October 2021 PMID 33963431

Long-term fasting improves lipoprotein-associated atherogenic risk in humans.

Franziska Grundler, Dietmar Plonné, Robin Mesnage, Diethard Müller, Cesare R Sirtori, Massimiliano Ruscica, Françoise Wilhelmi de Toledo

Mentions

44
Peak: 32 in May 2021
across 2 sources since May 2021

Extended reach

392,823
potential audience

Total likes

3,394

Video views

91,871

Mentions per month

May 2021 – Aug 2024

Where it's discussed

  • X / Twitter42 posts
  • YouTube2 videos

AI synopsis

What people are saying

The collective discussions demonstrate a strong interest in the effects of long-term fasting on lipid profiles, with posts highlighting key findings like decreases in harmful lipoproteins and changes specific to lipoprotein subclasses. The tone varies from cautious optimism to curiosity, with some users referencing the study's implications for cardiovascular health and others questioning the detailed mechanisms, which reflect a recognition of the study's potential importance but also a need for further validation.

AgreementModerate agreement

Most discussions seem to acknowledge the findings, although some express cautious optimism or note the need for further research, indicating general support or tentative agreement.

InterestHigh interest

Posts show high curiosity about long-term fasting and its effects, with multiple commenters asking about extended fasting periods and commenting on the significance of the findings.

EngagementModerate engagement

Many posts reference specific details from the publication, such as lipoprotein profiles and cardiovascular risk, demonstrating some level of detailed analysis and reflection.

ImpactModerate impact

While some believe the study could influence health practices, there is also recognition that more evidence is needed, hence a moderate perception of impact with acknowledgment of its potential significance.

Abstract in brief

  • Long-term fasting for 14 days leads to significant improvements in lipid profiles by reducing harmful lipoprotein levels and changing their subclasses, which may lower cardiovascular risk.
  • The study observed decreases in triglycerides, VLDL, LDL cholesterol, and various LDL subclasses, along with changes in lipoprotein particle sizes, indicating a less atherogenic profile.
  • While some HDL levels decreased overall, the large HDL particles increased, and inflammatory markers remained unchanged, suggesting fasting may beneficially modify lipid-related cardiovascular risk factors.

Top posts

Most liked on X and Bluesky
Larronde Esteban
@EstebanDL · X

¿Qué pasa con algunas variables después de 14 días de ayuno? https://t.co/dfX8gygPAp Observacional 40 pacientes https://t.co/hhP5rJdb53

May 9, 2021 · 44 likes · 4 shares · 23,851 followers View post →
J P Fanton
@HealthyFellow · X

Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_ @_INPST @ScienceCommuni2 @PharmacistPaleo @nicknorwitz @FoodLiesOrg @Travis_Statham @livinlowcarbman @drjasonfung @RDValerie @bschermd @kojija @IntegrityHealth

May 7, 2021 · 31 likes · 11 shares · 26,013 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

May 11, 2021 · 18 likes · 4 shares · 9,737 followers View post →
Sam Tsimikas, MD
@Lpa_Doc · X

We have lots to learn about fasting and lipids, see latest paper showing increase in Lp(a), and apoB, with low caloric diet. Note Lp(a) goes opposite LDL-C. I would been interesting to see if @OxPL_apoB ⬇️like in obesity surgery https://t.co/mQSStMvISb https://t.co/5vDb5KCb8m https://t.co/vKBmCiXQz7

May 12, 2021 · 13 likes · 3 shares · 14,477 followers View post →
Live Vitae
@livevitaeuk · X

Any 14-day fasters takers? https://t.co/x6srvSzDMn

Jan 1, 2023 · 3 likes · 1 share · 13,060 followers View post →
Robin Mesnage
@Robin_Mesnage · X

Happy to announce the publication of our new study on long-term #fasting at the Buchinger Wilhelmi clinic, impact on lipoprotein profiles measured with @MassiRuscica was enormous, suggesting a reduction in cardiovascular risks https://t.co/KQFbuFxnQf

May 8, 2021 · 3 likes · 2 shares · 1,465 followers View post →

All mentions

Robin Mesnage
@Robin_Mesnage · X

We initially found in our other studies a decrease in HDL during fasting somewhat concerning for our patients because HDL is often referred to as "good cholesterol” Our 2021 paper: https://t.co/thBCIvtnfm However, our new study revealed that this decrease is only temporary. A

Aug 7, 2024 · 1 like · 1,465 followers View post →
Yelena Citor
@YCitor · X

RT @mike_lustgarten: Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

Sep 11, 2023 · 4 shares · 86 followers View post →
DANM.
@MrDanDan77 · X

@the_godis 200 קלוריות ביום+שילוב של פעולות אקטיביות בעצימות נמוכה למשך 10 יום צום. https://t.co/Lf8zAx0d5e 250 קלוריות ביום, 14 יום https://t.co/KfPePhralM https://t.co/7mOSzfPzFT

Feb 16, 2023 · 1,955 followers View post →
Marlon Torres
@morritomtv · X

RT @livevitaeuk: Any 14-day fasters takers? https://t.co/x6srvSzDMn

Jan 3, 2023 · 1 share · 84 followers View post →
Live Vitae
@livevitaeuk · X

Any 14-day fasters takers? https://t.co/x6srvSzDMn

Jan 1, 2023 · 3 likes · 1 share · 13,060 followers View post →
Tellit Likeitis
@Tellit007 · X

@kyle_tengler @garytaubes @bschermd Yes, 10 folks were studied and only for 5 days. Longer-term fasting in 40 folks for 14+ days showed opposite. https://t.co/nHFfrNA1k3

Dec 26, 2022 · 1 like · 149 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/TMKBEKlX9O

Sep 23, 2022 · 1 share · 3,154 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/TMKBEKlX9O

Sep 23, 2022 · 1 share · 3,154 followers View post →
Robin Mesnage
@Robin_Mesnage · X

We tried to understand changes looking at lipoprotein profiles in details but I don't think this explains this discrepancy https://t.co/thBCIvtnfm

Sep 19, 2022 · 1,465 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@tomp729 @ethanjweiss this one looked at a LONG fasting period (14d). no difference in ApoB https://t.co/5zj06k0AIF observational though you see my point. fact-check claims. whatever the data shows. maybe there are others with larger effects (?). ask for the evidence. ignore story-telling

Jan 19, 2022 · 1 like · 28,059 followers View post →
alephh
@alephh · X

14 days of 250 kcal/day — Significant fall in HDL-C (− 0.16 mmol/L) but concentration in large HDL particles up — Significant reduction in large (−244.13 nmol/L) & small LDL (−38.45 nmol/L) — Unchanged: Apolipoprotein B, lipoprotein(a), fibrinogen, CRP https://t.co/hpG8ki317m https://t.co/v2pbeLxiGT

May 17, 2021 · 389 followers View post →
Ravi Kamepalli
@woundphysician · X

https://t.co/zAPPU3LPgB fasting improves lipoprotein levels and lipoprotein subclasses and ameliorates the lipoprotein-associated atherogenic risk profile, suggesting a reduction in the cardiovascular risk linked to dyslipidemia. #removingbarrierstohealing #obesity @drjasonfung

May 14, 2021 · 1,470 followers View post →
Jose Puentes
@JossePuentes · X

RT @Lpa_Doc: We have lots to learn about fasting and lipids, see latest paper showing increase in Lp(a), and apoB, with low caloric diet. N…

May 12, 2021 · 3 shares · 353 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @Lpa_Doc: We have lots to learn about fasting and lipids, see latest paper showing increase in Lp(a), and apoB, with low caloric diet. N…

May 12, 2021 · 3 shares · 1,365 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @Lpa_Doc: We have lots to learn about fasting and lipids, see latest paper showing increase in Lp(a), and apoB, with low caloric diet. N…

May 12, 2021 · 3 shares · 1,639 followers View post →
Sam Tsimikas, MD
@Lpa_Doc · X

We have lots to learn about fasting and lipids, see latest paper showing increase in Lp(a), and apoB, with low caloric diet. Note Lp(a) goes opposite LDL-C. I would been interesting to see if @OxPL_apoB ⬇️like in obesity surgery https://t.co/mQSStMvISb https://t.co/5vDb5KCb8m https://t.co/vKBmCiXQz7

May 12, 2021 · 13 likes · 3 shares · 14,477 followers View post →
Orlando_uy
@Orlando_uy · X

RT @mike_lustgarten: Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

May 11, 2021 · 4 shares · 694 followers View post →
Orest Bulcano
@dekentro · X

RT @mike_lustgarten: Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

May 11, 2021 · 4 shares · 1,039 followers View post →
AgingResearch
@TheAgingField · X

RT @mike_lustgarten: Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

May 11, 2021 · 4 shares · 5,261 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Long-term fasting improves lipoprotein-associated atherogenic risk in humans https://t.co/hFwhOIiiIR

May 11, 2021 · 18 likes · 4 shares · 9,737 followers View post →
Dola Sinha
@DolaSinha8 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 11, 2021 · 11 shares · 2 followers View post →
Urology of Virginia
@UrologyofVA · X

Long-term fasting improves lipoprotein-associated atherogenic risk in humans #healthyliving https://t.co/tgtodWd64I

May 10, 2021 · 1 like · 1 share · 750 followers View post →
Rocio Rocio Jibla
@RSRGIBLA · X

RT @EstebanDL: ¿Qué pasa con algunas variables después de 14 días de ayuno? https://t.co/dfX8gygPAp Observacional 40 pacientes https://t.c…

May 10, 2021 · 4 shares · 77 followers View post →
My Spine Relief
@myspinerelief · X

Long-term fasting improves lipoprotein-associated atherogenic risk in humans #healthyliving https://t.co/dCr2EjgaSe

May 10, 2021 · 1 like · 10 followers View post →
Crazy for health food
@Crazyforhealth1 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 10, 2021 · 11 shares · 33 followers View post →
Sergio Zapata
@serzaparin · X

RT @EstebanDL: ¿Qué pasa con algunas variables después de 14 días de ayuno? https://t.co/dfX8gygPAp Observacional 40 pacientes https://t.c…

May 9, 2021 · 4 shares · 312 followers View post →
F.Yusufzai
@obsurfer84 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 9, 2021 · 11 shares · 295 followers View post →
Joan Franco
@joanulloa1 · X

RT @EstebanDL: ¿Qué pasa con algunas variables después de 14 días de ayuno? https://t.co/dfX8gygPAp Observacional 40 pacientes https://t.c…

May 9, 2021 · 4 shares · 319 followers View post →
Larronde Esteban
@EstebanDL · X

¿Qué pasa con algunas variables después de 14 días de ayuno? https://t.co/dfX8gygPAp Observacional 40 pacientes https://t.co/hhP5rJdb53

May 9, 2021 · 44 likes · 4 shares · 23,851 followers View post →
Monika Mesnage
@monika_mesnage · X

RT @Robin_Mesnage: Happy to announce the publication of our new study on long-term #fasting at the Buchinger Wilhelmi clinic, impact on lip…

May 9, 2021 · 2 shares · 143 followers View post →
Ronita De, PhD
@dronita_de · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 9, 2021 · 11 shares · 1,511 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 124,312 followers View post →
KOJI@プライマルコーチ
@kojija · X

【断食とコレステロール】 40名が250kcal/日の断食を14日間 蜂蜜20g + フルーツジュース250ml 中性脂肪とコレステロールの大幅な低下 糖質は摂らない方が精神的に安定して断食できるのですけどね https://t.co/4msCTh07xD https://t.co/qShjOdpiGk https://t.co/3pCuhPyMXN

May 8, 2021 · 2 likes · 2,313 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 2,887 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 10,280 followers View post →
Massimiliano Ruscica
@MassiRuscica · X

RT @Robin_Mesnage: Happy to announce the publication of our new study on long-term #fasting at the Buchinger Wilhelmi clinic, impact on lip…

May 8, 2021 · 2 shares · 165 followers View post →
Robin Mesnage
@Robin_Mesnage · X

Happy to announce the publication of our new study on long-term #fasting at the Buchinger Wilhelmi clinic, impact on lipoprotein profiles measured with @MassiRuscica was enormous, suggesting a reduction in cardiovascular risks https://t.co/KQFbuFxnQf

May 8, 2021 · 3 likes · 2 shares · 1,465 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 632 followers View post →
AgingResearch
@TheAgingField · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 5,261 followers View post →
Beau Ned Wels
@BNWels · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 91 followers View post →
DiscoStew
@DiscoStew66 · X

RT @HealthyFellow: Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_…

May 8, 2021 · 11 shares · 10,794 followers View post →
J P Fanton
@HealthyFellow · X

Long-term #fasting improves #lipoprotein-associated #atherogenic risk in humans https://t.co/koAdaul4We Attn: @_atanas_ @_INPST @ScienceCommuni2 @PharmacistPaleo @nicknorwitz @FoodLiesOrg @Travis_Statham @livinlowcarbman @drjasonfung @RDValerie @bschermd @kojija @IntegrityHealth

May 7, 2021 · 31 likes · 11 shares · 26,013 followers View post →