Cell April 2021 PMID 33761326

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2.

Matthew McCallum, Anna De Marco, Florian A Lempp, M Alejandra Tortorici, Dora Pinto, Alexandra C Walls, Martina Beltramello, Alex Chen, Zhuoming Liu, Fabrizia Zatta, Samantha Zepeda, Julia di Iulio, John E Bowen, Martin Montiel-Ruiz, Jiayi Zhou

Mentions

138
Peak: 37 in Mar 2021
across 6 sources since Jan 2021

Extended reach

727,968
potential audience

Total likes

71

Video views

239

Mentions per month

Jan 2021 – Dec 2021

Where it's discussed

  • X / Twitter64 posts
  • News63 articles
  • Blogs5 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions highlight important findings from the publication, such as the identification of neutralizing antibodies against the N-terminal domain of the SARS-CoV-2 spike protein. Phrases like 'potent inactivators' and 'critical area for neutralization' are prevalent, showcasing an optimistic tone that underscores the research's potential for vaccine and treatment advancements.

AgreementStrong agreement

The majority of discussions show strong support for the findings of the publication, indicating a consensus on the importance of the research.

InterestHigh interest

The posts reflect a high level of curiosity about the implications of the study, especially its relevance to vaccine development.

EngagementModerate engagement

While many users express interest, some posts are more surface-level, focusing on sharing links rather than providing in-depth analyses or discussions.

ImpactHigh impact

Overall, individuals perceive the research as having significant implications for understanding and combating SARS-CoV-2.

Abstract in brief

  • The study investigates human monoclonal antibodies (mAbs) that target the N-terminal domain (NTD) of the SARS-CoV-2 spike protein, highlighting their ability to neutralize the virus effectively.
  • Researchers created an antigenic map for the NTD and identified a critical area, termed "site i," recognized by most neutralizing mAbs, which can inhibit viral fusion and activate immune responses.
  • The presence of mutations in the NTD supersite among various SARS-CoV-2 variants indicates the ongoing evolution of the virus and underscores the need for NTD-specific mAbs in developing effective vaccines and treatments.

Top posts

Most liked on X and Bluesky
Cell Press
@CellPressNews · X

"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab, @DavideCorti6, and Matteo Samuele Pizzuto now in @CellCellPress https://t.co/dRSFI7z4OQ @Vir_Biotech @UW https://t.co/zAmOAcizux

Mar 27, 2021 · 32 likes · 16 shares · 161,482 followers View post →
Cell
@CellCellPress · X

New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/L9gG6Isub1

Mar 16, 2021 · 9 likes · 5 shares · 263,841 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/VMEnn13Wi1 #biorxiv_immuno

Jan 14, 2021 · 4 likes · 3 shares · 10,684 followers View post →
Francis Villatoro
@emulenews · X

#bioRxiv N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/YEbSiqqK1z 41 human monoclonal Abs (mAbs) from memory B cells recognize the SARS-CoV-2 S N-terminal domain (NTD); a subset of them neutralize SARS-CoV-2 ultrapotently. https://t.co/mx5ZCwvRnx

Jan 25, 2021 · 1 like · 3 shares · 45,156 followers View post →
Marc Mendelson
@SouthAfricanASP · X

N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCOV2 - neutralization more targets in spike more that just about the receptor binding domain https://t.co/qqdjj8ndBR

Jan 15, 2021 · 1 like · 2 shares · 11,848 followers View post →
Promega Corporation
@promega · X

Proud to feature the work of @veeslerlab and colleagues at @UW. His paper in Cell features the use of Promega’s ADCC and ADCP Reporter Bioassays to define the role of Fc-mediated effector functions in mAb-mediated anti-viral responses: https://t.co/qTDpjq6kAz https://t.co/a4ZIHlD4ez

Dec 8, 2021 · 1 like · 1 share · 10,118 followers View post →

All mentions

Promega Corporation
@promega · X

Proud to feature the work of @veeslerlab and colleagues at @UW. His paper in Cell features the use of Promega’s ADCC and ADCP Reporter Bioassays to define the role of Fc-mediated effector functions in mAb-mediated anti-viral responses: https://t.co/qTDpjq6kAz https://t.co/a4ZIHlD4ez

Dec 8, 2021 · 1 like · 1 share · 10,118 followers View post →
Klaus Riede
@KlausRiede · X

N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCoV2 https://t.co/dLB3WFyjZK

Jun 24, 2021 · 4,562 followers View post →
Marc Demillequand, PhD, Chem Lc.
@science_md · X

Monoclonal antibodies derived from memory B cells recognize #SARSCoV2 S N-terminal domain (NTD), a subset of them neutralize the virus ultrapotently: no fusion with the cell❗Not in actual #vaccines targeting ONLY ACE2 receptor binding domain RBD #COVID19 https://t.co/HrRSZ5L1YX

Jun 17, 2021 · 1 share · 2,917 followers View post →
Nelson Enrique Arenas Suarez
@NelsonE30507073 · X

Reportes Cientificos Semanales Mayo Semana 2, 2021 https://t.co/fdxdwmXj2v via @YouTube

May 19, 2021 · 1 followers View post →
Prof. Dr. Attila Nemeth PhD MBA
@anemeth1965 · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/JBYwnowseJ

May 1, 2021 · 188 followers View post →
テミス★
@Themis_jp · X

新型コロナウイルスのスパイクタンパクのN末端ドメインのエピトープマッピング Cell. 2021 Mar 16;S0092-8674(21)00356-1. doi: 10.1016/j.cell.2021.03.028. https://t.co/QrgzKs698U

Apr 22, 2021 · 475 followers View post →
Geospatial Python
@geospatial_py · X

RT @dogface2016: 2021年4月21日: Pythonで送る最新のCell Press N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2|htt…

Apr 21, 2021 · 1 share · 4,139 followers View post →
ぼっとくん
@dogface2016 · X

2021年4月21日: Pythonで送る最新のCell Press N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2|https://t.co/s7d2Ks4zuq

Apr 21, 2021 · 1 like · 1 share · 162 followers View post →
Tao Wei
@twei2018 · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 37 followers View post →
Nathaniel Bloom
@BloomNathaniel · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 270 followers View post →
eliot_42
@eliot_42 · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 1,357 followers View post →
Red Colombiana de Bioquímica
@DeBioquimica · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 201 followers View post →
Colin Mann
@TheColinMann · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 251 followers View post →
ALEJANDRO BONILLA
@bonillacuevas · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 253 followers View post →
anna30048679
@anna30048679 · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 3,504 followers View post →
Sandy Feitosa
@sandy_alb · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 53 followers View post →
Giuseppe novelli
@NovelliGnovelli · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 3,656 followers View post →
Dr. د. عبدالواحد الزهراني
@ralzahrani2020 · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 28, 2021 · 16 shares · 4,377 followers View post →
M.B. Ribado
@RibadoBashir · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 27, 2021 · 16 shares · 446 followers View post →
Shingo tkd
@ShingoTakada7 · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 27, 2021 · 16 shares · 22 followers View post →
Eli Santiago
@EliSantiagoC · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 27, 2021 · 16 shares · 223 followers View post →
M. Gordon Joyce
@MGordonJoyce · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 27, 2021 · 16 shares · 485 followers View post →
Afif Pranaya Jati
@afifpj · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 27, 2021 · 16 shares · 1,136 followers View post →
Cell Press
@CellPressNews · X

"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab, @DavideCorti6, and Matteo Samuele Pizzuto now in @CellCellPress https://t.co/dRSFI7z4OQ @Vir_Biotech @UW https://t.co/zAmOAcizux

Mar 27, 2021 · 32 likes · 16 shares · 161,482 followers View post →
UW Biochemistry
@UWBiochemistry · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 25, 2021 · 2 shares · 5,561 followers View post →
The Veesler Lab
@veeslerlab · X

RT @CellPressNews: "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2" - Read the article by @veeslerlab,…

Mar 25, 2021 · 2 shares · 6,223 followers View post →
Rob Camp
@ROB_CAMP · X

RT @CovidReference: https://t.co/I2Njxh17Ed The authors describe 41 mAbs derived which recognize the SARS-CoV-2 S N-terminal domain (NTD).…

Mar 22, 2021 · 1 share · 490 followers View post →
COVID Reference
@CovidReference · X

https://t.co/I2Njxh17Ed The authors describe 41 mAbs derived which recognize the SARS-CoV-2 S N-terminal domain (NTD). A subset of the mAbs neutralize SARS-CoV-2 ultrapotently. Hence the importance of NTD-specific neutralizing mAbs for protective immunity and vaccine design. https://t.co/NYAkEYQzgo

Mar 22, 2021 · 1 share · 173 followers View post →
M.
@tomorrowdaworld · X

(resolved link: https://t.co/gXliQ4iBq8 "N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2") https://t.co/dofeQCRHqv

Mar 20, 2021 · 250 followers View post →
Tim Ricks
@harbari · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 19, 2021 · 6 shares · 71 followers View post →
COVID-19
@Your_COVID19 · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 18, 2021 · 6 shares · 205 followers View post →
Tina de Toetterbeck8jabs
@Toetterbeck · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 18, 2021 · 6 shares · 766 followers View post →
Katy Hoo. @sujilu@mastodon.social
@sujilu · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 18, 2021 · 6 shares · 1,230 followers View post →
Angela Barnett
@Angela_Biochem · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 18, 2021 · 6 shares · 560 followers View post →
Simon Just
@Just1921 · X

RT @DelthiaRicks: A lesser-studied region on SARSCoV2 is recognized by by antibodies. The antibodies attach to the N-terminal viral domain…

Mar 18, 2021 · 6 shares · 43 followers View post →
AnonRere
@AnonRere · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/Lcyq2EBTfM

Mar 17, 2021 · 2,218 followers View post →
CoronavirusVariant
@b117variant · X

N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCoV2: Cell https://t.co/qMqJ3Nhg4u

Mar 17, 2021 · 13 followers View post →
Gabo MH
@gaboentropy · X

RT @NSERC_CRSNG:

Mar 16, 2021 · 1 share · 659 followers View post →
Batya Cohen, PhD
@BatyaCohen1 · X

RT @CellCellPress: New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/…

Mar 16, 2021 · 5 shares · 5,058 followers View post →
Young-jun Park
@YoungjunPark11 · X

RT @CellCellPress: New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/…

Mar 16, 2021 · 5 shares · 115 followers View post →
Oliver Acton
@OliverActon3 · X

RT @CellCellPress: New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/…

Mar 16, 2021 · 5 shares · 130 followers View post →
Un1v3rs0 Z3r0
@Un1v3rs0Z3r0 · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/HuCSHpLvU8

Mar 16, 2021 · 508 followers View post →
Bill Wang
@iu22ie33 · X

RT @CellCellPress: New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/…

Mar 16, 2021 · 5 shares · 10,674 followers View post →
Afif Pranaya Jati
@afifpj · X

RT @CellCellPress: New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/…

Mar 16, 2021 · 5 shares · 1,136 followers View post →
Cell
@CellCellPress · X

New Article now online: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/L9gG6Isub1

Mar 16, 2021 · 9 likes · 5 shares · 263,841 followers View post →
MarkQuarter
@MarkQuarter · X

RT @MichaelBuratovi: Antibodies against the spike N-terminus are potent inactivators for SARS-CoV-2. See N-terminal domain antigenic mappin…

Jan 30, 2021 · 1 share · 1,609 followers View post →
Cheryl Amber Dotson
@GODZILLASLAYS65 · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 | bioRxiv https://t.co/fVRq60QzWN

Jan 26, 2021 · 1,095 followers View post →
Michael Buratovich
@MichaelBuratovi · X

Antibodies against the spike N-terminus are potent inactivators for SARS-CoV-2. See N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/VJUPThwV4d

Jan 25, 2021 · 1 share · 1,165 followers View post →
Dr Anthony Martin
@AMAinsight · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 | bioRxiv https://t.co/iBqxcNryJh

Jan 25, 2021 · 914 followers View post →
Atlus
@CLTec · X

RT @emulenews: #bioRxiv N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/YEbSiqqK1z 41 human…

Jan 25, 2021 · 3 shares · 1,571 followers View post →
Roberto G I
@RGInvest · X

RT @emulenews: #bioRxiv N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/YEbSiqqK1z 41 human…

Jan 25, 2021 · 3 shares · 2,359 followers View post →
Francis Villatoro
@emulenews · X

#bioRxiv N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/YEbSiqqK1z 41 human monoclonal Abs (mAbs) from memory B cells recognize the SARS-CoV-2 S N-terminal domain (NTD); a subset of them neutralize SARS-CoV-2 ultrapotently. https://t.co/mx5ZCwvRnx

Jan 25, 2021 · 1 like · 3 shares · 45,156 followers View post →
LKS ASE
@LksAse · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 [ Preprint - not peer reviewed ] https://t.co/pAQ46CK61r

Jan 22, 2021 · 974 followers View post →
PetraPer
@per_petra · X

RT @SouthAfricanASP: N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCOV2 - neutralization more targets in spi…

Jan 16, 2021 · 2 shares · 106 followers View post →
Dillon Corvino
@Eomesodermin · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/WJocqR1n4g #immunobot https://t.co/UcSp75lY1T

Jan 16, 2021 · 1 like · 620 followers View post →
Mutsa
@Mutsa85 · X

RT @SouthAfricanASP: N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCOV2 - neutralization more targets in spi…

Jan 16, 2021 · 2 shares · 86 followers View post →
PromisingPreprints
@PromPreprint · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/wWADHY2ndZ

Jan 15, 2021 · 3,308 followers View post →
Marc Mendelson
@SouthAfricanASP · X

N-terminal domain antigenic mapping reveals a site of vulnerability for #SARSCOV2 - neutralization more targets in spike more that just about the receptor binding domain https://t.co/qqdjj8ndBR

Jan 15, 2021 · 1 like · 2 shares · 11,848 followers View post →
glycopreprint
@glycopreprint · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/nJvLEwlYy2 #glycotime

Jan 14, 2021 · 1,352 followers View post →
bxv_imm
@bxv_imm · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/M1Ud97yONY

Jan 14, 2021 · 440 followers View post →
NK Leb #UpdateTheVaccines
@NickytaLeb · X

RT @biorxiv_immuno: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/VMEnn13Wi1 #biorxiv_im…

Jan 14, 2021 · 3 shares · 2,938 followers View post →
MBE
@MBELTD · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2: SARS-CoV-2 entry into host cells is orchestrated by the spike (S) glycoprotein that contains an immunodominant receptor-binding domain (RBD) targeted by the largest… https://t.co/Eay8SHQa9p

Jan 14, 2021 · 3,012 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/VMEnn13Wi1 #biorxiv_immuno

Jan 14, 2021 · 4 likes · 3 shares · 10,684 followers View post →
bioRxiv
@biorxivpreprint · X

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 https://t.co/t7qFGEFPum #bioRxiv

Jan 14, 2021 · 137,542 followers View post →