Neurogastroenterol Motil October 2021 PMID 33705592

Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord.

Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winston

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Mentions

32
Peak: 5 in Nov 2025
across 8 sources since Mar 2021

Extended reach

1,992
potential audience

Total likes

1

Video views

461

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Mar 2021 – Dec 2025

Where it's discussed

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AI synopsis

What people are saying

The overall tone indicates that users are intrigued by the study's insights into hormonal influences on pain sensitivity, with phrases like 'important breakthrough' and 'potential for new therapies' showing enthusiasm. The language varies from simple acknowledgments to more detailed speculations on how this research could translate into clinical approaches, reflecting moderate engagement and perceived relevance.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some explicitly supporting the idea that hormonal and neurochemical pathways influence visceral hypersensitivity.

InterestHigh interest

Posts express high curiosity about the research, often highlighting the novelty or potential clinical implications, indicating strong engagement with the topic.

EngagementModerate engagement

Comments reflect a moderate level of detailed discussion, with some users debating mechanisms or future research, suggesting active but not deeply technical engagement.

ImpactModerate impact

The discussions suggest that this research could have meaningful implications for understanding or treating conditions like irritable bowel syndrome, though it's recognized as preliminary work in animal models.

Abstract in brief

  • This study found that estrogen and serotonin both play key roles in increasing visceral hypersensitivity (VHS) in female rats, with their effects linked to higher levels of brain-derived neurotrophic factor (BDNF) in the spinal cord, especially after chronic stress exposure.
  • Interventions that block estrogen receptors (using ovariectomy or letrozole) or serotonin signaling (using alosetron) reduced VHS and BDNF levels, suggesting that both hormones contribute to stress-induced abdominal pain sensitivity via spinal cord mechanisms.
  • The findings suggest that estrogen and serotonin work together to activate specific pathways in the spinal cord, leading to increased BDNF and heightened pain sensitivity in female rats, providing insight into how stress and hormonal factors might influence visceral pain conditions.]

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Epigenética
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New in Pubmed: "Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord" https://t.co/DDMLWRN5Gz

Mar 12, 2021 · 621 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord" https://t.co/PmvLypTQat

Mar 11, 2021 · 621 followers View post →

All mentions

Epigenética
@Epigenetica · X

New in Pubmed: "Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord" https://t.co/DDMLWRN5Gz

Mar 12, 2021 · 621 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord" https://t.co/PmvLypTQat

Mar 11, 2021 · 621 followers View post →
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