Obes Rev March 2021 PMID 33543573

Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation.

Abdul G Dulloo

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Mentions

23
Peak: 5 in Feb 2021
across 5 sources since Feb 2021

Extended reach

67,264
potential audience

Total likes

648

Video views

26,157

Mentions per month

Feb 2021 – Dec 2025

Where it's discussed

  • X / Twitter15 posts
  • YouTube2 videos
  • Instagram2 posts
  • Reddit2 posts
  • News2 articles

AI synopsis

What people are saying

Discussions reflect support and fascination with the research, with posts emphasizing how the findings challenge dieting myths, such as condemning calorie restriction as futile, and referencing complex biological signals involved in weight regain, which suggests a moderate but meaningful recognition of the research's significance.

AgreementModerate agreement

Most discussions recognize the importance of the research, especially in explaining the body's natural tendency to regain weight after dieting.

InterestHigh interest

Comments show high curiosity about the biological mechanisms and implications, with many urging others to learn more or highlighting new insights.

EngagementModerate engagement

Several posts engage deeply by referencing specific concepts like 'famine reaction,' feedback loops, and potential signals involved in weight regain.

ImpactModerate impact

The discussion indicates that the article could influence opinions about dieting practices and understanding weight regulation, although some remarks are more general.

Abstract in brief

  • The Minnesota Starvation Experiment, conducted in 1950, provides key insights into how the human body responds to long-term food deprivation, impacting physiology and behavior, and informing issues like eating disorders and obesity.
  • Recent analyses of the experiment's data reveal complex internal control systems that regulate body composition through feedback loops involving fat and lean mass, sensitive to initial fat levels, and linked to appetite and energy expenditure.
  • Understanding these autoregulatory mechanisms helps explain the body's natural tendency for weight regain after dieting, highlighting why weight cycling and obesity relapse are driven by fundamental physiological responses.

Top posts

Most liked on X and Bluesky
komm, süssy tod
@punished3liza · X

https://t.co/iQCcsIe0dT this is a really interesting revisiting of the Minnesota Starvation Experiment that is so dense i don't think i can pull a quote or summarize. give it a skim. it supports the "dieting changes your metabolism and brain-gut signaling in weird ways" principle

May 13, 2024 · 16 likes · 2 shares · 6,054 followers View post →
Jens Lund
@jens_lund · X

The unknown biological signals and sensors of starvation and body weight regain: “… feedback loops between the state of depletion of fat mass, as well as FFM, and the hunger–appetite centers play a central role in poststarvation hyperphagia”. https://t.co/9KICNLsGnh

Feb 6, 2021 · 10 likes · 3 shares · 2,098 followers View post →
IberianCitizen
@IberianCitizen · X

Fisiología de la recuperación de peso: lecciones del clásico experimento de inanición de Minnesota sobre la regulación de la composición del cuerpo humano sci-hub: статья не найдена / article not found☹️ https://t.co/hRT52WXnyt https://t.co/7TzFxwD8SK

Feb 5, 2021 · 4 likes · 12,901 followers View post →
JORGE FERNANDEZ
@drjorfer · X

Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation - Dulloo - 2021 - Obesity Reviews - Wiley Online Library

Mar 17, 2025 · 1 like · 1,016 followers View post →
Andy Grannell
@Grannell_ · X

@StephenORahilly Amazing work. Potentially some muscle derived signals interacting directly or indirectly with MC3R in the context of weight regain? https://t.co/eOUl1vUUFn https://t.co/XiEgWbclD0

Nov 3, 2021 · 1 like · 989 followers View post →
toe, lover
@carobunga · X

@slingymoose @actually_lia @growing_daniel It’s called the famine reaction. https://t.co/ZbTpg4bW05 https://t.co/QC1lKZMNIi https://t.co/OrCwZCF0Nb

Oct 19, 2022 · 11,714 followers View post →

All mentions

JORGE FERNANDEZ
@drjorfer · X

Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation - Dulloo - 2021 - Obesity Reviews - Wiley Online Library

Mar 17, 2025 · 1 like · 1,016 followers View post →
INNOVADIETA
@INNOVADIETA · X

Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation - Dulloo - 2021 - Obesity Reviews - Wiley Online Library https://t.co/WdYKydbz3B https://t.co/MTio2rXpVP

Jan 22, 2025 · 1,366 followers View post →
Truth Cooperators
@SkrivenaIstina · X

This is why fasting and low calorie diets are trash. Repeated over and over and cannot but lead into obesity. https://t.co/bvDc05bevz

Oct 4, 2024 · 84 followers View post →
Charles
@Mr_Indigo · X

RT @punished3liza: https://t.co/iQCcsIe0dT this is a really interesting revisiting of the Minnesota Starvation Experiment that is so dense…

May 13, 2024 · 2 shares · 293 followers View post →
Of Quartz
@PunishedQuartz · X

RT @punished3liza: https://t.co/iQCcsIe0dT this is a really interesting revisiting of the Minnesota Starvation Experiment that is so dense…

May 13, 2024 · 2 shares · 561 followers View post →
komm, süssy tod
@punished3liza · X

https://t.co/iQCcsIe0dT this is a really interesting revisiting of the Minnesota Starvation Experiment that is so dense i don't think i can pull a quote or summarize. give it a skim. it supports the "dieting changes your metabolism and brain-gut signaling in weird ways" principle

May 13, 2024 · 16 likes · 2 shares · 6,054 followers View post →
Fuel for Remewal
@fuelforrenewal · X

If you want to learn more about this experiment: https://t.co/Mupn8ZxIgs

Jan 8, 2024 · 6 followers View post →
toe, lover
@carobunga · X

@slingymoose @actually_lia @growing_daniel It’s called the famine reaction. https://t.co/ZbTpg4bW05 https://t.co/QC1lKZMNIi https://t.co/OrCwZCF0Nb

Oct 19, 2022 · 11,714 followers View post →
Wind94Rain
@Wind94Rain · X

https://t.co/1JQa7Xxub7

Sep 3, 2022 · 140 followers View post →
Andy Grannell
@Grannell_ · X

@StephenORahilly Amazing work. Potentially some muscle derived signals interacting directly or indirectly with MC3R in the context of weight regain? https://t.co/eOUl1vUUFn https://t.co/XiEgWbclD0

Nov 3, 2021 · 1 like · 989 followers View post →
Kevin Kennedy
@RealfoodKev · X

RT @jens_lund: The unknown biological signals and sensors of starvation and body weight regain: “… feedback loops between the state of de…

Feb 6, 2021 · 3 shares · 1,436 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @jens_lund: The unknown biological signals and sensors of starvation and body weight regain: “… feedback loops between the state of de…

Feb 6, 2021 · 3 shares · 1,364 followers View post →
Andy Grannell
@Grannell_ · X

RT @jens_lund: The unknown biological signals and sensors of starvation and body weight regain: “… feedback loops between the state of de…

Feb 6, 2021 · 3 shares · 989 followers View post →
Jens Lund
@jens_lund · X

The unknown biological signals and sensors of starvation and body weight regain: “… feedback loops between the state of depletion of fat mass, as well as FFM, and the hunger–appetite centers play a central role in poststarvation hyperphagia”. https://t.co/9KICNLsGnh

Feb 6, 2021 · 10 likes · 3 shares · 2,098 followers View post →
IberianCitizen
@IberianCitizen · X

Fisiología de la recuperación de peso: lecciones del clásico experimento de inanición de Minnesota sobre la regulación de la composición del cuerpo humano sci-hub: статья не найдена / article not found☹️ https://t.co/hRT52WXnyt https://t.co/7TzFxwD8SK

Feb 5, 2021 · 4 likes · 12,901 followers View post →
Άννα Κολοκοτρώνη | Διαιτολόγος - Διατροφολόγος | Ο σωστός ...
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doi: 10.1111/obr. 12253 doi:10.1017/thg.2019.106 do: 10.1038/ijo.2011.160 doi: 10.3945/ajen. 115.109173 doi: 10.1111/obr.13189

Dec 11, 2025 View →
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doi: 10.1111/obr. 12253 doi:10.1017/thg.2019.106 do: 10.1038/ijo.2011.160 doi: 10.3945/ajen. 115.109173 doi: 10.1111/obr.13189

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