Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/MzSxcsnmpI #medRxiv
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Oct 2020 – Sep 2024Where it's discussed
-
X / Twitter10 posts
-
YouTube2 videos
-
News2 articles
AI synopsis
What people are saying
The social discussions demonstrate strong support and fascination with the research, highlighted by phrases like 'promising target for new drug development' and references to therapeutic implications such as amantadine. The tone indicates a recognition of the study's potential to impact COVID-19 treatment, with some posts exploring the mechanistic role of Cathepsin L, reflecting a moderate level of detailed engagement.
Most discussions strongly support the findings, emphasizing the role of Cathepsin L as a key factor in infection and drug development.
Posts express high interest, focusing on therapeutic potential and mechanistic insights, with mentions of drugs like amantadine and targeted treatments.
While some users delve into mechanistic details and therapeutic implications, others simply echo the importance of the research, showing moderate deep engagement.
Overall, the discussions suggest this research could significantly influence COVID-19 treatment strategies and drug development efforts.
Abstract in brief
- Cathepsin L (CTSL) plays a crucial role in SARS-CoV-2 infection, with elevated levels correlating with disease severity in COVID-19 patients.
- SARS-CoV-2 infection increases CTSL expression in human cells and mouse models, and CTSL helps the virus enter cells by cleaving its spike protein.
- Inhibiting CTSL, using drugs like amantadine, can significantly reduce infection, making CTSL a promising target for developing new COVID-19 treatments.]
Top posts
Most liked on X and Bluesky@KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co/byA055noDb
2/2 Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/Kz5YmnE69v
#agedcare #frailty #publichealth #COVID19 #longCOVID Cathepsin L plays a key role in SARS-CoV-2 infection. The cathepsin L mRNA level is twice that of controls in muscles from animals treated with the synthetic glucocorticoid analogue, dexamethasone. . https://t.co/2U6l2LtoEX
RT @Greg21143362: @KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co…
All mentions
Role of Cathepsin L in SARS-CoV-2 Infection and Therapeutic Potential
Cathepsin L (CTSL) plays a crucial role in SARS-CoV-2 infection by aiding viral entry through spike protein cleavage. Elevated CTSL levels are linked to COVID-19 severity, and inhibiting this enzyme shows promise for…
Role of Cathepsin L in SARS-CoV-2 Infection and Therapeutic Potential
Cathepsin L is crucial in SARS-CoV-2 infection, aiding virus entry by cleaving spike proteins. Elevated levels correlate with disease severity, and inhibiting CTSL reduces infection, highlighting it as a promising…
2/2 Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/Kz5YmnE69v
RT @Greg21143362: @KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co…
@KeithEv84928885 So here we have an obvious synergy....CSTL cleavage sites and.... https://t.co/qpBXP2abyQ https://t.co/byA055noDb
2/2 https://t.co/LRR3ecIn14 Amantadine significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in vivo To gain further mechanistic & therapeutic insights into COVID-19: https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW https://t.co/2JiOI16wz7
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new… https://t.co/LRR3ecIn14 https://t.co/2vZdud9uAa
#agedcare #frailty #publichealth #COVID19 #longCOVID Cathepsin L plays a key role in SARS-CoV-2 infection. The cathepsin L mRNA level is twice that of controls in muscles from animals treated with the synthetic glucocorticoid analogue, dexamethasone. . https://t.co/2U6l2LtoEX
Trend new: Zhao MM, ..., Yang JK (Signal Transduct Target Ther) __Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development__ https://t.co/Ir2T9T3myt
New: Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/rznUzX7ni5 read/write/request review https://t.co/RnurTL3DyM #influenza #COVID19
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development https://t.co/MzSxcsnmpI #medRxiv