Microbiome January 2021 PMID 33431052

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice.

Joan Serrano, Kathleen R Smith, Audra L Crouch, Vandana Sharma, Fanchao Yi, Veronika Vargova, Traci E LaMoia, Lydia M Dupont, Vanida Serna, Fenfen Tang, Laisa Gomes-Dias, Joshua J Blakeslee, Emmanuel Hatzakis, Scott N Peterson, Matthew Anderson

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Mentions

81
Peak: 16 in Jan 2021
across 6 sources since Jan 2021

Extended reach

777,166
potential audience

Total likes

4,306

Video views

117,302

Mentions per month

Jan 2021 – Nov 2025

Where it's discussed

  • X / Twitter44 posts
  • News23 articles
  • Blogs6 articles
  • Facebook3 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group shows strong agreement with the study's conclusion that high-dose saccharin does not affect gut microbiota or glucose intolerance, as seen in supportive phrases like 'Pretty compelling' and 'Most posts support the publication's conclusions.' Interest is evident in mentions of scientific methods and previous conflicting studies, such as 'meta-analysis' and 'validation studies,' illustrating a thoughtful engagement with the topic. Tone varies from cautious optimism to scientific curiosity, contributing to a nuanced understanding of the research's significance.

AgreementStrong agreement

Most discussions strongly support the findings, emphasizing the study's reassurance regarding saccharin's safety and aligning with existing literature.

InterestModerate interest

The discussions demonstrate a moderate level of curiosity, especially among those interested in nutrition and microbiome research, but some posts remain general.

EngagementModerate engagement

Participants reference multiple sources, such as meta-analyses and prior studies, indicating engagement with scientific details and calls for further validation.

ImpactModerate impact

The posts suggest a modest potential influence on health and nutrition policies, but the overall tone remains cautious with calls for additional research.

Top posts

Most liked on X and Bluesky
Layne Norton, PhD
@BioLayne · X

In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTppn https://t.co/kWZbkQjScS https://t.co/zCgCiMiOt7 https://t.co/I4vdeShtpj https://t.co/kg14flppGg https://t.co/yutwuylLfP https://t.co/DtAGGp3RhG GET REKT

Oct 15, 2021 · 44 likes · 4 shares · 223,500 followers View post →
Jacob Gudiol
@JacobGudiol · X

@DanielJDrucker The same group published similar results on just saccharin in Nature in 2014. Another group could not replicate the findings a couple of years later https://t.co/T2fDFEn1P2 https://t.co/JgfOaQYnOD

Aug 19, 2022 · 13 likes · 2 shares · 24,401 followers View post →
Colby Vorland
@nutsci · X

Pretty compelling: "High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice" https://t.co/Z3kVYf594z

Jan 13, 2021 · 11 likes · 2,238 followers View post →
Karl Nadolsky
@DrKarlNadolsky · X

Randomized-controlled trial of high dose saccharin (artificial sweetener) did not adversely alter gut microbiome or glucose tolerance. https://t.co/wPORFus4wo https://t.co/pYHNg4zRdw

Jan 15, 2021 · 9 likes · 5,860 followers View post →
Jacob Gudiol
@JacobGudiol · X

@DrNadolsky @nicknorwitz The study in Nature didn't replicate either https://t.co/T2fDFEn1P2

Dec 5, 2021 · 6 likes · 24,401 followers View post →
Christoffer Clemmensen
@ClemmensenC · X

@videnskabdk https://t.co/Hz2gElvwWs

Aug 20, 2022 · 6 likes · 2,394 followers View post →

All mentions

Heart of a Lion ❤️
@Lionheartdom · X

@NicisLetsPlays @BassSultanHSV Zu keinen Veränderungen des Darm Mikrobioms gekommen ist und in normaler Verzehrmenge absolut unbedenklich ist. Das kannst du hier dir in der Studie selbst durchlesen: https://t.co/jGK1y4ug6R

Dec 3, 2024 · 82 followers View post →
HoopsW
@13BoltSD · X

RT @BioLayne: In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTpp…

Jul 27, 2024 · 4 shares · 296 followers View post →
Aryaman Singh
@Aareyaman · X

@Biju11218746 @hyderabaddoctor https://t.co/PTn4mvYbsS https://t.co/2eUKlQAzRr https://t.co/vim4XBwAiZ https://t.co/k9yekfI6QL https://t.co/GSzJOoF6nq https://t.co/N5fUZ0SU6i https://t.co/uhL3kbfeZW https://t.co/GSzJOoF6nq Do check these studies out and especially focus on the meta analysis

Apr 23, 2024 · 5 followers View post →
Zorkex
@Zorkex · X

@savola_sami @byVNTY Bereits 2021 haben Studien diese Aussagen auch schon tatsächlich an Menschen widerlegt und dabei eine deutlich bessere Studiendurchführung aufgewiesen (samt klinischer Feldstudie + Kontrollgruppen) z.B. https://t.co/gDiglUPCVc oder https://t.co/8XI0X05HCg

Mar 24, 2024 · 1 like · 9 followers View post →
Alicia Kowaltowski
@AJKowaltowski · X

@julianobs @NexoJornal Não se pode fundamentar políticas públicas de saúde com um estudo usando altas doses em camundongos, cujos resultados são inclusive contrabalanceados por outros: https://t.co/CIbkAJPybE

Jun 2, 2023 · 1 like · 6,176 followers View post →
Fat Fighting
@FatFightingClub · X

นอกเหนือจากงานนี้ก็มีงานที่ศึกษาผลของการทาน Saccharin โดยทำการศึกษาทั้งในคนและในหนูทดลอง ก็ไม่พบว่ามีผลต่อการเปลี่ยนแปลงของจุลินทรีย์ในลำไส้ และความทนน้ำตาล https://t.co/xJAzGIK7Eu

Dec 9, 2022 · 2 likes · 10,044 followers View post →
Erik Arnesen
@erik_arnesen · X

@Fimland Det må være opp til hver enkelt inntil videre, jeg anbefaler hverken det ene eller andre. Dette må gjennomgås systematisk og også sees i lys av f.eks. denne artikkelen fra ifjor. https://t.co/r8y1VY9GM7

Nov 26, 2022 · 2,118 followers View post →
Jacob Gudiol
@JacobGudiol · X

@DanielJDrucker The same with saccharin https://t.co/T2fDFEn1P2

Nov 20, 2022 · 1 like · 24,401 followers View post →
Sam
@SamtheNightOwl · X

@AsimovSophi @kkbb087 @MargBarAmerica https://t.co/JBFRHHUdky

Sep 30, 2022 · 11,354 followers View post →
Research Square
@researchsquare · X

As use of non-caloric artificial sweeteners increases, health officials have become concerned with their effects, but previous studies have had conflicting results. A @MicrobiomeJ study sought to shed some light on the issue: https://t.co/89QlaCDm6Y #sugar #sugarintake https://t.co/lEnPybYFG3

Sep 23, 2022 · 1 like · 16,591 followers View post →
AJE: American Journal Experts
@journalexperts · X

As use of non-caloric artificial sweeteners increases, health officials have become concerned with their effects, but previous studies have had conflicting results. A @MicrobiomeJ study sought to shed some light on the issue: https://t.co/eWsxkoUj66 #sugar #sugarintake https://t.co/O5etB3DoIn

Sep 23, 2022 · 4,322 followers View post →
Christoffer Clemmensen
@ClemmensenC · X

@videnskabdk https://t.co/Hz2gElvwWs

Aug 20, 2022 · 6 likes · 2,394 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

RT @JacobGudiol: @DanielJDrucker The same group published similar results on just saccharin in Nature in 2014. Another group could not rep…

Aug 19, 2022 · 2 shares · 57,018 followers View post →
Daniel J Drucker
@DanielJDrucker · X

RT @JacobGudiol: @DanielJDrucker The same group published similar results on just saccharin in Nature in 2014. Another group could not rep…

Aug 19, 2022 · 2 shares · 34,194 followers View post →
Jacob Gudiol
@JacobGudiol · X

@DanielJDrucker The same group published similar results on just saccharin in Nature in 2014. Another group could not replicate the findings a couple of years later https://t.co/T2fDFEn1P2 https://t.co/JgfOaQYnOD

Aug 19, 2022 · 13 likes · 2 shares · 24,401 followers View post →
DYLΛN
@fysiologik · X

Mar 9, 2022 · 1,692 followers View post →
FittrwithKJ | Kapil Jadhav
@Fittrwithkj · X

@sohamdas @nitishj_123 I’d like to draw your attention to the following study published in January 2021 DOI: 10.1186/s40168-020-00976-w It is a randomized, placebo-controlled, double-blind, interventional study unlike the ones you shared. Please note that these are gold standards of scientific studies https://t.co/l2GVtWvi8a

Jan 20, 2022 · 7,279 followers View post →
Jacob Gudiol
@JacobGudiol · X

@DrNadolsky @nicknorwitz The study in Nature didn't replicate either https://t.co/T2fDFEn1P2

Dec 5, 2021 · 6 likes · 24,401 followers View post →
ZKForTre
@ZKForTre · X

@CaloriesProper @nicknorwitz @DrNadolsky Sure, but we can also just look at the confluence of data in mice, too. Again, Nick, if you actually want to discuss Suez, let me know. https://t.co/3S18vf1uRG https://t.co/LZkKJr10aN https://t.co/vzQ2zvNud1 https://t.co/9pk6irtUwb

Dec 4, 2021 · 1 like · 2,755 followers View post →
DRDANNYPHAM
@Drdannypham · X

@x_finesse_ @_saintcola https://t.co/lwqMr4WSVd

Nov 15, 2021 · 2,640 followers View post →
Ragi Mudde
@2emkay · X

RT @BioLayne: In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTpp…

Oct 26, 2021 · 4 shares · 970 followers View post →
Chirag Barjatya
@chiragbarjatyaa · X

RT @BioLayne: In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTpp…

Oct 26, 2021 · 4 shares · 96,930 followers View post →
Fat Fighting
@FatFightingClub · X

สารทดแทนความหวานไม่กระตุ้นอินซูลินนะครับ อธิบายกันจนไม่รู้จะอธิบายยังไง เอาเปเปอร์ไปอ่านเถอะ https://t.co/xngtB4Tqok https://t.co/UGpPNpNO5b https://t.co/1A89jM8ZdO https://t.co/NdaQHAtCNn https://t.co/uJTgkdC6nM https://t.co/LRSfC22Kxc https://t.co/It1DV26EGA

Oct 24, 2021 · 3 likes · 10,044 followers View post →
Jose C Souto, MD
@jcsouto · X

RT @BioLayne: In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTpp…

Oct 15, 2021 · 4 shares · 14,595 followers View post →
Layne Norton, PhD
@BioLayne · X

In fact, HUMAN studies show NO effect of artificial sweeteners on gut microflora & insulin sensitivity https://t.co/Qk8OkpTppn https://t.co/kWZbkQjScS https://t.co/zCgCiMiOt7 https://t.co/I4vdeShtpj https://t.co/kg14flppGg https://t.co/yutwuylLfP https://t.co/DtAGGp3RhG GET REKT

Oct 15, 2021 · 44 likes · 4 shares · 223,500 followers View post →
Sasera
@Sasera_beauty · X

دراسه كنترول جديده بينت ان استخدام محلي السكرين بالكميه المسموحه القصوى لأسبوعين لم يسبب اي تغيير في البكتريا النافعه بالامعاء او في سكر الدم في بشر اصحاء او في الفئران. لا يوجد دليل كافي يدل على ان السكرين بالجرع المسموحه يضر البكتريا النافعه في البشر. https://t.co/WSHZ141NbU https://t.co/rUxce2CjRT

May 23, 2021 · 1 like · 254 followers View post →
Vicky Pyrogianni, MSc, RDN
@vicky_rdn · X

What do you think about video or graphical abstracts? I find them helpful and I think they are a step forward in nutrition science communication. Here's an example of a video abstract presenting results of a new RCT on saccharin & gut microbiota: https://t.co/grk7xnvWkR

Feb 22, 2021 · 2 likes · 1,487 followers View post →
Rachele Pojednic, PhD, CSCS
@rachelepojednic · X

Interesting --> Short-term saccharin consumption at maximum acceptable levels is not sufficient to alter gut microbiota or induce glucose intolerance in apparently healthy humans and mice. https://t.co/rzWP7IRSQS

Feb 5, 2021 · 1 like · 3,081 followers View post →
DERC
@DERC · X

High doses of saccharin won't lead to diabetes in healthy adults. https://t.co/BlbKHM4enh

Jan 31, 2021 · 286 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Sacarina y diabetes https://t.co/3SAikvmtxu Más información: High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice https://t.co/fiK46DMX9r

Jan 23, 2021 · 158 followers View post →
Bug Speaks
@BugSpeaks · X

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice https://t.co/PHjiJnMkif #microbiome

Jan 21, 2021 · 287 followers View post →
Karl Nadolsky
@DrKarlNadolsky · X

Randomized-controlled trial of high dose saccharin (artificial sweetener) did not adversely alter gut microbiome or glucose tolerance. https://t.co/wPORFus4wo https://t.co/pYHNg4zRdw

Jan 15, 2021 · 9 likes · 5,860 followers View post →
Johannes Johnson-Martínez, PhD
@jamespjohnsonuw · X

Relevant to using alternative sweeteners in foods such as saccharin: “High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice” https://t.co/9JFhRHoX79

Jan 15, 2021 · 310 followers View post →
Dr Rahul D Barmanray
@RahulDBarmanray · X

Small numbers and a short study to be sure, but reassuring that one artificial sweetener doesn't induce glucose intolerance in what seems to be a well-conducted study. Bring on the validation studies! #diabetes #endotwitter #MedTwitter https://t.co/JorDhnTzmm

Jan 14, 2021 · 378 followers View post →
Colby Vorland
@nutsci · X

Pretty compelling: "High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice" https://t.co/Z3kVYf594z

Jan 13, 2021 · 11 likes · 2,238 followers View post →
LAN FITNESS
@LAN_FITNESS · X

RT @ToshiyukiHorie: https://t.co/LYFffqa9ew

Jan 13, 2021 · 3 shares · 58 followers View post →
PICO
@msmiminta · X

RT @ToshiyukiHorie: https://t.co/LYFffqa9ew

Jan 13, 2021 · 3 shares · 857 followers View post →
Shreya Ghosh
@shrez07 · X

RT @HRoager: Non-caloric artificial #sweeteners have been suggested to unfavorable change #glucose homeostasis via changes in the gut #micr…

Jan 13, 2021 · 1 share · 144 followers View post →
Henrik M. Roager
@HRoager · X

Non-caloric artificial #sweeteners have been suggested to unfavorable change #glucose homeostasis via changes in the gut #microbiome. Yet, 2-weeks daily consumption of saccharin did not affect the gut microbiome or glucose intolerance in healthy humans https://t.co/1deEtWBROl

Jan 13, 2021 · 3 likes · 1 share · 1,893 followers View post →
TEAM LAN
@TEAM_LAN · X

RT @ToshiyukiHorie: https://t.co/LYFffqa9ew

Jan 13, 2021 · 3 shares · 15,988 followers View post →
Toshiyuki Horie|堀江 俊之
@ToshiyukiHorie · X

https://t.co/LYFffqa9ew

Jan 13, 2021 · 5 likes · 3 shares · 25,227 followers View post →
Melody Davis
@mrdphd · X

RT @MicrobiomeJ: High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mi…

Jan 12, 2021 · 1 share · 1,581 followers View post →
Microbiome
@MicrobiomeJ · X

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice https://t.co/PNXVfvjDqU

Jan 12, 2021 · 3 likes · 1 share · 20,370 followers View post →
Symbiosis papers
@Symbiosispapers · X

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice https://t.co/bdFGqRZHxX

Jan 12, 2021 · 1,113 followers View post →