PubHawk
July 2020 PMID 34123130

Catalytic three-component C-C bond forming dearomatization of bromoarenes with malonates and diazo compounds.

Hiroki Kato, Itsuki Musha, Masaaki Komatsuda, Kei Muto, Junichiro Yamaguchi

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Mentions

17
Peak: 9 in Aug 2020
across 3 sources since Jul 2020

Extended reach

149,669
potential audience

Total likes

59

Video views

2,415

Mentions per month

Jul 2020 – Aug 2020

Where it's discussed

  • X / Twitter11 posts
  • News5 articles
  • YouTube1 videos

AI synopsis

What people are saying

The collective discussions demonstrate high engagement and interest, with comments highlighting the method’s potential to speed up drug development and improve chemical synthesis. Words like 'promises to accelerate' and 'good job' convey both enthusiasm and appreciation for the research’s significance.

AgreementModerate agreement

Most posts recognize the significance of the new catalytic method, with several expressing congratulations and noting its potential for advancing organic synthesis.

InterestHigh interest

Discussions reflect high interest, especially in the method's applications for drug discovery and chemical synthesis, using enthusiastic language and specific mentions.

EngagementModerate engagement

Posts include references to the publication and related social discussions, showing a moderate level of engagement with the scientific details.

ImpactModerate impact

The emphasis on potential applications, like accelerating drug research, indicates recognition of the method's importance, though some responses are more focused on publication acknowledgment.

Abstract in brief

  • This study reports a new catalytic method using palladium (Pd) to enable a three-component reaction that converts bromoarenes (a type of aromatic compound) into substituted alicyclic (ring-shaped) molecules through dearomatization, involving diazo compounds and malonates.
  • The process involves forming a benzylpalladium intermediate that reacts with malonates to produce a Pdenolate species, allowing the transformation of various bromoarenes, including benzenoids, azines, and heteroles, into complex, multisubstituted alicyclic compounds.
  • This method provides a quick route to create diverse alicyclic structures by modifying the dearomatized products afterward, offering a versatile approach for synthesizing complex molecules in organic chemistry.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Kei Muto
@DJmuto · X

Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dearomatization of Bromoarenes with Malonates and Diazo Compounds https://t.co/G00JiXgXUn

Jul 29, 2020 · 22 likes · 3 shares · 417 followers View post →
Yamaguchi Lab
@jyamaguchilab · X

Our paper just came out in @ChemicalScience Good job Kei, Hiroki, Itsuki, and Masaaki!! :Catalytic Three-component C–C Bond Forming Dearomatization of Bromoarenes with Malonates and Diazo Compounds - now published in Chemical Science https://t.co/ehuAwHLSsx

Jul 29, 2020 · 19 likes · 4 shares · 2,657 followers View post →
Chem-Station
@chemstation · X

スポットライトリサーチムービーの見本です。ベンゼンなどから三次元分子を合成（早大・山口研究室） https://t.co/55rljPstab

Aug 6, 2020 · 3 likes · 32,318 followers View post →
Yamaguchi Lab
@jyamaguchilab · X

ベンゼンなどから三次元分子を合成（早大・山口研究室） https://t.co/CaMb3G3UB8 @YouTubeより

Aug 6, 2020 · 2 likes · 2,657 followers View post →
Indrani
@icu_idcu1994 · X

This new method of producing a specific class of organic compounds, promises to accelerate drug discovery research for several diseases. Read more: https://t.co/CQAUyPoTOZ https://t.co/wm5rOIrux5

Aug 19, 2020 · 1 like · 101 followers View post →
Chemical Science
@ChemicalScience · X

RT @DJmuto: Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dear…

Jul 30, 2020 · 3 shares · 99,403 followers View post →

All mentions

Indrani
@icu_idcu1994 · X

This new method of producing a specific class of organic compounds, promises to accelerate drug discovery research for several diseases. Read more: https://t.co/CQAUyPoTOZ https://t.co/wm5rOIrux5

Aug 19, 2020 · 1 like · 101 followers View post →
Energy Materials
@EnergyMaterial4 · X

Catalytic three-component C–C bond forming dearomatization of bromoarenes with malonates and diazo compounds https://t.co/u95v2W8Jbr https://t.co/3sWyU9lNBO

Aug 7, 2020 · 166 followers View post →
Chem-Station
@chemstation · X

スポットライトリサーチムービーの見本です。ベンゼンなどから三次元分子を合成（早大・山口研究室） https://t.co/55rljPstab

Aug 6, 2020 · 3 likes · 32,318 followers View post →
Yamaguchi Lab
@jyamaguchilab · X

ベンゼンなどから三次元分子を合成（早大・山口研究室） https://t.co/CaMb3G3UB8 @YouTubeより

Aug 6, 2020 · 2 likes · 2,657 followers View post →
うろ
@uro9000 · X

RT @jyamaguchilab: Our paper just came out in @ChemicalScience Good job Kei, Hiroki, Itsuki, and Masaaki!! :Catalytic Three-component C–C B…

Aug 3, 2020 · 4 shares · 1,101 followers View post →
Gabriel Merino
@theochemmerida · X

RT @DJmuto: Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dear…

Jul 30, 2020 · 3 shares · 6,850 followers View post →
K Mitsudo
@kmitsudo · X

RT @DJmuto: Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dear…

Jul 30, 2020 · 3 shares · 1,069 followers View post →
Chemical Science
@ChemicalScience · X

RT @DJmuto: Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dear…

Jul 30, 2020 · 3 shares · 99,403 followers View post →
Kei Muto
@DJmuto · X

RT @jyamaguchilab: Our paper just came out in @ChemicalScience Good job Kei, Hiroki, Itsuki, and Masaaki!! :Catalytic Three-component C–C B…

Jul 29, 2020 · 4 shares · 417 followers View post →
Kei Muto
@DJmuto · X

Our new paper came out! Congrats, Hiroki, Itsuki, and Masaaki. @ChemicalScience Catalytic Three-component C–C Bond Forming Dearomatization of Bromoarenes with Malonates and Diazo Compounds https://t.co/G00JiXgXUn

Jul 29, 2020 · 22 likes · 3 shares · 417 followers View post →
Yamaguchi Lab
@jyamaguchilab · X

Our paper just came out in @ChemicalScience Good job Kei, Hiroki, Itsuki, and Masaaki!! :Catalytic Three-component C–C Bond Forming Dearomatization of Bromoarenes with Malonates and Diazo Compounds - now published in Chemical Science https://t.co/ehuAwHLSsx

Jul 29, 2020 · 19 likes · 4 shares · 2,657 followers View post →
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