Signal Transduct Target Ther March 2021 PMID 33774649

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.

Miao-Miao Zhao, Wei-Li Yang, Fang-Yuan Yang, Li Zhang, Wei-Jin Huang, Wei Hou, Chang-Fa Fan, Rong-Hua Jin, Ying-Mei Feng, You-Chun Wang, Jin-Kui Yang

Download social card

Mentions

14
Peak: 3 in Oct 2020
across 3 sources since Oct 2020

Extended reach

35,296
potential audience

Total likes

6

Video views

86

Mentions per month

Oct 2020 – Sep 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The social discussions demonstrate strong support and fascination with the research, highlighted by phrases like 'promising target for new drug development' and references to therapeutic implications such as amantadine. The tone indicates a recognition of the study's potential to impact COVID-19 treatment, with some posts exploring the mechanistic role of Cathepsin L, reflecting a moderate level of detailed engagement.

AgreementStrong agreement

Most discussions strongly support the findings, emphasizing the role of Cathepsin L as a key factor in infection and drug development.

InterestHigh interest

Posts express high interest, focusing on therapeutic potential and mechanistic insights, with mentions of drugs like amantadine and targeted treatments.

EngagementModerate engagement

While some users delve into mechanistic details and therapeutic implications, others simply echo the importance of the research, showing moderate deep engagement.

ImpactHigh impact

Overall, the discussions suggest this research could significantly influence COVID-19 treatment strategies and drug development efforts.

Abstract in brief

  • Cathepsin L (CTSL) plays a crucial role in SARS-CoV-2 infection, with elevated levels correlating with disease severity in COVID-19 patients.
  • SARS-CoV-2 infection increases CTSL expression in human cells and mouse models, and CTSL helps the virus enter cells by cleaving its spike protein.
  • Inhibiting CTSL, using drugs like amantadine, can significantly reduce infection, making CTSL a promising target for developing new COVID-19 treatments.]

Top posts

Most liked on X and Bluesky
medRxiv
@medrxivpreprint · X

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/MzSxcsnmpI #medRxiv

Oct 27, 2020 · 2 likes · 17,464 followers View post →
Greg
@Greg21143362 · X

@KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co/byA055noDb

May 15, 2023 · 2 likes · 1 share · 2,018 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Oct 27, 2020 · 1 like · 4,518 followers View post →
Woody Nist
@Woodynist · X

2/2 Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/Kz5YmnE69v

Sep 13, 2024 · 1 like · 1,314 followers View post →
For health-promoting environments
@SilkeLeFay · X

#agedcare #frailty #publichealth #COVID19 #longCOVID Cathepsin L plays a key role in SARS-CoV-2 infection. The cathepsin L mRNA level is twice that of controls in muscles from animals treated with the synthetic glucocorticoid analogue, dexamethasone. . https://t.co/2U6l2LtoEX

Apr 4, 2021 · 4,601 followers View post →
Greg
@Greg21143362 · X

RT @Greg21143362: @KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co…

May 15, 2023 · 1 share · 2,018 followers View post →

All mentions

Woody Nist
@Woodynist · X

2/2 Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/Kz5YmnE69v

Sep 13, 2024 · 1 like · 1,314 followers View post →
Greg
@Greg21143362 · X

RT @Greg21143362: @KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co…

May 15, 2023 · 1 share · 2,018 followers View post →
Greg
@Greg21143362 · X

@KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co/byA055noDb

May 15, 2023 · 2 likes · 1 share · 2,018 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

2/2 https://t.co/LRR3ecIn14 Amantadine significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in vivo To gain further mechanistic & therapeutic insights into COVID-19: https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW https://t.co/2JiOI16wz7

Oct 28, 2021 · 880 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new… https://t.co/LRR3ecIn14 https://t.co/2vZdud9uAa

Oct 28, 2021 · 880 followers View post →
For health-promoting environments
@SilkeLeFay · X

#agedcare #frailty #publichealth #COVID19 #longCOVID Cathepsin L plays a key role in SARS-CoV-2 infection. The cathepsin L mRNA level is twice that of controls in muscles from animals treated with the synthetic glucocorticoid analogue, dexamethasone. . https://t.co/2U6l2LtoEX

Apr 4, 2021 · 4,601 followers View post →
the paper link
@the_paper_link · X

Trend new: Zhao MM, ..., Yang JK (Signal Transduct Target Ther) __Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development__ https://t.co/Ir2T9T3myt

Mar 31, 2021 · 138 followers View post →
Outbreak Science
@outbreaksci · X

New: Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/rznUzX7ni5 read/write/request review https://t.co/RnurTL3DyM #influenza #COVID19

Oct 28, 2020 · 1,376 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Oct 27, 2020 · 1 like · 4,518 followers View post →
medRxiv
@medrxivpreprint · X

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/MzSxcsnmpI #medRxiv

Oct 27, 2020 · 2 likes · 17,464 followers View post →