J Sex Med March 2021 PMID 33531255

A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen.

Giulia Gava, Francesca Armillotta, Paolo Pillastrini, Silvia Giagio, Stefania Alvisi, Ilaria Mancini, Paolo Giovanni Morselli, Renato Seracchioli, Maria Cristina Meriggiola

Mentions

3
Peak: 2 in May 2024
across 2 sources since Jan 2023

Extended reach

28,498
potential audience

Total likes

617

Video views

28,499

Mentions per month

Jan 2023 – May 2025

Where it's discussed

  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The social discussions mention the study's results without deep analysis, such as noting muscle and fat changes, but lack critical evaluation or emotional investment. The tone is neutral, with phrases like 'interesting biomarker changes' suggesting mild interest rather than strong engagement or impact.

AgreementNeither agree nor disagree

The discussions do not strongly support or oppose the study, indicating neutrality or mixed opinions.

InterestModerate interest

Participants show some curiosity about the findings but do not express high enthusiasm.

EngagementNeutral engagement

The exchange appears superficial, with little detailed discussion or critical analysis.

ImpactNeutral impact

The discussions seem to recognize some relevance but do not indicate substantial influence or change prompted by the research.

Abstract in brief

  • This study investigated how 54 weeks of testosterone undecanoate (TU), with or without the 5-reductase inhibitor dutasteride (DT), affects muscle strength, body composition, and metabolic health in transmen, finding that muscle strength and lean mass increased while fat mass decreased regardless of the treatment.
  • Both groups showed improvements in handgrip and leg strength, with no significant differences between the TU only and TU plus DT groups, and metabolic health remained stable except for a decrease in HDL cholesterol.
  • The findings suggest that testosterone therapy can improve muscle and body composition in transmen without major adverse effects, which is especially relevant for managing androgen-related skin issues and developing non-5-reductase androgen therapies.]

Top posts

Most liked on X and Bluesky
The Science of Parkinson's
@scienceofpd.bsky.social · Bluesky

The results of a randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in #Parkinsons (n=30 & 30; 3 months) reports no sig. diff. in UPDRS scores, but some interesting biomarker changes www.frontiersin.org/journals/pha...

May 20, 2025 View post →

All mentions

The Science of Parkinson's
@scienceofpd.bsky.social · Bluesky

The results of a randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in #Parkinsons (n=30 & 30; 3 months) reports no sig. diff. in UPDRS scores, but some interesting biomarker changes www.frontiersin.org/journals/pha...

May 20, 2025 View post →