Nutrients April 2021 PMID 33923589

Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans?

Peyman Rezaie, Vida Bitarafan, Michael Horowitz, Christine Feinle-Bisset

Mentions

16
Peak: 4 in Jul 2025
across 4 sources since Jun 2021

Extended reach

16,393
potential audience

Total likes

271

Video views

13,950

Mentions per month

Jun 2021 – Sep 2025

Where it's discussed

  • TikTok10 posts
  • Instagram3 posts
  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Several comments highlight the promising potential of bitter substances for health benefits, such as improving gut hormone responses, but also point out that these findings primarily come from preclinical studies, reflecting cautious optimism. Words like 'potential' and 'might help' demonstrate a balanced tone with some engagement and interest, without overstating the impact.

AgreementModerate agreement

Most discussions recognize the potential relevance of bitter substances' effects on GI function and metabolic health, with some emphasizing translational challenges.

InterestModerate interest

Participants show moderate curiosity, discussing topics like gut hormone release and dietary impacts, but not with high enthusiasm or urgency.

EngagementModerate engagement

The discussions include references to research processes, mechanisms, and implications, indicating active but moderate-level engagement.

ImpactNeutral impact

The overall tone suggests some awareness of clinical relevance but does not convincingly portray immediate or high-impact changes.

Abstract in brief

  • This text discusses how bitter substances found in plants can influence gastrointestinal (GI) functions, energy intake, and blood sugar levels, primarily based on preclinical studies.
  • It highlights the potential of these substances to stimulate gut hormone release, modify gut motility, reduce food intake, and lower post-meal blood glucose, suggesting possible benefits for obesity and type 2 diabetes management.
  • The article emphasizes the need to determine whether results from animal and cell studies translate effectively to humans and whether bitter substances can genuinely help in weight loss and blood sugar control in clinical settings.

Top posts

Most liked on X and Bluesky
KOJI@プライマルコーチ
@kojija · X

【苦みは植物毒】 苦みは多くの植物に含まれるがしばしば有毒 苦味を検出する能力は、主に毒素消費回避のために進化 苦味物質 →胃腸ホルモンの分泌を刺激 →胃腸の運動性を調節 カラダの異常への対処としては考えられるけど、異常がないカラダに入れる必要はあるのかな https://t.co/tssaj7Pe0l

Jun 12, 2021 · 3 likes · 2,314 followers View post →

All mentions

KOJI@プライマルコーチ
@kojija · X

【苦みは植物毒】 苦みは多くの植物に含まれるがしばしば有毒 苦味を検出する能力は、主に毒素消費回避のために進化 苦味物質 →胃腸ホルモンの分泌を刺激 →胃腸の運動性を調節 カラダの異常への対処としては考えられるけど、異常がないカラダに入れる必要はあるのかな https://t.co/tssaj7Pe0l

Jun 12, 2021 · 3 likes · 2,314 followers View post →
ra.joyful0 (@ra.joyful0) | TikTok
TikTok

Read doi:10.3390/nu13041317. This bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease. This is not medical advice and ...

Dec 18, 2025 View →
Receptores do sabor amargo não estão apenas na língua, mas sim ...
Instagram

... 10.3390/nu13041317 doi: 10.1016/j.molmet.2024.102002. doi: 10.5056 ... 10.3390/nu13041317 doi: 10.1016/j.molmet.2024.102002. doi ...

Sep 24, 2025 View →
Improve Gut Health with Natural Remedies and Diet Tips | TikTok
TikTok

Read doi:10.3390/nu13041317 This review is AIGC and is not intended to diagnose, treat, cure or prevent any disease. This is not medical advice ...

Sep 13, 2025 View →
The best way to get rid off puffy face!! #digestivehealth #herbalmedic ...
TikTok

Read doi:10.3390/nu13041317 This review is AIGC and is not intended to diagnose, treat, cure or prevent any disease. This is not medical advice ...

Sep 1, 2025 View →
Cuanto más lo tomo más me chupa! #soursop #digestion ...
TikTok

Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease.

Jul 20, 2025 View →
Por qué no se me ocurrió antes #hinchazonabdominal ...
TikTok

Read doi:10.3390/nu13041317 This bitter review is AIGC and is not ... Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter ...

Jul 9, 2025 View →
Remedio de Sandra Bullock para la distensión abdominal | TikTok
TikTok

Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease.

Jul 6, 2025 View →
#parati #fyp #hinchazonabdominal #womenshealth #estreñimiento ...
TikTok

Read doi:10.3390/nu13041317 This bitter review is AIGC and is not ... Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter ...

Jul 5, 2025 View →
Remedies for Bloating and Fatigue in Women | TikTok
TikTok

Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease.

Jun 16, 2025 View →
#womenshealth #holistichealth #soursop #liver #digestivehealth ...
TikTok

Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease.

Jun 12, 2025 View →
Quantas vezes meu pai foi mãe. Quantas vezes minha mãe foi pai ...
Instagram

doi: 10.3390/nu13041317 doi: 10.1016/j.molmet.2024.102002. doi: 10.5056/jnm15028. more. View all 4 comments. 1 day ago · leoborba12's profile ...

May 10, 2025 View →
#weightloss #bloodsugar #diabetes #oatmeal #nutrition #wellness ...
TikTok

Read doi:10.3390/nu13041317 This Serene Herbs Soursop bitter review is AIGC and is not intended to diagnose, treat, cure or prevent any disease.

Apr 16, 2025 View →
A caspa está associada à uma complicação da dermatite seborreica ...
Instagram

doi: 10.3390/nu13041317 doi: 10.1016/j.molmet.2024.102002. doi: 10.5056/jnm15028. more. View all 4 comments. 3 days ago · leoborba12's profile ...

Jan 21, 2025 View →