medRxiv February 2021 PMID 33619509

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies.

Dami A Collier, Anna De Marco, Isabella A T M Ferreira, Bo Meng, Rawlings Datir, Alexandra C Walls, Steven A Kemp S, Jessica Bassi, Dora Pinto, Chiara Silacci Fregni, Siro Bianchi, M Alejandra Tortorici, John Bowen, Katja Culap, Stefano Jaconi

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Mentions

76
Peak: 8 in Feb 2021
across 5 sources since Jan 2021

Extended reach

11,116
potential audience

Total likes

9

Video views

204

Mentions per month

Jan 2021 – Mar 2021

Where it's discussed

  • News59 articles
  • X / Twitter11 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone reveals a focused interest in mutations like E484K and the implications for vaccine effectiveness, as shown in posts referencing the emergence of new variants and vaccine responses, which reflects eagerness to understand and respond to evolving threats. The use of words like 'threat,' 'update,' and 'effectiveness' demonstrate serious consideration of the article's significance and potential influence on public health strategies.

AgreementModerate agreement

Many discussions express support or acknowledgment of the findings, indicating general agreement, though some note limitations or skepticism.

InterestModerate interest

Discussions show moderate curiosity, with mentions of vaccine effectiveness and mutation implications reflecting genuine scientific interest or concern.

EngagementModerate engagement

Posts often reference specific mutations like E484K and include technical details or calls for updates, indicating active engagement.

ImpactModerate impact

The topics discussed highlight the relevance of the research to ongoing vaccine efficacy debates and mutation concerns, suggesting a moderate to high perceived impact.

Abstract in brief

  • The study investigates how well the mRNA vaccine BNT162b2 protects against the B117 variant of SARS-CoV-2, finding that neutralizing antibody responses are only modestly reduced against B117 compared to the original strain.
  • The research shows that some convalescent sera and monoclonal antibodies, especially those targeting specific regions like the N-terminal domain and Receptor Binding Motif, exhibit decreased effectiveness against B117, particularly when additional mutations like E484K are present.
  • The emergence of the E484K mutation alongside B117 significantly challenges vaccine effectiveness, leading to a substantial loss of neutralization capacity, which indicates a potential threat to current vaccination efforts.]

Top posts

Most liked on X and Bluesky
Dr. Thomas Wilckens
@Thomas_Wilckens · X

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies "E484K emergence on a B.1.1.7 background represents a threat to the #vaccine BNT162b" #vaccination #immunity #coronavirus #covid19 https://t.co/DOv0c5fbGR https://t.co/ymtMq9lQPQ

Feb 16, 2021 · 2 likes · 1 share · 6,814 followers View post →
Jason Fink MD, MPH, MHA
@IndelibleFink · X

New initial report (https://t.co/yoHBRNWplr) re effectiveness of Pfizer vaccine BNT162b2 vax on mutated forms of #COVID19 (technically Sars-CoV-2, the actual virus): boils down to "seems to work ok."

Jan 22, 2021 · 1 share · 1,150 followers View post →
Jason Fink MD, MPH, MHA
@IndelibleFink · X

RT @IndelibleFink: New initial report (https://t.co/yoHBRNWplr) re effectiveness of Pfizer vaccine BNT162b2 vax on mutated forms of #COVID1…

Jan 23, 2021 · 1 share · 1,150 followers View post →
Michael Johansson
@majohanss · X

Update: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies https://t.co/lWJ1vyNPce read/write/request review https://t.co/C4shXKM0FN #coronavirus #COVID19

Feb 17, 2021 · 1 share · 358 followers View post →
SciScore Reports
@SciscoreReports · X

The preprint “SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-eli…” (https://t.co/s9T4JBewuO) has been reviewed by automated tools, find results here: https://t.co/Nz5a3XgMFx. We detected 1 of 5 rigor criteria, 0 resources, and no limitations statement.

Mar 5, 2021 · 330 followers View post →
NFTdose
@PaperbirdsH · X

New article: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies https://t.co/Ty9Qhgjq7L #coronavirus #COVID19 #2019ncov https://t.co/hcRVxUAICf

Feb 23, 2021 · 302 followers View post →

All mentions

the paper link
@the_paper_link · X

Trend up+1: Collier DA, ..., Gupta RK (medRxiv) __SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies__ https://t.co/YORys7lDy3

Mar 19, 2021 · 137 followers View post →
SciScore Reports
@SciscoreReports · X

The preprint “SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-eli…” (https://t.co/s9T4JBewuO) has been reviewed by automated tools, find results here: https://t.co/Nz5a3XgMFx. We detected 1 of 5 rigor criteria, 0 resources, and no limitations statement.

Mar 5, 2021 · 330 followers View post →
the paper link
@the_paper_link · X

Trend new: Collier DA, ..., Gupta RK (medRxiv) __SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies__ https://t.co/YORys7lDy3

Feb 24, 2021 · 137 followers View post →
NFTdose
@PaperbirdsH · X

New article: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies https://t.co/Ty9Qhgjq7L #coronavirus #COVID19 #2019ncov https://t.co/hcRVxUAICf

Feb 23, 2021 · 302 followers View post →
Phil Walkuphill
@walkuphill · X

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies 15/02/21 [Preprint] / Dami A. Collier et al // medRXiv https://t.co/aDF47johQp https://t.co/yNGabKJpIN

Feb 19, 2021 · 151 followers View post →
Phil Walkuphill
@walkuphill · X

RT @Thomas_Wilckens: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies "E484K emergence on a…

Feb 19, 2021 · 1 share · 151 followers View post →
David Peck
@overseasdem · X

RT @majohanss: Update: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies https://t.co/lWJ1vyN…

Feb 18, 2021 · 1 share · 221 followers View post →
Michael Johansson
@majohanss · X

Update: SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies https://t.co/lWJ1vyNPce read/write/request review https://t.co/C4shXKM0FN #coronavirus #COVID19

Feb 17, 2021 · 1 share · 358 followers View post →
Dr. Thomas Wilckens
@Thomas_Wilckens · X

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies "E484K emergence on a B.1.1.7 background represents a threat to the #vaccine BNT162b" #vaccination #immunity #coronavirus #covid19 https://t.co/DOv0c5fbGR https://t.co/ymtMq9lQPQ

Feb 16, 2021 · 2 likes · 1 share · 6,814 followers View post →
Jason Fink MD, MPH, MHA
@IndelibleFink · X

RT @IndelibleFink: New initial report (https://t.co/yoHBRNWplr) re effectiveness of Pfizer vaccine BNT162b2 vax on mutated forms of #COVID1…

Jan 23, 2021 · 1 share · 1,150 followers View post →
Jason Fink MD, MPH, MHA
@IndelibleFink · X

New initial report (https://t.co/yoHBRNWplr) re effectiveness of Pfizer vaccine BNT162b2 vax on mutated forms of #COVID19 (technically Sars-CoV-2, the actual virus): boils down to "seems to work ok."

Jan 22, 2021 · 1 share · 1,150 followers View post →