Trials April 2021 PMID 33892777

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers.

Robin J Murphy, Rachael L Sumner, William Evans, David Menkes, Ingo Lambrecht, Rhys Ponton, Frederick Sundram, Nicholas Hoeh, Sanya Ram, Lisa Reynolds, Suresh Muthukumaraswamy

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Mentions

13
Peak: 6 in Apr 2021
across 3 sources since Apr 2021

Extended reach

1,312,697
potential audience

Total likes

32,479

Video views

1,295,561

Mentions per month

Apr 2021 – May 2023

Where it's discussed

  • X / Twitter8 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions highlight the scientific rigor of the study, with mentions of its controlled design and potential to shape future research, using words like 'protocol' and 'study' to emphasize its credibility. The tone suggests a balanced curiosity and recognition of its significance, as seen in phrases like 'interesting approach' and 'important research,' indicating a cautious yet engaged perspective.

AgreementModerate agreement

Most discussions show support or neutrality toward the study, reflecting general acknowledgment of its scientific approach.

InterestModerate interest

Participants demonstrate moderate interest, recognizing the significance of the research without strong enthusiasm.

EngagementModerate engagement

Posts discuss methodological details and potential implications, indicating active engagement but not deep debate.

ImpactModerate impact

The overall tone suggests the study is seen as an important step toward understanding microdosing, with some posts mentioning its possible influence on mental health treatments.

Abstract in brief

  • This study investigates the effects of microdosing LSD on healthy volunteers by giving them 14 doses over 6 weeks, measuring changes in personality, mood, creativity, cognition, brain plasticity, and brain imaging, to see if microdosing truly offers the benefits often reported in less controlled settings.
  • The trial involves 80 male participants receiving either LSD or a placebo, with assessments before and after the treatment, as well as during the first dose, including questionnaires, EEG, fMRI scans, and activity tracking, to gather objective data on the effects of microdosing.
  • The goal is to test claims from popular microdosing sources with scientific rigor, which could lead to future clinical research exploring LSD microdosing as a treatment option for mental health conditions like depression, addiction, and OCD, or as a supplement to psychotherapy.

Top posts

Most liked on X and Bluesky
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers https://t.co/6UIQC1JRge

Apr 24, 2021 · 9 likes · 2 shares · 3,987 followers View post →
Microdose
@microdose_io · X

@tipado @reflect10133017 @Psy_Invest @MindBioTherap here’s the link to the article :) https://t.co/hj0xd3iP7e

Nov 3, 2022 · 1 like · 3,473 followers View post →
THERADELICS
@theradelics · X

RT @APRA_bot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volu…

Apr 26, 2021 · 2 shares · 3,381 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @drugSciBot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in healthy v…

Apr 29, 2021 · 2 shares · 2,045 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in heal…

Aug 11, 2021 · 2 shares · 2,045 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in healthy volunteers https://t.co/4VJejG4g17

Apr 29, 2021 · 2 shares · 2,045 followers View post →

All mentions

Microdose
@microdose_io · X

@tipado @reflect10133017 @Psy_Invest @MindBioTherap here’s the link to the article :) https://t.co/hj0xd3iP7e

Nov 3, 2022 · 1 like · 3,473 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in heal…

Aug 11, 2021 · 2 shares · 2,045 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @drugSciBot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in healthy v…

Apr 29, 2021 · 2 shares · 2,045 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of #LSD in healthy volunteers https://t.co/4VJejG4g17

Apr 29, 2021 · 2 shares · 2,045 followers View post →
THERADELICS
@theradelics · X

RT @APRA_bot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volu…

Apr 26, 2021 · 2 shares · 3,381 followers View post →
Bianca
@BiancaMimsr · X

RT @APRA_bot: MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volu…

Apr 25, 2021 · 2 shares · 4 followers View post →
Hazel
@take_daily · X

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers https://t.co/TrxjCZjBlE

Apr 24, 2021 · 103 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers https://t.co/6UIQC1JRge

Apr 24, 2021 · 9 likes · 2 shares · 3,987 followers View post →
The Emerging Science of Microdosing: A Systematic Review of ...
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structure of an LSD-bound human serotonin receptor. Cell 168 (3), 377–389 e12. org/10.1186/s13063-021-05243-3. https://doi.org/ ...

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... 10.1186/s13063-021-05243-3. Kurzportrait. Geb. 26.02.1941 in Wien. Ausbildung: Studium der Medizin; Facharzt für Psychiatrie und Neurologie ...

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