June 2021 PMID 33891706

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings.

Andrew J Kesner, David M Lovinger

Mentions

20
Peak: 11 in May 2021
across 3 sources since Apr 2021

Extended reach

264,150
potential audience

Total likes

8,012

Video views

242,193

Mentions per month

Apr 2021 – Oct 2025

Where it's discussed

  • X / Twitter16 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Discussions highlight the article's comprehensive review of cannabis's neurobiological mechanisms, with posts like 'provides a one-stop-shop for research' and 'important insights into withdrawal,' emphasizing the significance and curiosity sparked by thorough scientific analysis. The tone reflects excitement and recognition of the article's potential impact on both scientific understanding and clinical approaches.

AgreementModerate agreement

Most discussions acknowledge the importance of research on cannabis, with several posts referencing its clinical and neurobiological significance, indicating general support.

InterestHigh interest

Posts demonstrate high interest, especially with mentions of new reviews, mechanisms, and potential treatments, showing enthusiasm for the topic.

EngagementHigh engagement

Discussions include references to specific studies, mechanisms, and implications for understanding cannabis withdrawal and use disorder, reflecting deep engagement.

ImpactModerate impact

The conversation suggests the research could influence future treatment approaches and understanding of cannabis-related issues, but it remains somewhat preliminary.

Abstract in brief

  • Cannabis sativa is the most common illicit drug globally, with THC being its main psychoactive component associated with both recreational use and therapeutic benefits.
  • Many frequent users may develop cannabis use disorder, characterized by cravings, tolerance, and withdrawal, but currently, there are no effective treatments for this condition.
  • Research using animal models has shed light on the neurobiological mechanisms of cannabis, specifically its impact on the cannabinoid type-one receptor, which helps bridge the gap between basic science and clinical observations related to cannabis use disorder.

Top posts

Most liked on X and Bluesky
Drew Kesner
@DrewKesner · X

New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a one-stop-shop for both clinical and preclinical research on CUD and CWS. Text and refs ideal for anyone coming up to speed on the topic https://t.co/yXRhWMBIjz

May 17, 2021 · 39 likes · 10 shares · 577 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 10,832 followers View post →
Leah Mayo
@MayoOnTheBrain · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 2,844 followers View post →
AbizaidAlfie
@AbizaidAlfie · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 1,585 followers View post →
Darwin De La Encina
@Darwin_Encina · X

DETOX: BAJA TU TOLERANCIA AL CANNABIS https://t.co/7LaY9A9LgH a través de @YouTube

Sep 28, 2022 · 1,102 followers View post →
Dr. Alex Chisholm, PhD
@DrAlexChisholm · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 903 followers View post →

All mentions

Reducing Cannabis Tolerance with Detox Strategies

This video explains how to reset cannabis tolerance using the detox method known as tolerance breaks or tbreaks. It highlights the benefits and current scientific evidence on reducing tolerance to improve effects for…

En Volá · Sep 26, 2022 241,293 views
Chris Breadon
@chrisbreadon · X

@kynohy @ClarkeMicah @gurprinderdeep Addiction is real/ Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings https://t.co/NKRZwE6gWA

Oct 12, 2025 · 195 followers View post →
lucioo ⭐⭐⭐
@Luciooo25 · X

https://t.co/BaKt0r2NNc

Oct 3, 2022 · 75 followers View post →
saem.eth
@tavellaeze · X

https://t.co/OxVVO04z8Y

Sep 29, 2022 · 290 followers View post →
Darwin De La Encina
@Darwin_Encina · X

DETOX: BAJA TU TOLERANCIA AL CANNABIS https://t.co/7LaY9A9LgH a través de @YouTube

Sep 28, 2022 · 1,102 followers View post →
JNC_DCE_Reviews
@DceJnc · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 19, 2021 · 10 shares · 25 followers View post →
Yanina Pepino
@YaniPepino · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 18, 2021 · 10 shares · 214 followers View post →
Dennis Burke
@dennis_a_burke · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 18, 2021 · 10 shares · 769 followers View post →
Elise Weerts
@EliseWeertsPhD · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 18, 2021 · 10 shares · 597 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 10,832 followers View post →
AbizaidAlfie
@AbizaidAlfie · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 1,585 followers View post →
Dr. Alex Chisholm, PhD
@DrAlexChisholm · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 903 followers View post →
David Lovinger
@LovingerDavid · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 856 followers View post →
Leah Mayo
@MayoOnTheBrain · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 2,844 followers View post →
Vijay Ramchandani (Masks Save Lives)
@VijayR_One · X

RT @DrewKesner: New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a on…

May 17, 2021 · 10 shares · 723 followers View post →
Drew Kesner
@DrewKesner · X

New review out in *Special Issue - Neurochemistry of Reward-Seeking* @JNeurochem. @LovingerDavid and I provide readers a one-stop-shop for both clinical and preclinical research on CUD and CWS. Text and refs ideal for anyone coming up to speed on the topic https://t.co/yXRhWMBIjz

May 17, 2021 · 39 likes · 10 shares · 577 followers View post →
The Richard Rose Report
@TheRRreport · X

Cannabis use, abuse, and withdrawal: cannabinergic mechanisms, clinical, and preclinical findings https://t.co/iCUqoOVzG3 #hemp #CBD Cannabis use, abuse, and withdrawal: cannabinergic mechanisms, clinical, and preclinical findings J Neurochem. 2021 Apr 23. doi: 10.1111...

Apr 24, 2021 · 1 share · 148 followers View post →