I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis"- My response.... .@BenBikmanPhD .@BrianLenzkes .@FatEmperor .@DaveKeto .@ChrisPalmerMD and others, what do you think about it? https://t.co/Bj21bmC1ca https://t.co/CHtBdE7PeI
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.
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Feb 2021 – Jul 2025Where it's discussed
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What people are saying
Several discussions revolve around the study's conclusions, with comments like 'healthy individuals should reconsider the use of a KD for weight loss' indicating significant concern. Phrases such as 'can possibly harm' and referencing the biogenesis of mitochondria demonstrate the nuanced conversations about the implications of the findings. The tone often combines caution with curiosity, suggesting an eagerness to understand more about the potential risks of ketogenic diets.
Many discussions express concern or caution about the ketogenic diet, suggesting a general agreement with the study's findings.
Posts show high levels of curiosity about the study and its implications for health and diet.
Some users delve into the details of the research, but many posts are still surface-level responses.
There is a strong perception that the study's results could influence dietary choices and public health discussions.
Abstract in brief
- Prolonged ketogenic diets (KDs) in rats led to cardiac fibrosis by reducing mitochondrial biogenesis, increasing cell death in heart cells, and promoting the accumulation of harmful ketone bodies.
- Increased levels of the ketone body hydroxybutyrate (OHB) were found to inhibit mitochondrial function by activating Sirt7, a protein that negatively regulates genes necessary for mitochondrial ribosome production.
- Similar effects, such as decreased mitochondrial biogenesis and increased cardiac fibrosis, were also observed in human heart tissues from patients with atrial fibrillation, suggesting potential risks associated with ketogenic diets even for individuals who may require them for medical reasons.
Top posts
Most liked on X and BlueskyKetogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy https://t.co/tVeR4tbGpy
Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https://t.co/KYC87AYgBZ
¿La DIETA CETOGÉNICA es PELIGROSA? ¡Nuevo video, nueva evidencia!
At @agingdoc1, I make an effort to represent + & null findings, & those supporting & refuting hypotheses. This will be controversial: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/tfjBkZCG0L Some debate here: https://t.co/r7td6Fnnvk
All mentions
Risks of Prolonged Ketogenic Diets on Heart Health
This video explores the potential dangers of ketogenic diets, highlighting recent findings that link prolonged adherence to these diets with cardiac fibrosis and reduced mitochondrial function. Understanding these risks…
Impact of Vaccination and Exercise on Health Outcomes in 2021
This edition of Weekly Scientific Reports features studies on the effects of COVID-19 vaccination, including its impact on older populations. Additionally, we explore the minimal exercise required to maintain physical…
@Only1MoreThing @HelenHelen138 @ESYudkowsky @exfatloss @Pv @fizsh_ @richcollins @OhHiMarkos @cerv3ra @grok If keto us your choice, do it. "Our results strongly suggest that unless the adverse effects of a KD on the cardiac system can be effectively avoided, healthy individuals should reconsider the use of a KD for weight loss." https://t.co/TBNtxrVfR9
@nullbotto @raphaels7 This study in rats is titled "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis". I don't follow how this supports your claim. Also, you are talking about seed oils, not PUFA, right?
RT @EduOrtegaIbarra: Las dietas cetogénicas prolongadas pueden provocar fibrosis cardíaca al inhibir la biogénesis mitocondrial y aumentar…
Además se descubrió que
https://t.co/EfjZRqjS5l https://t.co/9EJcjiGeqW
Las dietas cetogénicas prolongadas pueden provocar fibrosis cardíaca al inhibir la biogénesis mitocondrial y aumentar la apoptosis en cardiomiocitos.
del músculo cardíaco y por lo tanto la fibrosis cardíaca (cicatrización). Fuente: https://t.co/Q1snZuruaz
@liverman_t @gerdosi @Peter_InNorfolk @TuckerGoodrich Even beta-HB can possibly harm, high level, cycling may be, it's weird, via SIRT7, longevity promoter. https://t.co/TBNtxrVNGH Way of SIRT7 activation could be important, this paper suggests. https://t.co/6UpJSJBB0f Acetate and butyrate activate it differently, so diff. effect?
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis 「ケトジェニック食はミトコンドリア生合成を阻害し、心線維症を誘発する」 https://t.co/oqRTK5CUu8
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis Article Open Access Published: 09 February 2021 https://t.co/A7bhgAVKM2 翻訳結果「ケトジェニックダイエットはミトコンドリアの生合成を阻害し、心臓線維化を誘発します」
@PIndeterminado Ya lo he encontrado, la referencia 7 fue un famoso estudio bastante polémico en ratas. https://t.co/yU2SrRxG2j… La dieta que usaron tampoco era muy sana. En este hilo tienes varios puntos de vista #dieta #cetogenica #keto https://t.co/PofLTSHad6…
Las dietas cetogénicas impiden la formación de mitocondrias e inducen fibrosis cardíaca; disminuyeron la respiración celular y el aumento de la apoptosis del músculo cardíaco y por lo tanto la fibrosis cardíaca. https://t.co/Hc4GeK3aJ3. Texto Dr.Garay García
@anyigonzal5 @endocrinorosero y por lo tanto la fibrosis cardíaca (cicatrización) Te dejo el artículo por si lo quieres consultar Fuente: https://t.co/zbZbOPtUzs. Texto Dr. Raymundo Garay García
RT @gabyamoran: @LoriShemek Lori! Hi, I want to send you a paper that I read today. I would like to know your comments. Thank you so much…
@LoriShemek Lori! Hi, I want to send you a paper that I read today. I would like to know your comments. Thank you so much
https://t.co/njJhjRRgxG.
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @lipo_fan: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/lak9jJISXh https://t.co/NBvidesdAK
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
@freddier Comparto algunos videos de @AriesTerron con información respaldada cientificamente. Sobre los problemas de estas formas de alimentarse. https://t.co/OdQUykp5SE https://t.co/P4Z3g69AuU
@SnupSnus Don't give case reports a lot of weight save to disprove an absolute or entertain hypothesis.⬆️concerning in the ketosis cardiac lit is mixed data, both bad (https://t.co/SRVTQvIfR2) & good (https://t.co/4DlOJsJXHA). For the former, cardiac fibrosis has been most controversial.
@welcome2thepark @BitrakerCap @LukeGromen @novogratz Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/HCEm4nw5Ft
RT @SaurabhGayali: Scientists at @FudanUniv, @SCUCN, @AnhuiChina, @ZZUofficial have conducted a research showing that Ketogenic diets inhib…
Scientists at @FudanUniv, @SCUCN, @AnhuiChina, @ZZUofficial have conducted a research showing that Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Published in @sigtrans_sttt, a part of @SpringerNature. #food #health #scicomm https://t.co/LxXahc3lal
#Ketogenic diets inhibit #mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy. @KetoCarnivore @TuitNutrition what are your thoughts here? “Adverse effects of a KD on the cardiac system.” https://t.co/j3kv1ZYunW
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/VUz8u2WBP2
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/ztuO7i1juI https://t.co/2DKBAKx1Ss
@martincarrizo_ https://t.co/u5mQy74kQu
@lainfantachini @martincarrizo_ https://t.co/u5mQy74kQu
Bibliografía: Xu, S., Tao, H., Cao, W. et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Sig Transduct Target Ther 6, 54 (2021). https://t.co/iOqOLj2E8c
Las dietas cetogénicas impiden la formación de mitocondrias e inducen fibrosis cardíaca. La dieta Keto, provoca una respiración celular reducida y el aumento de la apoptosis (muerte celular) del músculo cardíaco. Fuente: https://t.co/OQU2t0Mwg0. Texto: Dr. Raymundo Garay García
¿La DIETA CETOGÉNICA es PELIGROSA? ¡Nuevo video, nueva evidencia!
RT @MarianAlpizar: @OrlandoRPN ¿Les contamos? https://t.co/UA1IIhfur5
@OrlandoRPN ¿Les contamos? https://t.co/UA1IIhfur5
RT @MedClubPage: Xu, S., Tao, H., Cao, W. et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Nature. Sig…
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy https://t.co/O2rtBXFmZ9
RT @MedClubPage: Xu, S., Tao, H., Cao, W. et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Nature. Sig…
Xu, S., Tao, H., Cao, W. et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Nature. Sig Transduct Target Ther 6, 54 (2021). https://t.co/EYSSqSPxVq
Se puede bajar de peso sin quitar carbs muchis, no se expongan
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/87VshAbNpq
@DominicDAgosti2 Hi, could you share your insights about this article: Keto Diet and inhibition of mitochondrial biogenesis and induction of cardiac fibrosis? https://t.co/zfa4Ftb5Fh
@AriesTerron qué opinas de esta publicación? https://t.co/L62ykJonT2
RT @drmaln: Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https…
RT @drmaln: Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https…
@xanandra92 Wachea, son peligrosas. https://t.co/zBcvBaXMW2
La dieta Keto o el ayuno prolongado frecuente disminuyeron la producción de mitocondrias, la respiración celular reducida y el aumento de apopotosis del músculo cardiaco y por lo tanto fibrosis cardiaca https://t.co/SaqyGddL1X.
RT @drmaln: Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https…
"Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy" https://t.co/gEaheMC5Vv
RT @drmaln: Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https…
Al parecer las dietas keto, generan muerte de células del corazón, generando cicatrices. Fuente: https://t.co/WtWoQJJez7. https://t.co/KYC87AYgBZ
@ChristianAssad Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis Sha Xu et al. Signal Transduct Target Ther. 2021.
Las dietas Keto disminuyen la formación de mitocondrias. Con la respiración celular reducida y el aumento de la apoptosis (muerte celular) del músculo cardíaco provoca fibrosis cardíaca https://t.co/cLMd1jx3WE
Vaya vaya https://t.co/VQcZowB6Ii
la respiración celular reducida y el aumento de la apoptosis (muerte celular) del músculo cardíaco y por lo tanto la fibrosis cardíaca (cicatrización). Fuente: https://t.co/k4zzrUf4k0. Texto y créditos a Raymundo Garay García
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/Ha5rsO7a47
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
@askrenal What are you thoughts about this? Would you discourage your patients from keto diet or wait for more studies? Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/y55WB7pK5s #askrenal @hswapnil @thecurbsiders
RT @sralphmd: “ Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis”
RT @sralphmd: “ Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis”
RT @sralphmd: “ Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis”
RT @sralphmd: “ Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis”
“ Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis” https://t.co/Bv7HGAVhDV
RT @agingdoc1: At @agingdoc1, I make an effort to represent + & null findings, & those supporting & refuting hypotheses. This will be cont…
#keto @mercola Any comments on https://t.co/rLDUzEphr5 ?
At @agingdoc1, I make an effort to represent + & null findings, & those supporting & refuting hypotheses. This will be controversial: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/tfjBkZCG0L Some debate here: https://t.co/r7td6Fnnvk
RT @ToshiyukiHorie: #Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/RTeIqQlm8Y
RT @ToshiyukiHorie: #Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/RTeIqQlm8Y
RT @ToshiyukiHorie: #Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/RTeIqQlm8Y
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/ft3BKIsdNT could be the high-fat component, not the low-carb, high-protein aspect of the diet
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
#Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/RTeIqQlm8Y
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) https://t.co/SGajMBqR4B https://t.co/b9WIL1t28r #സമൂഹനന്മ
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
@PeterFaberSP @nicknorwitz @BenBikmanPhD @BrianLenzkes @FatEmperor @DaveKeto @ChrisPalmerMD Try this https://t.co/k9HEjXRveS
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
RT @nicknorwitz: I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibros…
I've been asked about this new paper 4 times - "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis"- My response.... .@BenBikmanPhD .@BrianLenzkes .@FatEmperor .@DaveKeto .@ChrisPalmerMD and others, what do you think about it? https://t.co/Bj21bmC1ca https://t.co/CHtBdE7PeI
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
New top story on Hacker News: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/0kmHlIiQxk
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/RQujQF6iHn
RT @Tweet_Nutrition: #Ketogenic diets inhibit #mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Thera…
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy https://t.co/rbYygMcvX4
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
RT @Tweet_Nutrition: #Ketogenic diets inhibit #mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Thera…
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) via /r/Nootropics https://t.co/SBUWCEcqCI
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
RT @Tweet_Nutrition: #Ketogenic diets inhibit #mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Thera…
#Ketogenic diets inhibit #mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduction and Targeted Therapy That’s why I always say it cannot be a pattern. Just a strategy for a while and for some people und must be assisted by professional. https://t.co/CmV7YsCHuW
"Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis" https://t.co/cXtRlk9DlV
Hey @quinrex Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) https://t.co/KlRrwlo6yV
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy https://t.co/JwOhjLSy2N
/r/science: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) . https://t.co/WdyMA0HLYo
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/Jzr75xw6ho Long-term KD exposure resulted in cardiac fibrosis To survey the potential pathological effects of a KD on cardiac disease, we fed rats either a KD or… https://t.co/2du3q27SSw
RT @sminaev2015: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy ht…
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | Signal Transduction and Targeted Therapy https://t.co/tVeR4tbGpy
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis Link: https://t.co/2MpMl52iIZ Comments: https://t.co/oLDu5xZ5Ux
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/bvQ7xmr9XO (https://t.co/GTkdL7S0J7)
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/285nOkwRV9 https://t.co/tvwSuYkQYg
New top story on Hacker News: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis https://t.co/epLkiGukUU
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis L: https://t.co/hZbAx3LxHz C: https://t.co/hyFLCG8b9Q
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) https://t.co/bLGZigvnb9 https://t.co/wrEOMpBDKr
https://t.co/3jNwJgyn7y Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) #sciencenews https://t.co/fSDWOWUW5r
#Health Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) https://t.co/Bzezp1oz0m
RT @kgusler: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis - https://t.co/lzbZlXg00d
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis - https://t.co/lzbZlXg00d
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021)
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021): https://t.co/sNS1rAPFWW
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (Feb 2021) via /r/science https://t.co/EoomYbj3ZO
RT @ribosome_papers: Pubmed: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/ecdSAoOrMM
Pubmed: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. https://t.co/ecdSAoOrMM
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (in rats) https://t.co/8rHzcL5CbX