The discussions reflect a consensus that the study demonstrates no significant advantage of ketogenic diets or exogenous ketones for fat loss over calorie-controlled low-fat diets, with tone emphasizing scientific validation via phrases like 'no difference' and 'supports calorie-based weight management,' which shows a critical yet engaged evaluation of the findings.
AgreementModerate agreement
Most discussions recognize that the study shows a lack of significant differences in fat loss between ketogenic diets, with many explicitly stating that ketosis or exogenous ketone salts do not enhance weight loss beyond caloric deficit, indicating genera
InterestHigh interest
The conversations demonstrate high curiosity, with many posts referencing specific details of the study, such as the six-week duration, comparison groups, and ketosis measures, signaling strong interest in the research outcomes.
EngagementHigh engagement
Respondents actively analyze the study’s methods, cite multiple examples, and debate implications—examples include discussions about nitrogen loss, calorie intake, and the role of exogenous ketones—highlighting deep engagement with the content.
ImpactModerate impact
While the discussions acknowledge the study's contribution to understanding keto diets, many emphasize that the findings reinforce the importance of calorie balance over specific diet composition, implying a moderate impact on long-term dietary strategies
Abstract in brief
The study investigated how a 6-week low-calorie ketogenic diet (KD), with and without exogenous ketone salts (KS), affects body weight and composition in overweight and obese adults, finding that both diets promoted fat loss but KS did not improve results beyond the KD alone.
Both ketogenic diets successfully induced nutritional ketosis, with slightly higher BHB levels in the KS group initially, but this did not lead to differences in muscle preservation or fat loss compared to the placebo or low-fat diet.
While the ketogenic diets reduced body mass and fat, adding exogenous ketones did not significantly enhance these effects, suggesting that KS may not provide additional benefits for body composition during caloric restriction.
New paper from the one and only Jeff Volek and coauthors! Looking at 6 weeks of a ketogenic diet with and without exogenous ketones. No difference. Time a factor? https://t.co/nLPnfEib3J
A multitude of isocaloric/isonitrogenous studies comparing disparate carb-fat proportions consistently failing to show body fat reduction advantages in the LCHF group has **more than sufficiently** invalidated CIM. And it continues, even in Volek’s work: https://t.co/f1nYPWBGij https://t.co/Ge5ELfdu1t
May 8, 2021 · 25 likes · 5 shares · 42,016 followersView post →
SM
Samuele Marcora
@SamueleMarcora · X
Although not directly measured, this study confirms that Ketogenic Diet does not increase energy expenditure compared to Low-Fat Diet. If it did, fat loss would be significantly higher in KD compared to LFD and it is clearly not (Figure 2B) https://t.co/BsfgUduOP6
@garytaubes @FoodFirst_Ty @davidludwigmd RCTs to date have shown that calorie intake has a powerful effect on body fatness, independent of carbohydrate. Carbohydrate intake does not have a reliably measurable effect independent of calories.
Recent trial from Jeff Volek's group.
https://t.co/HiIxlddWNB
Mar 30, 2021 · 17 likes · 2 shares · 54,776 followersView post →
GN
Gorka Nuñez
@gorkanunez · X
Como todas las afirmaciones categóricas, "Las calorías no importan" es una verdad a medias, o una medio mentira.
La perdida de peso dependió más del grado de restricción calórica que del grado de cetosis.
https://t.co/58iN5RRu0t
Mar 26, 2021 · 11 likes · 1 share · 2,762 followersView post →
DP
Douglas Kalman PhD
@dougkalmanphdrd · X
Supplementing with ketone salts found NOT to have added benefit during dieting for weight control or body comp improvement. If so, why use these? https://t.co/7xtY3RM2vL #keto #diet #strategy #science #noaddedbenefit
This video explores when to take exogenous ketones during fasting to enhance benefits, emphasizing that ketones work better after fasting rather than during. Learn the effects on body composition and health outcomes.
This video examines recent research on the effects of ketogenic diets and exogenous ketone supplements on body fat reduction. It discusses a 6-week study showing that while keto diets promote fat loss, adding ketone…
@davidludwigmd @DrEenfeldt Even Jeff Volek knows that in order to maintain the same weight, caloric intake must be adjusted. I'm sure you've read this study:
https://t.co/OrQR494YJi
Do exogenous ketones help you lose weight?
A while back, exogenous ketones were all the range. Many thought that if you could get your ketones higher with expensive ketone elixirs, you would lose weight.
Unfortunately, this is not the case!
https://t.co/iDzxD7Qi9A
RT @agingdoc1: The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive perfor…
Oct 18, 2022 · 1 share · 32,623 followersView post →
A
Agingdoc
@agingdoc1 · X
The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults https://t.co/DcQWphq8ql
Oct 18, 2022 · 4 likes · 1 share · 45,027 followersView post →
D
DesignedByNature
@DesignedNature · X
Posting "The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults. (Pub Date: 2022)" on reddit #ketoscience https://t.co/tUn9P1X98B
Cool feeding study by Volek's group comparing weight loss and lean mass retention on Keto, Keto + exog ketones, & low-fat
- No major differences between groups
- Nitrogen balance decreased more on keto than low-fat
- Protein at 1.5g/kg/day
> https://t.co/3TUEmf3PEk < https://t.co/sGbmCiHTVD
@KingManninen @BioLayne "The KD group excreted significantly more urea nitrogen than LFD (p = 0.004)"
Volek's study. Similar calories and protein, and greater nitrogen loss in the keto group
https://t.co/gL0OZb0K8F
https://t.co/DiPI7TFQHR
https://t.co/hUpOFU2kEA
Quick Fat Loss - How Important it is to Eliminate Those Unhealthy Belly Fats
Most women consider a quick fat loss to eliminate the fats around th
@garytaubes @the_hough @practicalbob @BioLayne A highly controlled 6-week study suggests no difference in fat loss (p = 0.82). (40 vs 260g of carbs, isocaloric)
Why do you think 16 weeks would be different?
https://t.co/gL0OZb0K8F
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses https://t.co/JJIqccABu8
RT @TheAlanAragon: A multitude of isocaloric/isonitrogenous studies comparing disparate carb-fat proportions consistently failing to show b…
May 22, 2021 · 5 shares · 1,389 followersView post →
KH
Kevin Hall
@KevinH_PhD · X
@davidludwigmd @benjaminrholmes @ScienceMagazine @JohnSpeakman4 I think he’s asking about the meta-analysis of body fat change with isocaloric diets which was not addressed in your paper. A recent study would have to be added to that meta-analysis that found no significant differences over 6 weeks of keto vs low fat: https://t.co/3ygkDDA2FL
May 18, 2021 · 4 likes · 38,740 followersView post →
FH
Frankie Granata IV, MSc (he/him)
@GranataIv · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
May 17, 2021 · 107 shares · 189 followersView post →
RD
Renato Dumbra
@renatodumbra · X
RT @TheAlanAragon: A multitude of isocaloric/isonitrogenous studies comparing disparate carb-fat proportions consistently failing to show b…
A multitude of isocaloric/isonitrogenous studies comparing disparate carb-fat proportions consistently failing to show body fat reduction advantages in the LCHF group has **more than sufficiently** invalidated CIM. And it continues, even in Volek’s work: https://t.co/f1nYPWBGij https://t.co/Ge5ELfdu1t
May 8, 2021 · 25 likes · 5 shares · 42,016 followersView post →
KI
Kerry Ireland
@kezzybear1968 · X
RT @KetoCarnivore: On the other hand, this study showed no difference in weight or body composition between a KD with and without added ket…
@Gsev7n @DoctorTro Right! So let’s do a super controlled study where we measure BHB to ensure ketosis. Then compare to a low fat diet. Keto wins right?! Nope:
https://t.co/TEo1y0hnwP
May 1, 2021 · 1 like · 12,144 followersView post →
HP
Herman Pontzer
@HermanPontzer · X
@AKA_Sadrien @freethinkCDN If keto worked the magic it’s supposed to, people would lose more weight on keto than on low fat diets like this one (spoiler: they don’t):
https://t.co/TEo1y0hnwP
May 1, 2021 · 1 like · 12,144 followersView post →
HP
Herman Pontzer
@HermanPontzer · X
@DoctorTro Hmm... which lit is that? How about the recent one showing *exactly the same* weight loss on a 6 week diet, ketogenic vs low fat?
https://t.co/TEo1y0hnwP
May 1, 2021 · 6 likes · 12,144 followersView post →
ZM
zorn49 #MaskenRunter
@zorn49_derAlte · X
RT @KetoCarnivore: On the other hand, this study showed no difference in weight or body composition between a KD with and without added ket…
May 1, 2021 · 1 share · 5,145 followersView post →
LH
L. Amber O'Hearn
@KetoCarnivore · X
On the other hand, this study showed no difference in weight or body composition between a KD with and without added ketone salts.
https://t.co/7HOLF7WETW https://t.co/CAkNY1Hr0V
Supplementing with ketone salts found NOT to have added benefit during dieting for weight control or body comp improvement. If so, why use these? https://t.co/7xtY3RM2vL #keto #diet #strategy #science #noaddedbenefit
6-weeks of Energy-matched hypocaloric ketogenic diets favorably affected body composition but were not further impacted by administration of an exogenous Ketone salts that augmented ketosis.
https://t.co/F3nzhhFHUR
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses https://t.co/TSKF0tXxY7
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses
https://t.co/uy7g9ZTUXF
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses https://t.co/QKU8bxdeza https://t.co/uBAvqyzquP
@SamueleMarcora @garytaubes @CharlesMBrenner @BioLayne While we are highlighting items, can we get a verdict here and here? Dr. Volek not exactly know as a carbohydrate acolyte...
https://t.co/y2Rlpxopvw
https://t.co/prPQzJsj8j
https://t.co/UJMLXI6JTp
Apr 19, 2021 · 1 like · 2,905 followersView post →
SW
Shaun Ward
@MyNutritionSci · X
@fbrown2014 @garytaubes @DavidMacklinMD @BioLayne @TheAlanAragon I linked the wrong study. Sorry, this is the one.
https://t.co/S1w2pN4pY3
@garytaubes @CaloriesProper @SamueleMarcora @bigfatsurprise Oh! I know - let's compare Keto diets (like the ones touted in your new book) against low fat diets for weight loss in a controlled feeding study over 6 weeks. We'll even add ketone salts to one. Surely the keto diets will lead to more weight loss! Nope. https://t.co/6CJzOqeuNj
@KetoCarnivore @_eleanorina @Zrudin21 @tednaiman @KETOGAINS Wasted through breath and urine so agree with that but this study showed no effect on fat mass in an isocaloric setting. https://t.co/q9ZnnvsVub
Although not directly measured, this study confirms that Ketogenic Diet does not increase energy expenditure compared to Low-Fat Diet. If it did, fat loss would be significantly higher in KD compared to LFD and it is clearly not (Figure 2B) https://t.co/BsfgUduOP6
New paper from the one and only Jeff Volek and coauthors! Looking at 6 weeks of a ketogenic diet with and without exogenous ketones. No difference. Time a factor? https://t.co/nLPnfEib3J
RT @whsource: @garytaubes @FoodFirst_Ty @davidludwigmd RCTs to date have shown that calorie intake has a powerful effect on body fatness, i…
Mar 31, 2021 · 2 shares · 1,389 followersView post →
SG
Stephan J. Guyenet
@sguyenet · X
@garytaubes @FoodFirst_Ty @davidludwigmd RCTs to date have shown that calorie intake has a powerful effect on body fatness, independent of carbohydrate. Carbohydrate intake does not have a reliably measurable effect independent of calories.
Recent trial from Jeff Volek's group.
https://t.co/HiIxlddWNB
Mar 30, 2021 · 17 likes · 2 shares · 54,776 followersView post →
KZ
Keto Diet Zone
@KetoDietZone · X
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses https://t.co/G2FxpyZGIl
#keto
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 2,743 followersView post →
A
Annette
@polityczna19 · X
RT @Kamil_Paprotny: W dalszym ciągu to nie ograniczenie węglowodanów czy tłuszczów per se powoduje ubytek masy ciała. To dieta niskoenerget…
Mar 26, 2021 · 1 share · 1,121 followersView post →
KZ
Keto Diet Zone
@KetoDietZone · X
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses https://t.co/G2FxpyI5QN
#keto
Mar 26, 2021 · 2 likes · 1 share · 13,062 followersView post →
C
C
@ckeewm · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 67 followersView post →
ER
ENACT Research
@ENACTResearch · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 13 followersView post →
MG
Martin Greguš
@martingregus1 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 2 followersView post →
SJ
Scott Jr.
@rush1_scott · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 142 followersView post →
JA
Jay Adam
@JadamJay · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 341 followersView post →
OP
One propylcyclobutane
@CShamone · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 341 followersView post →
SM
Scott Morgans
@Scott_Morgans1 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 268 followersView post →
AG
Alan GH
@AlanGH26 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 127 followersView post →
JM
Jerry Gabriel-MD
@JerryGa18988557 · X
New diet randomized controlled trial comparing:
a) Keto
b) Keto + ketone salts
c) Low-fat
Matched for calories & protein
6 weeks
No difference in fat loss
Neither keto nor ketone salts cause fat loss beyond expected by calorie balance
https://t.co/qsGrphnzAa https://t.co/q1q1rGT5Va
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 1,089 followersView post →
SD
Stephanie deGiorgio
@DrSdeG · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 24,998 followersView post →
DF
Dr Ellen Fallows
@ellenfallows · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 1,894 followersView post →
GN
Gorka Nuñez
@gorkanunez · X
Como todas las afirmaciones categóricas, "Las calorías no importan" es una verdad a medias, o una medio mentira.
La perdida de peso dependió más del grado de restricción calórica que del grado de cetosis.
https://t.co/58iN5RRu0t
Mar 26, 2021 · 11 likes · 1 share · 2,762 followersView post →
AD
Almighty Keto Diet
@KetoDiet365 · X
RT @dj_surfista: #Cetonas exógenas não fazem diferença no emagrecimento. A perda de peso tem tudo a ver com um déficit de energia, não seus…
RT @nick_krontiris: The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Compos…
Mar 26, 2021 · 2 shares · 1,389 followersView post →
JC
Jorge Ruiz-Carrascal
@Elorges · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 1,170 followersView post →
O
Olihory
@Olihory · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 70 followersView post →
CH
Caroline Weight Loss Hacks
@WeightLosHacks · X
RT @nick_krontiris: The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Compos…
Mar 26, 2021 · 2 shares · 1,347 followersView post →
NK
Nick Krontiris
@nick_krontiris · X
The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses (open access)
https://t.co/o5iW4nmL1P
#nutrition #diet #weightloss
Mar 26, 2021 · 4 likes · 2 shares · 19,553 followersView post →
PT
PT_Thunem
@PT_Thunem · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 82 followersView post →
KT
Kevin Tipton
@proftipper · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 26, 2021 · 107 shares · 18,141 followersView post →
JM
Jose C Souto, MD
@jcsouto · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 14,495 followersView post →
MH
M.Haziq
@MHaziqPT · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 257 followersView post →
PA
Pablo Arrona
@PabloArrNutSci · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 247 followersView post →
A
atzayactl
@fragar09 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 54 followersView post →
DC
Dr. Helen E. Collins
@DrHelenECollin1 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 2,241 followersView post →
JC
Joe Zucchi, PA-C, CPT
@JPZfitness · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 248 followersView post →
HH
Helene H
@HeleneH14 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 693 followersView post →
NM
No Misdirection
@NoMisdirection · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 655 followersView post →
DN
Dean Nakos
@deannakos · X
RT @HealthyFellow: Effects of a Controlled, #Hypocaloric #Ketogenic #Diet, w/ & w/o #Exogenous #Ketone Salts, on Body Composition Attn: @_…
Mar 25, 2021 · 10 shares · 211 followersView post →
VH
Victor H.
@vickh90 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 38 followersView post →
GA
Gerardo Avelar
@Gerave7 · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 234 followersView post →
BY
Best Health 4 You
@besthealthyou · X
RT @HealthyFellow: Effects of a Controlled, #Hypocaloric #Ketogenic #Diet, w/ & w/o #Exogenous #Ketone Salts, on Body Composition Attn: @_…
Mar 25, 2021 · 10 shares · 508 followersView post →
Z
Zaahid
@Nutell5sandwich · X
RT @KevinH_PhD: Interesting new 6 week controlled feeding study comparing body composition changes following three isocaloric diets: low fa…
Mar 25, 2021 · 107 shares · 47 followersView post →
A
AMMFEN
@AMMFEN_OFICIAL · X
RT @FrontNutrition: New Research: The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts,…
Mar 25, 2021 · 3 shares · 4,103 followersView post →
FN
Fundación Iberoamericana de Nutrición
@FinutOrg · X
RT @FrontNutrition: New Research: The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts,…
Mar 25, 2021 · 3 shares · 4,056 followersView post →
FN
Frontiers - Nutrition
@FrontNutrition · X
New Research: The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses: Background: Ketogenic diets (KDs) that elevate beta-hydroxybutyrate (BHB) promote weight and… https://t.co/XoGCHRXIMw #Nutrition
Mar 24, 2021 · 2 likes · 3 shares · 3,920 followersView post →
F
Yes super! Exogenous Ketones are amazing but basically training ...
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Unfortunately, this is not the case! https://www.frontiersin.org/articles/10.3389/fnut. 2021.618520/full · Becky Ward and 7 others ·