Cell April 2021 PMID 33826908

Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer.

Michael Levin

Mentions

86
Peak: 13 in Nov 2021
across 5 sources since Apr 2021

Extended reach

1,809,791
potential audience

Total likes

1,526

Video views

46,731

Mentions per month

Apr 2021 – Nov 2025

Where it's discussed

  • X / Twitter73 posts
  • News4 articles
  • Blogs4 articles
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Posts highlight the importance of the research by discussing how bioelectric signaling relates to gene expression and anatomical repair. For instance, one user mentions, "membrane potentials control gene expression for anatomical repair," showcasing a technical understanding that adds credibility. The use of terms like 'groundbreaking' and 'state of the art' in various posts underscores a shared excitement and appreciation for the research, reflecting a collective recognition of its potential impact.

AgreementModerate agreement

While there are some differing opinions, most discussions validate the importance and relevance of the publication's findings.

InterestHigh interest

Many users express a strong curiosity about the topic, indicating a high level of interest in bioelectric signaling and its implications.

EngagementModerate engagement

Some discussions show depth by exploring specific mechanisms and applications of bioelectric signaling, although not all posts engage at this level.

ImpactHigh impact

The consensus appears to be that the publication has significant implications for fields like regenerative medicine and cancer therapy.

Abstract in brief

  • Bioelectric signaling involves networks of ion channels and gap junctions that help cells coordinate behaviors during development and regeneration, leading to consistent anatomical outcomes despite disruptions.
  • Recent advancements in studying these bioelectrical circuits show how they influence gene expression and collective cell decisions, promoting orderly organ growth.
  • This understanding opens up possibilities for using bioelectric signaling in treating developmental disorders, advancing regenerative medicine, and improving cancer therapies and synthetic bioengineering efforts.

Top posts

Most liked on X and Bluesky
Michael Levin
@drmichaellevin · X

@OdedRechavi Here are some, made by the very talented Jeremy Guay of Peregrine Creative. Had been meant for https://t.co/joo2WPPOTG and https://t.co/PIgKLzzyUs https://t.co/FQnxlUhLtP

Nov 19, 2021 · 35 likes · 65,374 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's important for heart contraction, signalling and glucose transport. Also development & #rejuvenation --> https://t.co/eMcg8IgRvK #scicomm #AcademicYouTube https://t.co/Iqxv3cal38

Nov 13, 2021 · 24 likes · 6 shares · 4,888 followers View post →
Cell
@CellCellPress · X

New Perspective now online! Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer - https://t.co/QTnbCqR4KY

Apr 6, 2021 · 20 likes · 3 shares · 263,836 followers View post →
Michael Levin
@drmichaellevin · X

@KyleMcnease If you mean "text" as in "book", there really isn't one (yet). For papers, I tried my best to integrate these concepts here: https://t.co/cMyNTq7Vql (and https://t.co/yWpa0MwFsb and https://t.co/KdfLl7cUOP ). But *much* more remains to be done along those lines!

May 18, 2022 · 13 likes · 2 shares · 65,374 followers View post →
benjamin conner
@connerben · X

April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/Y9ff0rpVyf https://t.co/NQRv8DXXo0

Jun 9, 2024 · 12 likes · 6 shares · 1,999 followers View post →
Michael Levin
@drmichaellevin · X

@tony_breu I have a theory for skeletal muscle and heart, don't have data for thyroid and spleen. Cancer won't do well in tissues that have very strong control of resting potential (and are hyperpolarized a lot): https://t.co/hYB2kGrcBy ; https://t.co/Ehz7woCSTZ ; https://t.co/cMyNTq7Vql

May 2, 2022 · 11 likes · 1 share · 65,374 followers View post →

All mentions

Omkar
@OmkarChandra · X

RT @drmichaellevin: @OmkarChandra Outside of academia? haha yeah at this point that's just unfamiliarity with the state of the art, for li…

Jul 21, 2025 · 1 share · 207 followers View post →
Michael Levin
@drmichaellevin · X

@OmkarChandra Outside of academia? haha yeah at this point that's just unfamiliarity with the state of the art, for like 30 years. That world has moved on. Here's a review in Cell, arguably the #1 journal in relevant fields: https://t.co/cMyNTq7Vql Here's one in Development, the top journal

Jul 21, 2025 · 4 likes · 1 share · 65,374 followers View post →
Sterling Cooley
@SterlingCooley · X

Papers like "Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer" discuss how membrane potentials control gene expression for anatomical repair . https://t.co/iuzZTHNb9A

Jul 5, 2025 · 1 like · 20,951 followers View post →
Michael Levin
@drmichaellevin · X

@katclone I have no idea what a bioelectrician is, what web3 is, what claims anyone is making in chats, or what situations need monitoring, but if you'd like to be informed about the state of the field, there are many resources such as this overview in Cell: https://t.co/JlT5GMuZin , or

Jun 21, 2025 · 9 likes · 65,374 followers View post →
NuLiform
@NuLiForm · X

https://t.co/G95iaCYpYd

Dec 28, 2024 · 1,514 followers View post →
LannisterTown
@Olmoyenebro · X

RT @drmichaellevin: @JLMaldoSanchez There's no book yet (mine is due to publisher in 1 month), so meanwhile reviews with background: https:…

Dec 14, 2024 · 3 shares · 45 followers View post →
D.Eng Szymon Łukaszyk
@szymongus · X

RT @drmichaellevin: @JLMaldoSanchez There's no book yet (mine is due to publisher in 1 month), so meanwhile reviews with background: https:…

Dec 8, 2024 · 3 shares · 406 followers View post →
Michael Levin
@drmichaellevin · X

@JLMaldoSanchez There's no book yet (mine is due to publisher in 1 month), so meanwhile reviews with background: https://t.co/edKLSAwJ35 https://t.co/cMyNTq7Vql https://t.co/AisWEs9fe9

Dec 7, 2024 · 11 likes · 3 shares · 65,374 followers View post →
Natalie Kuprijanova
@natashak8720 · X

https://t.co/2i99wO2tVF

Jul 3, 2024 · 319 followers View post →
Finn Synnott
@Freefornow57 · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 1,515 followers View post →
INDIGOSAPPHIRE
@indigosapphire0 · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 4,721 followers View post →
crystal lane
@crystal51999028 · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 444 followers View post →
Kristie Iushkova
@KristieIushkova · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 3,476 followers View post →
sal
@sal069010022845 · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 4,184 followers View post →
Jo Mirek
@JosMirek · X

RT @connerben: April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https:/…

Jun 9, 2024 · 6 shares · 2,292 followers View post →
benjamin conner
@connerben · X

April 6, 2021... Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/Y9ff0rpVyf https://t.co/NQRv8DXXo0

Jun 9, 2024 · 12 likes · 6 shares · 1,999 followers View post →
Michael Levin
@drmichaellevin · X

@MoEbrahimkhani @biorxivpreprint My hypothesis: it's at least partly because of depolarization of resting potential by DMSO (well known in neural cells, & we've seen it a lot in non-neural). Vmem drives a lot of downstream outcomes: https://t.co/SK9K7eajIE https://t.co/OgztEmOBaC https://t.co/cMyNTq8tfT

Jan 2, 2024 · 2 likes · 1 share · 65,374 followers View post →
Thalía Fung Goizueta
@thaliafung · X

RT @thaliafung: @drmichaellevin, it's all here: https://t.co/s01PlWUIJ9 ... Excellent! I have proposed that the cardiac potential facilitat…

Nov 25, 2023 · 1 share · 593 followers View post →
Thalía Fung Goizueta
@thaliafung · X

@drmichaellevin, it's all here: https://t.co/s01PlWUIJ9 ... Excellent! I have proposed that the cardiac potential facilitates cellular structural cooperation, and that downward bias-activation, unrelated to what is necessary in the context, would explain a wide range of diseases. https://t.co/T6BGTujdGC

Nov 25, 2023 · 1 like · 1 share · 593 followers View post →
Michael Levin
@drmichaellevin · X

@thaliafung @Qivshi1 @pai_vaibhav @SantoshManicka it's all here: https://t.co/cMyNTq7Vql and in other reviews by Matthew Harris, Emily Bates, Mustafa Djamgoz, and others.

Nov 24, 2023 · 4 likes · 65,374 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/BaAPw3NREW

Oct 13, 2023 · 1 like · 2,239 followers View post →
Frank Paul Mora
@InTime_49 · X

@SteveMitoengram @philosophising4 @MedEckardt The link to the paper he is citing to demonstrate cellular adaptation to environment. https://t.co/OYIvQnfZlP

Apr 2, 2023 · 1 like · 404 followers View post →
Michael Levin
@drmichaellevin · X

@MADbuster9_67 Sure. tons of stuff here: https://t.co/8qy5n5QepR but you can start with https://t.co/cMyNTq7Vql or https://t.co/jGhro8PLPy

Mar 26, 2023 · 2 likes · 65,374 followers View post →
Michael Levin
@drmichaellevin · X

@AllRoadsSame Many papers on this: https://t.co/8qy5n67Php for example, https://t.co/cMyNTqpwhT

Dec 3, 2022 · 2 likes · 65,374 followers View post →
Jay
@jckellyinc · X

Bioelectricity - the reason we're alive (& therapeutic potential) https://t.co/BSGpCpheaA via @YouTube

Nov 8, 2022 · 18 followers View post →
Dr. S Sengupta
@sengupso · X

@drmichaellevin I read the following review article by you, as I do not have access, to the above article. Regards. 3/ https://t.co/CmszwiLeJ7

Sep 13, 2022 · 1 like · 1,512 followers View post →
Marcelo P. Lima
@MarceloPLima · X

Source: this great review article by @drmichaellevin https://t.co/TUJ66y9OEU

Sep 12, 2022 · 3 likes · 25,533 followers View post →
Shamini Jain, Ph.D.
@drShaminiJain · X

Dr. Mike Levin at @TuftsUniversity is doing groundbreaking work, examining how manipulating voltage across ion channels in cell membranes can help grow new tissue in the brain & body. Read more on "Bioelectric signaling..." here: https://t.co/5KospwGhFt #bioelectromagnetics https://t.co/6aRtt2byga

Jul 9, 2022 · 6 likes · 1,483 followers View post →
Michael Levin
@drmichaellevin · X

@NajJanetto You can see mine at https://t.co/mjJ08m39UD but here are some really cool general audience ones: https://t.co/peei9fb4Re and https://t.co/uNZmXHSATs

Jul 9, 2022 · 1 like · 65,254 followers View post →
Kyle R. McNease
@KyleMcnease · X

RT @drmichaellevin: @KyleMcnease If you mean "text" as in "book", there really isn't one (yet). For papers, I tried my best to integrate th…

May 18, 2022 · 2 shares · 3,552 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

RT @drmichaellevin: @KyleMcnease If you mean "text" as in "book", there really isn't one (yet). For papers, I tried my best to integrate th…

May 18, 2022 · 2 shares · 1,302 followers View post →
Michael Levin
@drmichaellevin · X

@KyleMcnease If you mean "text" as in "book", there really isn't one (yet). For papers, I tried my best to integrate these concepts here: https://t.co/cMyNTq7Vql (and https://t.co/yWpa0MwFsb and https://t.co/KdfLl7cUOP ). But *much* more remains to be done along those lines!

May 18, 2022 · 13 likes · 2 shares · 65,374 followers View post →
Tony Breu
@tony_breu · X

RT @drmichaellevin: @tony_breu I have a theory for skeletal muscle and heart, don't have data for thyroid and spleen. Cancer won't do well…

May 2, 2022 · 1 share · 83,288 followers View post →
Michael Levin
@drmichaellevin · X

@tony_breu I have a theory for skeletal muscle and heart, don't have data for thyroid and spleen. Cancer won't do well in tissues that have very strong control of resting potential (and are hyperpolarized a lot): https://t.co/hYB2kGrcBy ; https://t.co/Ehz7woCSTZ ; https://t.co/cMyNTq7Vql

May 2, 2022 · 11 likes · 1 share · 65,374 followers View post →
Andrew C Ahn
@AndrewCAhn2 · X

"Also, they can receive transplanted organs from other individuals and accept them without rejection.: Plus, if a tail gets grafted onto its flank, it can remodel to a limb! https://t.co/OPyYbabHnU https://t.co/yIQnXa19IY

Apr 15, 2022 · 4 likes · 2,341 followers View post →
Zedd
@TrdisOprtr · X

RT @drmichaellevin: @_fernando_rosas @Abelaer @SantoshManicka Start here: https://t.co/JlT5GMuZin Lots more details here: https://t.co/vNb…

Mar 26, 2022 · 1 share · 349 followers View post →
Michael Levin
@drmichaellevin · X

@uthmanzi No; voltage doesn't distinguish frog from human cells - it's about cell collectives. Difference between some anatomical shapes, even though made from same species' cells, can be large-scale voltage patterns. https://t.co/cMyNTq7Vql

Mar 24, 2022 · 11 likes · 1 share · 65,374 followers View post →
Michael Levin
@drmichaellevin · X

@_fernando_rosas @Abelaer @SantoshManicka Start here: https://t.co/JlT5GMuZin Lots more details here: https://t.co/vNbeShAZFl and here: https://t.co/Z7NFEAELa5

Mar 23, 2022 · 4 likes · 1 share · 65,374 followers View post →
Gohsuke Takama
@gohsuket · X

(ΦωΦ)フフフ… Nov 2021 "Bioelectricity - the reason we're alive (& therapeutic potential)" on YouTube - https://t.co/6GzrvMdehg

Mar 13, 2022 · 1 like · 2,987 followers View post →
Flâneur
@GROEMODEL · X

RT @drmichaellevin: @EleanorSheekey very cool video: https://t.co/peei9fb4Re amazing!

Mar 9, 2022 · 3 shares · 456 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

RT @drmichaellevin: @EleanorSheekey very cool video: https://t.co/peei9fb4Re amazing!

Mar 8, 2022 · 3 shares · 4,888 followers View post →
Alex Trapp
@AlexandreTrapp · X

RT @drmichaellevin: @EleanorSheekey very cool video: https://t.co/peei9fb4Re amazing!

Mar 7, 2022 · 3 shares · 1,180 followers View post →
Michael Levin
@drmichaellevin · X

@EleanorSheekey very cool video: https://t.co/peei9fb4Re amazing!

Mar 7, 2022 · 10 likes · 3 shares · 65,254 followers View post →
Michael Levin
@drmichaellevin · X

@aourirabderahim @IntuitMachine It's not only electrical, there are biochemical and biomechanical components of course (and maybe biophotonic, etc.). Some thoughts on the details of what guides what are here: https://t.co/cMyNTq7Vql and https://t.co/edKLSAwJ35 .

Feb 12, 2022 · 9 likes · 65,374 followers View post →
Michael Levin
@drmichaellevin · X

@AndreeaNRD Thanks. Everything of ours on #bioelectricity is here: https://t.co/Z7NFEAELa5 We have new papers on this coming out in the next few months. A review of what's happened so far is https://t.co/JlT5GMuZin

Dec 19, 2021 · 8 likes · 65,374 followers View post →
Liz Rose
@LizRose14449371 · X

RT @drmichaellevin: @SMcfarnell There's lots, email me for reprints; examples shown in: https://t.co/5z5aTEOw4J, https://t.co/cMyNTq7Vql, h…

Dec 3, 2021 · 2 shares · 147 followers View post →
Scott McFarnell
@SMcfarnell · X

RT @drmichaellevin: @SMcfarnell There's lots, email me for reprints; examples shown in: https://t.co/5z5aTEOw4J, https://t.co/cMyNTq7Vql, h…

Nov 19, 2021 · 2 shares · 7,751 followers View post →
Michael Levin
@drmichaellevin · X

@SMcfarnell There's lots, email me for reprints; examples shown in: https://t.co/5z5aTEOw4J, https://t.co/cMyNTq7Vql, https://t.co/22stS4RUsi, https://t.co/jKGdXhN6lS, https://t.co/hJZzb0Z3kT, etc. A major part of it is in the standing electric pattern of a multicell bioelectrical circuit.

Nov 19, 2021 · 9 likes · 2 shares · 65,374 followers View post →
Michael Levin
@drmichaellevin · X

@OdedRechavi Here are some, made by the very talented Jeremy Guay of Peregrine Creative. Had been meant for https://t.co/joo2WPPOTG and https://t.co/PIgKLzzyUs https://t.co/FQnxlUhLtP

Nov 19, 2021 · 35 likes · 65,374 followers View post →
ScienceStop
@B0tSci · X

RT @EleanorSheekey: Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's impor…

Nov 15, 2021 · 6 shares · 4,072 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's impor…

Nov 15, 2021 · 6 shares · 2,103 followers View post →
Gohsuke Takama
@gohsuket · X

(ΦωΦ)フフフ… "Bioelectricity - the reason we're alive (& therapeutic potential)" on YouTube - https://t.co/6GzrvMdehg

Nov 13, 2021 · 2,987 followers View post →
Alex Freeman
@alex__freeman · X

RT @EleanorSheekey: Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's impor…

Nov 13, 2021 · 6 shares · 39 followers View post →
Nicholas Steel
@bogizemlja · X

Bioelectricity - the reason we're alive (& therapeutic potential) https://t.co/8OAgMQp7ul via @YouTube

Nov 13, 2021 · 2 likes · 14,680 followers View post →
nopara73
@nopara73 · X

RT @EleanorSheekey: Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's impor…

Nov 13, 2021 · 6 shares · 12,207 followers View post →
ScienceStop
@B0tSci · X

RT @EleanorSheekey: Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's impor…

Nov 13, 2021 · 6 shares · 4,072 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Our bodies are #electric. Proteins found on our cell membranes pump ions generating electrical potentials. It's important for heart contraction, signalling and glucose transport. Also development & #rejuvenation --> https://t.co/eMcg8IgRvK #scicomm #AcademicYouTube https://t.co/Iqxv3cal38

Nov 13, 2021 · 24 likes · 6 shares · 4,888 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

inspiration came from @drmichaellevin recent review article --> https://t.co/0jW3PHMPij

Nov 13, 2021 · 2 likes · 4,889 followers View post →
Liz Rose
@LizRose14449371 · X

RT @realNathanCheng: Discussing this paper right now on Clubhouse: https://t.co/xWqfEeCmCU

Oct 15, 2021 · 4 shares · 147 followers View post →
Catarina Cunha
@clemoscatarina · X

RT @realNathanCheng: Discussing this paper right now on Clubhouse: https://t.co/xWqfEeCmCU

Oct 15, 2021 · 4 shares · 1,764 followers View post →
io
@io_1337 · X

@leecronin https://t.co/pmOCuoXVTs Bump ^ https://t.co/kukcgaRE8j

Oct 15, 2021 · 2,765 followers View post →
io
@io_1337 · X

RT @realNathanCheng: Discussing this paper right now on Clubhouse: https://t.co/xWqfEeCmCU

Oct 15, 2021 · 4 shares · 2,765 followers View post →
Nathan S. Cheng thinks you should work on aging.
@realNathanCheng · X

Discussing this paper right now on Clubhouse: https://t.co/xWqfEeCmCU

Oct 15, 2021 · 6 likes · 4 shares · 14,709 followers View post →
Nathan S. Cheng thinks you should work on aging.
@realNathanCheng · X

2/ The paper : https://t.co/xWqfEeCmCU

Oct 15, 2021 · 14,709 followers View post →
Agingdoc
@agingdoc1 · X

From @realNathanCheng @LongevityMcap - Today at 11 PDT (suitable for gen audiences) the 1st ODLB j club re: Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/0VHYXmvmL2 It’s @Clubhouse PS @wisdomapp1 has launched. https://t.co/yVOGpqJEPd

Oct 14, 2021 · 3 likes · 41,921 followers View post →
Michael Levin
@drmichaellevin · X

@IntuitMachine the time of bacterial biofilms (Gurol Suel) that there is a better, higher level API: #bioelectric circuits https://t.co/cMyNTq7Vql, https://t.co/bPdV2qUFDf, https://t.co/k4Zf7hbAPL, to solve inverse problem (https://t.co/KMYI3X9Cqt) for evolvability, robustness, & biomed.

Sep 9, 2021 · 8 likes · 65,374 followers View post →
Rudradeep Mukherjee
@RudraMukh · X

Review from 2021. https://t.co/KsPSYnFu5K

Jun 15, 2021 · 2 likes · 233 followers View post →
T⁷ MD,PhD
@tokitky · X

2021年4月18日: Pythonで送る最新のCell Press Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer|https://t.co/Pd2FvhQmnp https://t.co/ikLEnEOwsj

Apr 18, 2021 · 4,002 followers View post →
INOUE, Takeshi
@PlanarianBrain · X

Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/lOK3ZUfBus

Apr 15, 2021 · 3 likes · 438 followers View post →
PubMed Trending
@PubTrend · X

Trending on PubMed: Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer. https://t.co/buNz5KHd3q

Apr 14, 2021 · 5,169 followers View post →
Kıvanç Görgülü
@kivancgorgulu · X

And lastly I am really happy to see this amazing perspective @CellCellPress from @drmichaellevin whom I have been following since my medical faculty years! Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer https://t.co/XcR9HlaE7d

Apr 11, 2021 · 6 likes · 1,014 followers View post →
David Krizaj
@dkrizaj · X

RT @CellCellPress: New Perspective now online! Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and c…

Apr 6, 2021 · 3 shares · 185 followers View post →
Cell
@CellCellPress · X

New Perspective now online! Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer - https://t.co/QTnbCqR4KY

Apr 6, 2021 · 20 likes · 3 shares · 263,836 followers View post →