Anesthesiology July 2021 PMID 33872345

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain.

Keith M Vogt, James W Ibinson, C Tyler Smith, Ally T Citro, Caroline M Norton, Helmet T Karim, Vencislav Popov, Aman Mahajan, Howard J Aizenstein, Lynne M Reder, Julie A Fiez

Mentions

152
Peak: 100 in Oct 2025
across 4 sources since Apr 2021

Extended reach

269,320
potential audience

Total likes

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Video views

10,500

Mentions per month

Apr 2021 – Oct 2025

Where it's discussed

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AI synopsis

What people are saying

Several comments directly mention the research, such as reposts of scientific summaries and reflections on neural mechanisms, which indicates some level of engagement with the article's content. However, many posts are off-topic, sarcastic, or represent personal opinions, reflecting low overall impact and diverse interests that dilute the focus on the publication.

AgreementNeither agree nor disagree

The discussions include neutral mentions of the publication, with some posts referencing specific findings while others diverge into unrelated topics, resulting in a mixed or neutral stance.

InterestNeutral interest

Many posts show no clear focus or interest in the research, instead sharing opinions on unrelated subjects like politics, entertainment, or personal comments.

EngagementModerate engagement

There is some depth of engagement, especially from users quoting or referencing specific aspects of the study, but many posts are superficial or off-topic.

ImpactNeutral impact

Overall, the discussions appear to have limited influence on broader audiences or policy, mostly circulating among specific interest groups or personal social discussions.

Abstract in brief

  • The study investigated how midazolam and ketamine affect brain activity related to memory, pain, and fear in healthy adults, finding that both drugs impair memory but through different neural mechanisms.
  • Midazolam reduced recollection memory performance and increased connectivity in certain brain regions involved in memory and emotion, while ketamine also impaired memory but decreased connectivity across several areas.
  • These results highlight that although both drugs cause memory impairment, they influence the brain's memory, pain, and fear networks in distinct ways, involving different patterns of brain connectivity changes.]

Top posts

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Anesthesiology Journals
@_Anesthesiology · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract https://t.co/InyavkF05Q https://t.co/j3akrA90EK

Apr 23, 2021 · 61 likes · 24 shares · 38,180 followers View post →
Anesthesiology Journals
@_Anesthesiology · X

#VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain

Jun 17, 2022 · 24 likes · 16 shares · 38,180 followers View post →
ASA®
@ASALifeline · X

A randomized within-subject crossover study published in @_Anesthesiology showed reduced memory recollection of periodic pain in healthy volunteers under light sedation with midazolam, but not with ketamine. Read more: https://t.co/D4DFVcoFh9 #anesthesiology

May 3, 2021 · 3 likes · 2 shares · 37,467 followers View post →
FAER
@FAERanesthesia · X

More valuable content from former #FAERgrantees coming your way! Don't miss this article from 2017 MRTG @KeithVogtMD et al in @_Anesthesiology https://t.co/nvZrC1VtY9 #Anesthesiology #Research

Aug 27, 2021 · 2 likes · 3 shares · 5,043 followers View post →
Kimberly Curseen
@Curseen · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain - PubMed https://t.co/lxlQgKROBY

Sep 12, 2021 · 2 likes · 2,995 followers View post →
john morley
@drjohnmorley · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain https://t.co/Yjr4rTXg8T

Sep 12, 2021 · 1 like · 8,320 followers View post →

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Listening now!!

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hi i decided you have to look at my creature again okay

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I need more of this shit send me this shit lol

Oct 10, 2025 · 1 like View post →
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土橋「そんなこと言わんでー、こっからが腕の見せどころやねん、うまくいけば君たちがちゃんと霊障なしで共存していける未来もあるってことや。俺の作るモンがあればな、そう、恭一クンの鼻血と俺のおふだを交換し続ければ、俺はいつか必ず完璧な浄化の札を完成さして、君たちはいつまでも一緒におれるんやで?」 柏木「今の生活も悪くないよ、そんな支障きたしてへんし」 土橋「そ〜〜は言うとるけどー……そのまんまにしとくと大変なことになるで? 今は大丈夫でも後々やばいって」 柏木「わかったよー、じゃあほんまに完璧なのが完成したら、それをもらうってことでええやろ?」 土橋「ういうい、卒業後もよしなにお願いしますー」

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yes.

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She has a line?????

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Now I gotta ask who is your favorite character from the show and why

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Definitely not lol

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Well HE gets the updated vaccines, not you, peasant.

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What would that look like?

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What's a man got to do to get someone to rest their legs in my lap and let me mindlessly pet them while we relax on the couch?

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Oh no. He's hot.

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Well said

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@705-naoko.bsky.social · Bluesky

絶対になる!( ´ ▽ ` )

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@malcolmsjustice.bsky.social · Bluesky

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No idea but cannot wait to see. And the restaurants.

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Rami Diab
@RamiDiab · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 27, 2022 · 16 shares · 1,439 followers View post →
Claudia M Simoes
@Claudia_anest · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 22, 2022 · 16 shares · 390 followers View post →
Mady Hady Shady
@MadyHadyShady · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 106 followers View post →
pietroilpotente
@pietroilpotente · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 3 followers View post →
Katia Donadello
@KatiaDonadello · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 1,204 followers View post →
Luigi Vetrugno, MD,
@LuigiVetrugnoMD · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 2,410 followers View post →
Libert Nicolas
@dr_Libert_N · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 54 followers View post →
Professor Dr Debesh Bhoi,MBBS,MD,MNAMS,
@DebeshBhoi · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 18, 2022 · 16 shares · 503 followers View post →
Stefano Romagnoli
@StefanoRomagno9 · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 805 followers View post →
Allan F. Simpao, MD, MBI
@asimpao · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 1,261 followers View post →
ゆ@麻酔科
@yukanes22 · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 2,459 followers View post →
Jose Chavez Martinez
@matracaelcan · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 156 followers View post →
Carlos A. Lanz M.
@DrCarlosALanzM · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 483 followers View post →
Abel Abrego
@Abelgavino · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 1,088 followers View post →
orson orsi guimaraes
@orsonguimaraes · X

RT @_Anesthesiology: #VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear N…

Jun 17, 2022 · 16 shares · 51 followers View post →
Anesthesiology Journals
@_Anesthesiology · X

#VisualAbstract in Anesthesiology - Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain

Jun 17, 2022 · 24 likes · 16 shares · 38,180 followers View post →
Politics Polly
@PoliticsPolly1 · X

Midazolam & Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain https://t.co/yn08tzn4W1

Dec 26, 2021 · 1 like · 1,197 followers View post →
john morley
@drjohnmorley · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain https://t.co/Yjr4rTXg8T

Sep 12, 2021 · 1 like · 8,320 followers View post →
Kimberly Curseen
@Curseen · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain - PubMed https://t.co/lxlQgKROBY

Sep 12, 2021 · 2 likes · 2,995 followers View post →
Sean Barnes (he/him), MD, MBA
@DrSeanBarnes · X

RT @FAERanesthesia: More valuable content from former #FAERgrantees coming your way! Don't miss this article from 2017 MRTG @KeithVogtMD et…

Sep 6, 2021 · 3 shares · 3,836 followers View post →
Pitt Anesthesiology and Perioperative Medicine
@PittAnes · X

RT @FAERanesthesia: More valuable content from former #FAERgrantees coming your way! Don't miss this article from 2017 MRTG @KeithVogtMD et…

Sep 1, 2021 · 3 shares · 1,586 followers View post →
Anesthesiology Journals
@_Anesthesiology · X

RT @FAERanesthesia: More valuable content from former #FAERgrantees coming your way! Don't miss this article from 2017 MRTG @KeithVogtMD et…

Aug 30, 2021 · 3 shares · 38,180 followers View post →
FAER
@FAERanesthesia · X

More valuable content from former #FAERgrantees coming your way! Don't miss this article from 2017 MRTG @KeithVogtMD et al in @_Anesthesiology https://t.co/nvZrC1VtY9 #Anesthesiology #Research

Aug 27, 2021 · 2 likes · 3 shares · 5,043 followers View post →
Anesthesiology Journals
@_Anesthesiology · X

RT @ASALifeline: A randomized within-subject crossover study published in @_Anesthesiology showed reduced memory recollection of periodic p…

May 3, 2021 · 2 shares · 38,180 followers View post →
ASA®
@ASALifeline · X

A randomized within-subject crossover study published in @_Anesthesiology showed reduced memory recollection of periodic pain in healthy volunteers under light sedation with midazolam, but not with ketamine. Read more: https://t.co/D4DFVcoFh9 #anesthesiology

May 3, 2021 · 3 likes · 2 shares · 37,467 followers View post →
Rita “Proudly Vaccinated” Agarwal MD
@Ritaagarwal6 · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

May 1, 2021 · 24 shares · 2,473 followers View post →
Gigih Adetya
@gijoenaedi · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 28, 2021 · 24 shares · 164 followers View post →
sic
@kimvie · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 28, 2021 · 24 shares · 2,528 followers View post →
Keith Vogt
@KeithVogtMD · X

Thanks to @RupertMcShane and Sara Costi from @UniofOxford Psychiatry for the invitation to present our @_Anesthesiology pub (https://t.co/gwlMNVpmp4) at the International Ketamine Journal Club today. Great discussion with a non-anesthesiology audience!

Apr 27, 2021 · 501 followers View post →
Emily Sharpe, MD, FASA
@emilysharpe · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 27, 2021 · 24 shares · 7,642 followers View post →
Pitt OB & Women's Anesthesiology
@OBAnesUPMC · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 27, 2021 · 24 shares · 553 followers View post →
Pitt Anesthesiology and Perioperative Medicine
@PittAnes · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 27, 2021 · 24 shares · 1,586 followers View post →
Chaminda Wijeratne
@CWijeratne · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 24, 2021 · 24 shares · 65 followers View post →
Claudia M Simoes
@Claudia_anest · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 390 followers View post →
Stefano Romagnoli
@StefanoRomagno9 · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 805 followers View post →
alan espra
@alanespra · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 298 followers View post →
Dušan Vlahović
@vlah58 · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 2,317 followers View post →
ali uyar
@aliuyar1963 · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 214 followers View post →
Allan F. Simpao, MD, MBI
@asimpao · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 1,261 followers View post →
Alfredo Abad Gurumeta
@AbadGurumeta · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 1,357 followers View post →
Eduardo cruz
@edogro14 · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 136 followers View post →
Morfeo
@kev_morpheus · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 198 followers View post →
ismail latheef
@isseylatif · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 1,252 followers View post →
Okunola Akeju. MD (Shobaloju of Agbooro )
@MooAkee · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 1,414 followers View post →
iwahyudis
@iwahyudis · X

RT @_Anesthesiology: Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract…

Apr 23, 2021 · 24 shares · 6,586 followers View post →
Anesthesiology Journals
@_Anesthesiology · X

Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain #visualabstract https://t.co/InyavkF05Q https://t.co/j3akrA90EK

Apr 23, 2021 · 61 likes · 24 shares · 38,180 followers View post →