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Adv Sci (Weinh) January 2021 PMID 33511022

Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation.

Ying Zhang, Mirjam M P Zegers, Anika Nagelkerke, Alan E Rowan, Paul N Span, Paul H J Kouwer

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Mentions

5
Peak: 2 in Dec 2020
across 3 sources since Dec 2020

Extended reach

35,116
potential audience

Total likes

11

Video views

24

Mentions per month

Dec 2020 – Sep 2025

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  • X / Twitter2 posts
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AI synopsis

What people are saying

The discussion highlights the significance of designing improved matrices for studying complex cell behaviors, using enthusiastic phrases like 'help illuminate' and 'better cell growth matrices,' which underscore the perceived importance and promising potential of the research in advancing biological understanding.

AgreementModerate agreement

The post shows strong support for the research by emphasizing its potential to enhance our understanding of cell formation processes.

InterestHigh interest

The discussion demonstrates high interest, with enthusiasm for novel insights into tissue morphogenesis, supported by positive language like 'illuminate' and 'better matrix design.'

EngagementModerate engagement

The post encourages further reading and discussion, mentioning specific labs and calling for the article to be read, indicating moderate engagement.

ImpactModerate impact

The emphasis on improving understanding of biological structure formation suggests an acknowledgment of meaningful impact in the field of tissue engineering and regenerative medicine.

Abstract in brief

  • The study explores how hybrid hydrogel matrices made from Matrigel and synthetic polyisocyanides (PICs) can be precisely tuned to influence epithelial cell shapes and behaviors, particularly in the MDCK cell model.
  • By adjusting the stiffness and cell-matrix adhesion in these hybrid matrices, researchers observed a transition from round cysts to flat monolayers and tubular structures, with YAP protein activity serving as an indicator of mechanotransduction signals.
  • These hybrid gels offer a versatile platform for understanding how physical cues from the environment regulate tissue morphogenesis, which could be extended to more complex biological systems in the future.
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Advanced Portfolio News
@AdvPortfolio · X

Designing better cell growth matrices can help illuminate the processes through which cells become complex biological structures. @PSpan3 @KouwerLab @Radboud_Uni Read the #openaccess article https://t.co/WjJKgwAPvH https://t.co/HyyMIcFzjs

Dec 16, 2020 · 10 likes · 4 shares · 34,827 followers View post →
Society of Plastics Engineers - Medical Plastics
@SPE_MPD · X

RT @AdvSciNews: Designing better cell growth matrices can help illuminate the processes through which cells become complex biological struc…

Dec 16, 2020 · 4 shares · 239 followers View post →

All mentions

Society of Plastics Engineers - Medical Plastics
@SPE_MPD · X

RT @AdvSciNews: Designing better cell growth matrices can help illuminate the processes through which cells become complex biological struc…

Dec 16, 2020 · 4 shares · 239 followers View post →
Advanced Portfolio News
@AdvPortfolio · X

Designing better cell growth matrices can help illuminate the processes through which cells become complex biological structures. @PSpan3 @KouwerLab @Radboud_Uni Read the #openaccess article https://t.co/WjJKgwAPvH https://t.co/HyyMIcFzjs

Dec 16, 2020 · 10 likes · 4 shares · 34,827 followers View post →
Towards a new generation of plant-inspired growing artefacts ...
News

Publisher: John Wiley & Sons Ltd. DOI: 10.1002/adfm.202003380. 3D ... DOI: 10.1002/advs.202301496. Electrical Actuation of Coated and ...

Sep 1, 2025 View →