Nat Commun March 2021 PMID 33707434

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation.

Yilei Zhang, Robert V Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen

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Mentions

Peak: 4 in Mar 2021

across 3 sources since Mar 2021

Extended reach

42,358

potential audience

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Mentions per month

Mar 2021 – Jul 2023

Where it's discussed

X / Twitter4 posts
News2 articles
YouTube1 videos

AI synopsis

What people are saying

The discussions consistently reflect a strong consensus of support, with posts citing the key findings, such as the coupling of cysteine availability with GPX4 synthesis mediated by mTORC1, and emphasize its potential in cancer treatment. The tone is positive and appreciative, suggesting recognition of the study’s significance and potential applications in biomedical research.

AgreementStrong agreement

All posts express strong support and recognition of the study’s significance, emphasizing the importance of the findings related to mTORC1, cysteine, and ferroptosis control.

InterestModerate interest

The discussions show a moderate level of curiosity, highlighting the relevance of the findings to ongoing cancer research and cell death mechanisms.

EngagementModerate engagement

Posts are somewhat engaged, mainly sharing the core message and implications rather than deep technical analysis or critique.

ImpactHigh impact

The community perceives the research as highly impactful, indicating potential for new therapeutic strategies and scientific advancements.

Abstract in brief

This study explains how cells regulate the production of GPX4, an important protein that prevents a type of cell death called ferroptosis, by linking it to the availability of cysteine, an amino acid.
It shows that cysteine not only helps produce glutathione (GSH), which GPX4 needs to function, but also activates a key pathway called mTORC1, which boosts GPX4 protein synthesis through specific signaling mechanisms.
The research suggests that inhibiting mTORC1 makes cancer cells more vulnerable to ferroptosis and that combining mTORC1 inhibitors with ferroptosis inducers could be an effective cancer treatment strategy.]

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All mentions

mTORC1 Links Cysteine to GPX4 Synthesis and Ferroptosis Control

This study explains how cells regulate GPX4 production, a key protein preventing ferroptosis, by linking it to cysteine availability. It highlights how mTORC1 activation enhances GPX4 synthesis, suggesting potential…

STEM RTCL TV · Jul 2, 2023 20 views

the paper link

@the_paper_link · X

RT @the_paper_link: Trend up+10: Zhang Y, ..., Gan B (Nat Commun) __mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and…

Mar 13, 2021 · 1 share · 137 followers View post →

the paper link

@the_paper_link · X

Trend up+10: Zhang Y, ..., Gan B (Nat Commun) __mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation__ https://t.co/qCtB8zmthM

Mar 13, 2021 · 1 share · 137 followers View post →

Agingdoc

@agingdoc1 · X

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation ⁦@NatureComms⁩ https://t.co/XlFUIDHMDQ

Mar 12, 2021 · 41,463 followers View post →

Vipin Suri

@VipinSuri4 · X

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation https://t.co/lPWiaEoRGU

Mar 11, 2021 · 1 like · 598 followers View post →