Sex Med August 2021 PMID 34090245

The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy.

Nahid Punjani, Helen Bernie, Carolyn Salter, Jose Flores, Nicole Benfante, John P Mulhall

Mentions

6
Peak: 2 in Mar 2022
across 2 sources since Mar 2022

Extended reach

12,480
potential audience

Total likes

81

Video views

1,680

Mentions per month

Mar 2022 – Mar 2025

Where it's discussed

  • X / Twitter5 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions show a balanced acknowledgment of the article's findings, with examples like comments on the importance of E2 monitoring and treatment thresholds (e.g., E2 > 65), along with mentions of limiting polypharmacy and titrating medication. The tone combines professional insights and personal clinical practices, emphasizing the relevance and potential impact of the research on individualized patient care.

AgreementModerate agreement

Most discussions acknowledge the importance of monitoring E2 levels in men undergoing testosterone therapy and support the use of aromatase inhibitors in specific cases.

InterestHigh interest

People demonstrate high interest due to the clinical relevance, referencing thresholds and treatment approaches for elevated E2 levels.

EngagementModerate engagement

Participants actively share their practices and opinions, indicating meaningful engagement with the research findings.

ImpactModerate impact

The discussions reflect an awareness of the potential influence on clinical decision-making, although mostly from a practitioner perspective.

Abstract in brief

  • The study investigates how aromatase inhibitor therapy, specifically anastrozole (AZ), affects men with elevated estradiol (E2) levels on testosterone therapy (TTH), aiming to reduce E2 levels while maintaining testosterone levels.
  • Among 1708 men on TTH, 44 with high E2 levels received AZ; results showed a significant decrease in E2 levels post-treatment without changing total testosterone, but no clear predictors of who responds best to AZ therapy were identified.
  • The research highlights that AZ can effectively lower E2 in men on TTH, although factors predicting response remain unclear, indicating a need for further studies to optimize treatment strategies.]

Top posts

Most liked on X and Bluesky
Helen L. Bernie
@drhelenbernie · X

@AmyPearlman1 @alextatem @DrDenise_ @clavelluro @DrTomMasterson I check E2 w every lab check on all my T pts. I do NOT always treat elevated E2 if asymptomatic. I also try to titrate off anastrozole & limit polypharmacy when I can. E2 is IMP for men & women. My threshold for tx is E2 >65. We published on this https://t.co/YtLfHOBAGt

Mar 16, 2022 · 9 likes · 1 share · 5,225 followers View post →
Helen L. Bernie
@drhelenbernie · X

@kjdelay1 @mjziegelmann @SexHealthMD @alextatem @drrachelrubin @AshleyGWinter @JaredLMossMD @SPuro88 @PBajicMD @AmyPearlman1 @clavelluro I RARELY prescribe Anastrazole. I also try to titrate off anastrozole & limit polypharmacy when I can (⬇️T dosing) E2 is IMP for men & women! I also dont treat elevated E2 if asymptomatic. My threshold for tx is E2 >65 or symptomatic. We published on this https://t.co/YtLfHOBAGt

Apr 19, 2022 · 3 likes · 1 share · 5,225 followers View post →
Hill_D*A-PP-APRN*
@hbdursty · X

RT @drhelenbernie: @kjdelay1 @mjziegelmann @SexHealthMD @alextatem @drrachelrubin @AshleyGWinter @JaredLMossMD @SPuro88 @PBajicMD @AmyPearl…

Apr 21, 2022 · 1 share · 130 followers View post →
Hill_D*A-PP-APRN*
@hbdursty · X

RT @drhelenbernie: @AmyPearlman1 @alextatem @DrDenise_ @clavelluro @DrTomMasterson I check E2 w every lab check on all my T pts. I do NOT a…

Mar 19, 2022 · 1 share · 130 followers View post →

All mentions

SouthSuperman
@SouthSuperman · X

@christopher_erc @antidoc32 No, the basis of the study is in the title "The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy" Metabolic issues or not, E2 levels can elevate on standard TRT. So your supposition "No one on TRT needs an AI.

Jan 24, 2025 · 82 followers View post →
Hill_D*A-PP-APRN*
@hbdursty · X

RT @drhelenbernie: @kjdelay1 @mjziegelmann @SexHealthMD @alextatem @drrachelrubin @AshleyGWinter @JaredLMossMD @SPuro88 @PBajicMD @AmyPearl…

Apr 21, 2022 · 1 share · 130 followers View post →
Helen L. Bernie
@drhelenbernie · X

@kjdelay1 @mjziegelmann @SexHealthMD @alextatem @drrachelrubin @AshleyGWinter @JaredLMossMD @SPuro88 @PBajicMD @AmyPearlman1 @clavelluro I RARELY prescribe Anastrazole. I also try to titrate off anastrozole & limit polypharmacy when I can (⬇️T dosing) E2 is IMP for men & women! I also dont treat elevated E2 if asymptomatic. My threshold for tx is E2 >65 or symptomatic. We published on this https://t.co/YtLfHOBAGt

Apr 19, 2022 · 3 likes · 1 share · 5,225 followers View post →
Hill_D*A-PP-APRN*
@hbdursty · X

RT @drhelenbernie: @AmyPearlman1 @alextatem @DrDenise_ @clavelluro @DrTomMasterson I check E2 w every lab check on all my T pts. I do NOT a…

Mar 19, 2022 · 1 share · 130 followers View post →
Helen L. Bernie
@drhelenbernie · X

@AmyPearlman1 @alextatem @DrDenise_ @clavelluro @DrTomMasterson I check E2 w every lab check on all my T pts. I do NOT always treat elevated E2 if asymptomatic. I also try to titrate off anastrozole & limit polypharmacy when I can. E2 is IMP for men & women. My threshold for tx is E2 >65. We published on this https://t.co/YtLfHOBAGt

Mar 16, 2022 · 9 likes · 1 share · 5,225 followers View post →