PubHawk
April 2021 PMID 33728821

Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging.

Akaitz Dorronsoro, Fernando E Santiago, Diego Grassi, Tianpeng Zhang, Ruenn Chai Lai, Sara J McGowan, Luise Angelini, Mitra Lavasani, Lana Corbo, Aiping Lu, Robert W Brooks, Marta Garcia-Contreras, Donna B Stolz, Antonio Amelio, Siddaraju V Boregowda

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Mentions

36
Peak: 23 in Mar 2021
across 5 sources since Mar 2021

Extended reach

127,859
potential audience

Total likes

84

Video views

777

Mentions per month

Mar 2021 – Nov 2024

Where it's discussed

  • X / Twitter27 posts
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The overall discussions reflect a positive perception, with posts emphasizing the promising applications, such as one mentioning that injections of extracellular vesicles from young mice extend lifespan, and others highlighting that the approach might safely mimic stem cell therapy benefits. Words like 'reduce senescence,' 'extend health span,' and 'promising' contribute to a tone of optimism and potential significance, indicating that social discussions see this work as a meaningful step toward innovative anti-aging treatments.

AgreementModerate agreement

Most discussions express support or optimism regarding the research findings, such as references to the potential health benefits and effectiveness of extracellular vesicles from mesenchymal stem cells in extending lifespan and reducing aging.

InterestHigh interest

The posts show high relevance and curiosity, with several commentators highlighting the novelty or importance of the approach, like noting how these vesicles could offer safe, alternative therapies or emphasizing the promising results in aging models.

EngagementModerate engagement

While many discuss or retweet the publication, few delve into technical details or critically analyze the study, indicating a moderate but positive level of engagement.

ImpactModerate impact

The overall perception is that this research could have meaningful implications for aging therapies and regenerative medicine, though some posts remain optimistic rather than definitively assessing high-impact outcomes.

Abstract in brief

  • The study shows that mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) can reduce cellular aging and extend both lifespan and health span in mice models, particularly by rescuing the function of aged or senescent cells.
  • MSCs from young mice, and their EVs, were effective in improving health in aging mice and in experimentally aging (Ercc1) mice, with EVs from human stem cells also reducing cell aging in lab and live settings.
  • Using EVs from MSCs offers a safe and effective way to replicate the benefits of stem cell therapy, avoiding risks like tumor formation or rejection, and may be useful as treatments for aging-related conditions.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/gfQDRRwy0d

Mar 18, 2021 · 20 likes · 3 shares · 30,806 followers View post →
Bea Carames
@Bcarper6 · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/CWaT3mNvpP

Mar 17, 2021 · 17 likes · 9 shares · 111 followers View post →
Jette Lengefeld
@JetteLeng · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/SQNp6RLDrz

Mar 17, 2021 · 5 likes · 1 share · 3,134 followers View post →
Mesenchymal Cell News
@MesenchymalCell · X

Mar 18, 2021 · 4 likes · 6,295 followers View post →
Ichor Grad Student
@IchorGrad · X

1) https://t.co/h13kkDgNJt 2) https://t.co/h13kkDgNJt 3) https://t.co/l5T1OITW55 Diagram: https://t.co/LtgS42D4Gh

Dec 11, 2023 · 2 likes · 2,739 followers View post →
Hasan Jaafari
@hasan_jaafari · X

Interesting work Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/r4Ns96DQug

Mar 24, 2021 · 2 likes · 190 followers View post →

All mentions

Maria Robles
@RBioceutics · X

Did you know that young exosomes can stimulate regeneration? The patent-pending processes developed by Robles BioCeutics generate more exosomes and higher quality exosomes compared to previous approaches. https://t.co/xZsO5Mc9D1

Oct 3, 2024 · 1 like · 2,770 followers View post →
Ichor Grad Student
@IchorGrad · X

1) https://t.co/h13kkDgNJt 2) https://t.co/h13kkDgNJt 3) https://t.co/l5T1OITW55 Diagram: https://t.co/LtgS42D4Gh

Dec 11, 2023 · 2 likes · 2,739 followers View post →
Feras Al Battah
@ferasalbattah · X

RT @JetteLeng: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https…

Jun 8, 2021 · 1 share · 985 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https…

Apr 9, 2021 · 1 share · 41,925 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/HT6cSgdoj5

Mar 25, 2021 · 14,482 followers View post →
Cryoniss
@Cryoniss_Ltd · X

Bone-marrow derived mesenchymal stem cells (BM-MSC) readily senesce in culture & are involved in ageing. Injection of extracellular vesicles from young BM-MSC extends aged mouse lifespan indicating effectiveness as senotherapeutics https://t.co/xMH18vqAN4 #research #health #bio https://t.co/zE7W5VeSsR

Mar 25, 2021 · 71 followers View post →
Hasan Jaafari
@hasan_jaafari · X

Interesting work Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/r4Ns96DQug

Mar 24, 2021 · 2 likes · 190 followers View post →
Johnathon Anderson
@J_D_Anderson_UC · X

RT @MartaGarciaCon2: Really Glad to have been able to contribute to this work!! Stem cell EVs reduce senescence and extend health span in a…

Mar 23, 2021 · 2 shares · 3,361 followers View post →
Qwoook
@Qwoook3 · X

RT @MartaGarciaCon2: Really Glad to have been able to contribute to this work!! Stem cell EVs reduce senescence and extend health span in a…

Mar 23, 2021 · 2 shares · 59 followers View post →
The Secretome
@TheSecretome · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging #stemcells #EVs #secretome #aging https://t.co/5qSwYR6gSU https://t.co/0gCyRUTMuJ

Mar 22, 2021 · 1 like · 890 followers View post →
Nikki Noren Hooten
@nnhooten · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/B0UM665apt

Mar 22, 2021 · 1,321 followers View post →
Cell Biology Research & Therapy (CBRT)
@cellbiologyres1 · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 20, 2021 · 9 shares · 167 followers View post →
Mesenchymal Cell News
@MesenchymalCell · X

Mar 18, 2021 · 4 likes · 6,295 followers View post →
AgingResearch
@TheAgingField · X

RT @AgingBiology: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging ht…

Mar 18, 2021 · 3 shares · 5,262 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

RT @AgingBiology: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging ht…

Mar 18, 2021 · 3 shares · 4,790 followers View post →
Juan Fafián-Labora
@fafian_juan · X

RT @AgingBiology: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging ht…

Mar 18, 2021 · 3 shares · 1,008 followers View post →
Aging Science News
@AgingBiology · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/gfQDRRwy0d

Mar 18, 2021 · 20 likes · 3 shares · 30,806 followers View post →
Bérénice A. Benayoun, PhD
@BBParis1984 · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 18, 2021 · 9 shares · 3,415 followers View post →
AutoCRAT
@AutoCRAT2020 · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 18, 2021 · 9 shares · 252 followers View post →
Isabelle ADER
@isaperarnau · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 18, 2021 · 9 shares · 492 followers View post →
Coralie Sengenès
@CoraSen · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 18, 2021 · 9 shares · 103 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/kIQoCukYOa https://t.co/ev3fKAQQ7D

Mar 17, 2021 · 884 followers View post →
Audrey Varin
@varin_audrey · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 17, 2021 · 9 shares · 120 followers View post →
Dr. pheno
@Phenomena_mw · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 17, 2021 · 9 shares · 242 followers View post →
Juan Fafián-Labora
@fafian_juan · X

RT @Bcarper6: Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https:…

Mar 17, 2021 · 9 shares · 1,008 followers View post →
Bea Carames
@Bcarper6 · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/CWaT3mNvpP

Mar 17, 2021 · 17 likes · 9 shares · 111 followers View post →
Jette Lengefeld
@JetteLeng · X

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging https://t.co/SQNp6RLDrz

Mar 17, 2021 · 5 likes · 1 share · 3,134 followers View post →