Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Doris Bachtrog of @berkeleyIB. #Genetics
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome.
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Jul 2020 – Aug 2023Where it's discussed
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News51 articles
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X / Twitter22 posts
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What people are saying
Overall, the group shows a high level of interest and engagement, with posts mentioning key findings like increased repeat expression and heterochromatin loss in males with young Y chromosomes, often emphasizing the study's relevance to aging and genetic processes. The tone suggests that many see these results as impactful for understanding sex-specific aging mechanisms.
Most discussions acknowledge the findings about the toxic effects of the Y chromosome on male aging, indicating general support and recognition of the study's conclusions.
The discussions show high interest, with many posts highlighting concepts like heterochromatin loss, repeat expression, and implications for aging, suggesting a strong engagement with the topic.
Posts reference specific mechanisms such as TE activity and heterochromatin changes, demonstrating a meaningful level of analysis and discussion beyond surface-level reactions.
The emphasis on how Y chromosome repeats influence lifespan and gene regulation indicates that the discussions see this work as having significant ramifications for understanding sex-specific aging and genetic health.
Abstract in brief
- The study investigates how the young Y chromosome in Drosophila miranda affects aging, showing that males with more repetitive DNA and a less stable heterochromatin structure have higher levels of transposable elements (TEs), which are linked to shorter male lifespan.
- Results indicate that heterochromatin loss and repeat expression, especially in TEs and satellite DNA, are more severe in aging males compared to females, suggesting that the toxic effects of the Y chromosome contribute to male aging.
- The research highlights the interaction between the evolutionary stage of the Y chromosome and aging, demonstrating that a young, active Y chromosome impairs epigenetic silencing, increases TE expression, and ultimately reduces male fitness.]
Top posts
Most liked on X and Bluesky♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differences in #lifespan They find that #Drosophila Y chromosomes with more repeats less effectively silence transposable elements
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/gwZOsrWMio #transposon
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/NvHPsLu8P8
Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Aging Cell: e13348. https://t.co/fdDnb6QdKf https://t.co/gUbZ2O2Sut
Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male #Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438. https://t.co/gUbZ2O2Sut
All mentions
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@PGonz8 Nada mi error, los accidentes si se cuentan. Sin embargo hay un factor genético que es prevalente en la mayoría de animales (en los mamíferos los XY tienden a vivir menos que los XX y se sugiere un factor genético). https://t.co/IgZKyedO0U
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Doris Bachtrog of @berkeleyIB. #Genetics
RT @PLOS: Large numbers of Y chromosome repeats can become toxic later in life & shorten the lifespan of male flies, say Alison Nguyen & Do…
Yer literal Toxic Masculinity, via @PLOS https://t.co/AIv1MU8v88
RT @interactivefly: Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromat…
RT @interactivefly: Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein…
Ngian, Z. K., Lin, W. Q. and Ong, C. T. (2021). NELF-A controls #Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance. Aging Cell: e13348. https://t.co/fdDnb6QdKf https://t.co/gUbZ2O2Sut
Nguyen, A. H. and Bachtrog, D. (2021). Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male #Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438. https://t.co/gUbZ2O2Sut
RT @PLOSGenetics: ♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differenc…
♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differences in #lifespan They find that #Drosophila Y chromosomes with more repeats less effectively silence transposable elements
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/tJkiKk1LdX https://t.co/uwdQjWV2KW
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/NvHPsLu8P8
RT @MobDNAjournal: Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young…
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/gwZOsrWMio #transposon
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/romQyGrVIO
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/Imxamb1Uar #biorxiv_evobio
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome https://t.co/U8VhFNdMkg #bioRxiv