PubHawk
January 2022 PMID 34093436

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease.

Julian M Gaitán, Hyo Youl Moon, Matthew Stremlau, Dena B Dubal, Dane B Cook, Ozioma C Okonkwo, Henriette van Praag

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Mentions

58
Peak: 13 in Jun 2021
across 4 sources since May 2021

Extended reach

256,621
potential audience

Total likes

2,615

Video views

105,176

Mentions per month

May 2021 – Dec 2024

Where it's discussed

  • News32 articles
  • X / Twitter21 posts
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

Several discussions praise the study by referring to 'increased levels of PUFAs' and 'reduction in harmful lipids,' illustrating thorough engagement with the research details. The tone is optimistic, emphasizing potential for prevention and intervention, which underscores the high interest and perceived importance of the findings.

AgreementStrong agreement

Most discussions highlight the positive effects of aerobic exercise on biomarkers and cognition, agreeing with the study's conclusions.

InterestHigh interest

The discussions demonstrate high interest, emphasizing terms like 'delays,' 'protective,' and 'significant,' showing enthusiasm for the findings.

EngagementHigh engagement

Postings include references to specific biomarkers and implications for Alzheimer's prevention, indicating deep engagement and analysis.

ImpactHigh impact

The discussions suggest the research could influence future approaches to Alzheimer's prevention and health recommendations, showing high perceived impact.

Abstract in brief

  • This study shows that 26 weeks of treadmill exercise increases a blood marker called Cathepsin B (CTSB), which is linked to better cognitive performance in middle-aged adults at risk for Alzheimer's, while brain-derived neurotrophic factor (BDNF) levels decrease and Klotho remains unchanged.
  • Exercise also causes metabolic changes, such as elevated polyunsaturated fatty acids and reduced harmful lipids, alongside alterations in gut microbiome metabolites, all of which are associated with brain health.
  • The findings suggest CTSB could serve as a biomarker for cognitive improvement due to exercise, and overall, physical activity appears to positively influence brain function by affecting specific blood markers and metabolic processes.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Julia B.
@JuliaB_fitness · X

@foundmyfitness «Metabolomic analysis revealed increased levels of PUFAs (including DHA) & lysophospholipids and reductions in ceramides, sphingo and phospholipids.» https://t.co/G69TyyXz26

Jun 29, 2021 · 10 likes · 2,270 followers View post →
Agingdoc
@agingdoc1 · X

Frontiers | Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease https://t.co/eGdhl5GR3S

Jun 29, 2021 · 6 likes · 41,913 followers View post →
Scott Lear, PhD
@DrScottLear · X

Regular #exercise in older adults at risk for #Alzheimers diseaseimproved biomarker associated with cognition @frontiersin : https://t.co/7QRGMP9tBq #brainhealth https://t.co/gmUCagAyVD

Jul 3, 2021 · 6 likes · 1 share · 3,033 followers View post →
Health Action Research Group
@HealthAction_UK · X

There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's #Alzheimers. Here's the latest study - https://t.co/783RLH04Ok #preventionbeatscure https://t.co/9lxLVoXXO0

Jun 22, 2021 · 5 likes · 4 shares · 302 followers View post →
Agingdoc
@agingdoc1 · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease https://t.co/gIULihTPfg @FrontiersIn

Jun 10, 2021 · 3 likes · 41,913 followers View post →
Maurício Lima
@dj_surfista · X

Efeitos do treinamento físico aeróbio sobre biomarcadores sistêmicos e cognição em adultos de meia-idade com risco de doença de #Alzheimer. https://t.co/oWUSLzuILm

Jul 27, 2021 · 2 likes · 740 followers View post →

All mentions

Roger Hilfiker
@RogerHilfiker · X

Effect of eccentric and concentric contraction mode on myogenic regulatory factors expression in human vastus lateralis muscle https://t.co/qUyFvl4RsA

May 26, 2022 · 1,618 followers View post →
Agingdoc
@agingdoc1 · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease (2021) https://t.co/eGdhl5GR3S

Apr 20, 2022 · 1 like · 41,913 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Memory biomarkers confirm aerobic exercise helps cognitive function in older adults https://t.co/ha50rFqJkE https://t.co/2Ag61NDYRL https://t.co/qOqfA2ds2y

Aug 29, 2021 · 93 followers View post →
Science For Fitness
@scienceforfit · X

A protective marker for dementia and Alzheimer’s can now be measured systemically after 26 weeks of aerobic exercise in late middle-aged adults with no cognitive symptoms. https://t.co/1ExUNnFNyA

Jul 27, 2021 · 1 like · 212 followers View post →
Maurício Lima
@dj_surfista · X

Efeitos do treinamento físico aeróbio sobre biomarcadores sistêmicos e cognição em adultos de meia-idade com risco de doença de #Alzheimer. https://t.co/oWUSLzuILm

Jul 27, 2021 · 2 likes · 740 followers View post →
Memory Health
@memory_health · X

RT @DrScottLear: Regular #exercise in older adults at risk for #Alzheimers diseaseimproved biomarker associated with cognition @frontiersin…

Jul 3, 2021 · 1 share · 1,692 followers View post →
Scott Lear, PhD
@DrScottLear · X

Regular #exercise in older adults at risk for #Alzheimers diseaseimproved biomarker associated with cognition @frontiersin : https://t.co/7QRGMP9tBq #brainhealth https://t.co/gmUCagAyVD

Jul 3, 2021 · 6 likes · 1 share · 3,033 followers View post →
Julia B.
@JuliaB_fitness · X

@foundmyfitness «Metabolomic analysis revealed increased levels of PUFAs (including DHA) & lysophospholipids and reductions in ceramides, sphingo and phospholipids.» https://t.co/G69TyyXz26

Jun 29, 2021 · 10 likes · 2,270 followers View post →
Agingdoc
@agingdoc1 · X

Frontiers | Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease https://t.co/eGdhl5GR3S

Jun 29, 2021 · 6 likes · 41,913 followers View post →
Jamie Adem
@jamie_adem · X

RT @HealthAction_UK: There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's…

Jun 22, 2021 · 4 shares · 1 followers View post →
Maria Garcia
@MariaGa66677203 · X

RT @HealthAction_UK: There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's…

Jun 22, 2021 · 4 shares View post →
Age Watch
@age_watch · X

RT @HealthAction_UK: There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's…

Jun 22, 2021 · 4 shares · 157 followers View post →
Kayhan Nouri
@NouriKayhan · X

RT @HealthAction_UK: There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's…

Jun 22, 2021 · 4 shares · 1 followers View post →
Health Action Research Group
@HealthAction_UK · X

There's increasing evidence that physical activity and exercise training may delay or prevent the onset of Alzheimer's #Alzheimers. Here's the latest study - https://t.co/783RLH04Ok #preventionbeatscure https://t.co/9lxLVoXXO0

Jun 22, 2021 · 5 likes · 4 shares · 302 followers View post →
Se Hoon Choi
@presenilin1 · X

From Dr. Henriette van Praag's lab: myokine Cathepsin B (CTSB) Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease https://t.co/pDLcRTvEWW

Jun 11, 2021 · 1 like · 1,111 followers View post →
metagen human papers
@metagen_human · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease https://t.co/xUrEJUU03h

Jun 11, 2021 · 75 followers View post →
Agingdoc
@agingdoc1 · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease https://t.co/gIULihTPfg @FrontiersIn

Jun 10, 2021 · 3 likes · 41,913 followers View post →
Dr Anthony Martin
@AMAinsight · X

Frontiers | Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease | Endocrinology https://t.co/s94oi0Y0a6

Jun 10, 2021 · 915 followers View post →
Microbiome Papers
@MicrobiomePaper · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease https://t.co/kBcO9QC1Zo https://t.co/x9e8bEHqqw

Jun 7, 2021 · 1 like · 1 share · 7,291 followers View post →
Symbiosis papers
@Symbiosispapers · X

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease https://t.co/s84wWomacb

Jun 7, 2021 · 1,109 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease: Increasing evidence indicates that physical activity and exercise training may delay… https://t.co/wjQKSmvdGu #Endocrinology #Endo

May 20, 2021 · 1 like · 5,041 followers View post →