Discussions highlight the innovative nature of the COSI technique and its ability to examine thrombus formation without labels, with users expressing enthusiasm about its clinical relevance by using words like 'game-changer' and 'cutting-edge'. They also explore mechanistic insights, such as the role of metalloproteinases, signaling a thoughtful and impactful engagement with the research.
AgreementModerate agreement
Most discussions recognize the significance of the new imaging technique and its potential for advancing thrombus research, reflected in phrases like 'breakthrough' and 'innovative approach'.
InterestModerate interest
Participants show moderate interest, evident from comments emphasizing curiosity about clinical applications and methodological details.
EngagementHigh engagement
Many comments delve into technical aspects, such as the nanoscale tracking of platelet changes and the implications of inhibiting metalloproteinases, demonstrating deep engagement.
ImpactModerate impact
The discussions suggest the publication could influence future research directions and clinical strategies, indicated by comments on its potential to improve diagnosis and treatment.
Abstract in brief
The article describes a new labelfree imaging technique called COSI that combines optical scattering and phase microscopy to measure thrombus formation and platelet activity in real-time under blood flow conditions.
COSI allows for highly precise, nanoscale tracking of platelet membrane changes and thrombus mass without the use of fluorescent labels, improving clinical relevance.
The study demonstrates that inhibiting metalloproteinases with GM6001 prevents receptor shedding and reduces platelet activity during thrombus development, revealing insights into the mechanisms of clot formation.]
This video showcases the COSI technique, a label-free multimodal imaging method that combines optical scattering and phase microscopy to track thrombus formation and platelet activity in real-time under blood flow…
This video illustrates a novel labelfree imaging technique called COSI, which combines optical scattering and phase microscopy to monitor thrombus formation and platelet activity in real-time under blood flow.
The video introduces COSI, a labelfree imaging technique combining optical scattering and phase microscopy to monitor thrombus formation and platelet activity in real-time under blood flow conditions, providing…
Movie S7 shows activity signals at the adhesive layer of a forming thrombus during embolization under physiological flow. Movie S8 presents the mass distribution map of the thrombus, illustrating mass variation during…
Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM Lee.
Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM Lee.
2022. Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM ...
The Lee Group - Optical Biofluidic Imaging Group | The John Curtin ...
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"Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro"; Tienan Xu, Yean Jin Lim, Yujie Zheng..., Woei Ming Lee, Lab On ...