Genome Biol April 2021 PMID 33926517

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data.

Dongyuan Song, Jingyi Jessica Li

Mentions

67
Peak: 28 in May 2021
across 3 sources since Oct 2020

Extended reach

427,080
potential audience

Total likes

182

Video views

2,123

Mentions per month

Oct 2020 – Aug 2024

Where it's discussed

  • X / Twitter63 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Many discussions highlight the significance of PseudotimeDE, mentioning its improved power and reliability in gene expression analysis. Phrases like 'valid p-values' and 'inference uncertainty' indicate a technical appreciation and strong interest in the publication's methodology, while comments from researchers inquire about future uses and extensions, suggesting that they find the research highly relevant.

AgreementModerate agreement

The majority of discussions show positive responses to the methodology presented in the article, with many emphasizing its relevance in current research.

InterestHigh interest

Posts reflect a high level of interest in the PseudotimeDE method, as users inquire about different applications and implications.

EngagementModerate engagement

While engagement is moderate, several posters delve into technical aspects, demonstrating some level of thoughtful consideration.

ImpactHigh impact

Users perceive the publication as having a significant impact on the field of bioinformatics and gene expression research.

Abstract in brief

  • PseudotimeDE is a new method for identifying differentially expressed (DE) genes based on pseudotime derived from single-cell RNA sequencing data.
  • It addresses issues with current methods that do not account for uncertainty in pseudotime inference, often resulting in unreliable p-values.
  • Simulations and real data show that PseudotimeDE is better at controlling false discovery rates and has increased detection power compared to existing techniques.

Top posts

Most liked on X and Bluesky
Jingyi Jessica Li (李婧翌)
@jsb_ucla · X

Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It considers the uncertainty of pseudotime inference, yields valid p-values, and has high power. https://t.co/AJHuSn9P4w

Apr 29, 2021 · 64 likes · 16 shares · 3,135 followers View post →
Single Cell papers
@scell_papers · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/iZIhj6N9q5

Nov 18, 2020 · 26 likes · 5 shares · 11,502 followers View post →
antisense.
@razoralign · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/3hLQzqvNhK https://t.co/wW4YGiT6GR

May 3, 2021 · 16 likes · 3 shares · 15,946 followers View post →
Genome Biology
@GenomeBiology · X

PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotime data inferred from single cell RNA-seq. It estimates inference uncertainty using subsampling to give well-calibrated p-values https://t.co/0X6Rilclhc https://t.co/W88g43P2mY

Apr 30, 2021 · 13 likes · 9 shares · 89,996 followers View post →
bioRxiv
@biorxivpreprint · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/NkUq4rsRmZ #bioRxiv

Nov 18, 2020 · 6 likes · 1 share · 137,016 followers View post →
BioDecoded
@BioDecoded · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data | Genome Biology https://t.co/3Tzd8igiIF #Bioinformatics https://t.co/HacbHvDAEF

May 4, 2021 · 5 likes · 5 shares · 8,894 followers View post →

All mentions

Yiling Chen
@yiling0210 · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

Jun 4, 2021 · 9 shares · 37 followers View post →
Samuel Marsh, Ph.D.
@samuel_marsh · X

@AlbertVilella @satijalab @LGMartelotto @hoheyn Also emerging pseudotime/trajectory DE methods: PseudotimeDE https://t.co/OkCpKYCjmE and others (not comprehensive): https://t.co/zZL9OWVbBv

Jun 3, 2021 · 2 likes · 1,848 followers View post →
Jingyi Jessica Li (李婧翌)
@jsb_ucla · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

May 26, 2021 · 9 shares · 3,135 followers View post →
@dmcg@genomic.social
@David_McGaughey · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 16, 2021 · 16 shares · 995 followers View post →
Alex Stockinger
@alexwstockinger · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 16, 2021 · 16 shares · 433 followers View post →
Florian Halbritter
@cancerbits · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 16, 2021 · 16 shares · 296 followers View post →
Yungang Xu (徐云刚)
@YungangXu · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 16, 2021 · 16 shares · 338 followers View post →
David Cook
@DavidPCook · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 1,441 followers View post →
Julien Limenitakis
@jlimenitakis · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 346 followers View post →
Ahmet F. Coskun
@ahmetfcoskun · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 1,622 followers View post →
Hong Qin
@hongqin · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 1,234 followers View post →
Alex Chamessian
@achamess · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 2,741 followers View post →
David Meyer
@Meyer_DH · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 1,245 followers View post →
Aman Ullah, PhD
@Amankhawajaa · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 2,155 followers View post →
Dylan Rausch
@dylanrausch · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

May 15, 2021 · 16 shares · 531 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @ajpbp_AME: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell…

May 4, 2021 · 1 share · 3,832 followers View post →
American J of Physiology,Biochemistry&Pharmacology
@ajpbp_AME · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data | Genome Biology https://t.co/FrcBbRxBCq https://t.co/H0qjQ2dmiA

May 4, 2021 · 1 share · 86 followers View post →
Empire of Atheism, Government of Science, Military
@EscherZen · X

RT @BioDecoded: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 4, 2021 · 5 shares · 179 followers View post →
رحابام
@Rehabiamu · X

RT @BioDecoded: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 4, 2021 · 5 shares · 252 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @BioDecoded: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 4, 2021 · 5 shares · 3,832 followers View post →
Invictus Samael
@InvictusSamael · X

RT @BioDecoded: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 4, 2021 · 5 shares · 660 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @BioDecoded: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 4, 2021 · 5 shares · 2,761 followers View post →
BioDecoded
@BioDecoded · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data | Genome Biology https://t.co/3Tzd8igiIF #Bioinformatics https://t.co/HacbHvDAEF

May 4, 2021 · 5 likes · 5 shares · 8,894 followers View post →
Cristian Padron
@Cristia58755362 · X

RT @razoralign: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 3, 2021 · 3 shares View post →
Deanne Taylor
@CellModel · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

May 3, 2021 · 9 shares · 528 followers View post →
The Single-Cell Ninjas
@Sc_Ninjas · X

RT @razoralign: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 3, 2021 · 3 shares · 6,296 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @razoralign: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cel…

May 3, 2021 · 3 shares · 3,832 followers View post →
antisense.
@razoralign · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/3hLQzqvNhK https://t.co/wW4YGiT6GR

May 3, 2021 · 16 likes · 3 shares · 15,946 followers View post →
KyloCrypto
@KyloCrypto · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

May 1, 2021 · 9 shares · 7 followers View post →
Hamim Zafar
@Quasarzafar · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

May 1, 2021 · 9 shares · 552 followers View post →
Saubashya Sur, PhD
@SaubashyaSur · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

Apr 30, 2021 · 9 shares · 770 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @sc_papers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell…

Apr 30, 2021 · 1 share · 3,832 followers View post →
single cell papers
@sc_papers · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/JUQYPTGvvZ https://t.co/34uvX3IPi6

Apr 30, 2021 · 2 likes · 1 share · 305 followers View post →
Eric Minwei Liu
@EricM_Liu · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

Apr 30, 2021 · 9 shares · 932 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

Apr 30, 2021 · 9 shares · 3,832 followers View post →
Maksim Nesterenko
@linux_maxima · X

RT @GenomeBiology: PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotim…

Apr 30, 2021 · 9 shares · 95 followers View post →
Genome Biology
@GenomeBiology · X

PseudotimeDE, from @SongDongyuan & @jsb_ucla , is a method for determining differentially expressed genes from pseudotime data inferred from single cell RNA-seq. It estimates inference uncertainty using subsampling to give well-calibrated p-values https://t.co/0X6Rilclhc https://t.co/W88g43P2mY

Apr 30, 2021 · 13 likes · 9 shares · 89,996 followers View post →
Wenyi Wang
@WenyiWang4 · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

Apr 30, 2021 · 16 shares · 556 followers View post →
Qian Cheng
@sgqcheng · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

Apr 30, 2021 · 16 shares · 604 followers View post →
Xuhang (Hang) Li
@Xuhang_Li · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

Apr 30, 2021 · 16 shares · 334 followers View post →
sciencepapers
@science_papers · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/7vV5Wnax5A

Apr 30, 2021 · 7 followers View post →
Fanglue Peng
@FanglueP · X

RT @jsb_ucla: Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It c…

Apr 29, 2021 · 16 shares · 176 followers View post →
Jingyi Jessica Li (李婧翌)
@jsb_ucla · X

Our new method PseudotimeDE developed by @SongDongyuan infers differentially expressed (DE) genes along cell pseudotime. It considers the uncertainty of pseudotime inference, yields valid p-values, and has high power. https://t.co/AJHuSn9P4w

Apr 29, 2021 · 64 likes · 16 shares · 3,135 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @CompBiolPapers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single…

Apr 23, 2021 · 1 share · 3,832 followers View post →
CompBiolPapers
@CompBiolPapers · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data [NEW RESULTS] https://t.co/YJkm24Nyb4

Apr 23, 2021 · 1 share · 1,780 followers View post →
Jorge “Coco” Del-Aguila
@Coco_Lucho2 · X

RT @scRNAtools: New tool: PseudotimeDE Inference of differential gene expression along cell pseudotime with well-calibrated p-values from…

Nov 22, 2020 · 1 share · 117 followers View post →
scRNA-tools.org
@scRNAtools · X

New tool: PseudotimeDE Inference of differential gene expression along cell pseudotime with well-calibrated p-values from scRNA-seq https://t.co/AWdwz65d4G

Nov 22, 2020 · 1 like · 1 share · 2,656 followers View post →
Faye
@Faye_Fei_Chang · X

RT @scell_papers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-c…

Nov 19, 2020 · 5 shares · 5 followers View post →
David Cook
@DavidPCook · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data. https://t.co/MKxaLWcesg

Nov 19, 2020 · 5 likes · 1,441 followers View post →
antisense.
@razoralign · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/wDKIpx7ia8

Nov 19, 2020 · 1 like · 15,946 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data #bioinfo https://t.co/SQdq6h4aLV

Nov 19, 2020 · 609 followers View post →
Ming "Tommy" Tang
@tangming2005 · X

RT @scell_papers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-c…

Nov 18, 2020 · 5 shares · 41,050 followers View post →
川田健太郎@産総研
@KawataKentaro · X

RT @scell_papers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-c…

Nov 18, 2020 · 5 shares · 139 followers View post →
Wenhao
@twh112358 · X

RT @scell_papers: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-c…

Nov 18, 2020 · 5 shares · 26 followers View post →
Single Cell papers
@scell_papers · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/iZIhj6N9q5

Nov 18, 2020 · 26 likes · 5 shares · 11,502 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @biorxiv_bioinfo: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from singl…

Nov 18, 2020 · 1 share · 3,832 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @biorxivpreprint: PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from singl…

Nov 18, 2020 · 1 share · 3,832 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA ... https://t.co/rOHCTCG0oa #biorxiv_bioinfo

Nov 18, 2020 · 2 likes · 1 share · 18,098 followers View post →
bioRxiv
@biorxivpreprint · X

PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/NkUq4rsRmZ #bioRxiv

Nov 18, 2020 · 6 likes · 1 share · 137,016 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @CMO_oaxaca: Dongyuang Song (UCLA), PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p…

Nov 16, 2020 · 2 shares · 3,832 followers View post →
BIRS
@BIRS_Math · X

RT @CMO_oaxaca: Dongyuang Song (UCLA), PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p…

Nov 16, 2020 · 2 shares · 5,711 followers View post →
Casa Matemática Oax
@CMO_oaxaca · X

Dongyuang Song (UCLA), PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data https://t.co/dhTYy3Cyn6

Nov 16, 2020 · 1 like · 2 shares · 922 followers View post →
UCLA QCBio
@UCLAQCBio · X

Dongyuan will be giving a talk in Comp. Genetics & Genomics at 11am PDT. Title: PseudotimeDE: inference of differential gene expression along cell pseudotime with valid p-values https://t.co/uBS6gOIIJ8

Oct 12, 2020 · 1,090 followers View post →