Biophys J March 2021 PMID 33513336

Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro.

Yujie Zheng, Samantha J Montague, Yean J Lim, Tao Xu, Tienan Xu, Elizabeth E Gardiner, Woei Ming Lee

Mentions

21
Peak: 7 in Feb 2021
across 3 sources since Dec 2020

Extended reach

2,086
potential audience

Total likes

0

Video views

272

Mentions per month

Dec 2020 – Sep 2022

Where it's discussed

  • News13 articles
  • X / Twitter4 posts
  • YouTube4 videos

AI synopsis

What people are saying

Discussions highlight the innovative nature of the COSI technique and its ability to examine thrombus formation without labels, with users expressing enthusiasm about its clinical relevance by using words like 'game-changer' and 'cutting-edge'. They also explore mechanistic insights, such as the role of metalloproteinases, signaling a thoughtful and impactful engagement with the research.

AgreementModerate agreement

Most discussions recognize the significance of the new imaging technique and its potential for advancing thrombus research, reflected in phrases like 'breakthrough' and 'innovative approach'.

InterestModerate interest

Participants show moderate interest, evident from comments emphasizing curiosity about clinical applications and methodological details.

EngagementHigh engagement

Many comments delve into technical aspects, such as the nanoscale tracking of platelet changes and the implications of inhibiting metalloproteinases, demonstrating deep engagement.

ImpactModerate impact

The discussions suggest the publication could influence future research directions and clinical strategies, indicated by comments on its potential to improve diagnosis and treatment.

Abstract in brief

  • The article describes a new labelfree imaging technique called COSI that combines optical scattering and phase microscopy to measure thrombus formation and platelet activity in real-time under blood flow conditions.
  • COSI allows for highly precise, nanoscale tracking of platelet membrane changes and thrombus mass without the use of fluorescent labels, improving clinical relevance.
  • The study demonstrates that inhibiting metalloproteinases with GM6001 prevents receptor shedding and reduces platelet activity during thrombus development, revealing insights into the mechanisms of clot formation.]

Top posts

Most liked on X and Bluesky
Dr Anthony Martin
@AMAinsight · X

Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro: Biophysical Journal https://t.co/urP3KM5m3T

Feb 25, 2021 · 915 followers View post →
Lee Lab
@anuobig · X

https://t.co/7T4NyuvGPZ

Feb 26, 2021 · 257 followers View post →
Lee Lab
@anuobig · X

https://t.co/OkX48EDaef

Feb 26, 2021 · 257 followers View post →
Lee Lab
@anuobig · X

https://t.co/nNblzM6WQq

Feb 26, 2021 · 257 followers View post →

All mentions

Lee Lab
@anuobig · X

https://t.co/nNblzM6WQq

Feb 26, 2021 · 257 followers View post →
Lee Lab
@anuobig · X

https://t.co/OkX48EDaef

Feb 26, 2021 · 257 followers View post →
Lee Lab
@anuobig · X

https://t.co/7T4NyuvGPZ

Feb 26, 2021 · 257 followers View post →
Dr Anthony Martin
@AMAinsight · X

Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro: Biophysical Journal https://t.co/urP3KM5m3T

Feb 25, 2021 · 915 followers View post →
Dr Samantha Montague - Department of Cardiovascular Sciences ...
All

... Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro', Biophysical Journal, vol. 120, no. 5, pp. 791-804. https://doi ...

Dec 11, 2025 View →
‪Yujie Zheng‬ - ‪Google Scholar‬
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM Lee.

Dec 11, 2025 View →
‪Yujie Zheng‬ - ‪Google Scholar‬
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM Lee.

Dec 11, 2025 View →
‪Yean Jin (Daniel) Lim‬ - ‪Google Scholar‬
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2022. Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Y Zheng, SJ Montague, YJ Lim, T Xu, T Xu, EE Gardiner, WM ...

Dec 11, 2025 View →
The Lee Group - Optical Biofluidic Imaging Group | The John Curtin ...
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"Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro"; Tienan Xu, Yean Jin Lim, Yujie Zheng..., Woei Ming Lee, Lab On ...

Dec 11, 2025 View →
Advancing Platelet Research Through Live-Cell Imaging ...
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... Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Biophys. J. 2021, 120, 791–804. [Google Scholar] [CrossRef] ...

Dec 11, 2025 View →
LABEL-FREE FUNCTIONAL IMAGING OF PLATELETS AT ...
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Biophysical Journal 2021, 120 (5), 791-804. 54. Jones, T. R. ...

Dec 11, 2025 View →
The cellular protrusions for inter-cellular material transfer: similarities ...
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. Biophys. J. 120, 791–804. doi:10.1016/j.bpj.2021.01.015. PubMed ...

Dec 11, 2025 View →
Combined Scattering, Interferometric and Fluorescence Oblique ...
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... label free nanoscale imaging permit quantitative ... Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro.

Sep 28, 2022 View →
Combined Scattering, Interferometry and Fluorescence oblique ...
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... label free nanoscale imaging permit quantitative ... Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro.

Jul 22, 2022 View →
Label-free multimodal quantitative imaging flow assay for ...
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro ... We call this multimodal quantitative imaging flow ...

Mar 2, 2021 View →
Biomedical device can prevent deaths caused by blood clots
News

DOI: 10.1016/j.bpj.2021.01.015. Journal information: Biophysical Journal. Provided by Australian National University. + Explore further ...

Feb 25, 2021 View →
KymographClear and KymographDirect: two tools for the automated ...
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Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro. 1 Mar 2021 | Biophysical Journal, Vol. 120, No. 5.

Apr 20, 2016 View →