Children whose parents had been exposed to radiation from the Chernobyl Nuclear Power Plant accident in 1986 had no excess germline mutations, a new whole-genome sequencing study in @ScienceMagazine by @LongakerLab shows. https://t.co/L5ggIAHUQK
Preventing activation in fibroblasts yields wound regeneration without scarring.
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Apr 2021 – Jul 2024Where it's discussed
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X / Twitter17 posts
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News16 articles
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Reddit5 posts
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Blogs5 articles
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YouTube3 videos
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Facebook3 posts
AI synopsis
What people are saying
The discussions reflect high enthusiasm, with mentions like 'Now possible to prevent scarring' and references to 'pharmacological blockade,' emphasizing the potential applications. The tone is optimistic, and users are connecting the research to clinical outcomes, showing deep engagement and recognition of its importance.
Most discussions express strong support and optimism about the research's findings, emphasizing the potential for scarless healing.
Posts demonstrate high engagement, with many noting the scientific significance and promising therapeutic implications.
Several users reference specific mechanisms like YAP signaling and pharmacological treatments, indicating active interest.
The discussions highlight the potential for substantial medical advances, viewing this research as transformative for wound healing and regenerative medicine.
Abstract in brief
- The study identifies a specific subpopulation of lineage-negative fibroblasts (ENFs) in the skin that can activate into pro-fibrotic fibroblasts (EPFs) during adult wound healing, which typically leads to scarring.
- Mechanical tension influences fibroblast activation through mechanotransduction signaling pathways, particularly involving YAP, a key regulator in this process.
- Blocking YAP signaling with drugs like verteporfin or genetic methods prevents fibroblast activation, leading to scarless wound healing and regeneration of skin structures, indicating two possible healing outcomes: fibrotic (scarring) or regenerative (free of scarring).]
Top posts
Most liked on X and BlueskyResearchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https://t.co/tosatQJodS via @statnews @ScienceMagazine DOI: 10.1126/science.aba2374
@_its_not_real_ @leepavelich @orthonormalist Nope but a quick dig found this https://t.co/OSajN5YEzg
@stuartacook1 This paper comes into my mind: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/6cs1uPFxn4
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmBqBF1 #woundhealing #scar #regeneration
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/QAY2SKkxRx
All mentions
Verteporfin and YAP Inhibition for Scarless Wound Healing Advances
This video explores recent research on regenerative wound healing. Using multi-omic analyses, scientists identify molecular pathways that lead to scarring or regeneration. Inhibiting YAP activates signals like Trps1 and…
Verteporfin's Role in Skin Regeneration and Scar Reduction
Dr. Bloxham discusses Verteporfin, an FDA-approved drug shown to fully regenerate skin including hair follicles, and its potential in preventing scarring by promoting regenerative wound healing through molecular…
Verteporfin and Microneedling for Hair Follicle Regeneration
This video explores the role of Verteporfin in hair follicle regeneration, highlighting its importance in hair transplantation and promoting follicle growth. It discusses wound healing, regeneration processes, and the…
@ImmunoFever Also, do a search for' verteporfin for wound healing', and check out: https://t.co/wd6nl1dOD5
@_its_not_real_ @leepavelich @orthonormalist Nope but a quick dig found this https://t.co/OSajN5YEzg
RT @AymanGradaMD: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmB…
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmBqBF1 #woundhealing #scar #regeneration
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring - PubMed https://t.co/ExkbzVv55g
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring - PubMed https://t.co/ExkbzVv55g
@ItsJakePerry @hubermanlab Mechanical forces and mechanotransduction Preventing Engrailed-1 activation in fibroblasts yields wound regen... https://t.co/5a6H9T2DGY Inhibiting Yes-associated protein prevents scarring and promotes regeneration in a large animal model of wound repair https://t.co/n9q3wXGET4 https://t.co/3zG1pwYYVs
@stuartacook1 This paper comes into my mind: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/6cs1uPFxn4
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/IWVbRoxSFx
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/QAY2SKkxRx
RT @ezattara: https://t.co/9n9dxkdEEH Great finding! Genetic or pharmacological blockade of engrailed-1 in a specific population of fibrob…
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/suUlTGScsN 手術痕を消せる可能性がある現代医学の進歩です
RT @tpulinil: Researchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https…
Researchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https://t.co/tosatQJodS via @statnews @ScienceMagazine DOI: 10.1126/science.aba2374
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. https://t.co/rIKOxtLZfa
#SKIN #LINEAGE Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/WV8M8TIOKN
Children whose parents had been exposed to radiation from the Chernobyl Nuclear Power Plant accident in 1986 had no excess germline mutations, a new whole-genome sequencing study in @ScienceMagazine by @LongakerLab shows. https://t.co/L5ggIAHUQK