June 2021 PMID 34112687

Inhibitors of bacterial HS biogenesis targeting antibiotic resistance and tolerance.

Konstantin Shatalin, Ashok Nuthanakanti, Abhishek Kaushik, Dmitry Shishov, Alla Peselis, Ilya Shamovsky, Bibhusita Pani, Mirna Lechpammer, Nikita Vasilyev, Elena Shatalina, Dmitri Rebatchouk, Alexander Mironov, Peter Fedichev, Alexander Serganov, Evgeny Nudler

Mentions

25
Peak: 14 in Jun 2021
across 4 sources since Jun 2021

Extended reach

12,359
potential audience

Total likes

26

Video views

492

Mentions per month

Jun 2021 – Dec 2025

Where it's discussed

  • News15 articles
  • X / Twitter7 posts
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

The digital discussions reflect strong interest and acknowledgment of the research's potential, with phrases like 'new research might have found a way to bust biofilm bacteria' and references to hydrogen sulfide's role in bacterial survival, which underscore curiosity and perceived significance of the findings. Words such as 'promising' and 'enhances the deadly effects' convey optimism, but the tone remains cautious, indicating respect for the scientific advancement without overhyping it.

AgreementModerate agreement

Most discussions agree on the significance of targeting bacterial hydrogen sulfide to combat antibiotic resistance, citing the potential for improving antimicrobial effectiveness.

InterestHigh interest

Posts demonstrate high curiosity, referencing detailed findings like hydrogen sulfide's role in bacterial defenses and the development of inhibitors.

EngagementModerate engagement

The discourse involves some depth, with mentions of the research process, mechanisms, and potential applications, but stops short of critical analysis.

ImpactModerate impact

The discussions recognize the research's importance, highlighting its promise for advancing antibiotic strategies, though they do not depict it as a guaranteed breakthrough.

Abstract in brief

  • The study focuses on combating antibiotic resistance by targeting bacterial hydrogen sulfide (HS) production, which helps bacteria defend against antibiotics.
  • Researchers identified cystathionine lyase CSE as the main enzyme producing HS in two major pathogens and developed small molecules to inhibit this enzyme.
  • These CSE inhibitors enhance the effectiveness of antibiotics, reduce bacterial biofilm formation and tolerance, and decrease persister bacteria, making them promising as adjuvants for antibiotic therapy.]

Top posts

Most liked on X and Bluesky
Meagan Phelan
@MeaganPhelan · X

Targeting hydrogen sulfide production in bacteria enhances the deadly effects of antimicrobials on drug-resistant pathogens, @nyulangone researchers report in @ScienceMagazine. The findings offer promise for developing highly effective #antibiotics https://t.co/c9044btmIA

Jun 10, 2021 · 1 like · 1,963 followers View post →
Rene Sugar
@renesugar · X

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance https://t.co/9xdta829ia

Sep 22, 2024 · 3,989 followers View post →
Rene Sugar
@renesugar · X

Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics https://t.co/QG89HPj8wg "By releasing hydrogen sulfide, bacteria avoid being killed by antibiotics." https://t.co/9xdta8jcka

Jan 7, 2022 · 3,989 followers View post →
pseudomonaspapers
@pseudo_papers · X

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance https://t.co/Y2dZH5gMHw

Jun 11, 2021 · 1,273 followers View post →
VlaDSSvetlov
@DsSvetlov · X

@cshperspectives Kostya isn't 70 yet, but over 60 and works at the bench still, and still has 1st author papers in Science. Shatalin K, et al. Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance. Science. 2021. doi: 10.1126/science.abd8377. PMID: 34112687.

Aug 17, 2023 · 352 followers View post →
Micro Instructor
@CRC_Micro · X

Targeting biofilm bacteria is very tough. New research might have found a way to bust biofilm bacteria: https://t.co/LnTmQ2JYAS

Nov 17, 2021 · 140 followers View post →

All mentions

Rene Sugar
@renesugar · X

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance https://t.co/9xdta829ia

Sep 22, 2024 · 3,989 followers View post →
VlaDSSvetlov
@DsSvetlov · X

@cshperspectives Kostya isn't 70 yet, but over 60 and works at the bench still, and still has 1st author papers in Science. Shatalin K, et al. Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance. Science. 2021. doi: 10.1126/science.abd8377. PMID: 34112687.

Aug 17, 2023 · 352 followers View post →
Rene Sugar
@renesugar · X

Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics https://t.co/QG89HPj8wg "By releasing hydrogen sulfide, bacteria avoid being killed by antibiotics." https://t.co/9xdta8jcka

Jan 7, 2022 · 3,989 followers View post →
Micro Instructor
@CRC_Micro · X

Targeting biofilm bacteria is very tough. New research might have found a way to bust biofilm bacteria: https://t.co/LnTmQ2JYAS

Nov 17, 2021 · 140 followers View post →
Nelson Enrique Arenas Suarez
@NelsonE30507073 · X

Reportes Científicos Semanales Mayo Semana 4, 2021 https://t.co/VVFUg73zIl via @YouTube

Jun 18, 2021 · 1 followers View post →
pseudomonaspapers
@pseudo_papers · X

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance https://t.co/Y2dZH5gMHw

Jun 11, 2021 · 1,273 followers View post →
Meagan Phelan
@MeaganPhelan · X

Targeting hydrogen sulfide production in bacteria enhances the deadly effects of antimicrobials on drug-resistant pathogens, @nyulangone researchers report in @ScienceMagazine. The findings offer promise for developing highly effective #antibiotics https://t.co/c9044btmIA

Jun 10, 2021 · 1 like · 1,963 followers View post →
Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance ...
News

Science. 11 Jun 2021. Vol 372, Issue 6547. pp. 1169-1175. DOI: 10.1126/science.abd8377 · PREVIOUS ARTICLE. Time-resolved structured illumination microscopy ...

Dec 18, 2025 View →
Molecular and Cellular Pathophysiology of the Von Hippel–Lindau ...
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https://www.science.org/doi/abs/10.1126/science.abd8377. Li, Q., Li, D., Zhang, X., Elly, C., Lee, J. H., & Liu, Y.-C. (2018, February 20) ...

Dec 12, 2025 View →
Research about H2S antimicrobial resistance : r/badbreath
Reddit

Here are a few scientific papers. I haven't had a chance to ... H2s production linked to persister cells doi: 10.1126/science.abd8377.

Aug 18, 2024 View →
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... (Science, DOI: 10.1126/science.abd8377). “I happen to have a physics background, and this explains why I am so curious about exploring what ...

Aug 22, 2023 View →
盘点2021年度:人类疾病十九大里程碑- 生物通
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摘要:DOI:10.1126/science.abe0348. 结果: 血液中低密度脂蛋白胆固醇(LDL ... abd8377. 结果: 在6月11日发表在《Science》杂志上的一项研究中 ...

Dec 27, 2021 View →
100个新靶点|介导|免疫|新靶点|肿瘤|靶点_手机网易网
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(推荐阅读:). 里程碑靶点②:B4GALT1. 杂志:Science. 领域:心血管疾病. 论文:DOI:10.1126/science. ... abd8377. 成果:6月11日,发表在Science上的一项研究 ...

Dec 24, 2021 View →
ANTIBIORÉSISTANCE : Sur la piste de l'hydrogène sulfuré | santé log
News

Source: Science 11 Jun 2021 DOI: 10.1126/science.abd8377 Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance.

Jun 24, 2021 View →
Science:釜底抽薪!抑制细菌硫化氢产生可阻止抗生素耐受性和抗 ...
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Science, 2021, doi:10.1126/science.abd8377. Thien-Fah Mah. Giving antibiotics an assist. Science, 2021, doi:10.1126/science.abj3062. 版权 ...

Jun 20, 2021 View →
Blocking bacteria's self-poisoning mechanism weakens their ...
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K Shatalin et al, Science, 2021, DOI: 10.1126/science.abd8377 · Jamie DurraniJamie Durrani is senior science correspondent for Chemistry World.

Jun 17, 2021 View →
This Week in Science | Science
News

Science, abd8377, this issue p. 1169; see ... Share. Copy the article link. https://www.science.org/doi/10.1126/science.2021.372.6547.twis.

Jun 11, 2021 View →
Inhibiting hydrogen sulfide production makes drug-resistant bacteria ...
News

American Association for the Advancement of Science (AAAS). Journal: Science; DOI: 10.1126/science.abd8377. Keywords. /Life sciences/ ...

Jun 10, 2021 View →
Hydrogen sulfide critical to innate ability of bacteria to survive ...
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DOI. 10.1126/science.abd8377. Disclaimer: AAAS and EurekAlert! are not ... 10.1126/science.abd8377. Keywords. /Life sciences/Microbiology ...

Jun 10, 2021 View →
抑制硫化氢生成可令耐药菌对抗生素敏感| EurekAlert!
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American Association for the Advancement of Science (AAAS). Journal: Science; DOI: 10.1126/science.abd8377. Keywords. /Life sciences/ ...

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La inhibición de la producción de sulfuro de hidrógeno hace que las ...
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硫化水素産生を阻害すると薬剤耐性細菌が抗菌薬感受性になる ...
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Researchers Discover Critical Role of Hydrogen Sulfide in Ability of ...
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... Science, 11 June 2021, (DOI is 10.1126/science.abd8377). In one defense mechanism, tolerant bacteria, also called "persisters," stop ...

Jun 10, 2021 View →