ACS Nano August 2021 PMID 34142817

Highly Efficient Transfection of Human Primary T Lymphocytes Using Droplet-Enabled Mechanoporation.

Byeongju Joo, Jeongsoo Hur, Gi-Beom Kim, Seung Gyu Yun, Aram J Chung

Mentions

27
Peak: 20 in Jun 2021
across 2 sources since Jun 2021

Extended reach

37,028
potential audience

Total likes

78

Video views

216

Mentions per month

Jun 2021 – Aug 2021

Where it's discussed

  • X / Twitter24 posts
  • YouTube3 videos

AI synopsis

What people are saying

Discussions underscore the novelty of droplet microfluidics combined with mechanoporation, with many posts describing the method as a 'game changer' for cell therapies. The tone is enthusiastic, with phrases like 'excited to share' and mentions of improved efficiency and scalability indicating strong interest and perceived high impact, although engagement remains somewhat focused on overviews rather than deep technical analysis.

AgreementModerate agreement

Most discussions express positive support and enthusiasm for the research, highlighting its innovation and potential benefits.

InterestHigh interest

Posts show high interest, emphasizing new methods and technological advances in cell transfection.

EngagementModerate engagement

Some comments discuss the methodology and implications, indicating a moderate level of detailed engagement.

ImpactModerate impact

Several posts suggest this research could significantly influence future cellular engineering practices, though some focus on its potential rather than definitive impacts.

Abstract in brief

  • This study introduces a new method for efficiently delivering genetic material into human primary T cells using droplet microfluidics combined with cell mechanoporation, which mechanically permeabilizes cell membranes as cells pass through narrow channels.
  • The approach reduces the amount of cargo needed, minimizes clogging issues, maintains high cell viability, and achieves better delivery efficiency compared to traditional techniques like viral vectors and electroporation.
  • Overall, this droplet-enabled mechanoporation method offers a scalable, cost-effective, and less cytotoxic way to modify cells, with potential applications in cell therapy and genetic engineering.

Top posts

Most liked on X and Bluesky
Aram Chung
@ac467 · X

Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechanoporation to bring intracellular delivery to the next level. Great job, Byeongju Joo! https://t.co/CDxXSrWVc9

Jun 21, 2021 · 50 likes · 15 shares · 243 followers View post →
Aram Chung
@ac467 · X

new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 24, 2021 · 16 likes · 3 shares · 243 followers View post →
Bioconjugate Chem
@BioconjChem · X

Transfection/electroporation are the current standards for modifying/loading #immune cells for #whole #cell therapy. Read in @acsnano how @ac467 et al new technique of #droplet-enabled #mechanoporation has high cargo #delivery and #scalability! https://t.co/MmhIQFj3He

Jun 25, 2021 · 8 likes · 4 shares · 4,005 followers View post →
ACS for Authors
@ACS4Authors · X

RT @ac467: new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 25, 2021 · 3 shares · 8,012 followers View post →
The Single-Cell Ninjas
@Sc_Ninjas · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 6,295 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 2,023 followers View post →

All mentions

ACS for Authors
@ACS4Authors · X

RT @ac467: new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 25, 2021 · 3 shares · 8,012 followers View post →
Amos Chungwon Lee
@ChoongwonLee · X

RT @ac467: new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 24, 2021 · 3 shares · 1,380 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 24, 2021 · 3 shares · 2,023 followers View post →
Aram Chung
@ac467 · X

new #ACSNano journal cover! #MyACSCover @ACS4Authors https://t.co/UDCtBA7U0Z https://t.co/0PuX1pOFrk

Aug 24, 2021 · 16 likes · 3 shares · 243 followers View post →
Sajad Razavi Bazaz
@Sajad_Rzv_Bazaz · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 30, 2021 · 15 shares · 530 followers View post →
Aram Chung
@ac467 · X

RT @BioconjChem: Transfection/electroporation are the current standards for modifying/loading #immune cells for #whole #cell therapy. Read…

Jun 25, 2021 · 4 shares · 243 followers View post →
Chiad Onyeje
@Chiad17 · X

RT @BioconjChem: Transfection/electroporation are the current standards for modifying/loading #immune cells for #whole #cell therapy. Read…

Jun 25, 2021 · 4 shares · 2 followers View post →
Gary Beane
@pollinus66 · X

RT @BioconjChem: Transfection/electroporation are the current standards for modifying/loading #immune cells for #whole #cell therapy. Read…

Jun 25, 2021 · 4 shares · 2,023 followers View post →
Bioconjugate Chem
@BioconjChem · X

Transfection/electroporation are the current standards for modifying/loading #immune cells for #whole #cell therapy. Read in @acsnano how @ac467 et al new technique of #droplet-enabled #mechanoporation has high cargo #delivery and #scalability! https://t.co/MmhIQFj3He

Jun 25, 2021 · 8 likes · 4 shares · 4,005 followers View post →
Dorsa M Rad
@rad_dorsa · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 23, 2021 · 15 shares · 459 followers View post →
LP Vaccine
@LP_Vaccine · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 23, 2021 · 15 shares · 475 followers View post →
NK Escareño
@NKcellMX · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 705 followers View post →
Toyota_Group_Komaba
@KomaToug · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 667 followers View post →
Dr. Neha Saini
@neha_scnn · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 249 followers View post →
Cecilia Wetzl
@cecilia_wetzl · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 262 followers View post →
at
@Qat00 · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 1,042 followers View post →
The Single-Cell Ninjas
@Sc_Ninjas · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 22, 2021 · 15 shares · 6,295 followers View post →
Yanxiang Deng
@DengYanxiang · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 1,247 followers View post →
Ilya Korsunsky
@ilyakorsunsky · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 733 followers View post →
Jeffrey E. Dick
@Jeffrey_E_Dick · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 1,338 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 2,023 followers View post →
Shingo Honda (本田 信吾)
@akg_entrance · X

RT @ac467: Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechan…

Jun 21, 2021 · 15 shares · 1,552 followers View post →
Aram Chung
@ac467 · X

Excited to share our new work published in @acsnano! We demonstrated how droplet microfluidics can be leveraged with cell mechanoporation to bring intracellular delivery to the next level. Great job, Byeongju Joo! https://t.co/CDxXSrWVc9

Jun 21, 2021 · 50 likes · 15 shares · 243 followers View post →
MyJournals
@myjournals · X

[ASAP] Highly Efficient Transfection of Human Primary T Lymphocytes Using Droplet-Enabled Mechanoporation https://t.co/ixCEM3QI1F

Jun 18, 2021 · 556 followers View post →