J Am Acad Dermatol March 2022 PMID 34044102

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement.

Celina Dubin, Jacob W Glickman, Ester Del Duca, Sumanth Chennareddy, Joseph Han, Dante Dahabreh, Yeriel D Estrada, Ning Zhang, Grace W Kimmel, Giselle Singer, Mashkura Chowdhury, Andrew Y Zheng, Michael Angelov, Jesús Gay-Mimbrera, Juan Ruano Ruiz

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Mentions

13
Peak: 6 in Mar 2022
across 3 sources since May 2021

Extended reach

73,574
potential audience

Total likes

111

Video views

5,870

Mentions per month

May 2021 – Dec 2025

Where it's discussed

  • X / Twitter8 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions predominantly reflect strong interest and support, evident through mentions of the study’s detailed immune and fibrosis profiling and potential for treatment strategies, such as targeting the JAK-STAT pathway. Words like 'latest research' and 'reveals' suggest a tone of scientific curiosity and optimism, while references to treatment implications indicate recognition of significant practical impact.

AgreementModerate agreement

Most discussions acknowledge and support the importance of the study, highlighting its scientific contributions.

InterestHigh interest

The majority find the research highly relevant, especially those focused on hair loss and autoimmune mechanisms.

EngagementModerate engagement

Participants show moderate engagement, discussing methodologies and potential implications without in-depth critique.

ImpactModerate impact

The findings are viewed as potentially impactful, informing future treatments and understanding of FFA.

Abstract in brief

  • The study found that frontal fibrosing alopecia (FFA) is primarily an inflammatory scalp condition involving immune system dysregulation, particularly with Th1 and JAK-STAT pathways, leading to scarring and fibrosis without affecting the rest of the body.
  • Researchers identified specific genes and biomarkers related to immune activation and fibrosis in scalp tissue, such as CXCL9, CXCL10, FOXP3, and TGFB1, which correlate with disease severity.
  • The findings suggest that targeting the JAK-STAT pathway could be a potential treatment approach for FFA, as the disease shows signs of being reversible through inhibition of this immune signaling pathway.]

Top posts

Most liked on X and Bluesky
JAAD Journals
@JAADjournals · X

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement https://t.co/eTbCXk6jHe https://t.co/hsmWhHSxOB

Mar 4, 2022 · 7 likes · 2 shares · 18,616 followers View post →
Dr. Jeff Donovan,
@DonovanMedical · X

This week’s Evidence Based Hair podcast addresses the latest research in scarring alopecia from the past 1-2 months. I’ll be reviewing 3 studies in FFA, 2 in LPP, 2 in CCCA and 1 in FD. https://t.co/60PoiNK9a2 #scarringalopecia

Mar 21, 2022 · 3 likes · 1 share · 3,482 followers View post →
Public Health Bulletin
@BulletinPublic · X

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement. https://t.co/MxojDXhrKH

Jun 4, 2021 · 1 like · 19 followers View post →
Dr. Sergio Vañó
@SergioVanoG · X

RT @JAADjournals: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic…

Mar 4, 2022 · 2 shares · 35,131 followers View post →
José R. Ribeiro
@JoseRodRibeiro · X

RT @RevPortPneumol: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemi…

Jun 12, 2021 · 1 share · 9,295 followers View post →
Lt Col MD David Perez-Meza FISHRS ABHRS
@drdaviperezmeza · X

RT @JAADjournals: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic…

Mar 4, 2022 · 2 shares · 858 followers View post →

All mentions

Duffy Moon Design
@duffymoondesign · X

RT @DonovanMedical: This week’s Evidence Based Hair podcast addresses the latest research in scarring alopecia from the past 1-2 months. I’…

Mar 21, 2022 · 1 share View post →
Dr. Jeff Donovan,
@DonovanMedical · X

This week’s Evidence Based Hair podcast addresses the latest research in scarring alopecia from the past 1-2 months. I’ll be reviewing 3 studies in FFA, 2 in LPP, 2 in CCCA and 1 in FD. https://t.co/60PoiNK9a2 #scarringalopecia

Mar 21, 2022 · 3 likes · 1 share · 3,482 followers View post →
Lt Col MD David Perez-Meza FISHRS ABHRS
@drdaviperezmeza · X

RT @JAADjournals: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic…

Mar 4, 2022 · 2 shares · 858 followers View post →
Dr. Sergio Vañó
@SergioVanoG · X

RT @JAADjournals: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic…

Mar 4, 2022 · 2 shares · 35,131 followers View post →
JAAD Journals
@JAADjournals · X

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement https://t.co/eTbCXk6jHe https://t.co/hsmWhHSxOB

Mar 4, 2022 · 7 likes · 2 shares · 18,616 followers View post →
José R. Ribeiro
@JoseRodRibeiro · X

RT @RevPortPneumol: Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemi…

Jun 12, 2021 · 1 share · 9,295 followers View post →
Public Health Bulletin
@BulletinPublic · X

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement. https://t.co/MxojDXhrKH

Jun 4, 2021 · 1 like · 19 followers View post →
Pulmonology
@RevPortPneumol · X

Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement https://t.co/m203KEmbKl

May 28, 2021 · 1 share · 254 followers View post →
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Feb 28, 2022 View →