Science April 2021 PMID 33888614

Preventing activation in fibroblasts yields wound regeneration without scarring.

Shamik Mascharak, Heather E desJardins-Park, Michael F Davitt, Michelle Griffin, Mimi R Borrelli, Alessandra L Moore, Kellen Chen, Bryan Duoto, Malini Chinta, Deshka S Foster, Abra H Shen, Michael Januszyk, Sun Hyung Kwon, Gerlinde Wernig, Derrick C Wan

Mentions

49
Peak: 5 in Apr 2021
across 6 sources since Apr 2021

Extended reach

84,245
potential audience

Total likes

1,321

Video views

46,067

Mentions per month

Apr 2021 – Jul 2024

Where it's discussed

  • X / Twitter17 posts
  • News16 articles
  • Reddit5 posts
  • Blogs5 articles
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

The discussions reflect high enthusiasm, with mentions like 'Now possible to prevent scarring' and references to 'pharmacological blockade,' emphasizing the potential applications. The tone is optimistic, and users are connecting the research to clinical outcomes, showing deep engagement and recognition of its importance.

AgreementStrong agreement

Most discussions express strong support and optimism about the research's findings, emphasizing the potential for scarless healing.

InterestHigh interest

Posts demonstrate high engagement, with many noting the scientific significance and promising therapeutic implications.

EngagementModerate engagement

Several users reference specific mechanisms like YAP signaling and pharmacological treatments, indicating active interest.

ImpactHigh impact

The discussions highlight the potential for substantial medical advances, viewing this research as transformative for wound healing and regenerative medicine.

Abstract in brief

  • The study identifies a specific subpopulation of lineage-negative fibroblasts (ENFs) in the skin that can activate into pro-fibrotic fibroblasts (EPFs) during adult wound healing, which typically leads to scarring.
  • Mechanical tension influences fibroblast activation through mechanotransduction signaling pathways, particularly involving YAP, a key regulator in this process.
  • Blocking YAP signaling with drugs like verteporfin or genetic methods prevents fibroblast activation, leading to scarless wound healing and regeneration of skin structures, indicating two possible healing outcomes: fibrotic (scarring) or regenerative (free of scarring).]

Top posts

Most liked on X and Bluesky
Meagan Phelan
@MeaganPhelan · X

Children whose parents had been exposed to radiation from the Chernobyl Nuclear Power Plant accident in 1986 had no excess germline mutations, a new whole-genome sequencing study in @ScienceMagazine by @LongakerLab shows. https://t.co/L5ggIAHUQK

Apr 22, 2021 · 2 likes · 1,960 followers View post →
Prof.Thomas Pulinilkunnil
@tpulinil · X

Researchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https://t.co/tosatQJodS via @statnews @ScienceMagazine DOI: 10.1126/science.aba2374

Apr 25, 2021 · 2 likes · 1 share · 1,085 followers View post →
0.005 Seconds (3/694)
@seconds_0 · X

@_its_not_real_ @leepavelich @orthonormalist Nope but a quick dig found this https://t.co/OSajN5YEzg

Jul 2, 2023 · 1 like · 15,082 followers View post →
Min Dai
@artofbiology · X

@stuartacook1 This paper comes into my mind: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/6cs1uPFxn4

May 2, 2022 · 1 like · 1,223 followers View post →
Ayman Grada, MD, MHA
@AymanGradaMD · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmBqBF1 #woundhealing #scar #regeneration

May 20, 2023 · 1 like · 1 share · 820 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/QAY2SKkxRx

Dec 20, 2021 · 11,918 followers View post →

All mentions

Paradigm Shift
@zWholeBeing · X

@ImmunoFever Also, do a search for' verteporfin for wound healing', and check out: https://t.co/wd6nl1dOD5

Dec 3, 2023 · 244 followers View post →
0.005 Seconds (3/694)
@seconds_0 · X

@_its_not_real_ @leepavelich @orthonormalist Nope but a quick dig found this https://t.co/OSajN5YEzg

Jul 2, 2023 · 1 like · 15,082 followers View post →
Dedee Murrell
@DedeeMurrell · X

RT @AymanGradaMD: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmB…

May 20, 2023 · 1 share · 1,622 followers View post →
Ayman Grada, MD, MHA
@AymanGradaMD · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring | Science https://t.co/oLfcmBqBF1 #woundhealing #scar #regeneration

May 20, 2023 · 1 like · 1 share · 820 followers View post →
Megan Elizabeth Graham
@grahamemegan · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring - PubMed https://t.co/ExkbzVv55g

Mar 18, 2023 · 303 followers View post →
Megan Elizabeth Graham
@grahamemegan · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring - PubMed https://t.co/ExkbzVv55g

Feb 22, 2023 · 303 followers View post →
不明
@_noakari · X

@ItsJakePerry @hubermanlab Mechanical forces and mechanotransduction Preventing Engrailed-1 activation in fibroblasts yields wound regen... https://t.co/5a6H9T2DGY Inhibiting Yes-associated protein prevents scarring and promotes regeneration in a large animal model of wound repair https://t.co/n9q3wXGET4 https://t.co/3zG1pwYYVs

Nov 5, 2022 · 21 followers View post →
Min Dai
@artofbiology · X

@stuartacook1 This paper comes into my mind: Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/6cs1uPFxn4

May 2, 2022 · 1 like · 1,223 followers View post →
Dr. Efe Ozturk
@EfeOzturkDPM · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/IWVbRoxSFx

Dec 20, 2021 · 483 followers View post →
David G. Armstrong follow @dgarmstrong.bsky.social
@DGArmstrong · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/QAY2SKkxRx

Dec 20, 2021 · 11,918 followers View post →
Sci-isms
@MercuryTimes · X

RT @ezattara: https://t.co/9n9dxkdEEH Great finding! Genetic or pharmacological blockade of engrailed-1 in a specific population of fibrob…

Dec 10, 2021 · 6 shares · 113 followers View post →
クゥ
@cielloup8 · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/suUlTGScsN 手術痕を消せる可能性がある現代医学の進歩です

Nov 5, 2021 · 195 followers View post →
Dr. Keith R. Brunt
@prof_brunt · X

RT @tpulinil: Researchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https…

Apr 25, 2021 · 1 share · 2,535 followers View post →
Prof.Thomas Pulinilkunnil
@tpulinil · X

Researchers decode the #chemical and #physical signals that trigger a particular type of #skin #cell to produce #scars. https://t.co/tosatQJodS via @statnews @ScienceMagazine DOI: 10.1126/science.aba2374

Apr 25, 2021 · 2 likes · 1 share · 1,085 followers View post →
Endocryne Papers
@Endocryne_reads · X

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. https://t.co/rIKOxtLZfa

Apr 24, 2021 · 21 followers View post →
Kursad Turksen
@kursadturksen · X

#SKIN #LINEAGE Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring https://t.co/WV8M8TIOKN

Apr 23, 2021 · 232 followers View post →
Meagan Phelan
@MeaganPhelan · X

Children whose parents had been exposed to radiation from the Chernobyl Nuclear Power Plant accident in 1986 had no excess germline mutations, a new whole-genome sequencing study in @ScienceMagazine by @LongakerLab shows. https://t.co/L5ggIAHUQK

Apr 22, 2021 · 2 likes · 1,960 followers View post →