J Cell Mol Med March 2021 PMID 33523605

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway.

Lingli Chen, Santie Li, Jianyu Zhu, Anfu You, Xingzhou Huang, Xinchu Yi, Mei Xue

Mentions

12
Peak: 6 in Dec 2024
across 3 sources since Aug 2021

Extended reach

83,021
potential audience

Total likes

7,636

Video views

57,053

Mentions per month

Aug 2021 – Apr 2025

Where it's discussed

  • X / Twitter8 posts
  • YouTube3 videos
  • Blogs1 articles

AI synopsis

What people are saying

The discussions reflect strong support and interest, with examples like the claim that mangoes 'prevent heart attacks and strokes' based on scientific confirmation, and mentions of specific pathways such as Sirt1/FoxO3a highlight the depth of engagement. The tone emphasizes the importance and potential impact of the research, portraying mangiferin as a promising natural remedy for heart health.

AgreementStrong agreement

Most discussions fully support the positive findings, emphasizing how mangiferin can prevent heart damage based on scientific evidence.

InterestHigh interest

The posts clearly demonstrate high interest by highlighting the health benefits of mangoes and mangiferin, citing scientific validation.

EngagementModerate engagement

The comments show some depth, with users mentioning specific mechanisms like Sirt1 and FoxO3a, though some focus mainly on general health improvements.

ImpactHigh impact

The overall tone suggests these discussions see the research as potentially transformative for heart health and preventive medicine.

Abstract in brief

  • Mangiferin, a natural compound from mangoes, helps protect the heart after a heart attack (myocardial infarction) by activating the Sirt1-FoxO3a pathway, which reduces cell death and prevents heart failure.
  • In experiments using mice and heart cells, mangiferin increased Sirt1 levels, decreased the size of heart damage, and prevented apoptosis, with these effects being dependent on Sirt1 activity.
  • The study suggests that mangiferin works by promoting the deacetylation of FoxO3a through Sirt1, thereby reducing cell death, and may have potential for future clinical use in treating heart attacks.

Top posts

Most liked on X and Bluesky
Jonathas Gagliardi Madeira.
@abripi · X

https://t.co/xEqFb9WSds

Dec 16, 2024 · 1 like · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

ESSA FRUTA (MANGA) PREVINE INFARTO e AVC! CONFIRMADO PELA CIÊNCIA! THIS FRUIT (MANGO) PREVENTS HEART ATTACKS AND STROKE! CONFIRMED BY SCIENCE! https://t.co/ZvykpXQcpl via @YouTube

Dec 16, 2024 · 1 like · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

RT @abripi: https://t.co/xEqFb9WSds

Dec 16, 2024 · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

RT @abripi: ESSA FRUTA (MANGA) PREVINE INFARTO e AVC! CONFIRMADO PELA CIÊNCIA! THIS FRUIT (MANGO) PREVENTS HEART ATTACKS AND STROKE! CONF…

Dec 16, 2024 · 1 share · 5,957 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure https://t.co/laBH40az0o -> Mangiferin increases FoxO3a deacetylation by up-regulating Sirtuin1 To gain therapeutic insights into cardiovascular disease: https://t.co/qF5sdy5tyE https://t.co/rZYlOc0u3a

Apr 20, 2022 · 890 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1.. https://t.co/laBH40rC2o This study suggests that "mangiferin prevents cardiomyocyte apoptosis and subsequent heart failure by activating the Sirt1/FoxO3a pathway." https://t.co/dae5RytJR8

Aug 22, 2021 · 890 followers View post →

All mentions

Filipe Meneses
@fcwork10 · X

https://t.co/qucxGBC2pn

Apr 6, 2025 · 65 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

RT @abripi: https://t.co/xEqFb9WSds

Dec 16, 2024 · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

https://t.co/xEqFb9WSds

Dec 16, 2024 · 1 like · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

RT @abripi: ESSA FRUTA (MANGA) PREVINE INFARTO e AVC! CONFIRMADO PELA CIÊNCIA! THIS FRUIT (MANGO) PREVENTS HEART ATTACKS AND STROKE! CONF…

Dec 16, 2024 · 1 share · 5,957 followers View post →
Jonathas Gagliardi Madeira.
@abripi · X

ESSA FRUTA (MANGA) PREVINE INFARTO e AVC! CONFIRMADO PELA CIÊNCIA! THIS FRUIT (MANGO) PREVENTS HEART ATTACKS AND STROKE! CONFIRMED BY SCIENCE! https://t.co/ZvykpXQcpl via @YouTube

Dec 16, 2024 · 1 like · 1 share · 5,957 followers View post →
Saathealth
@SaathealthHQ · X

❤️ Mangoes may help your heart The evidence says: Mangoes contain heart-healthy nutrients and compounds like magnesium, potassium, and mangiferin. These help regulate your blood pressure and protect your cells from damage. Ref: https://t.co/NjYhdabVoz

Apr 29, 2022 · 278 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure https://t.co/laBH40az0o -> Mangiferin increases FoxO3a deacetylation by up-regulating Sirtuin1 To gain therapeutic insights into cardiovascular disease: https://t.co/qF5sdy5tyE https://t.co/rZYlOc0u3a

Apr 20, 2022 · 890 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1.. https://t.co/laBH40rC2o This study suggests that "mangiferin prevents cardiomyocyte apoptosis and subsequent heart failure by activating the Sirt1/FoxO3a pathway." https://t.co/dae5RytJR8

Aug 22, 2021 · 890 followers View post →
Publications | Faculty of Medicine | Imperial College London
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