in-depth #psychedelics meta-analysis for #depression & negative #mood state. We found very promising data... Further robust research still needing to occur, with application within a psychotherapeutic framework & adequate medical oversight @MAPS https://t.co/7EtYENJL6j

Jan 11, 2021 · 34 likes · 9 shares · 343 followers View post →
Psychedelic Alpha
@Psyched_Alpha · X

New Research: Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants https://t.co/3x8Ce0YNO6

Jan 11, 2021 · 2 likes · 20,785 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants https://t.co/ndS9oX3uN3

Jan 11, 2021 · 437 followers View post →
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