Proc Natl Acad Sci U S A February 2021 PMID 33526697

Genome-wide role of codon usage on transcription and identification of potential regulators.

Fangzhou Zhao, Zhipeng Zhou, Yunkun Dang, Hyunsoo Na, Catherine Adam, Anna Lipzen, Vivian Ng, Igor V Grigoriev, Yi Liu

Mentions

12
Peak: 6 in Feb 2021
across 3 sources since Feb 2021

Extended reach

24,693
potential audience

Total likes

431

Video views

11,828

Mentions per month

Feb 2021 – Apr 2022

Where it's discussed

  • X / Twitter8 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The collective discussions reflect strong interest and recognition of the research's importance, exemplified by comments like 'how does this happen?' and references to candidate regulators, which show deep engagement. The tone and focus on mechanistic details and broader implications indicate a positive view of the study's potential impact.

AgreementModerate agreement

Most discussions acknowledge and reinforce the significance of the findings about codon usage and its regulatory roles, showing general support.

InterestHigh interest

The posts express high curiosity about the mechanisms and implications, often referencing specific candidates and processes.

EngagementModerate engagement

There is a moderate level of detailed discussion, with mentions of candidates, mechanisms, and related questions about how transcription is affected.

ImpactModerate impact

While not explicitly calling the research a game-changer, posts suggest it could influence future genetic and transcriptional studies, highlighting its potential significance.

Abstract in brief

  • Codon usage bias affects gene expression not only through translation but also plays a significant role in regulating transcription, influencing mRNA levels in the nucleus.
  • The study shows that the relationship between codon optimality and RNA levels is maintained in the nucleus and is correlated with chromatin regulators and transcription factors, indicating a translation-independent mechanism.
  • A genetic screen identified key factors, including chromatin modifiers like the H3K36 methyltransferase, that mediate the impact of codon usage on gene expression through multiple transcriptional regulatory pathways.]

Top posts

Most liked on X and Bluesky
Zeynep Baharoglu
@BaharogluZeynep · X

Codon usage also directly impacts mRNA levels, with an effect on transcription tremination, talk by Yu Liu at #EMBO_CU22 https://t.co/BGHl6tqYDA

Apr 9, 2022 · 5 likes · 1 share · 1,029 followers View post →
Javier Santoyo
@jsantoyo · X

Genome-wide role of codon usage on transcription and identification of potential regulators. #CodonsInTranscription https://t.co/lpNxNZ86Qj via #PNAS

Feb 2, 2021 · 2 likes · 1 share · 6,273 followers View post →
The Lab LaBella
@Lab_LaBella · X

Transcription of genes with optimal codon usage is higher in the nucleus – but how does this happen? Zhao et al uncover 18 candidates that may detect codon optimization during transcription. @rokaslab #3rdBaseThurs https://t.co/iVahOoXelp

Feb 18, 2021 · 2 likes · 1 share · 908 followers View post →
Brad Chapman
@chapmanb · X

RT @AbbeAtSea: Transcription of genes with optimal codon usage is higher in the nucleus – but how does this happen? Zhao et al uncover 18…

Feb 18, 2021 · 1 share · 2,773 followers View post →
Bozeng Tang
@BozengTang · X

Genome-wide role of codon usage on transcription and identification of potential regulators https://t.co/fSYItcXtjt

Apr 8, 2021 · 1,100 followers View post →
Victor Zegarra
@zegarrv · X

RT @BaharogluZeynep: Codon usage also directly impacts mRNA levels, with an effect on transcription tremination, talk by Yu Liu at #EMBO_CU…

Apr 9, 2022 · 1 share · 421 followers View post →

All mentions

Victor Zegarra
@zegarrv · X

RT @BaharogluZeynep: Codon usage also directly impacts mRNA levels, with an effect on transcription tremination, talk by Yu Liu at #EMBO_CU…

Apr 9, 2022 · 1 share · 421 followers View post →
Zeynep Baharoglu
@BaharogluZeynep · X

Codon usage also directly impacts mRNA levels, with an effect on transcription tremination, talk by Yu Liu at #EMBO_CU22 https://t.co/BGHl6tqYDA

Apr 9, 2022 · 5 likes · 1 share · 1,029 followers View post →
Bozeng Tang
@BozengTang · X

Genome-wide role of codon usage on transcription and identification of potential regulators https://t.co/fSYItcXtjt

Apr 8, 2021 · 1,100 followers View post →
Brad Chapman
@chapmanb · X

RT @AbbeAtSea: Transcription of genes with optimal codon usage is higher in the nucleus – but how does this happen? Zhao et al uncover 18…

Feb 18, 2021 · 1 share · 2,773 followers View post →
The Lab LaBella
@Lab_LaBella · X

Transcription of genes with optimal codon usage is higher in the nucleus – but how does this happen? Zhao et al uncover 18 candidates that may detect codon optimization during transcription. @rokaslab #3rdBaseThurs https://t.co/iVahOoXelp

Feb 18, 2021 · 2 likes · 1 share · 908 followers View post →
Susan Jones
@Su_Jo10 · X

RT @jsantoyo: Genome-wide role of codon usage on transcription and identification of potential regulators. #CodonsInTranscription https://t…

Feb 2, 2021 · 1 share · 19 followers View post →
Javier Santoyo
@jsantoyo · X

Genome-wide role of codon usage on transcription and identification of potential regulators. #CodonsInTranscription https://t.co/lpNxNZ86Qj via #PNAS

Feb 2, 2021 · 2 likes · 1 share · 6,273 followers View post →
micropapers
@micro_papers · X

Genome-wide role of codon usage on transcription and identification of potential regulators https://t.co/lo6TR8UtXF

Feb 2, 2021 · 331 followers View post →