J Biomed Sci January 2021 PMID 33435929

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications.

Ioannis P Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N Pavlakis, Meletios A Dimopoulos

Mentions

43
Peak: 2 in Apr 2021
across 3 sources since Feb 2021

Extended reach

96,669
potential audience

Total likes

26

Video views

366

Mentions per month

Feb 2021 – Apr 2024

Where it's discussed

  • News26 articles
  • X / Twitter15 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions are characterized by a recognition of the scientific research's importance, as seen in comments praising the understanding of SARS-CoV-2 mechanisms and the lifesaving role of vaccines. Conversely, some posts challenge treatment efficacy, reflecting engagement that balances support with skepticism, influenced by word choices like 'proof' and phrases questioning effectiveness or understanding.

AgreementModerate agreement

Most comments acknowledge the importance of scientific research and tools, especially those supporting vaccine efficacy and understanding the virus.

InterestModerate interest

Discussions show moderate curiosity about the virus's biology and treatments, with some posts sharing sources and more information.

EngagementNeutral engagement

While some users reference specific knowledge such as gene functions or vaccine mechanisms, others dismiss certain ideas, showing mixed depths of engagement.

ImpactModerate impact

The overall tone emphasizes the relevance of scientific insights to public health, though some posts express skepticism or highlight controversies.

Abstract in brief

  • The text explains that understanding how SARS-CoV-2 infects the body and causes disease is essential for developing targeted treatments, especially those that can address severe complications like multi-organ failure.
  • COVID-19 is described as a two-phase disease: the first phase involves rapid virus spread due to the widespread presence of specific human genes (ACE2, TMPRSS2, CTSBL) in respiratory and digestive tissues, and the second phase involves uncontrolled inflammation that damages organs, driven by immune responses and imbalanced signaling pathways.
  • Various strategies are discussed to combat COVID-19, including drugs that reduce viral infection, enhance immune recognition of the virus, or decrease the severe inflammatory response (cytokine storm), with the goal of preventing or reducing life-threatening complications like ARDS.]

Top posts

Most liked on X and Bluesky
Todd McKenzie
@ToddEBear · X

@farid__jalali Are there not many avenues of neuroinvasion? https://t.co/KnRDE3XXnF https://t.co/H484nUBniw https://t.co/fcv709Z3oW https://t.co/Y0BO1h5ioW

Apr 29, 2021 · 1 like · 2,282 followers View post →
Nick Reay
@nickareay · X

@davidkurten @stoicmel So you’re ok with the Covid-19 virus getting inside your cells and releasing its own mRNA (step 5 in Fig 1) In fact, do you even know what mRNA is? These vaccines have saved millions of lives and our thanks should go to the scientists who developed them. https://t.co/1ygXmdtFL8

Oct 3, 2021 · 1 like · 976 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/xX0rMPzTVp

May 3, 2021 · 1 like · 35 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/xX0rMPzTVp

Jun 3, 2021 · 1 like · 35 followers View post →
abdul ghani qiq
@cintaforex · X

https://t.co/uiRXL44O2C

Jan 7, 2022 · 75,479 followers View post →
European Virus Bioinformatics Center
@EVirusBioinfC · X

Insights to #SARSCoV2 life cycle, #pathophysiology, and rationalized #treatments that target #COVID19 clinical #complications. Review co-authored by EVBC member @dparask69 https://t.co/tBm10WaxcC

Feb 12, 2021 · 5,650 followers View post →

All mentions

Hugo Angulo
@thermotronica · X

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications - PMC Ok VIP is related and i dont know what CTSB/L gene is https://t.co/godbKP2DRE

Apr 13, 2024 · 3,004 followers View post →
Will B
@WILLBISM3 · X

@Johnincarlisle @SOSpectObsrvR (Trust the science part 6) More papers, more answers... https://t.co/3futMimyg6 https://t.co/1hu1SRhXQ4 https://t.co/G869GoCpFi https://t.co/wprfmkWV19 https://t.co/S9uMvyiQ9l https://t.co/OfOf6iw5IK

Mar 3, 2024 · 301 followers View post →
BrazilianVoz
@BrazilianVoz · X

@rajinhozinho @AdriPinatti @BlogdoNoblat @jairbolsonaro Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications https://t.co/kqKIg4EpKn

Jul 16, 2023 · 5,218 followers View post →
Healthcare IC
@healthcare_ic · X

is it increasing/evolving its' half-life in host...?? https://t.co/XrnozPv4we

Aug 12, 2022 · 1,021 followers View post →
Lyam
@Lyam17054994 · X

@coluche7100 @LukkJean @ElianeCarrier @vpecresse Et bon, je vous en donne des sources prouvant la non efficacité de l'hydroxychloroquine... https://t.co/fijoRJ1DBP https://t.co/txfmFprgzO Même les " journaux " scientifiques l'affirment... https://t.co/8LdM3nAhNk https://t.co/EI0bpTkfoo

Mar 28, 2022 · 5 followers View post →
abdul ghani qiq
@cintaforex · X

https://t.co/uiRXL44O2C

Jan 7, 2022 · 75,479 followers View post →
Mik.
@UmmQahtanFatima · X

@CaoimhinMacEoc1 Some reading for you https://t.co/lTWd8ZZFFt

Dec 29, 2021 · 237 followers View post →
FRANKY FOUR FINGERS
@media_77uk · X

RT @nickareay: @davidkurten @stoicmel So you’re ok with the Covid-19 virus getting inside your cells and releasing its own mRNA (step 5 in…

Oct 4, 2021 · 1,082 followers View post →
Nick Reay
@nickareay · X

@davidkurten @stoicmel So you’re ok with the Covid-19 virus getting inside your cells and releasing its own mRNA (step 5 in Fig 1) In fact, do you even know what mRNA is? These vaccines have saved millions of lives and our thanks should go to the scientists who developed them. https://t.co/1ygXmdtFL8

Oct 3, 2021 · 1 like · 976 followers View post →
_
@milesparker · X

@JanineJ28040350 @NNNN996 @ChristianTony1 @BCNursesUnion OMG. “It seems”? By who? Certainly not actual doctors or epidemiologists. Sorry to be rude but it just boggles my mind that this kind of ignorance is possible. https://t.co/LAPPxFNNZp

Sep 25, 2021 · 943 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/xX0rMPzTVp

Jun 3, 2021 · 1 like · 35 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/xX0rMPzTVp

May 3, 2021 · 1 like · 35 followers View post →
Todd McKenzie
@ToddEBear · X

@farid__jalali Are there not many avenues of neuroinvasion? https://t.co/KnRDE3XXnF https://t.co/H484nUBniw https://t.co/fcv709Z3oW https://t.co/Y0BO1h5ioW

Apr 29, 2021 · 1 like · 2,282 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/xX0rMPzTVp

Apr 8, 2021 · 35 followers View post →
European Virus Bioinformatics Center
@EVirusBioinfC · X

Insights to #SARSCoV2 life cycle, #pathophysiology, and rationalized #treatments that target #COVID19 clinical #complications. Review co-authored by EVBC member @dparask69 https://t.co/tBm10WaxcC

Feb 12, 2021 · 5,650 followers View post →