February 2021 PMID 33470505

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.

Mikolaj Ogrodnik, Shane A Evans, Edward Fielder, Stella Victorelli, Patrick Kruger, Hanna Salmonowicz, Bettina M Weigand, Ayush D Patel, Tamar Pirtskhalava, Christine L Inman, Kurt O Johnson, Stephanie L Dickinson, Azucena Rocha, Marissa J Schafer, Yi Zhu

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137

Peak: 34 in Jan 2021

across 7 sources since Jan 2021

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Jan 2021 – May 2025

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What people are saying

In the discussions, numerous users highlighted the recognition of the paper through accolades, such as mentions of winning the Best Paper Prize, reflecting the community's acknowledgment of its significance. The use of expressions like 'great news' and 'promising work' conveys a hopeful tone regarding the findings, while some discussions emphasize the ongoing curiosity about potential human applications, underscoring the word choices and context that align with optimism and interest in future research paths.

AgreementModerate agreement

The majority of discussions reflect a supportive stance toward the findings of the publication, indicating a general consensus among the users.

InterestHigh interest

Users exhibit a high level of enthusiasm, as evidenced by multiple mentions of the paper's acclaim and the potential implications of the research.

EngagementModerate engagement

While many posts echo similar sentiments, a few delve deeper into the study's methodology and findings, showing some degree of analytical engagement.

ImpactHigh impact

Many participants express belief that this research could have far-reaching implications for treating age-related cognitive decline, signifying high perceived impact.

Abstract in brief

Cellular senescence leads to irreversible cell cycle arrest and a pro-inflammatory state, contributing to aging and related diseases, particularly in the brain.
In experiments with aged mice, researchers used genetic methods to eliminate senescent cells and found a significant decrease in microglial activation and pro-inflammatory markers.
These interventions resulted in improved cognitive function in aged mice, suggesting that targeting senescent cells may be a promising strategy for treating age-related cognitive decline.

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4Marian

@4Marian44 · X

https://t.co/xptz3Sr0lb https://t.co/G3W9pnAbWU

May 9, 2025 · 66 followers View post →

Nadav Bruchiel

@NadavB · X

@ArbleMatan @orlyf6 למשל זה: https://t.co/X6ZQp0wwpH

Jul 8, 2023 · 1 like · 601 followers View post →

Ahmed Ibrahim

@TheIbrahimLab · X

RT @Aging_Cell: Checkout this amazing paper that won the 2021 Best Paper Prize during the Anatomical Society's 2022 Winter Conference! @ana…

Apr 24, 2023 · 1 share · 603 followers View post →

Aging_Cell

@Aging_Cell · X

Checkout this amazing paper that won the 2021 Best Paper Prize during the Anatomical Society's 2022 Winter Conference! @anat_soc #AcademicTwitter #AcademicChatter #SciTwitter #research #phdchat #AnatomicalSociety Click the link below: https://t.co/3bQnkW0FIN https://t.co/CYUjfvE6wh

Apr 24, 2023 · 2 likes · 1 share · 608 followers View post →

Aging_Cell

@Aging_Cell · X

RT @anat_soc: Another prize winning talk, @Aging_Cell Best Paper Prize 2021, given by, Dr Mikolaj Ogrodnik Whole-body senescent cell cle…

Apr 23, 2023 · 3 shares · 608 followers View post →

Simon H Parson

@NEAnatomist · X

RT @anat_soc: Another prize winning talk, @Aging_Cell Best Paper Prize 2021, given by, Dr Mikolaj Ogrodnik Whole-body senescent cell cle…

Apr 19, 2023 · 3 shares · 1,177 followers View post →

Anatomical Society

@anat_soc · X

Apr 19, 2023 · 10 likes · 3 shares · 7,009 followers View post →

KARLA VALDIVIESO

@Kaevaldivieso · X

RT @LBG_SHoW: Great news to start the week! @AgingCell's Best Paper Prize goes to "Whole-body senescent cell clearance alleviates age-relat…

Jun 13, 2022 · 3 shares · 140 followers View post →

LBI Trauma

@lbitrauma · X

RT @LBG_SHoW: Great news to start the week! @AgingCell's Best Paper Prize goes to "Whole-body senescent cell clearance alleviates age-relat…

Jun 13, 2022 · 3 shares · 278 followers View post →

Conny Schneider

@currifex · X

RT @LBG_SHoW: Great news to start the week! @AgingCell's Best Paper Prize goes to "Whole-body senescent cell clearance alleviates age-relat…

Jun 13, 2022 · 3 shares · 408 followers View post →

LBG Research Group: Senescence & Healing of Wounds

@LBG_SHoW · X

Great news to start the week! @AgingCell's Best Paper Prize goes to "Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in

Jun 13, 2022 · 9 likes · 3 shares · 290 followers View post →

UAB NSC

@NscUab · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice Aging Cell, Volume 20, Issue 2, February 2021, Pages 1-16 https://t.co/CrSeZkYYae

Jun 2, 2022 · 1 like · 305 followers View post →

Neal Asher

@nealasher · X

https://t.co/KR7YhKjMfu

Sep 4, 2021 · 1 like · 13,111 followers View post →

Mirre Simons

@MirreSimons · X

@Blagosklonny The latest example of "proof" I like is https://t.co/O4viVpnzHH Something goes up with ageing, you reduce it with carefully controlled experiment, you get "improved" phenotype. Not sure what more you want. One could argue this has not been shown as precisely for e.g. rapamycin.

Jul 27, 2021 · 3 likes · 1,038 followers View post →

Samuel Muggington

@SMuggington · X

https://t.co/3ByChoR9ur

Mar 27, 2021 · 1,563 followers View post →

SP8CEVC™

@SP8CEVCTeam · X

Mar 26, 2021 · 2 likes · 276 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice https://t.co/NSca6LHO3C https://t.co/gdNuBXR0Ow

Mar 23, 2021 · 884 followers View post →

Victor Stewart

@victorxstewart · X

@mike_lustgarten check this out too: https://t.co/HhaGckMumo

Feb 27, 2021 · 1 like · 156 followers View post →

Sainadh Chityala

@ranasaof · X

RT @elidourado: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co…

Feb 27, 2021 · 5 shares · 598 followers View post →

Alexander Kruel

@XiXiDu · X

RT @elidourado: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co…

Feb 27, 2021 · 5 shares · 4,861 followers View post →

cryoboy

@anku505 · X

RT @elidourado: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co…

Feb 26, 2021 · 5 shares · 844 followers View post →

Eli Dourado

@elidourado · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/NIvzPTY6O7

Feb 26, 2021 · 35 likes · 5 shares · 43,274 followers View post →

Daniel

@danielkoganbio · X

"Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice" https://t.co/QNN0CVUid8

Feb 26, 2021 · 1 like · 747 followers View post →

Siberian fox

@SilverVVulpes · X

RT @whsource: "Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice" Interested…

Feb 26, 2021 · 1 share · 6,286 followers View post →

Stephan J. Guyenet

@sguyenet · X

"Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice" Interested to see this get tested in humans. https://t.co/xz5v6P5HT6

Feb 26, 2021 · 13 likes · 1 share · 48,948 followers View post →

BILL GAMBRELL

@bgam796 · X

Clearing senescent cells in the brain to improve cognitive function. https://t.co/YEHN9gCshL

Feb 5, 2021 · 6 followers View post →

Ronnie Cutler

@cutleraging · X

https://t.co/wllBDDPYdC

Jan 31, 2021 · 1 like · 460 followers View post →

BILL GAMBRELL

@bgam796 · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/l8ZE3x0MWK

Jan 30, 2021 · 6 followers View post →

Osteoporosis-NL @osteoporosis-nl.bsky.social

@Osteoporosis_NL · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice. Mikolaj Ogrodnik et al. Ageing Cell 20 Jan 2021 https://t.co/aLQBffkkDl https://t.co/nqqFSmu29e

Jan 30, 2021 · 1 like · 3,389 followers View post →

Orlando_uy

@Orlando_uy · X

More Evidence for Senescent Cell Clearance as a Treatment for Neurodegenerative Conditions. However, it is still unknown whether senescent cell clearance alleviates cognitive dysfunction during the aging process. https://t.co/CNIeJAHpKG

Jan 27, 2021 · 693 followers View post →

Richardsonlab

@GDRichardsonlab · X

RT @LBG_SHoW: Pharmacogenetic clearance of senescent cells or treatment with senolytic cocktail Dasatinib & Quercetin improved cognitive fu…

Jan 26, 2021 · 3 shares · 377 followers View post →

Nikki Noren Hooten

@nnhooten · X

New paper on #aging #senescence #cognition @AgingCell from @MayoClinic scientists including @NKLeBRASSEUR @marissa_schafer Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/Wb5TwuCqhn

Jan 25, 2021 · 1,321 followers View post →

Björn Schumacher

@schumacherbj · X

RT @AgeingUK: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/n…

Jan 25, 2021 · 1 share · 18,961 followers View post →

john morley

@drjohnmorley · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/1LKdGUSaCI

Jan 25, 2021 · 8,310 followers View post →

AgeingUK

@AgeingUK · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/nh04suWmRq From @AgeingCell https://t.co/hY1LXXB4Za

Jan 25, 2021 · 4 likes · 1 share · 3,023 followers View post →

Ludwig Boltzmann Gesellschaft

@LBG_research · X

RT @LBG_SHoW: Pharmacogenetic clearance of senescent cells or treatment with senolytic cocktail Dasatinib & Quercetin improved cognitive fu…

Jan 25, 2021 · 3 shares · 838 followers View post →

Conny Schneider

@currifex · X

RT @LBG_SHoW: Pharmacogenetic clearance of senescent cells or treatment with senolytic cocktail Dasatinib & Quercetin improved cognitive fu…

Jan 25, 2021 · 3 shares · 408 followers View post →

LBG Research Group: Senescence & Healing of Wounds

@LBG_SHoW · X

Jan 25, 2021 · 9 likes · 3 shares · 290 followers View post →

Hanna Salmonowicz

@HSalmonowicz · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 24, 2021 · 7 shares · 1,901 followers View post →

Nathan Taylor

@ntaylor963 · X

Yeah yeah yeah, in mice. But still interesting. Clearing senescent cells was already shown to help mice if neurodegenerative disease. This paper goes on to show that for non-diseased aged mice, clearing senescent cells improves cognitive function. https://t.co/HnVMoOqTaT https://t.co/753UVd7fPh

Jan 24, 2021 · 1 like · 1,610 followers View post →

zaheer

@zaheer534149081 · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice - PubMed https://t.co/exIS7BJUTi

Jan 24, 2021 · 140 followers View post →

Alessandro Bartolomucci Lab

@BartolomucciLab · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/eMGY4REtaU

Jan 24, 2021 · 3 likes · 1,518 followers View post →

UpToPhate

@UpToPhate · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice. https://t.co/SvPbS9y37f

Jan 23, 2021 · 193 followers View post →

Peptide Sciences

@PeptideScience · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/kNM7PsTqjQ

Jan 22, 2021 · 4 likes · 1 share · 6,644 followers View post →

Rahul Samant

@SamantLab · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 21, 2021 · 7 shares · 1,665 followers View post →

AntiAgify - Science will set you free

@AntiAgify · X

https://t.co/GRFrnAtxwH

Jan 21, 2021 · 1,353 followers View post →

Alish Palmos

@alishpalmos · X

Clearing "cell debris" with certain drugs reduces age‐related brain inflammation and improves cognitive performance in mice https://t.co/XvVWQGecFs

Jan 21, 2021 · 448 followers View post →

the paper link

@the_paper_link · X

Trend new: **Ogrodnik M** et al (Aging Cell) __Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice__ https://t.co/9yJhue8Ghb

Jan 21, 2021 · 137 followers View post →

Alexander Kruel

@XiXiDu · X

"Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice", Ogrodnik et al 2021 https://t.co/IRMgI7yYyg

Jan 21, 2021 · 2 likes · 4,861 followers View post →

Raquel R. Martins

@Raquel_RMartins · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 21, 2021 · 7 shares · 100 followers View post →

Marcin Majda

@MarcinBio · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 21, 2021 · 7 shares · 76 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/C57lkaZB7B https://t.co/LCEQrGuUkM https://t.co/fjTahuipTt

Jan 20, 2021 · 884 followers View post →

Orlando_uy

@Orlando_uy · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice. Senolytic interventions seems to be a potential therapeutic avenue for alleviating age‐associated cognitive impairment. https://t.co/ZLwQHCN4pX

Jan 20, 2021 · 693 followers View post →

JJ もうすぐ5歳

@KkaneiSuper · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 20, 2021 · 7 shares · 335 followers View post →

Agingdoc

@agingdoc1 · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice https://t.co/4vTcENQyZv Promising work by Kirkland. Both genetic elimination and D&Q were effective in aged mice, w/⬇️SASP & significantly improved cognitive function.

Jan 20, 2021 · 4 likes · 41,931 followers View post →

Chez la Dania

@DacoDaniia · X

RT @AgingBiology: Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk…

Jan 20, 2021 · 7 shares · 179 followers View post →

Aging Science News

@AgingBiology · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice @dianajurk https://t.co/6Vomm49ova

Jan 20, 2021 · 29 likes · 7 shares · 30,804 followers View post →

Marcus Böhme

@boehmemarcus.bsky.social · Bluesky

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13296#

Jan 20, 2021 View post →

Marcus Böhme

@BoehmeMarcus · X

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice https://t.co/BxhidC0GyI

Jan 20, 2021 · 2 likes · 4,308 followers View post →

-Seq Papers

@SeqTheWorld · X

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice https://t.co/69S1m42eMN

Jan 20, 2021 · 6 followers View post →

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.

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Insights on Aging: Longevity Updates from April 2021

Latest Longevity Developments: February 2021 Updates