PLoS Genet April 2021 PMID 33886541

Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome.

Alison H Nguyen, Doris Bachtrog

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Mentions

82
Peak: 6 in Jun 2021
across 4 sources since Jul 2020

Extended reach

6,312,983
potential audience

Total likes

77,640

Video views

5,899,053

Mentions per month

Jul 2020 – Aug 2023

Where it's discussed

  • News51 articles
  • X / Twitter22 posts
  • Blogs5 articles
  • YouTube4 videos

AI synopsis

What people are saying

Overall, the group shows a high level of interest and engagement, with posts mentioning key findings like increased repeat expression and heterochromatin loss in males with young Y chromosomes, often emphasizing the study's relevance to aging and genetic processes. The tone suggests that many see these results as impactful for understanding sex-specific aging mechanisms.

AgreementModerate agreement

Most discussions acknowledge the findings about the toxic effects of the Y chromosome on male aging, indicating general support and recognition of the study's conclusions.

InterestHigh interest

The discussions show high interest, with many posts highlighting concepts like heterochromatin loss, repeat expression, and implications for aging, suggesting a strong engagement with the topic.

EngagementModerate engagement

Posts reference specific mechanisms such as TE activity and heterochromatin changes, demonstrating a meaningful level of analysis and discussion beyond surface-level reactions.

ImpactModerate impact

The emphasis on how Y chromosome repeats influence lifespan and gene regulation indicates that the discussions see this work as having significant ramifications for understanding sex-specific aging and genetic health.

Abstract in brief

  • The study investigates how the young Y chromosome in Drosophila miranda affects aging, showing that males with more repetitive DNA and a less stable heterochromatin structure have higher levels of transposable elements (TEs), which are linked to shorter male lifespan.
  • Results indicate that heterochromatin loss and repeat expression, especially in TEs and satellite DNA, are more severe in aging males compared to females, suggesting that the toxic effects of the Y chromosome contribute to male aging.
  • The research highlights the interaction between the evolutionary stage of the Y chromosome and aging, demonstrating that a young, active Y chromosome impairs epigenetic silencing, increases TE expression, and ultimately reduces male fitness.]

Top posts

Most liked on X and Bluesky
PLOS
@PLOS · X

Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Doris Bachtrog of @berkeleyIB. #Genetics

Sep 22, 2021 · 10 likes · 7 shares · 148,347 followers View post →
PLOS Genetics
@PLOSGenetics · X

♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differences in #lifespan They find that #Drosophila Y chromosomes with more repeats less effectively silence transposable elements

Jun 23, 2021 · 9 likes · 1 share · 34,757 followers View post →
Mobile DNA
@MobDNAjournal · X

Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/gwZOsrWMio #transposon

Jul 29, 2020 · 6 likes · 1 share · 2,165 followers View post →
SexGenomics
@sexgenomics · X

Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/NvHPsLu8P8

Apr 23, 2021 · 5 likes · 815 followers View post →
Thomas Brody
@interactivefly · X

Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Aging Cell: e13348. https://t.co/fdDnb6QdKf https://t.co/gUbZ2O2Sut

Jun 29, 2021 · 1 like · 1 share · 2,023 followers View post →
Thomas Brody
@interactivefly · X

Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male #Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438. https://t.co/gUbZ2O2Sut

Jun 29, 2021 · 1 like · 1 share · 2,023 followers View post →

All mentions

Bluebird
@bluebird_gwc · X

@PGonz8 Nada mi error, los accidentes si se cuentan. Sin embargo hay un factor genético que es prevalente en la mayoría de animales (en los mamíferos los XY tienden a vivir menos que los XX y se sugiere un factor genético). https://t.co/IgZKyedO0U

Feb 15, 2023 · 80 followers View post →
Bindikannan
@Bindikannan963 · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Sep 23, 2021 · 7 shares · 1,103 followers View post →
PLOS Genetics
@PLOSGenetics · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Sep 23, 2021 · 7 shares · 34,757 followers View post →
Jorge Luis Pino
@jorgelpino · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Sep 22, 2021 · 7 shares · 468 followers View post →
Mar de Miguel
@MarJungle · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Sep 22, 2021 · 7 shares · 1,962 followers View post →
気まぐれアブスタドリ
@feketerigoremet · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Sep 22, 2021 · 7 shares · 595 followers View post →
PLOS
@PLOS · X

Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Doris Bachtrog of @berkeleyIB. #Genetics

Sep 22, 2021 · 10 likes · 7 shares · 148,347 followers View post →
PLOS Genetics
@PLOSGenetics · X

RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…

Aug 18, 2021 · 1 share · 34,757 followers View post →
Prof Neil Martin
@ThatNeilMartin · X

Yer literal Toxic Masculinity, via @PLOS https://t.co/AIv1MU8v88

Aug 18, 2021 · 2,786 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @interactivefly: Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromat…

Jun 30, 2021 · 1 share · 1,367 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @interactivefly: Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein…

Jun 30, 2021 · 1 share · 1,367 followers View post →
Thomas Brody
@interactivefly · X

Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Aging Cell: e13348. https://t.co/fdDnb6QdKf https://t.co/gUbZ2O2Sut

Jun 29, 2021 · 1 like · 1 share · 2,023 followers View post →
Thomas Brody
@interactivefly · X

Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male #Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438. https://t.co/gUbZ2O2Sut

Jun 29, 2021 · 1 like · 1 share · 2,023 followers View post →
Manny Ares
@RiboGuy · X

RT @PLOSGenetics: ♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differenc…

Jun 23, 2021 · 1 share · 1,894 followers View post →
PLOS Genetics
@PLOSGenetics · X

♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differences in #lifespan They find that #Drosophila Y chromosomes with more repeats less effectively silence transposable elements

Jun 23, 2021 · 9 likes · 1 share · 34,757 followers View post →
ychrompapers
@ychrom_papers · X

Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/tJkiKk1LdX https://t.co/uwdQjWV2KW

Apr 23, 2021 · 32 followers View post →
SexGenomics
@sexgenomics · X

Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/NvHPsLu8P8

Apr 23, 2021 · 5 likes · 815 followers View post →
Liudmila
@Liudmil35146132 · X

RT @MobDNAjournal: Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young…

Jul 29, 2020 · 1 share · 48 followers View post →
Mobile DNA
@MobDNAjournal · X

Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/gwZOsrWMio #transposon

Jul 29, 2020 · 6 likes · 1 share · 2,165 followers View post →
Dr. Wen-Juan Ma | 马文娟
@WenJuanMa84 · X

Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/romQyGrVIO

Jul 28, 2020 · 1 like · 1,182 followers View post →
bioRxiv Evobio
@biorxiv_evobio · X

Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/Imxamb1Uar #biorxiv_evobio

Jul 22, 2020 · 4,440 followers View post →
bioRxiv
@biorxivpreprint · X

Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/U8VhFNdMkg #bioRxiv

Jul 22, 2020 · 136,861 followers View post →