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Nat Neurosci March 2021 PMID 33558695

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.

Kristen R Maynard, Leonardo Collado-Torres, Lukas M Weber, Cedric Uytingco, Brianna K Barry, Stephen R Williams, Joseph L Catallini, Matthew N Tran, Zachary Besich, Madhavi Tippani, Jennifer Chew, Yifeng Yin, Joel E Kleinman, Thomas M Hyde, Nikhil Rao

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Mentions

89
Peak: 28 in Feb 2021
across 5 sources since Feb 2020

Extended reach

555,085
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Total likes

111

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659

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Feb 2020 – May 2024

Where it's discussed

  • X / Twitter73 posts
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  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

Many discussions emphasize the innovative methods used in the research, with phrases like 'super excited to see this in press' and 'very interesting webinar' reflecting high interest and enthusiasm. Posts mentioning the spatial topography of gene expression and their relation to psychiatric disorders indicate a deeper acknowledgment of the research's significance. The tone across these discussions is largely positive, characterized by expressions of support and motivation to dive deeper into the findings.

AgreementModerate agreement

The majority of discussions reflect a positive reception towards the publication, indicating at least general support for the methodologies and findings presented.

InterestHigh interest

There are strong indications of curiosity and interest, as many participants express eagerness to explore further details and implications of the study.

EngagementModerate engagement

While many posts share excitement and relevant details, the depth of engagement is moderate, focusing mostly on sharing rather than in-depth analysis.

ImpactHigh impact

Several contributors highlight the significant implications of the findings, especially regarding neuropsychiatric disorders, suggesting that the research holds considerable relevance in the field.

Abstract in brief

  • The study utilized the 10x Genomics Visium platform to analyze gene expression in the human dorsolateral prefrontal cortex, uncovering distinct gene expression patterns across its six layers.
  • Researchers correlated these expression patterns with data from single-nucleus RNA sequencing, revealing specific gene expressions linked to neuropsychiatric disorders like schizophrenia and autism, emphasizing their clinical significance.
  • They established a framework for identifying clusters within spatial transcriptomics data and created a web application to allow other scientists to access and explore their findings for further research in neuroscience.
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Most liked on X and Bluesky
bioRxiv
@biorxivpreprint · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/90FFxGC1qB #bioRxiv

Feb 28, 2020 · 17 likes · 3 shares · 136,915 followers View post →
lcolladotor
@lcolladotor · X

May 24, 2024 · 16 likes · 4 shares · 2,945 followers View post →
Daianna
@daianna_glez · X

Hey

Mar 20, 2024 · 12 likes · 1,029 followers View post →
Stephanie Hicks, PhD
@stephaniehicks · X

Super excited to see this in press @NatureNeuro! Congratulations to @kr_maynard @fellgernon @lmwebr @mattntran @andrewejaffe @martinowk @10xgenomics and others @LieberInstitute!

Feb 12, 2021 · 11 likes · 3 shares · 9,028 followers View post →
BioTuring
@bioturing · X

Using @10xGenomics Visium Platform, @kr_maynard & @lcolladotor et al. @LieberInstitute define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex. All 12 different slides are now accessible in BBrowser: https://t.co/8MggszhTIy https://t.co/q4Zp6Ipd45

Mar 31, 2021 · 10 likes · 6 shares · 957 followers View post →
lcolladotor
@lcolladotor · X

May 25, 2024 · 8 likes · 1 share · 2,948 followers View post →

All mentions

Ale Zayas
@licloona1487 · X

RT @lcolladotor:

May 26, 2024 · 1 share · 658 followers View post →
lcolladotor
@lcolladotor · X

May 25, 2024 · 8 likes · 1 share · 2,948 followers View post →
LIBD rstats club
@LIBDrstats · X

RT @lcolladotor:

May 24, 2024 · 4 shares · 409 followers View post →
10x Genomics
@10xGenomics · X

RT @lcolladotor:

May 24, 2024 · 4 shares · 28,650 followers View post →
Lieber Institute
@LieberInstitute · X

RT @lcolladotor:

May 24, 2024 · 4 shares · 1,550 followers View post →
Dervis Salih
@DervisSalih1 · X

RT @lcolladotor:

May 24, 2024 · 4 shares · 4,509 followers View post →
lcolladotor
@lcolladotor · X

May 24, 2024 · 16 likes · 4 shares · 2,945 followers View post →
Daianna
@daianna_glez · X

Hey

Mar 20, 2024 · 12 likes · 1,029 followers View post →
lcolladotor
@lcolladotor · X

I'd be really curious to see how it works with our 6 pairs of spatially adjacent replicates (<10 µm apart) from #Visium @kr_maynard & #spatialLIBD team https://t.co/sArTNkds9q cc @10xGenomics Or how far can you go in µm? Can you combine H&E + smFISH images? #GPSA

May 12, 2022 · 1 like · 2,948 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @LindaOrzolek: Journal Club 10am! #SingleCell "Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex”…

Mar 24, 2022 · 1 share · 8,155 followers View post →
Linda Orzolek
@LindaOrzolek · X

Journal Club 10am! #SingleCell "Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex” “Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain” https://t.co/PDd5c39fHc

Mar 24, 2022 · 1 like · 1 share · 274 followers View post →
r-craft.org
@R_Craft_Org · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/e1shhJNhUN

May 15, 2021 · 135 followers View post →
LIBD rstats club
@LIBDrstats · X

RT @PardoBree: And the paper of the work from Maynard et al (2021) here: https://t.co/zXTk1GHsTu 6/9

Apr 30, 2021 · 2 shares · 410 followers View post →
lcolladotor
@lcolladotor · X

RT @PardoBree: And the paper of the work from Maynard et al (2021) here: https://t.co/zXTk1GHsTu 6/9

Apr 30, 2021 · 2 shares · 2,948 followers View post →
Brenda Pardo
@PardoBree · X

And the paper of the work from Maynard et al (2021) here: https://t.co/zXTk1GHsTu 6/9

Apr 30, 2021 · 2 likes · 2 shares · 333 followers View post →
Dr. Neil Ashley
@NotWIMM · X

RT @bioturing: Using @10xGenomics Visium Platform, @kr_maynard & @lcolladotor et al. @LieberInstitute define the spatial topography of gene…

Mar 31, 2021 · 6 shares · 1,048 followers View post →
Wenhao
@twh112358 · X

RT @bioturing: Using @10xGenomics Visium Platform, @kr_maynard & @lcolladotor et al. @LieberInstitute define the spatial topography of gene…

Mar 31, 2021 · 6 shares · 26 followers View post →
BioTuring
@bioturing · X

Using @10xGenomics Visium Platform, @kr_maynard & @lcolladotor et al. @LieberInstitute define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex. All 12 different slides are now accessible in BBrowser: https://t.co/8MggszhTIy https://t.co/q4Zp6Ipd45

Mar 31, 2021 · 10 likes · 6 shares · 957 followers View post →
Paul McCullough
@ThePostsynaptic · X

RT @ThePostsynaptic: Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://…

Feb 21, 2021 · 1 share · 2,591 followers View post →
Claudia Colina, PhD
@ClaudiaColina16 · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co/yLGjkgeR1x

Feb 21, 2021 · 473 followers View post →
Paul McCullough
@ThePostsynaptic · X

Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/EmCXGFDLhq

Feb 20, 2021 · 2 likes · 1 share · 2,591 followers View post →
Paul McCullough
@ThePostsynaptic · X

Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/BN1TaVPoRg

Feb 20, 2021 · 2,591 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/HnFYTAJ5sU

Feb 18, 2021 · 434 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/MWF5tKy2hh

Feb 18, 2021 · 434 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Publisher Correction: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex - Nature Neuroscience via BrainSights for iOS https://t.co/cn6wIjKj4s

Feb 18, 2021 · 313 followers View post →
jhubiostat
@jhubiostat · X

@lmwebr, @stephaniehicks, and co-authors have published a paper in @NatureNeuro entitled: “Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex.” Check it out here: https://t.co/bBKZk2m2hq

Feb 18, 2021 · 1 like · 9,460 followers View post →
Rikejoy Zhang
@77JoyZhang · X

RT @ToruTakumi: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co/…

Feb 14, 2021 · 1 share · 34 followers View post →
Lukas Weber
@lmwebr · X

RT @stephaniehicks: Super excited to see this in press @NatureNeuro! Congratulations to @kr_maynard @fellgernon @lmwebr @mattntran @andre…

Feb 12, 2021 · 3 shares · 1,123 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @stephaniehicks: Super excited to see this in press @NatureNeuro! Congratulations to @kr_maynard @fellgernon @lmwebr @mattntran @andre…

Feb 12, 2021 · 3 shares · 8,155 followers View post →
Stephanie Hicks, PhD
@stephaniehicks · X

Super excited to see this in press @NatureNeuro! Congratulations to @kr_maynard @fellgernon @lmwebr @mattntran @andrewejaffe @martinowk @10xgenomics and others @LieberInstitute!

Feb 12, 2021 · 11 likes · 3 shares · 9,028 followers View post →
placenta_PE_papers
@PapersPe · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. https://t.co/GXVoEmebWF https://t.co/U465o66x1o

Feb 11, 2021 · 8 followers View post →
Transcriptomes
@transcriptomes · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. https://t.co/2dYY8cXt3E

Feb 10, 2021 · 1,810 followers View post →
Andrew Morris
@andrewmorrisuk · X

RT @Autism_Journal: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. https://t.co/JCglLwtvSP #PubMe…

Feb 10, 2021 · 1 share · 15,395 followers View post →
#Autism
@Autism_Journal · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. https://t.co/JCglLwtvSP #PubMed #Autism

Feb 10, 2021 · 1 share · 388 followers View post →
Paul McCullough
@ThePostsynaptic · X

RT @ThePostsynaptic: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/FWMIpLsyIM https:…

Feb 10, 2021 · 1 share · 2,591 followers View post →
Paul McCullough
@ThePostsynaptic · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/FWMIpLsyIM https://t.co/3DqQPhxa3z

Feb 9, 2021 · 1 share · 2,591 followers View post →
Paul McCullough
@ThePostsynaptic · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/MCOTQ6MNAk https://t.co/yn3XVcj2MI

Feb 9, 2021 · 2,591 followers View post →
Toru Takumi
@ToruTakumi · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co/xAwZOdOzQK

Feb 8, 2021 · 1 like · 1 share · 638 followers View post →
Sarah Jäkel
@JekyllSarah · X

RT @schirmerlab: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co…

Feb 8, 2021 · 6 shares · 642 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/e4BP8jvH3R

Feb 8, 2021 · 434 followers View post →
Nirav Patel
@Patel_omics · X

RT @schirmerlab: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co…

Feb 8, 2021 · 6 shares · 361 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex - Nature Neuroscience via BrainSights for iOS https://t.co/49hD4k36Ap

Feb 8, 2021 · 313 followers View post →
Isabel Zhang
@zhang_isaruihan · X

RT @schirmerlab: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co…

Feb 8, 2021 · 6 shares · 870 followers View post →
Paul Anastasiades
@P_Anastasiades · X

RT @schirmerlab: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co…

Feb 8, 2021 · 6 shares · 1,573 followers View post →
Alex Chamessian
@achamess · X

RT @schirmerlab: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co…

Feb 8, 2021 · 6 shares · 2,744 followers View post →
Lucas Schirmer
@schirmerlab · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | Nature Neuroscience https://t.co/mxmEIbQeaA

Feb 8, 2021 · 7 likes · 6 shares · 967 followers View post →
Wenhao
@twh112358 · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/0wIMQvNEAB

Jan 15, 2021 · 26 followers View post →
r-craft.org
@R_Craft_Org · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/XEid0b9MVQ

Sep 28, 2020 · 135 followers View post →
r-craft.org
@R_Craft_Org · X

Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex https://t.co/hDqYg0QKUV

Sep 26, 2020 · 135 followers View post →
Colin Tudhope
@TudhopeColin · X

Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex https://t.co/9EZUzKkwmE

Aug 10, 2020 · 205 followers View post →
Dr Nandkishor Prasad
@NandkishorDr · X

Video: Transcriptome-scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex https://t.co/BaHhVMyor6

Aug 1, 2020 · 9 followers View post →
Thomas Scientific, LLC
@ThomasSci · X

"Differences in pathology and gene expression associated with neuropsychiatric disorders can be localized to specific layers in the human brain." https://t.co/1vJnOGutFN

Jul 26, 2020 · 14,682 followers View post →
Edwin Hauw
@ehauw · X

RT @NeuroscienceSAS: Very interesting webinar from 10x Genomics on transcriptome-scale spatial gene expression in the human dorsolateral pr…

Mar 17, 2020 · 1 share · 52 followers View post →
NSAS
@NeuroscienceSAS · X

Very interesting webinar from 10x Genomics on transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. #neuroscience #brain #neuron #transcriptome #spatialtranscriptomics #singlecellRNAseq #RNAseq #geneexpression https://t.co/tgf9taBJH3

Mar 16, 2020 · 2 likes · 1 share · 1,790 followers View post →
Matt Regner (he/him)
@RegnerMJ · X

RT @TheScientistLLC: [FREE Webinar] “Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex" Join us Thurs…

Mar 12, 2020 · 2 shares · 235 followers View post →
Bree
@BreeKB_ · X

RT @TheScientistLLC: [FREE Webinar] “Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex" Join us Thurs…

Mar 12, 2020 · 2 shares · 3,692 followers View post →
The Scientist
@TheScientistLLC · X

[FREE Webinar] “Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex" Join us Thursday, March 19th at 2:30 PM ET. Register here: https://t.co/olMD6jLZoK https://t.co/uFYeReKzul

Mar 12, 2020 · 1 like · 85,419 followers View post →
BIOCIENCIA
@BIOCIENCIA2013 · X

Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex https://t.co/6v9bIhjTy0

Mar 5, 2020 · 1,020 followers View post →
Kursad Turksen
@kursadturksen · X

TS-Webinar Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex

Mar 5, 2020 · 231 followers View post →
The Scientist
@TheScientistLLC · X

[FREE Webinar] “Transcriptome-Scale Spatial Gene Expression in the Human Dorsolateral Prefrontal Cortex" Join us Thursday, March 19th at 2:30 PM ET. Register here: https://t.co/FaZ3TslSb3 https://t.co/T1hG4pyrjM

Mar 5, 2020 · 1 like · 2 shares · 85,419 followers View post →
@parkvillegeek
@ParkvilleGeek · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | #bioRxiv https://t.co/qG3HYYlJNJ https://t.co/mpzjeRrDye

Mar 2, 2020 · 2 likes · 2,682 followers View post →
Fabrice Leclerc
@rnomics · X

Top #tweeted story in #bioscience: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex | bioRxiv https://t.co/Tz8rEfefoy, see more https://t.co/kME3G1o122

Feb 29, 2020 · 1 like · 2,761 followers View post →
Alex Fornito
@AFornito · X

RT @StefanoBerto83: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/yhhzBhN8Zn

Feb 29, 2020 · 4 shares · 7,784 followers View post →
Michael Gandal
@mikejg84 · X

RT @StefanoBerto83: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/yhhzBhN8Zn

Feb 29, 2020 · 4 shares · 1,598 followers View post →
Jakob Seidlitz
@jakob_seidlitz · X

RT @StefanoBerto83: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/yhhzBhN8Zn

Feb 29, 2020 · 4 shares · 766 followers View post →
A Naqvi
@aanaqvi · X

RT @biorxivpreprint: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/90FFxGC1qB #bioR…

Feb 29, 2020 · 3 shares · 985 followers View post →
Armin Raznahan
@bogglerapture · X

RT @StefanoBerto83: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/yhhzBhN8Zn

Feb 29, 2020 · 4 shares · 2,219 followers View post →
Graham Murray (@gkmurray.bsky.social)
@gk_murray · X

RT @biorxiv_neursci: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/nWh15TMUa7 #bior…

Feb 29, 2020 · 2 shares · 1,440 followers View post →
lbgbox
@lbgbox · X

RT @biorxivpreprint: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/90FFxGC1qB #bioR…

Feb 29, 2020 · 3 shares · 51 followers View post →
Jeremy Day
@DayLabUAB · X

RT @biorxivpreprint: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/90FFxGC1qB #bioR…

Feb 28, 2020 · 3 shares · 5,245 followers View post →
Stefano Berto, PhD
@StefanoBerto83 · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/yhhzBhN8Zn

Feb 28, 2020 · 6 likes · 4 shares · 7,757 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/nWh15TMUa7 #biorxiv_neursci

Feb 28, 2020 · 7 likes · 2 shares · 59,809 followers View post →
bioRxiv
@biorxivpreprint · X

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex https://t.co/90FFxGC1qB #bioRxiv

Feb 28, 2020 · 17 likes · 3 shares · 136,915 followers View post →